Peripheral Blood Eosinophilia as a Potential Marker of Bowel Damage Progression in Crohnʼs Disease a 5 Year Natural History Study

Abstract Background Peripheral blood eosinophilia (PBE) is a biomarker of an aggressive multiyear natural history in adults with inflammatory bowel diseases (IBDs). Additionally, PBE at diagnosis is associated with higher disease activity in pediatric-onset IBD. We sought to determine if PBE can function as a biomarker of long-term disease severity in pediatric-onset IBD patients who are followed into adulthood. Methods We analyzed a consented, prospective, natural history IBD registry at an adult tertiary center from 2009 to 2018. Prevalence of PBE was evaluated in both pediatric- and adult-onset IBD patients. Demographics, clinical characteristics, and health care utilization data were compared in patients with and without PBE. Results Among 2800 adult IBD patients, 23.4% had pediatric-onset disease. PBE was found in 34% of the pediatric-onset patients compared with 26.8% of the adult-onset IBD patients (P < 0.001). In the pediatric-onset IBD cohort, PBE was associated with higher rates of allergies (P < 0.0001), but not of asthma, allergic rhinitis, or primary sclerosing cholangitis. In the adult IBD patients with pediatric-onset disease, PBE was associated with higher rates of C-reactive protein elevation (P < 0.0001), erythrocyte sedimentation rate elevation (P < 0.0001), higher health care utilization, and higher average health care charges per year (P < 0.00001). Conclusions Peripheral blood eosinophilia was more prevalent in adult IBD patients with pediatric-onset compared with adult-onset disease. Among all IBD patients with long-term follow-up, PBE defined a subgroup with more severe illness. These data suggest that PBE may be a biomarker for a high-risk subgroup with high cost trajectory and long-term severity in pediatric-onset IBD that persists into adulthood.

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A Case of Allergic Granulomatous Angiitis with Peripheral Blood Eosinophilia Revealing Resistance to Systemic Steroid

Nishi Nihon Hifuka ◽

10.2336/nishinihonhifu.68.19 ◽

2006 ◽

Vol 68 (1) ◽

pp. 19-23

Author(s):

Yuki SUZUKI ◽

Hideaki WATANABE ◽

Amane KITAMI ◽

Hirohiko SUEKI ◽

Masafumi IIJIMA ◽

...

Keyword(s):

Peripheral Blood ◽

Systemic Steroid ◽

Granulomatous Angiitis ◽

Blood Eosinophilia ◽

Allergic Granulomatous Angiitis ◽

Peripheral Blood Eosinophilia

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Malignant Fibrous Histiocytoma Associated with Peripheral Blood Eosinophilia

Oncology ◽

10.1159/000226372 ◽

1986 ◽

Vol 43 (4) ◽

pp. 230-233 ◽

Cited By ~ 9

Author(s):

Stefan Serke ◽

Monika Brenner ◽

Robert Zimmermann ◽

Hartmut Lobeck

Keyword(s):

Malignant Fibrous Histiocytoma ◽

Peripheral Blood ◽

Fibrous Histiocytoma ◽

Blood Eosinophilia ◽

Peripheral Blood Eosinophilia

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Allergic altered reactivity in the early neonatal period

Kazan medical journal ◽

10.17816/kazmj62202 ◽

1982 ◽

Vol 63 (4) ◽

pp. 11-13

Author(s):

A. G. Shamova ◽

R. M. Bakhtiarova

Keyword(s):

Enzymatic Activity ◽

Social Factors ◽

Peripheral Blood ◽

Neonatal Period ◽

Allergic Reactions ◽

Blood Eosinophilia ◽

Early Neonatal Period ◽

Peripheral Blood Eosinophilia

In 138 newborns with toxic (allergic) erythema, the mediation of allergic reactions by social factors was established. On the 2nd day of life, an allergically altered reactivity is clinically manifested, which is also expressed by an altered picture of peripheral blood (eosinophilia, lymphocytosis) and indicators of the enzymatic activity of leukocytes.

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Toxocariasis in children: epidemiological, clinical and laboratory aspects

Russian Medical Inquiry ◽

10.32364/2587-6821-2020-4-11-670-675 ◽

2020 ◽

Vol 4 (11) ◽

pp. 670-675

Author(s):

A.O. Andreeva ◽

◽

N.V. Golovchenko ◽

A.S. Zhuravlev ◽

◽

...

