A Greener Approach for Synthesis of Quinoline-3-carboxylate Building Block and their Biological Screening

2021 ◽  
Vol 6 (4) ◽  
pp. 259-263
Author(s):  
Kapilkumar Galachar ◽  
Ashokbhai R. Rathod ◽  
Chandankumar Pashavan ◽  
Yogesh Naliapara ◽  
Vipul Kataria ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Multicomponent Reactions ◽  
Spectroscopic Analysis ◽  
Ammonium Acetate ◽  
Biological Evaluation ◽  
Quinoline Derivatives ◽  
Industrial Chemistry ◽  
Biological Screening ◽  
A Value ◽  
Clean Synthesis

The analogs of nitrogen-based heterocycles occupy an exclusive position as a value of more than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. Among many N-containing heterocycles, quinolines have become important due to their variety of applications in medicinal, synthetic organic chemistry as well as in the field of industrial chemistry. Present work gives information about the green and clean synthesis using multicomponent reactions (MCRs) methods and L-proline and ammonium acetate as a catalyst for the synthesis of quinoline derivatives. Synthesized quinoline derivatives undergo spectroscopic analysis and their biological evaluation.

Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety

2019 ◽  
Vol 29 (1) ◽  
pp. 97-102 ◽  
Author(s):  
T.G. Shruthi ◽  
Sumesh Eswaran ◽  
Prasad Shivarudraiah ◽  
Shridhar Narayanan ◽  
Sangeetha Subramanian
Keyword(s):  
Biological Evaluation ◽  
Quinoline Derivatives

scholarly journals Synthesis, Biological Evaluation and Docking Studies of 1,2,4,5-Tetrasubstituted Imidazoles as Antibacterial Agents: Use of Niobia Supported Heteropoly Tungstate as an Efficient Reusable Catalyst

2021 ◽  
Vol 33 (10) ◽  
pp. 2423-2429
Author(s):  
Aravind Kurnool ◽  
Karunasree Merugu ◽  
Pachipulusu Shravya ◽  
P. Malleswarareddy
Keyword(s):  
Antibacterial Activity ◽  
Catalytic Activity ◽  
Antibacterial Agents ◽  
Ammonium Acetate ◽  
Reaction Times ◽  
Binding Mode ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Reusable Catalyst ◽  
Tetrasubstituted Imidazoles

The synthesis of novel 1,2,4,5-tetrasubstituted imidazoles was carried out in a single molecular motif using niobia supported heteropoly tungstate as a mild and efficient reusable catalyst. The condensation of 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde, aromatic amine, benzil, ammonium acetate and heteropoly tungstate supported on niobia was achieved under both conventional and non-conventional conditions. The employed protocol provides significant advantages, as it exhibits a remarkable catalytic activity on recovery, excellent yields and excellent reaction efficacy within short reaction times between 1-2 h (conventional) and 1-3 min (microwave radiation). All the obtained compounds were characterized by means of spectral data and elemental analysis. They were also screened for their antibacterial activity. To predict the binding mode of compounds with glutamine-fructose-6-phosphate transaminase (GlcN6P synthase), docking studies were performed.

Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors

2017 ◽  
Vol 25 (3) ◽  
pp. 886-896 ◽  
Author(s):  
Xiaoqiang Wang ◽  
Nan Jiang ◽  
Sijia Zhao ◽  
Shuancheng Xi ◽  
Jiao Wang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Quinoline Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of New 1,2,3‐Triazolyl‐Pyrazolyl‐Quinoline Derivatives as Potential Antimicrobial Agents

2020 ◽  
Vol 5 (15) ◽  
pp. 4722-4727 ◽  
Author(s):  
Prashant P. Thakare ◽  
Abhijit D. Shinde ◽  
Abhijit P. Chavan ◽  
Narendra V. Nyayanit ◽  
Vivek D. Bobade ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Quinoline Derivatives ◽  
Synthesis And Biological Evaluation

scholarly journals Recent applications of imines as key intermediates in the synthesis of alkaloids and novel nitrogen heterocycles

2009 ◽  
Vol 81 (2) ◽  
pp. 195-204 ◽  
Author(s):  
Stephen F. Martin
Keyword(s):  
Organic Chemistry ◽  
Natural Products ◽  
Multicomponent Reactions ◽  
Nitrogen Heterocycles ◽  
Biologically Active ◽  
Total Syntheses ◽  
Biological Interest ◽  
Cascade Processes ◽  
Novel Applications ◽  
Active Natural

One of the major challenges in contemporary synthetic organic chemistry is the design and development of new tactics and strategies and their application to concise and efficient syntheses of biologically active natural products. Strategies that utilize reactions that enable the rapid assembly of the skeletal framework of such targets are thus especially attractive. In this context, we have developed novel applications of imine chemistry in Mannich and related reactions, cascade processes, and multicomponent reactions (MCRs) to rapidly assemble structural subunits common to diverse families of alkaloids. The practical utility of these chemistries is evidenced by their use in the execution of facile total syntheses of (±)-epilupinine (1), (±)-tashiromine (2), (-)-epimyrtine (3), and (±)-roelactamine (4) as well as other nitrogen heterocycles of potential biological interest.

Gradualism: A Method for Primary Instruction on Spectroscopic Analysis in Introductory Organic Chemistry

1999 ◽  
Vol 76 (9) ◽  
pp. 1297 ◽  
Author(s):  
Christopher W. Alexander ◽  
Gary L. Asleson ◽  
Charles F. Beam ◽  
Marion T. Doig ◽  
Frederick J. Heldrich ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Spectroscopic Analysis

Synthesis and biological evaluation of new quinoline derivatives as antileishmanial and antitrypanosomal agents

2019 ◽  
Vol 83 ◽  
pp. 526-534 ◽  
Author(s):  
Santiago N. Chanquia ◽  
Facundo Larregui ◽  
Vanesa Puente ◽  
Carlos Labriola ◽  
Elisa Lombardo ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Quinoline Derivatives ◽  
Synthesis And Biological Evaluation

Glucosides from the Fresh Flowers of Juglans regia L. and Their Biological Evaluation

2019 ◽  
Vol 17 (1) ◽  
pp. 31-35
Author(s):  
Haibo Wang ◽  
Xikui Liu
Keyword(s):  
Spectroscopic Analysis ◽  
Juglans Regia ◽  
2D Nmr ◽  
Antibacterial Activities ◽  
Biological Evaluation ◽  
Chemical Investigation ◽  
Etoac Extract

The chemical investigation of the EtOAc extract of the fresh flowers of Juglans regia L. resulted in a new α-tetralonyl glucoside (1) and two known glucosides (2-3). The structure of the new compound was determined by extensive 1D and 2D NMR spectroscopic analysis and HRESIMS. The biological evaluation of the obtained glucosides showed that compound 1 and 3 displayed good antioxidant and antibacterial activities. These two compounds were identified as the main functional molecules in the fresh flowers of Juglans regia L.

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