Synthesis and Biological Activity of Some Thiosemicarbazide

2019 ◽  
Vol 4 (4) ◽  
pp. 228-231
Author(s):  
Rohit R. Wakodkar ◽  
Mazahar Farooqui ◽  
Pravin Kulkarni ◽  
Deepak D. Kayande
Keyword(s):  
Biological Activity ◽  
Sodium Chloride ◽  
Antifungal Activity ◽  
13C Nmr ◽  
Fungal Pathogens ◽  
Aqueous Ethanol ◽  
Antibacterial And Antifungal Activity ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal

In this paper, thiosemicarbazone derivatives have been prepared from substituted aromatic aldehyde and thiosemicarbazide in presence of sodium chloride. This method is an efficient, mild, inexpensive, non-toxic and environment benign catalyst. This protocol includes the reaction followed by using sodium chloride to accelerate the reaction in aqueous ethanol. The structure of synthesized compounds were determined by IR, 1H NMR, 13C NMR and mass spectroscopies as well as the compounds were also screened for antibacterial and antifungal activity against certain Gram-negative and Gram-positive bacteria and fungal pathogens.

Val-Geninthiocin: Structure Elucidation and MSn Fragmentation of Thiopeptide Antibiotics Produced by Streptomyces sp. RSF18

2008 ◽  
Vol 63 (10) ◽  
pp. 1223-1230 ◽  
Author(s):  
Imran Sajid ◽  
Khaled A. Shaaban ◽  
Holm Frauendorf ◽  
Shahida Hasnain ◽  
Hartmut Laatscha
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Structure Elucidation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Unusual Amino Acids ◽  
Streptomyces Sp ◽  
Gram Positive Bacteria ◽  
Thiopeptide Antibiotics

AbstractVal-Geninthiocin (2), a new member of thiopeptide antibiotics, was isolated from the mycelium of Streptomyces sp. RSF18, along with the closely related geninthiocin (1) and the macrolide, chalcomycin. By intensive NMR and MS studies, Val-geninthiocin (2) was identified as desoxygeninthiocin, a thiopeptide, containing several oxazole and thiazole units and a number of unusual amino acids. Compound 2 shows potent activity against Gram-positive bacteria and minor antifungal activity, while it is not effective against Gram-negative bacteria or microalgae. Here we describe the fermentation, isolation and structure elucidation as well as the biological activity of 2.

scholarly journals Antibacterial and Antifungal Activity of Zinc(II) Carboxylates With/Without N-Donor Organic Ligands

2002 ◽  
Vol 8 (5) ◽  
pp. 269-274 ◽  
Author(s):  
V. Zelenák ◽  
K. Györyová ◽  
D. Mlynarcík
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Organic Ligands ◽  
Antibacterial And Antifungal Activity ◽  
Bacterial Strains ◽  
Structural Types ◽  
Antibacterial And Antifungal

The antibacterial and antifungal activity of zinc(II) carboxylates with composition Zn(RCOO)2•nH2O(R =H-, CH3− , CH3CH2CH2- , (CH3)2CH- , XCH2- , X=Cl, Br, I, n=0 or 2), [ZnX2(Nia+CH2COO-)2] (Nia=nicotinamide, X=Cl, Br, I) and [Zn(XCH2COO)2(Caf)2]•2H2O (Car=caffeine, X=Cl, Br) is studied against bacterial strains Staphylococcus aureus, Escherichia coli and yeast Candida albicans. The structural types are assigned to the prepared compounds and the influence of (i) carboxylate chain length, (ii) substitution of hydrogen atom of carboxylate by halogen and (iii) presence of N-donor organic ligands on the biological activity is discussed.

scholarly journals Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid

2008 ◽  
Vol 5 (4) ◽  
pp. 963-968 ◽  
Author(s):  
Sabir Hussain ◽  
Jyoti Sharma ◽  
Mohd Amir
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Activities ◽  
Hydroxybenzoic Acid ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Gram Negative ◽  
Thiadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of

Various 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and evaluated for their antibacterial and antifungal activity. The compounds showed significant antibacterial activity againstS. aureus(gram-positive) andE.coli(gram-negative) bacteria and antifungal activity againstA. nigerfungi using cup plate technique

scholarly journals Synthesis and studies of the biological activity of novel pyrimido fused acridine derivatives

2006 ◽  
Vol 71 (10) ◽  
pp. 1015-1023 ◽  
Author(s):  
Bhavesh Patel ◽  
Ranjan Patel ◽  
Manish Patel
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Potassium Carbonate ◽  
Anthranilic Acid ◽  
Phosphorus Oxychloride ◽  
Type Ii ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

Anthranilic acid was reacted with various substituted 6-bromoquinazolinones in the presence of Cu-powder and anhydrous potassium carbonate in DMF to give acid intermediates (Ullmann Type-II condensation). All these acids were then cyclized in phosphorus oxychloride to give 11-chloropyrimido[4,5-b]acridin-4(3H)-ones. All the synthesized compounds were identified by conventional methods (1H-NMR, IR, elemental analysis) and were screened for their antimicrobial activity on some bacterial and fungal cultures. The results were compared with standard bactericides and fungicides. All the synthesized compounds exhibited moderate antibacterial and antifungal activity. .

