EFFECT OF DEXAMETHASONE GARGLE AND MgSO4 GARGLE ON INCIDENCE AND SEVERITY OF POST OPERATIVE SORE THROAT IN PATIENTS UNDERGOING SURGERY UNDER GA : A RANDOMISED COMPARATIVE STUDY

2021 ◽  
pp. 40-42
Author(s):  
Tamanna Baktier ◽  
Akash Gupta ◽  
Neeharika Arora ◽  
Ankur Garg ◽  
Ekta Singh ◽  
...  
Keyword(s):  
Comparative Study ◽  
General Anaesthesia ◽  
Sore Throat ◽  
Magnesium Sulphate ◽  
Lower Incidence ◽  
Post Anaesthesia Care Unit ◽  
Duration Of Surgery ◽  
The Mean ◽  
Anaesthesia Care ◽  
To Receive

BACKGROUND: Post operative sore throat (POST) is an unpleasant and troublesome sequelae after endotracheal intubation . The present study compares the efcacy of dexamethasone gargle versus magnesium sulphate gargle on incidence and severity of post operative sore throat in patients under General Anaesthesia. METHODS : 60 patients were randomly allocated to receive either magnesium sulphate gargle or dexamethasone gargle . 15 mins prior to induction of GA , the dexamethasone gargle group (n=30) received 8mg dexamethasone dissolved in 20ml of 5% dextrose whereas the magnesium sulphate gargle group received 1 gm of MgSO4 dissolved in 20ml of 5% of dextrose. Patients were assessed for incidence and severity of post operative sore throat , cough and hoarseness of voice in post anaesthesia care unit at 0hr, 2hrs, 4hrs, 6hrs and 24 hrs . RESULTS : Our study revealed that there was signicant (p<0.01) difference in the severity of sore throat between the groups at 0 hr, 2 hrs, 4 hrs , 6 hrs with patients receiving MgSO4 gargles showing decreased severity than gargling with dexamethasone. The two groups were found to be demographically comparable . In our current study , the mean duration of surgery in both groups was 2-2.5 hours and difference was statistically insignicant . SUMMARY : Among patients who gargled with 1gm of MgSO4 exhibited lower incidence and severity of POST as compared to patients who gargled with 8mg of dexamethasone

A COMPARISON OF EFFECT OF NEBULISED KETAMINE AND NEBULISED MAGNESIUM SULPHATE IN REDUCTION OF INCIDENCE AND SEVERITY OF POSTOPERATIVE SORE THROAT - A PROSPECTIVE RANDOMIZED DOUBLE BLINDED STUDY

2021 ◽  
pp. 38-40
Author(s):  
M. Selvi Annie Geeta ◽  
M. Ramesh Ram
Keyword(s):  
Tracheal Intubation ◽  
General Anesthesia ◽  
Sore Throat ◽  
Magnesium Sulphate ◽  
Success Rates ◽  
Postoperative Sore Throat ◽  
It Effectiveness ◽  
Duration Of Surgery ◽  
The Mean ◽  
Group B

Introduction: Postoperative sore throat (POST) is a common occurrence following general anesthesia with endotracheal intubation. The incidence of POST is estimated to be 21%-65% in various studies. Irritation and inammation of the air way are considered to be the cause of POST. Although considered a minor and self limiting complication, it may cause a signicant patient morbidity, dissatisfaction and increased the length of duration of hospital stay. Various pharmacological and non pharmacological methods have been tried to decrease POST with varying success rates. Among the interventions, the use of ketamine gargle or lozenges has highest success rates, but the problem with this is the bitter taste of the drug and the risk of aspiration, so aerosol route of drug administration gained popularity among the anesthesiologists with good acceptance from the patients. It is known that N-methyl-D-aspartate (NMDA) receptors have a role in nociception and inammation. Hence, this study is aimed at using the aerosol route of magnesium sulphate and ketamine and to nd it effectiveness in preventing POST. Aim Of The Study: To evaluate the effect of nebulized ketamine and nebulized magnesium sulphate for attenuation of postoperative sore throat in patients undergoing surgeries under general anesthesia with tracheal intubation. Materials And Methods: This study was done in the Department of Anesthesiology in collaboration with the Department of Surgery in Kanyakumari Government Medical College from January 2019 to December 2019. Patient planned for surgery under general anesthesia except head, neck & ENT surgeries were selected and randomized into two groups (35 each). Each group received nebulisation for 15 min before induction of general anaesthesia. Group M: Nebulization with 500mg magnesium sulphate in 5ml NS. Group K: Nebulization with 50mg ketamine in 5ml NS. The Parameters related to the study such as duration of laryngoscopy, time taken to intubate, duration of surgery, number of attempts to intubate were recorded. Incidence and severity of sore throat were assessed by four point scale. Incidence of sore throat is assessed for 24 hours. Complication were recorded. Results: We found that the demographic parameters were comparable and statistically insignicant. The mean duration of laryngoscopy difference between the two groups Group M - 24.54± 1.12 seconds and Group K - 24.49 ±1.15 seconds was not statistically signicant P= 0.834 (P>0.05). The mean time taken to intubate in Group M - 27.54± 1.12 seconds and Group K - 27.54± 1.12 seconds was not statistically signicant with P=1.000 respectively (P>0.05). The mean duration of surgery in Group M - 90.71±15.67 minutes and the Group K - 88.20 ±16.53 minutes between the two groups was not statistically signicant P= 0.516 (P>0.05). The mean difference of number of attempts taken to intubate between the two groups was statistically insignicant P=0.771 (P>0.05). The overall incidence of sore throat in Group M was 91% and in Group B was 34%. The severity of sore throat between Group M and Group K is statistically signicant at 2, 4, 6 hrs at grade 1 and grade 2. Conclusion: On the basis of our result, we can suggest that the use of perioperative ketamine nebulization when compared magnesium sulphate nebulization reduces the incidence and severity of post-operative sore throat at 4th and 6th hour during postoperative period in patients who had received general anesthesia with tracheal intubation.

