scholarly journals Synthesis and studies of the biological activity of novel pyrimido fused acridine derivatives

2006 ◽  
Vol 71 (10) ◽  
pp. 1015-1023 ◽  
Author(s):  
Bhavesh Patel ◽  
Ranjan Patel ◽  
Manish Patel
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Potassium Carbonate ◽  
Anthranilic Acid ◽  
Phosphorus Oxychloride ◽  
Type Ii ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

Anthranilic acid was reacted with various substituted 6-bromoquinazolinones in the presence of Cu-powder and anhydrous potassium carbonate in DMF to give acid intermediates (Ullmann Type-II condensation). All these acids were then cyclized in phosphorus oxychloride to give 11-chloropyrimido[4,5-b]acridin-4(3H)-ones. All the synthesized compounds were identified by conventional methods (1H-NMR, IR, elemental analysis) and were screened for their antimicrobial activity on some bacterial and fungal cultures. The results were compared with standard bactericides and fungicides. All the synthesized compounds exhibited moderate antibacterial and antifungal activity. .

scholarly journals Antibacterial and Antifungal Activity of Zinc(II) Carboxylates With/Without N-Donor Organic Ligands

2002 ◽  
Vol 8 (5) ◽  
pp. 269-274 ◽  
Author(s):  
V. Zelenák ◽  
K. Györyová ◽  
D. Mlynarcík
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Organic Ligands ◽  
Antibacterial And Antifungal Activity ◽  
Bacterial Strains ◽  
Structural Types ◽  
Antibacterial And Antifungal

The antibacterial and antifungal activity of zinc(II) carboxylates with composition Zn(RCOO)2•nH2O(R =H-, CH3− , CH3CH2CH2- , (CH3)2CH- , XCH2- , X=Cl, Br, I, n=0 or 2), [ZnX2(Nia+CH2COO-)2] (Nia=nicotinamide, X=Cl, Br, I) and [Zn(XCH2COO)2(Caf)2]•2H2O (Car=caffeine, X=Cl, Br) is studied against bacterial strains Staphylococcus aureus, Escherichia coli and yeast Candida albicans. The structural types are assigned to the prepared compounds and the influence of (i) carboxylate chain length, (ii) substitution of hydrogen atom of carboxylate by halogen and (iii) presence of N-donor organic ligands on the biological activity is discussed.

scholarly journals Studies on NovelN4-[4,6-Diaryl-2-pyrimidinyl]-7-chloro-4-quinolinamine and their Microbicidal Efficacy

2009 ◽  
Vol 6 (s1) ◽  
pp. S406-S412 ◽  
Author(s):  
Arvind G. Mehta ◽  
Avnish A. Patel
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
Guanidine Nitrate ◽  
Aryl Aldehyde ◽  
Antibacterial And Antifungal

The required chalcones1a-hwere prepared by reaction of substituted acetophenone with different aryl aldehyde, which in turn treated with guanidine nitrate, yielded 4-(substituted phenyl)-6-(substituted phenyl)-2-pyrimidinamine2a-h. Novel pyrimidine quinoline clubbed molecules3a-hhave been prepared by reaction of2a-hwith 4,7-dichloroquinoline. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

scholarly journals Synthesis , spectroscopic characterization and biological study of some new Schiff bases based on 2-hydroxybenzadehyde

2017 ◽  
Vol 13 (2) ◽  
pp. 5995-6005
Author(s):  
S. Abdelnabi ◽  
Chasib K. Bkhakh ◽  
Mouayed Y. Kadhum
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Schiff Bases ◽  
Aromatic Amines ◽  
Spectroscopic Characterization ◽  
Biological Study ◽  
Antibacterial And Antifungal Activity ◽  
Element Analysis ◽  
Antibacterial And Antifungal