scholarly journals Synthesis, Characterization of Biologically Potent Novel Chalcones Bearing Urea, Thiourea and Acetamide Linkages

2014 ◽  
Vol 36 ◽  
pp. 281-294
Author(s):  
Nirali S. Mewada ◽  
Dhruvin R. Shah ◽  
Kishor H. Chikhalia
Keyword(s):  
Antifungal Activity ◽  
Dilution Method ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antibacterial And Antifungal ◽  
Antimicrobial And Antifungal Activities

Three series of some novel chalcone based urea, thiourea and acetamide derivatives were designed, synthesized and screened for their antimicrobial and antifungal activities. All the synthesized compounds are first reported. The structures of the compounds were elucidated with the aid of elemental analysis and spectral methods including IR, 1H-NMR spectral data. The prepared compounds were evaluated for antibacterial activity against two Gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus), two Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also investigated for their antifungal activity using the broth micro dilution method. The bioassay results showed that compounds a few compounds showed good to superior in vitro antibacterial and antifungal activity.

Design, Synthesis and Antimicrobial Activity of Some Triazine Chalcone Derivatives

2021 ◽  
Vol 18 (4) ◽  
pp. 332-338
Author(s):  
Ravindra Sandipan Shinde ◽  
Satish Ashruba Dake ◽  
Rajendra Pundalikrao Pawar
Keyword(s):  
Escherichia Coli ◽  
Candida Glabrata ◽  
Gram Negative Bacteria ◽  
Antibacterial And Antifungal Activity ◽  
Design Synthesis ◽  
Gram Negative ◽  
Chalcone Derivatives ◽  
Gram Positive Bacteria ◽  
Target Molecules ◽  
Antibacterial And Antifungal

Background: A series of Triazine Chalcone derivatives were synthesized by the condensation of 1-(4-((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)phenyl)ethanone with substituted benzaldehyde in methanol solvent. Methods: All the synthesized derivatives (3a-l) were screened for their anti-bacterial evaluation against Gram negative bacteria Escherichia coli (NCIM 2137) and Pseudomonas aeruginosa (NCIM 2036); Gram positive bacteria Staphylococcus aureus, Bacillus subtilis (NCIM 2250) and four fungal stains. Candida albicans (MTCC 227), Aspergillus niger (NCIM 545), Candida tropicalis (NCIM 3110) and Candida glabrata (NCIM 3236). Results and Conclusion: Several target molecules throughout the series showed good antibacterial and antifungal activity against tested stains.

scholarly journals Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety

2020 ◽  
Vol 67 (4) ◽  
pp. 1024-1034
Author(s):  
Elsherbiny Hamdy El-Sayed ◽  
Ahmed Ali Fadda ◽  
Ahmed Mohamed El-Saadaney
Keyword(s):  
Antifungal Activity ◽  
13C Nmr ◽  
Spectroscopic Data ◽  
Antibacterial And Antifungal Activity ◽  
Pyrimidine Derivatives ◽  
1H And 13C Nmr ◽  
Triazine Derivatives ◽  
Bifunctional Nucleophiles ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

A number of important fused heterocyclic systems have been prepared by the reaction of 4-((3,5-diamino-1H-pyrazol-4-yl)-diazenyl)-N-(thiazol-2-yl)-benzenesulfonamide with some bifunctional nucleophiles such as ethyl acetoacetate, acetylacetone or arylidenemalonononitrile derivatives to obtain pyrazolo[1,5-a]pyrimidine derivatives. The structures of the newly synthesized compounds were determined based on their IR, 1H and 13C NMR and mass spectroscopic data. Most of the compounds produced showed good antibacterial and antifungal activity

scholarly journals Comparative Study of Antimicrobial and Staining Activity of Selected Anthraquinone Dyes

2019 ◽  
Vol 62 (2) ◽  
pp. 92-97
Author(s):  
Olufunmilayo Adeola Ajayi ◽  
Gabriel Ademola Olatunji
Keyword(s):  
Biological Activity ◽  
Antifungal Activity ◽  
Cell Walls ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activity ◽  
Anthraquinone Dye ◽  
Anthraquinone Dyes ◽  
Fungal Identification ◽  
Mechanism Of Reaction ◽  
Antibacterial And Antifungal

The staining activity of twelve (12) anthraquinone dye derivatives was carried out to investigate the potential of the compounds as staining agents. The reactions of the compounds on organism cell walls were determined, and a comparison was drawn between the mechanism of action of the compounds against established mechanism of reaction of standard dyes used in biological staining. These compounds are BRAM/acetylated PPD, BRAM/PAP/p-TsCl, BRAM/Biaryl/PAP and BRAM/BzCl/PAP, BRAM/aniline, BRAM/o-toluidine, BRAM/p-toluidine, BRAM/m-toluidine, BRAM/p-anisidine, BRAM/m-anisidine, BRAM/PAP, and BRAM/p-iodoaniline. The antibacterial and antifungal activity of these compounds was determined. BRAM/BzCl/PAP exhibited higher biological activity on the bacterial types than most of the controls. From the results of the antifungal test, BRAM/m-toluidine and BRAM/acetylated PPD indicated very significant activity as much as the controls. The staining tests carried out on the compounds show that they are viable alternatives to existing dyes currently used in bacterial and fungal identification.

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