Betamethasone Gel and Lignocaine Jelly Applied Over Endotracheal Tube to Reduce Post-Operative Sore Throat and Hoarseness of Voice - A Comparative Study

2021 ◽  
Vol 8 (27) ◽  
pp. 2423-2427
Author(s):  
Sridevi Boddu ◽  
Chenna Kesava Swamy Kakaraparthi
Keyword(s):  
Endotracheal Tube ◽  
General Anaesthesia ◽  
Sore Throat ◽  
Endotracheal Intubation ◽  
Orotracheal Intubation ◽  
P Value ◽  
Post Anaesthesia Care Unit ◽  
Grade 3 ◽  
American Society ◽  
Anaesthesia Care

BACKGROUND Although post-operative sore throat, cough and hoarseness of voice (HOV) are minor sequelae after general anaesthesia (GA), these can be troublesome to the patient. This study was done to compare the efficacy of betamethasone gel and lignocaine jelly as lubricants in reducing post-operative sore throat and hoarseness of voice in patients operated under general anaesthesia with orotracheal intubation. METHODS This interventional study compares the incidence of post-operative sore throat and hoarseness of voice after endotracheal intubation on applying betamethasone gel (betamethasone group) or lignocaine jelly (lignocaine group) on the tracheal tube. 120 American Society of Anaesthesiologist (ASA) class I and class II patients who had undergone elective surgeries under general anaesthesia were divided into two groups: betamethasone group and lignocaine group. All patients were enquired on post-operative sore throat and hoarseness of voice at 1, 6 and 24 hours after extubation in the post-anaesthesia care unit. RESULTS The incidence of no sore throat, mild, moderate and severe post-operative sore throat at 24 hours after extubation in betamethasone group was 75.0 %, 23.3 %, 1.7 % and 0 % respectively compared to lignocaine group which was 33.3 %, 53.3 %, 6.7 % and 6.7 % respectively (P value < 0.05). The incidence of sore throat was found lower in the betamethasone group than in lignocaine group at intervals 1, 6, 24 hours post extubation with P value < 0.05. The incidence of no HOV, grade 1 HOV, grade 2 HOV and grade 3 HOV in betamethasone group was 46.7 %, 48.3 %, 5.0 % and 0 % respectively compared to lignocaine group which was 25.0 %, 46.7 %, 25.0 % and 3.3 % respectively with P value < 0.05. CONCLUSIONS This study proves that betamethasone gel, when used for lubrication of endotracheal tube pre-operatively, has shown to be effective in decreasing postoperative sore throat and hoarseness of voice. KEYWORDS Betamethasone, Lignocaine, Sore Throat, Hoarseness of Voice, Endotracheal Intubation

scholarly journals Cortisol and Insulin Levels during Major Gynaecological Operations: The influence of Two Anaesthetic Techniques

2014 ◽  
Vol 2 (4) ◽  
pp. 608-612
Author(s):  
Oyebola O. Adekola ◽  
Ibironke Desalu ◽  
John O. Olatosi ◽  
Olushola T. Kushimo ◽  
Godwin O. Ajayi
Keyword(s):  
General Anaesthesia ◽  
Epidural Anaesthesia ◽  
Anaesthetic Techniques ◽  
Hormonal Changes ◽  
Combined Spinal Epidural ◽  
The Mean ◽  
Spinal Epidural ◽  
Mean Glucose ◽  
Type Of Injury ◽  
To Receive