Four new Schiff bases were synthesized from condensation of aldehyde ( 2-hydroxy benzaldehyde ) with aromatic amines (4-introaniline ; 4,4-oxydianiline ; 4,4-diaminodipleny sulfone and sulfanilamide) . These Schiff bases were characterized by IR, NMR , GC. mass and element analysis. Moreover, the Schiff bases were screened for their antibacterial and antifungal activity against various microorganisms and compared with standard compounds. In general , the results were indicated that some Schiff bases had good antimicrobial activity.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5-[1(H)-Benzotriazole methylene]-8-quinolinol

2009 ◽  
Vol 6 (2) ◽  
pp. 371-376 ◽  
Author(s):  
H. S. Patel ◽  
K. K. Oza
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Properties ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Potassium Carbonate ◽  
Antifungal Agents ◽  
Metal Chelates ◽  
Spectral Studies ◽  
Transition Metal Chelates ◽  
Metal Ligand

5-Chloromethyl-8-quinolinol was condensed stoichiometrically with benzotriazole in presence of potassium carbonate. The resulting 5-[1(H)-benzo triazole methylene]-8-quinolinol (BTMQ) was characterized by elemental analysis and spectral studies. The transition metal chelatesviz. Cu2+, Ni2+, Co3+, Mn2+and Zn2+of BTMQ were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectral studies and magnetic properties. The antifungal activity of BTMQ and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents.

scholarly journals Synthesis and Antimicrobial Activity of 7-Hydroxy-3',4'-Methylenedioxy- and 7-Benzyloxy-3',4'-Methylenedioxy Flavanones

2017 ◽  
Vol 9 (3) ◽  
pp. 297-306 ◽  
Author(s):  
R. Ali ◽  
A. Rahim ◽  
A. Islam
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
The Other ◽  
Antifungal Activities ◽  
Fungal Strains ◽  
Antibacterial And Antifungal Activities ◽  
Other Hand ◽  
Antibacterial And Antifungal

7-Hydroxy-3',4'-methylenedioxy- and 7-benzyloxy-3',4'-methylenedioxy flavanones have been synthesized starting from 2,4-dihydroxyacetophenone. Subsequently biocidal activities of the flavanones have been investigated along with their corresponding chalcones against some bacterial and fungal strains. 2'-Hydroxy-4'-benzyloxy-3,4-methylenedioxy chalcone (5) and its corresponding flavanone (7) showed good antibacterial and antifungal activities against some selected bacterial and fungal strains. On the other hand, 2',4'-dihydroxy-3,4-methylenedioxy chalcone (4) showed no antibacterial and antifungal activities while its corresponding flavanone (6) showed a little antibacterial activity only at higher concentration but did not show antifungal activity. The synthesized chalcones and flavanones have been characterized using UV-Vis, IR and 1H NMRspectral data together with elemental analysis.

Bioactive Chemical Constituents and Comparative Antimicrobial Activity of Callus Culture and Adult Plant Extracts from Alternanthera tenella

2009 ◽  
Vol 64 (5-6) ◽  
pp. 373-381 ◽  
Author(s):  
Marcos J. Salvador ◽  
Paulo S. Pereira ◽  
Suzelei C. França ◽  
Regina C. Candido ◽  
Izabel Y. Ito ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Callus Culture ◽  
Culture Media ◽  
Chemical Constituents ◽  
Adult Plant ◽  
Antibacterial And Antifungal Activity ◽  
Crude Extracts ◽  
Antibacterial And Antifungal ◽  
Adult Plants

Crude extracts of a callus culture (two culture media) and adult plants (two collections) from Alternanthera tenella Colla (Amaranthaceae) were evaluated for their antibacterial and antifungal activity, in order to investigate the maintenance of antimicrobial activity of the extracts obtained from plants in vivo and in vitro. The antibacterial and antifungal activity was determined against thirty strains of microorganisms including Gram-positive and Gram-negative bacteria, yeasts and dermatophytes. Ethanolic and hexanic extracts of adult plants collected during the same period of the years 1997 and 2002 [Ribeirão Preto (SP), collections 1 and 2] and obtained from plant cell callus culture in two different hormonal media (AtT43 and AtT11) inhibited the growth of bacteria, yeasts and dermatophytes with inhibition halos between 6 and 20 mm. For the crude extracts of adult plants bioassay-guided fractionation, purification, and isolation were performed by chromatographic methods, and the structures of the isolated compounds were established by analysis of chemical and spectral evidences (UV, IR, NMR and ES-MS). Steroids, saponins and flavonoids (aglycones and C-glycosides) were isolated. The minimum inhibitory concentration (MIC) of the isolated compounds varied from 50 to 500 μg/mL

