Classification and analysis of measuring transducers of intensity (induction) of alternating magnetic fields

The current state of technology is characterized by the mass use of electricity, the use of various electrical, electronic and radio devices. This causes expansion of magnetic measurements and the need to develop new highly sensitive measuring equipment for a wide range of frequencies. One of its main elements, that largely determines the accuracy, frequency and dynamic ranges, are the primary measuring sensors of strength (induction) of alternating magnetic fields. Many works have been devoted to the analysis and development of various sensors of strength (induction) of magnetic fields. At the same time, it can be noted the lack of a systematic approach to the measurement of alternating magnetic fields. The problem of the general classification of methods of measurement of alternating magnetic fields and, accordingly, primary measuring sensors of strength (induction) of alternating magnetic fields is not solved. In most cases, separate issues of measuring alternating magnetic fields and certain types of sensors are considered. That does not allow obtaining a holistic picture in this area and make the right choice of direction for solving assigned tasks. The comprehensive analysis of methods of measuring alternating magnetic fields was carried out in this work. Based on it, the classification of primary measuring sensors of strength (induction) of alternating magnetic fields, on the physical principles of transformation was proposed. Accordingly, the available measuring sensors of alternating magnetic fields following to the group of used physical phenomena can be divided into: magnetomechanical, induction, galvanomagnetic, quantum, magneto-optical and photomagnetic. Depending on the characteristics of each of these phenomena, separate measurement methods and types of measuring sensors were highlighted. The current state of development of each of the types of measuring sensors of strength of alternating magnetic fields was analyzed, their advantages and disadvantages were determined, the limits of dynamic and frequency ranges, the maximum values of errors were outlined. The obtained results allow to significantly simplify and reduce the time of choosing the necessary method of strength (induction) of alternating magnetic fields measuring and to choose the necessary type of measuring sensor to effectively solve the tasks.

Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis

Electrospun polycaprolactone nanofibers with embedded magnetic nanoparticles were developed for use in the topical delivery of antipsoriatic drugs. To test a hydrophobic drug, a tazarotene has been used, which is an efficient retinoid derivative. Such a smart hyperthermia nanofiber system with self-generated heat from the incorporated magnetic nanoparticles induced drug release in response to on–off switching of alternating magnetic fields for the delivery of tazarotene through the skin, as quantified using Franz cells. This highly efficient external field-controllable system with minimal skin irritation could create a new avenue for the topical therapy of psoriasis.

Physical model for effects of microwaves on nucleoids in living cells: role of carrier frequency, modulation and DC and AC magnetic field

The effect of static and alternating magnetic fields on the conformation of nucleoids in cells of different types is considered. The model of slow and nonuniform rotation of the charged DNA domain is used. An equation is obtained for the resonance frequencies of the alternating magnetic field.

Calculation Method of Allowable Continuous Current for Direct Burial Laying HVDC Underground Cable

The calculation of the continuous allowable current of an underground cable is determined by various characteristics. To calculate the allowable current in cables with alternating magnetic fields such as AC, special phenomena such as the proximity effect and skin effect must be applied. However, there are no standards or research related to the calculation of the continuous allowable current of a DC power cable that does not have an alternating magnetic field. In this paper, a quantitative DC cable continuous allowable current calculation formula of direct burial laying was derived by applying the existing AC cable continuous allowable current calculation method to the DC system. We developed a calculation tool that can calculate the continuous allowable current of DC cables using the derived formula. Assuming the cable conditions (cable specification, laying conditions, soil characteristics, arrangement, and number of strands, etc.), a continuous allowable current simulation of DC cables was performed. In addition, the level of contribution to the continuous allowable current value was analyzed by classifying the parameter categories into major and minor factors in the order of influence on the allowable current among the determined calculated parameters. As a result, the effectiveness of the DC cable continuous allowable current calculation tool derived by performing the allowable current calculation simulation was evaluated, and the allowable current calculation method of the HVDC cable was established.

Alternating magnetic fields and antibiotics eradicate biofilm on metal in a synergistic fashion

Hundreds of thousands of human implant procedures require surgical revision each year due to infection. Infections are difficult to treat with conventional antibiotics due to the formation of biofilm on the implant surface. We have developed a noninvasive method to eliminate biofilm on metal implants using heat generated by intermittent alternating magnetic fields (iAMF). Here, we demonstrate that heat and antibiotics are synergistic in biofilm elimination. For Pseudomonas aeruginosa biofilm, bacterial burden was reduced >3 log with iAMF and ciprofloxacin after 24 h compared with either treatment alone (p < 0.0001). This effect was not limited by pathogen or antibiotic as similar biofilm reductions were seen with iAMF and either linezolid or ceftriaxone in Staphylococcus aureus. iAMF and antibiotic efficacy was seen across various iAMF settings, including different iAMF target temperatures, dose durations, and dosing intervals. Initial mechanistic studies revealed membrane disruption as one factor important for AMF enhanced antibacterial activity in the biofilm setting. This study demonstrates the potential of utilizing a noninvasive approach to reduce biofilm off of metallic implants.

The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields

Superparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host the unstable and water-insoluble quercetin as well as deliver and localize quercetin directly to the desired site. The chemical and physical properties were validated by X-ray powder diffraction (XRPD), field emission scanning electron microscopy (FE–SEM), atomic force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, FTIR spectroscopy and dynamic light scattering (DLS). The kinetics of in vitro quercetin release from MNPs followed by UV/VIS spectroscopy was controlled by employing combined stationary and alternating magnetic fields. The obtained results have shown an increased response of quercetin from superparamagnetic MNPs under a lower stationary magnetic field and s higher frequency of alternating magnetic field. The achieved findings suggested that we designed promising targeted quercetin delivery with fine-tuning drug release from magnetic MNPs.

Superparamagnetic Fe/Au Nanoparticles and Their Feasibility for Magnetic Hyperthermia

Today, magnetic hyperthermia constitutes a complementary way to cancer treatment. This article reports a promising aspect of magnetic hyperthermia addressing superparamagnetic and highly Fe/Au core-shell nanoparticles. Those nanoparticles were prepared using a wet chemical approach at room temperature. We found that the as-synthesized core shells assembled with spherical morphology, including face-centered-cubic Fe cores coated and Au shells. The high-resolution transmission microscope images (HRTEM) revealed the formation of Fe/Au core/shell nanoparticles. The magnetic properties of the samples showed hysteresis loops with coercivity (HC) close to zero, revealing superparamagnetic-like behavior at room temperature. The saturation magnetization (MS) has the value of 165 emu/g for the as-synthesized sample with a Fe:Au ratio of 2:1. We also studied the feasibility of those core-shell particles for magnetic hyperthermia using different frequencies and different applied alternating magnetic fields. The Fe/Au core-shell nanoparticles achieved a specific absorption rate of 50 W/g under applied alternating magnetic field with amplitude 400 Oe and 304 kHz frequency. Based on our findings, the samples can be used as a promising candidate for magnetic hyperthermia for cancer therapy.