BACKGROUND: Metabolic and hormonal changes are noticed within the first few hours after surgical injury. These changes are influenced by the intensity, duration, type of injury, and the anaesthetic techniques.AIM: To investigate the effects of anaesthesia on cortisol, insulin and glucose concentrations during major gynaecological surgeries.METHODS: Forty patients were randomly allotted to receive either balanced general anaesthesia (n=20) or combined spinal epidural anaesthesia extending from T5 to S5 (n=20). Blood samples were collected for cortisol and glucose at preinduction, 1, 3 and 4 hours, and for insulin at preinduction and 24 hours after incision.RESULTS: The mean cortisol concentration was significantly lower 4 hours after incision with combined spinal epidural anaesthesia (19.96 ± 11.32) μg/dl than with balanced general anaesthesia (38.94 ± 10.6) μg/dl, p = 0.018. The mean insulin concentration, 24 hours after incision decreased with combined spinal epidural anaesthesia, but increased with balanced general anaesthesia p = 0.403. The mean glucose concentrations were significantly lower with combined spinal epidural anaesthesia than with balanced general anaesthesia during the 4 hour study period p ≤ 0.05.CONCLUSION: combined spinal epidural anaesthesia extending from T5 to S5 resulted in lower cortisol, insulin and glucose concentrations during major gynaecological surgeries. This may be of benefit in patients scheduled for surgical operations below the umbilicus.

scholarly journals Comparative Study of Rectal Misoprostol to Oxytocin Infusion in Preventing Postpartum Haemorrhage After Caesarean Section

2014 ◽  
Vol 8 (2) ◽  
pp. 34-37 ◽  
Author(s):  
AI Adanikin ◽  
E Orji ◽  
PO Adanikin ◽  
O Olaniyan
Keyword(s):  
Caesarean Section ◽  
Blood Loss ◽  
Comparative Study ◽  
Postpartum Haemorrhage ◽  
Post Partum ◽  
Operative Blood Loss ◽  
Oxytocin Infusion ◽  
The Mean ◽  
Post Partum Haemorrhage ◽  
To Receive

Aims: This comparative study aimed to compare the efficacy of rectal misoprostol to oxytocin infusion in preventing primary postpartum haemorrhage after caesarean section. Methods: Fifty pregnant women with identifiable risk factors for post-partum haemorrhage who delivered baby by caesarean section were randomized to receive 600 μg rectal misoprostol and a placebo infusion intravenously or placebo rectally and a 20 iu oxytocin infusion. Post-operative blood loss four hours after surgery was estimated by application of pads of known weight. Results: The mean immediate four hours post-operative blood loss was not significantly different between the rectal misoprostol and oxytocin infusion group (100.08 ± 24.85 ml versus 108.20 ± 29.93 ml; p =0.144) and the change between the pre-operative and post-operative hematocrit was similar. Conclusions: Post-caesarean section rectal misoprostol has comparative efficacy to oxytocin infusion in preventing post-partum haemorrhage. It is recommended for use as alternative uterotonic in settings where there is low refrigeration capacity.Nepal Journal of Obstetrics and Gynaecology / Vol 8 / No. 2 / Issue 16 / July-Dec, 2013 / 34-37 DOI: http://dx.doi.org/10.3126/njog.v8i2.9767

scholarly journals Spinal Anaesthesia or General Anaesthesia for Emergency Hip Surgery in Elderly Patients

1981 ◽  
Vol 9 (4) ◽  
pp. 352-358 ◽  
Author(s):  
F. M. Davis ◽  
V. G. Laurenson
Keyword(s):  
Elderly Patients ◽  
General Anaesthesia ◽  
Hip Surgery ◽  
Subarachnoid Block ◽  
Vein Thrombosis ◽  
The Mean ◽  
Uptake Test ◽  
Deep Vein ◽  
To Receive ◽  
Surgery In Elderly

One hundred and thirty-two elderly patients undergoing emergency hip surgery were randomly allocated to receive subarachnoid block (SAB) or general anaesthesia (GA). Using the 125-I fibrinogen uptake test, deep vein thrombosis was found to occur in 17 of 37 patients in the SAB group and 30 of 39 patients in the GA group (P 0.05). Blood loss was 513 ml (± SEM 44) in the SAB group and 714 ml (± SEM 67) in the GA group (P < 0.01). Hypoxaemia was present preoperatively (mean PaO2 9.2 kPa). Immediately following general anaesthesia, the mean fall in PaO2 was 0.86 kPa compared with preoperative values but only 0.16 kPa following subarachnoid block (P < 0.01). At 24 hours postoperatively the fall in PaO2 was similar in both groups and recovered only slowly during the first week. Twelve patients died, three in the SAB group and nine in the GA group. This difference in mortality was not statistically significant.

