scholarly journals Fabrication of Substituted-Hydroxyapatite/Poly(vinyl pyrrolidone)- Poly(methyl methacrylate) Biocomposites for Bone Tissue Engineering Applications

2021 ◽  
Vol 33 (11) ◽  
pp. 2774-2780
Author(s):  
G. Priya ◽  
N. Vijayakumari

Present work based on the development and incorporation of zinc-cerium substituted hydroxyapatite (ZCHA) nanoparticles into the host material of the dual polymer blend of poly(vinyl pyrrolidone) (PVD)-poly(methyl methacrylate) (PMMA). Numerous characterization techniques such as FTIR, XRD and SEM-EDX have been used in morphological and structural investigations of prepared nanoparticles and ZCHA reinforced PMMA-PVD biocomposites. The mechanical properties of ZCHA/PVD-PMMA biocomposites, like compressive strength was evaluated. To examine the biocompatibility of biocomposites, hemocompatibility experiments have been carried out. The antimicrobial activities of biocomposites toward Gram-positive and Gram-negative bacteria have also been tested and the cytotoxic existence of biocomposites has been evaluated using the MTT assay experiment. The developed ZCHA/PVD-PMMA biocomposites is suggested to provide the finest medicinal benefits in the application of biomaterials.

2008 ◽  
Vol 396-398 ◽  
pp. 493-496
Author(s):  
D. Ionita ◽  
G. Tihan ◽  
A.T. Marques

The purpose of this study is the obtaining of different orthopedic materials and chemical and mechanical characterization. The chemical tests used were setting time, water absorption and from the point of view of mechanical properties the Young modulus, compressive strength, and maximum strength. Also, the surface of orthopedic bioceramics materials was characterized by porosity test.


2006 ◽  
Vol 60 (11-12) ◽  
pp. 327-332 ◽  
Author(s):  
Ljubisa Nikolic ◽  
Vesna Nikolic ◽  
Miroslav Stankovic ◽  
Zoran Todorovic ◽  
Zorica Vukovic

The characteristics of two types of porous polymers: poly(methyl methacrylate) and copolymers of methyl methacrylate and acrylamide were investigated in this study. Poly(methyl methacrylate) was synthesized in suspension, using ethylene glycol dimethacrylate as the cross-linking agent, poly(vinyl pyrrolidone) as the protective colloid, and benzoyl peroxide as the initiator. The synthesis of poly(methyl methacrylate-co-acrylamide) was initiated in emulsion in the presence of dioctyl sulfosuccinate sodium salt, followed by a sol-gel process, and completely reacted to the solid state. Potassium persulfate was used as the initiator, and tetramethylol glycoluril as the cross-linking agent. Both types of syntheses were carried out in the presence of ethyl acetate. The porosity, specific surface and distribution of the pore sizes of the obtained polymers were determined by mercury porosimetry. The polymers were used as inert carriers for the immobilization of enzymes and whole cells of Saccharomyces cerevisiae yeast.


2021 ◽  
Vol 36 (2) ◽  
pp. 93-110
Author(s):  
Princy Philip ◽  
Tomlal Jose ◽  
Sarath KS ◽  
Sunny Kuriakose

Silver nanoparticles with 5–10 nm diameters are synthesised using Couroupita guianensis flower extract. The synthesised silver nanoparticles found to show good antimicrobial activity against gram negative and gram positive bacteria. Poly(methyl methacrylate) nanofibers with pristine, surface roughened and coaxial hollow forms are prepared by electrospinning. The structural and morphological properties of these pure and structurally modified poly(methyl methacrylate) nanofibers are evidenced by various analytical techniques. The antimicrobial studies of poly(methyl methacrylate) nanofibers having different architectures incorporated with silver nanoparticles are carried out. It is found that, all the three forms of poly(methyl methacrylate) nanofibers incorporated with silver nanoparticles show antibacterial properties against both gram positive and gram negative bacteria. Among these, surface roughened poly(methyl methacrylate) nanofibers incorporated with silver nanoparticles show highest antibacterial activity than the other two structural forms. The present study offers an alternative to the existing optical lenses. People especially those who suffer from eye problems can protect their eyes in a better way from infectious agents by wearing optical lens made from C. guianensis stabilised silver nanoparticles incorporated poly(methyl methacrylate) nanofibers than that made from pure poly(methyl methacrylate) nanofibers or films.


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