Keyword(s):

Peripheral Blood ◽

Laboratory Data ◽

Enzyme Linked Immunosorbent Assay ◽

Blood Eosinophilia ◽

Rights Protection ◽

Human Wellbeing ◽

Consumer Rights ◽

Positive Rate ◽

Peripheral Blood Eosinophilia ◽

Research Institute

Aim: to optimize the diagnosis of toxocariasis based on the analysis of epidemiological, clinical and laboratory data in children with the infestation. Patients and Methods: the analysis of official statistical data for the period of 2014–2018, literature sources, a retrospective analysis of 57 medical records of patients (40 children and 17 adults) who received treatment and diagnostic in the clinic of the Rostov Research Institute of Microbiology and Parasitology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing in 2015–2018 was conducted. Results: a decrease in the incidence of newly diagnosed infestation cases was revealed (registered in the clinic of the Rostov Research Institute of Microbiology and Parasitology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing). It correlated with official statistics (r=0.9, p=0.05). Based on clinical and laboratory examination, the diagnosis was established in 26 patients (45.6%). Among patients with a verified diagnosis of toxocariasis, the proportion of children aged 1 years and 1 months to 10 years old, was 96%. An analysis of epidemiological data showed that 76% of children had close contact with the soil. The infestation occurred in the form of latent toxocariasis in 36% of patients. In more than half of the cases, the disease was clinically manifested by geophagy (56.0%). A permanent laboratory parameter was the eosinophilic leukemoid reaction in patients with toxocariasis. Peripheral blood eosinophilia ranged from 15.66.2±9.31% in latent toxocariasis to 25.5±15.0 % in visceral toxocariasis. The positive rate in ELISA with Toxocara antigen was higher than that in the group of patients with visceral toxocariasis. However, there was no correlation between the eosinophilia level and positive rate (r=0.1, p=0.05). Conclusion: in areas where the incidence of toxocariasis and environmental contamination with invasive helminth eggs are high, it is advisable to perform tests of the peripheral blood in children at least one time per year in the autumn for timely diagnosis of infestation. The use of ELISA with Toxocara antigen is reasonable in the cases of peripheral blood eosinophilia. KEYWORDS: toxocariasis, statistics, incidence, eosinophilia, enzyme-linked immunosorbent assay, Toxocara antigen. FOR CITATION: Andreeva A.O., Golovchenko N.V., Zhuravlev A.S. Toxocariasis in children: epidemiological, clinical and laboratory aspects. Russian Medical Inquiry. 2020;4(11):670–675. DOI: 10.32364/2587-6821-2020-4-11-670-675.

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Squamous cell carcinoma of the lung associated with non-invasive aspergillosis and localised and peripheral blood eosinophilia

Cytopathology ◽

10.1111/cyt.12418 ◽

2017 ◽

Vol 28 (4) ◽

pp. 347-348

Author(s):

E. Enoki ◽

M. Kimura ◽

T. Yaguchi

Keyword(s):

Squamous Cell Carcinoma ◽

Invasive Aspergillosis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Peripheral Blood ◽

Blood Eosinophilia ◽

Non Invasive ◽

Peripheral Blood Eosinophilia

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Concurrent sensitization to Aspergillus Fumigatus in tropical pulmonary eosinophilia

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2015.736 ◽

2016 ◽

Vol 81 (1-2) ◽

Author(s):

Sunil K. Chhabra ◽

Devi Jyoti Dash

Keyword(s):

Aspergillus Fumigatus ◽

Severe Asthma ◽

Lung Tissue ◽

Peripheral Blood ◽

Allergic Bronchopulmonary Aspergillosis ◽

Pulmonary Eosinophilia ◽

Blood Eosinophilia ◽

Future Risk ◽

Serum Total Ige ◽

Peripheral Blood Eosinophilia

Tropical pulmonary eosinophilia (TPE) is characterized by lung tissue and peripheral blood eosinophilia. Serum total IgE is also markedly increased in TPE. However, an association with asthma or other hypersensitivity conditions has not been described. During the diagnostic workup of three patients eventually confirmed to have TPE, hypersensitivity to the fungus, Aspergillus Fumigatus was found. However, there was no evidence of diseases of aspergillus hypersensitivity such as severe asthma with fungal sensitization (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). This association however raises the possibility of a future risk of these potentially serious allergic respiratory manifestations.RiassuntoL’eosinofilia polmonare tropicale (TPE) è caratterizzata da tessuto polmonare e eosinofilia nel sangue periferico. Anche il siero IgE totale è notevolmente aumentato in TPE. Tuttavia, un’associazione con asma o altre condizioni di ipersensibilità non è stata descritta. Durante l'iter diagnostico di tre pazienti, che alla fine si sono rivelati presentare TPE, ipersensibilità al fungo, è stato trovato l’Aspergillus fumigatus. Tuttavia, non vi era alcuna evidenza di malattie di Aspergillus ipersensibilità come l'asma grave con sensibilizzazione fungina (SAF) e aspergillosi broncopolmonare allergica (ABPA). Questa associazione pone tuttavia la possibilità di un rischio futuro di queste potenzialmente gravi manifestazioni allergiche respiratorie.

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