scholarly journals Effect of Preoperative Nebulised Dexamethasone and Nebulised Magnesium Sulphate on Postoperative Sore Throat in Prone Position Surgeries- A Randomised Double-Blind Study

2021 ◽  
Author(s):  
G Manuj Kumar ◽  
BT Arish
Keyword(s):  
General Anaesthesia ◽  
Sore Throat ◽  
Prone Position ◽  
Magnesium Sulphate ◽  
Nmda Receptor Antagonist ◽  
P Value ◽  
Double Blind Study ◽  
Continuous Variables ◽  
Postoperative Sore Throat ◽  
Double Blind

Introduction: Postoperative Sore Throat (POST) is a frequently encountered complication after general anaesthesia with tracheal intubation and positional changes. Magnesium Sulphate (MgSO4) is a N-Methyl D-Aspartate (NMDA) receptor antagonist and dexamethasone is a glucocorticoid, both drugs helps in reducing POST by various mechanisms. Aim: To compare the effects of preoperative dexamethasone nebulisation vs preoperative MgSO4 nebulisation on sore throat in prone position surgeries. Materials and Methods: Eighty patients undergoing lumbar spine surgeries from October 2017 to April 2019, under general anaesthesia in prone position, were randomly allocated into two groups- A and B. Thirty minutes before surgery patients in each group were nebulised with respective drugs, dexamethasone 8 mg in group A and 250 mg of MgSO4 in group B. Haemodynamic parameters during laryngoscopy were noted. A standardised protocol for providing general anaesthesia was followed for all patients. After extubation, at 0, 4, 6 and 24 hours all patients were asked to grade POST, hoarseness and cough. The severity of POST was graded with four-point scale. Continuous variables were expressed as mean±SD and analysed using student t-test. The p-value <0.05 was considered statistically significant. Results: The overall incidence of sore throat in dexamethasone group was 37.5% and 20% in MgSO4 group. The incidence (p=0.026) and severity (p=0.011) of POST was significantly decreased in MgSO4 group at 6 hours where none of the patient had sore throat compared to dexamethasone where 15 (37.5%) of them had sore throat (p=0.026). None of the patients had cough and hoarseness in both groups. Conclusion:Nebulisation with MgSO4preoperatively significantly decreases the incidence and severity of POST when compared to dexamethasone and there was no statistically significant haemodynamic variability between the two groups.

scholarly journals Randomized comparison of stapled haemorrhoidopexy and open haemorrhoidectomy

2018 ◽  
Vol 5 (9) ◽  
pp. 3118
Author(s):  
Suresh Kumar Rulaniya ◽  
Soumitra Chandra
Keyword(s):  
Comparative Study ◽  
Conventional Method ◽  
Stapled Haemorrhoidopexy ◽  
Stapled Haemorrhoidectomy ◽  
Duration Of Surgery ◽  
Conventional Haemorrhoidectomy ◽  
Prospective Comparative Study ◽  
Vas Scores ◽  
The Mean

Background: Surgical management of haemorrhoids is reserved for stage III and IV haemorrhoids. Both Milligan-Morgan technique (CH-Conventional Haemorrhoidectomy) and stapled haemorrhoidopexy technique are used as surgical therapy. Our prospective, comparative study of conventional haemorrhoidectomy versus stapled haemorrhoidectomy was designed in present institution.Methods: This prospective randomised comparative study was carried out in present Surgery Dept from July 2016 to December 2017 with total 60 sample size. All data were analysed according to applicable statistical methods. The results were compared to previous studies so as to arrive at a conclusion.Results: The mean duration of surgery with stapled method was 30.76±3.13 minutes and with conventional method was 49.36±4.08 minutes which was significantly high in conventional method. VAS scores for pain at 12 hours, 24 hours, 72 hours and 7 days for stapled group were 2.63±0.76, 1.66±0.88, 0.90±0.71 and 0.50±0.43 while that for the conventional group were 5.63±0.72, 4.56±1.22, 3.26±1.25 and 2.00±0.69. At all points of time the VAS was significantly lower in stapled group. The mean duration of hospital stay of the patients with stapled method was 3.10±0.75 days and with conventional method was 6.06±0.94 days, which was significantly high in conventional method. The mean time to return to normal activities of the patients with stapled method was 8.16±1.93 days and with conventional method was 12.60±1.67 days, which also significantly high in conventional method.Conclusions: Present study inferred that stapled haemorrhoidopexy is faster, minimally invasive for treatment of haemorrhoids as compared to Conventional haemorrhoidectomy. It is associated less pain and provides a more satisfactory alternative to Conventional surgery because of reduced hospitalisation and earlier return of patient to daily activities, with no significant differences in short term follow up.

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