Connective tissue dysplasia syndrome as a risk factor of severe course of bronchial obstruction syndrome in children

The aim: to improve the early diagnosis of arrhythmia in combination with gastroesophageal reflux disease (GERD) in children, by studying the risk of connective tissue dysplasia on the occurrence of this pathology. Materials and methods. We examined 100 children aged 8 to 18 years, mean age 13.7±2.7 years, of which 32 children with arrhythmias without combined pathology were group I, 36 children with concomitant GERD - group II and 32 children with GERD without concomitant arrhythmias - group III. Patients underwent clinical and instrumental studies (electrocardiography, Holter daily ECG monitoring, esophagogastroduodenoscopy and pH-metry) and evaluation of phenotypic signs of NDST according to the criteria of T. Milkovskaya-Dimitrova and A. Karkasho. Results. A risk factor for the formation of combined pathology in children in the form of arrhythmia and GERD was identified, namely the next main phenotypic feature of NDST (undifferentiated connective tissue dysplasia) – dysplastic tooth growth. Also, predictors of both an isolated variant of arrhythmia in children and arrhythmia in combination with GERD – high height and scoliotic posture were identified. In this case, the risk factor for an isolated variant of arrhythmia in children, according to the results of the study is asthenic constitution. The severity of NDST in the studied groups was determined. The analysis of the results revealed the absence of a statistically significant relationship between the severity of NDST and study groups, although it should be noted that in children of group III the first degree of NDST was not observed in general. Conclusions. It was found that asthenic constitution, dysplastic tooth growth, tall stature and scoliotic posture are statistically significant risk factors for the development of the studied pathologies. There were no statistically significant differences between the study groups regarding the severity of NDST, but there was a complete lack of detection in children of group III (children with isolated GERD without concomitant arrhythmia) of the first degree of NDST

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CONNECTIVE TISSUE DYSPLASIA AS A POTENTIAL RISK FACTOR FOR MYOCARDIAL ELECTRIC INSTABILITY IN YOUNG ATHLETES

Human Sport Medicine ◽

10.14529/hsm190415 ◽

2020 ◽

Vol 19 (4) ◽

pp. 125-132 ◽

Cited By ~ 1

Author(s):

V Timokhina ◽

K Mekhdieva ◽

F Blyakhman

Keyword(s):

Risk Factor ◽

Connective Tissue ◽

Respiratory System ◽

Recovery Time ◽

Stress Test ◽

Physical Exertion ◽

National Guidelines ◽

Young Athletes ◽

System Adaptation ◽

Connective Tissue Dysplasia

The proposed study was focused on search for the potential interrelations between the degree of connective tissue dysplasia (CTD) and efficiency of cardio-respiratory system adaptation to load in young athletes. Materials and methods. Parameters of cardio-respiratory system were evaluated in 200 athletes aged from 11 to 23 years with the use of cycling spiroergometry and 12-lead ECG at rest, during and after stress test. The degree of connective tissue dysplasia was assessed as per the score scale of National Guidelines. Results. It was revealed that 86% of studied athletes had moderate or marked degree of system CTD. Generally, CTD limited athletes’ cardio-respiratory system adaptation to load and was associated with myocardium repolarization disorders. Conclusion. The results of this study demonstrated that athletes with CTD showed certain changes in the electrical activity of the heart at rest and during physical exertion. Athletes with CTD compared to athletes without dysplasia have initially lower economization of the cardiovascular system and a significantly longer recovery time after exercise. This means that CTD limits the mobilization of CRS for adaptation to load, especially if the loads are cyclical.

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