Correlation of Computed Tomography Guided Visceral Adiposity & Sagittal Abdominal Diameter with Atherogenic Index of Plasma in Type 2 Diabetic Patients

BACKGROUND Type 2 diabetic patients are at high risk for many cardiovascular diseases which are associated with obesity and abdominal fat that includes visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Visceral adiposity contributes to impairment of insulin resistance which is a prerequisite for diabetes and dyslipidaemia. Computed tomography (CT) scan is the gold standard for measurement of VAT but due to its limitations, sagittal abdominal diameter (SAD) is considered which also has a strong correlation with VAT. There is a good relation between VAT and isolated lipid parameters. However, lipid ratios, such as Atherogenic Index of Plasma (AIP) are of higher predictive value for cardiovascular risk. The present study is focused on exploring the relationship between CT guided visceral adiposity and sagittal abdominal diameter with AIP in type 2 diabetic patients. METHODS This study was carried out with a study group of 53 type 2 diabetes patients aged between 25 to 65 years, incorporating appropriate inclusion and exclusion criteria in a tertiary care hospital. The biochemical assays done include triglycerides, HDLcholesterol and blood glucose by standard techniques. AIP was calculated by taking the logarithmic ratio of triglyceride and HDL-cholesterol levels. Measurement of visceral adiposity was done by SAD and CT scan. RESULTS A total of 53 patients with type II diabetes mellitus (DM) were recruited for the study comprising of 35 males and 18 females. Mean age of the patients was 41.717 ± 11.658 years. Mean value of SAD was 22.755 ± 2.70. Mean value of AIP was 0.164 + 0.15. Mean value of CT measured visceral adiposity was - 77.875 ± 24.54 HU. Pearson’s correlation coefficient for the relationship between SAD and AIP was 0.741 and Pvalue was less than 0.0001 indicating a positive correlation. Pearson’s correlation coefficient for the relationship between CT measured visceral adiposity and AIP was 0.765 and P-value was less than 0.0001 which also shows a positive correlation. CONCLUSIONS In our study we demonstrated that SAD and CT guided visceral adiposity was correlating with AIP in patients with type 2 diabetes mellitus. KEY WORDS Visceral Adiposity, Sagittal Abdominal Diameter, Atherogenic Index of Plasma, Diabetes Mellitus, Computed Tomography Scan

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Visceral adiposity index and atherogenic index of plasma: Simple markers of insulin resistance in type 2 diabetic patients

Endocrine Abstracts ◽

10.1530/endoabs.73.aep220 ◽

2021 ◽

Author(s):

Asma Kardi ◽

Ibtissem Oueslati ◽

Meriem Yazidi ◽

Bassem Hammami ◽

Fatma Boukhayatia ◽

...

Keyword(s):

Insulin Resistance ◽

Visceral Adiposity ◽

Atherogenic Index ◽

Diabetic Patients ◽

Visceral Adiposity Index ◽

Type 2 Diabetic Patients ◽

Atherogenic Index Of Plasma ◽

Adiposity Index ◽

Type 2 Diabetic

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Inverse Association of Serum Fibroblast Growth Factor 19 and Atherogenic Index of Plasma in Type 2 Diabetic Patients

10.21203/rs.2.24087/v1 ◽

2020 ◽

Author(s):

Wangshu Liu ◽

Tianli Xu ◽

Mengjie Tang ◽

Xue-Qin Wang ◽

Jianbin Su ◽

...

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Atherogenic Index ◽

Diabetic Patients ◽

Fibroblast Growth ◽

Type 2 Diabetic Patients ◽

Atherogenic Index Of Plasma ◽

Fibroblast Growth Factor 19 ◽

Type 2 Diabetic

Abstract BackgroundWe aimed to explore the relationship between serum fibroblast growth factor 19 (FGF19) and the atherogenic index of plasma (AIP) in type 2 diabetic patients.MethodsSerum FGF19 levels and lipid profiles were measured in 200 patients with type 2 diabetes (T2D). The levels of serum FGF19 were measured by ELISA. Lipid profiles were measured by enzymatic analysis. AIP and NAFLD fibrosis scores were calculated.ResultsT2D patients showed a significant decreasing trend of FGF19 concentrations depending on the tertiles of AIP (p for trend < 0.05). Simultaneously, the AIP level was closely related to the serum FGF19 level (p < 0.05). Furthermore, after adjusting for age, sex, duration, BMI, hypertension, and diabetic treatment, the correlation was still significant (p < 0.01), and it remained significant even after further adjusting for non-alcoholic fatty liver disease (NAFLD) and NAFLD fibrosis score (NFS) (p < 0.01). However, when stratified by BMI, AIP was positively correlated with FGF19 in normal-weight and overweight T2D patients but not in obese T2D subjects. After adjusting for sex, age, BMI, duration, hypertension, HbA1c, 2hPG, HOMA-IR, AIP, antidiabetic treatments, NAFLD and NFS via multiple stepwise linear regression, AIP was an independent factor affecting serum FGF19 concentrations (SE = 0.238, β = -0.290, p < 0.01).ConclusionsSerum FGF19 levels might be a good predictor for atherosclerosis and cardiovascular disease in T2D patients, especially among non-obese patients; serum FGF19 levels were significantly inversely associated with AIP.

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Evaluation of lipid profile pattern and atherogenic index of plasma (AIP) having type-2 diabetes mellitus in Bangladesh

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20180595 ◽

2018 ◽

Vol 6 (3) ◽

pp. 776

Author(s):

Mahfuza Anjum ◽

Md. Salah Uddin ◽

Naima Ahmed Tamanna ◽

Md. Abdullah Al-Zobair ◽

A. T. M. Mijanur Rahman

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Density Lipoprotein ◽

Atherogenic Index ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Atherogenic Index Of Plasma ◽

Type 2 Diabetic

Background: Dyslipidemia has been noted to play an integral role in the pathogenesis and progression of micro and macrovascular complications in Diabetes Mellitus (DM) patients. The study was aimed to evaluate the prevalence and pattern of dyslipidemia and atherogenic index of plasma (AIP) in type 2 diabetes mellitus patients as it has not been reported previously in BangladeshMethods: This cross-sectional study was conducted at Armed Forces Institute of pathology, Bangladesh from November 2016 to October 2017. A total number of 300 patients having diabetes in the age group of 30-60 years have been selected using a non-probability method. Fasting plasma glucose (FPG), serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels were estimated by laboratory tests.Results: The prevalence of dyslipidemia in at least one lipid parameter was found in 282 patients (94%), while 18 patients (6%) had no dyslipidemia. High levels of TC, TG and LDL-C were found in 134 (47.3%), 230 (76.7%) and 124 (41.3%) patients, respectively. On the other hand, low levels of HDL-C were found in 180 patients (60%). An increased risk of AIP was found in 298 patients (99.3%), whereas only 2 patients (0.7%) were in low risk. FPG was positively correlated with TC, TG, LDL-C and AIP, while negatively correlated with HDL-C. A significant positive correlation was also observed between FPG and AIP.Conclusions: The Study revealed that dyslipidemia is very common in type 2 diabetic patients and the most common abnormality observed was increased serum triglyceride levels followed by decreased serum HDL-C levels. The AIP is also significantly higher in type 2 diabetic patients.

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