A COMPARATIVE STUDY OF INFUSION DEXMEDETOMIDINE AND INFUSION MAGNESIUM SULPHATE ON ATTENUATION OF BLOOD PRESSURE SURGE IN LAPAROSCOPIC SURGERY UNDER GENERAL ANAESTHESIA

Background: Shivering is commonly encountered both after regional and general anaesthesia (GA) with a little higher incidence in patients receiving GA. The aim of study was to compare the effectiveness of dexmedetomidine and tramadol in decreasing postoperative shivering in patients undergoing laparoscopic surgery.Methods: Total 120 patients were included in this study. In order to get a 5% level of significance and 80% power number of patients required in each group was 40, with a total of 120 patients. Randomization of groups was done based on closed envelope method. Patients were allocated into three groups group I, II and III of 40 patients each. Patients in group I and group II were administered 0.75 μg/kg of dexmedetomidine and 1.5 mg /kg of tramadol in 100 ml NS respectively half a before extubation, while patients in group III did not receive any pharmacological intervention.Results: All three groups were comparable regarding distribution of age, gender, ASA grade and temperature at beginning and end of surgery and were non-significant.Conclusions: Dexmedetomidine seems to possess anti-shivering properties and was found to reduce the occurrence of shivering in patients undergoing general anaesthesia with minimal side effects although its anti-shivering effect was not superior to tramadol.

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A Study of Effect of Intravenous Magnesium Sulphate with Lignocaine and Intravenous Clonidine with Lignocaine on Blood Pressure in Response to Laryngoscopy and Tracheal Intubation during General Anaesthesia

Indian Journal of Anaesthesia and Analgesia ◽

10.21088/ijaa.2349.8471.3116.6 ◽

2016 ◽

Vol 3 (1) ◽

pp. 33-38

Author(s):

Anuradha H. ◽

Ramesh K. ◽

Siddharam Jamagond ◽

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Keyword(s):

Blood Pressure ◽

Tracheal Intubation ◽

General Anaesthesia ◽

Magnesium Sulphate ◽

Intravenous Magnesium

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EFFECT OF DEXAMETHASONE GARGLE AND MgSO4 GARGLE ON INCIDENCE AND SEVERITY OF POST OPERATIVE SORE THROAT IN PATIENTS UNDERGOING SURGERY UNDER GA : A RANDOMISED COMPARATIVE STUDY

10.36106/ijar/4501618 ◽

2021 ◽

pp. 40-42

Author(s):

Tamanna Baktier ◽

Akash Gupta ◽

Neeharika Arora ◽

Ankur Garg ◽

Ekta Singh ◽

...

Keyword(s):

Comparative Study ◽

General Anaesthesia ◽

Sore Throat ◽

Magnesium Sulphate ◽

Lower Incidence ◽

Post Anaesthesia Care Unit ◽

Duration Of Surgery ◽

The Mean ◽

Anaesthesia Care ◽

To Receive

BACKGROUND: Post operative sore throat (POST) is an unpleasant and troublesome sequelae after endotracheal intubation . The present study compares the efcacy of dexamethasone gargle versus magnesium sulphate gargle on incidence and severity of post operative sore throat in patients under General Anaesthesia. METHODS : 60 patients were randomly allocated to receive either magnesium sulphate gargle or dexamethasone gargle . 15 mins prior to induction of GA , the dexamethasone gargle group (n=30) received 8mg dexamethasone dissolved in 20ml of 5% dextrose whereas the magnesium sulphate gargle group received 1 gm of MgSO4 dissolved in 20ml of 5% of dextrose. Patients were assessed for incidence and severity of post operative sore throat , cough and hoarseness of voice in post anaesthesia care unit at 0hr, 2hrs, 4hrs, 6hrs and 24 hrs . RESULTS : Our study revealed that there was signicant (p<0.01) difference in the severity of sore throat between the groups at 0 hr, 2 hrs, 4 hrs , 6 hrs with patients receiving MgSO4 gargles showing decreased severity than gargling with dexamethasone. The two groups were found to be demographically comparable . In our current study , the mean duration of surgery in both groups was 2-2.5 hours and difference was statistically insignicant . SUMMARY : Among patients who gargled with 1gm of MgSO4 exhibited lower incidence and severity of POST as compared to patients who gargled with 8mg of dexamethasone

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Comparative Study of Single Dose Intravenous Ondansetron and Metoclopramide as a Premedication for Prevention of Post Operative Nausea and Vomiting in Obstetrical Laparoscopic Surgery under General Anaesthesia

The Internet Journal of Anesthesiology ◽

10.5580/22db ◽

2007 ◽

Vol 13 (2) ◽

Keyword(s):

Single Dose ◽

Laparoscopic Surgery ◽

Comparative Study ◽

General Anaesthesia ◽

Nausea And Vomiting ◽

Post Operative Nausea

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EVALUATION OF HAEMODYNAMIC STABILITY FOLLOWING INDUCTION OF GENERAL ANAESTHESIA WITH PROPOFOL AND ETOMIDATE IN NORMOTENSIVE AND HYPERTENSIVE PATIENTS: A COMPARATIVE STUDY

10.36106/gjra/7510742 ◽

2020 ◽

pp. 117-122

Author(s):

Ann Mary Alappat ◽

Jui Yeshavant Lagoo ◽

Vikram Shivappagoudar

Keyword(s):

Blood Pressure ◽

Comparative Study ◽

General Anaesthesia ◽

Elective Surgery ◽

Induction Agent ◽

Hypertensive Patients ◽

Haemodynamic Stability ◽

Prospective Comparative Study ◽

Post Intubation ◽

Induction Of Anaesthesia

Background: Induction of anaesthesia and endotracheal intubation are associated with adverse haemodynamic effects which are detrimental in hypertensive patients. Although etomidate is found to be a cardio stable induction agent, its advantages in hypertensive patients are not yet investigated. Aim of the present study is to compare the haemodynamic parameters following induction of anaesthesia with etomidate and propofol in normotensive and hypertensive patients. Methods: In a prospective comparative study, 120 patients aged 18 to 60 years, of both sex and ASA status I & II posted for elective surgery under general anaesthesia were divided into 4 groups of 30 each. Anaesthesia was induced with either propofol or etomidate. Heart rate(HR), Systolic Blood Pressure(SBP), Diastolic Blood Pressure(DBP), Mean Arterial Pressure(MAP) and SpO2 were noted down at baseline, pre-induction, after induction, at laryngoscopy and 1, 3 & 5 minutes post intubation. Results: There was a significant fall in HR after induction with propofol which was more in the hypertensive group. After intubation, a rise in HR was observed in all 4 groups which returned to baseline by 5 minutes. A fall in MAP, SBP and DBP were observed in all the groups following induction, which shooted up after intubation. The fall in MAP with propofol was significantly higher when compared to etomidate which offered stable haemodynamic conditions. Conclusion: The present study suggests that induction of anaesthesia with etomidate is associated with better stability of MAP in normotensive as well as hypertensive patients when compared with propofol. However, HR is better maintained with propofol. Thus there is no clear evidence supporting induction by etomidate in hypertensive patients.

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