scholarly journals Synthesis and Studies of Novel Optically Active Schiff’s Base Derivatives and their Antimicrobial Activities

2010 ◽  
Vol 7 (2) ◽  
pp. 617-623 ◽  
Author(s):  
Ishwar J. Patel ◽  
Shailesh J. Parmar
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
Acid Catalyst ◽  
Antimicrobial Activities ◽  
Optically Active ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Base ◽  
Antibacterial And Antifungal

Several new Schiff’s base derivatives were prepared by condensing various substituted benzaldehyde with 1-(4-aminophenyl)-2-{4-[(S)-(4-chlorophenyl)(phenyl) methyl]-1-piperazinyl}ethanone in presence of acid catalyst under reflux condition. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

scholarly journals Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives

2011 ◽  
Vol 8 (s1) ◽  
pp. S149-S154 ◽  
Author(s):  
P. Panneerselvam ◽  
G. Geete Ganesh
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
New Compounds

The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR,1H-NMR and Mass spectral data. All newly synthesized compounds were screened for their antimicrobial activityi.e. antibacterial activity againstS. aureusandE. coliand antifungal activity against fungusA. nigar. CompoundsG5andG7exhibited significant both antibacterial and antifungal activity whileG2,G10andG3,G9showed antibacterial and antifungal activity respectively. These compounds were 2, 5-disubstituted 1, 3, 4-oxadiazole moiety at position two and five showed reasonable antibacterial and antifungal activity.

scholarly journals ANTIMICROBIAL ACTIVITY OF SYZYGIUM GARDNERI Thw. (MYRTACEAE).

2015 ◽  
Vol 2 (1) ◽  
pp. 53-55
Author(s):  
Asha devi V ◽  
Shalimol A ◽  
Arumugasamy K ◽  
Nantha kumar R ◽  
Abdul kaffoor H
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Antifungal Activity ◽  
Positive Control ◽  
Antibacterial And Antifungal Activity ◽  
Penicillium Notatum ◽  
Antibacterial And Antifungal ◽  
Alternaria Alternate

The present study was evaluated the antibacterial and antifungal activity of various extracts of S.gardneri against four different bactria and fungal strains like Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella para typhi b, Alternaria alternate, Aspergillus flavus, Penicillium notatum and Cladosporium carrionii. All the results were compared with respective positive control.

scholarly journals Synthesis and Antimicrobial Screening of Quinazolone Containing Novel Heterocyclic Schiff Base and Azetidinone by Niementowski Reaction

2005 ◽  
Vol 2 (2) ◽  
pp. 101-108
Author(s):  
A. R. Desai ◽  
R. U. Roy ◽  
K. R. Desai
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Schiff Base ◽  
Antifungal Activity ◽  
Sulfonic Acid ◽  
Antibacterial And Antifungal Activity ◽  
Antimicrobial Screening ◽  
Antibacterial And Antifungal ◽  
Phenyl Vinyl

Several 2-[2-{(4-substitutedbenzylidene)-phenyl}vinyl]-4-oxo-3,4-dihydroquinazolone-6-sulfonicacid4(a-l)and 2-[2-{4-(3-chloro-4-substituedphenyl-azetidin-2-one)-phenyl}vinyl]-4-oxo-3,4-dihydroqui-nazolone-6-sulfonic acid5(a-l)were synthesized by using conventional techniques and were screened for antibacterial and antifungal activity. The compounds showed good to moderate antimicrobial activity and were characterized on the basis of spectral analysis.

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