Short Term Mortality in Young Patients (<40 y/o) With Alcoholic Liver Cirrhosis After First Hospitalization: Carilion Clinic Experience

Hepatic encephalopathy is a frequent and serious complication of liver cirrhosis; the pathophysiology of this complication is not fully understood although great efforts have been made during the last years. There are few prospective studies on the epidemiology of this complication; however, it is known that it confers with high short-term mortality. Hepatic encephalopathy has been classified into different groups depending on the degree of hepatic dysfunction, the presence of portal-systemic shunts, and the number of episodes. Due to the large clinical spectra of overt EH and the complexity of cirrhotic patients, it is very difficult to perform quality clinical trials for assessing the efficacy of the treatments proposed. The physiopathology, clinical manifestation, and the treatment of HE is a challenge because of the multiple factors that converge and coexist in an episode of overt HE.

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Investigation of Bacteremia due toAeromonasSpecies and Comparison with That due to Enterobacteria in Patients with Liver Cirrhosis

Gastroenterology Research and Practice ◽

10.1155/2011/930826 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Toru Shizuma ◽

Chiharu Tanaka ◽

Hidezo Mori ◽

Naoto Fukuyama

Keyword(s):

Liver Cirrhosis ◽

Japanese Patients ◽

Meld Score ◽

Short Term ◽

E Coli ◽

End Stage Liver Disease ◽

Short Term Mortality ◽

Clinical Background ◽

End Stage

Background. The role ofAeromonasspecies (sp.) in bacteremia in Japanese patients with liver cirrhosis is poorly understood.Aim. To establish the importance ofAeromonassp. as a cause of bacteremia in patients with liver cirrhosis.Methods. Clinical and serological features and short-term prognosis were retrospectively investigated and compared in Japanese patients with bacteremia due toAeromonassp. () and due to enterobacteria (E. coli, Klebsiellasp., andEnterobactersp.) ().Results. There were no significant differences in patients’ clinical background, renal dysfunction, or short-term mortality rate between the two groups. However, in theAeromonasgroup, the model for end-stage liver disease (MELD) score and Child-Pugh score were significantly higher than in the enterobacteria group.Conclusion. These results indicate that the severity of liver dysfunction inAeromonas-induced bacteremia is greater than that in enterobacteria-induced bacteremia in Japanese patients with liver cirrhosis.

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Effect of short term nutritional rehabilitation in malnourished patients with alcoholic liver cirrhosis on nutritional status and glucose homeostasis

Clinical Nutrition ◽

10.1016/0261-5614(90)90126-d ◽

1990 ◽

Vol 9 (1) ◽

pp. XX

Author(s):

D. Wahl ◽

J.M. Dollet

Keyword(s):

Liver Cirrhosis ◽

Nutritional Status ◽

Glucose Homeostasis ◽

Alcoholic Liver Cirrhosis ◽

Nutritional Rehabilitation ◽

Short Term

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Elevated Soluble Tumour Necrosis Factor Receptor Serum Concentrations and Short-Term Mortality in Liver Cirrhosis without Acute Infections

Digestion ◽

10.1159/000007777 ◽

2000 ◽

Vol 62 (1) ◽

pp. 44-51 ◽

Cited By ~ 7

Author(s):

Christoph Reichel ◽

Thomas Sudhop ◽

Barbara Braun ◽

Karl-Anton Kreuzer ◽

Corinna Hahn ◽

...

Keyword(s):

Liver Cirrhosis ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Tumour Necrosis Factor Receptor ◽

Serum Concentrations ◽

Short Term ◽

Acute Infections ◽

Short Term Mortality ◽

Necrosis Factor

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Human fetuin/α2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer

European Journal of Gastroenterology & Hepatology ◽

10.1097/00042737-200204000-00009 ◽

2002 ◽

Vol 14 (4) ◽

pp. 389-394 ◽

Cited By ~ 54

Author(s):

László Kalabay ◽

Lajos Jakab ◽

Zoltán Prohászka ◽

George Füst ◽

Zsuzsa Benkö ◽

...

Keyword(s):

Liver Cirrhosis ◽

Liver Cancer ◽

Liver Cell ◽

Cell Function ◽

Short Term ◽

Short Term Mortality

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Does liver cirrhosis affect the surgical outcome of primary colorectal cancer surgery? A meta-analysis

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02267-6 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Yu-Xi Cheng ◽

Wei Tao ◽

Hua Zhang ◽

Dong Peng ◽

Zheng-Qiang Wei

Keyword(s):

Colorectal Cancer ◽

Liver Cirrhosis ◽

Mortality Rate ◽

Meta Analysis ◽

Cochrane Library ◽

Short Term ◽

Poor Overall Survival ◽

Operation Rate ◽

Short Term Mortality ◽

Cirrhotic Group

Abstract Purpose The purpose of this meta-analysis was to evaluate the effect of liver cirrhosis (LC) on the short-term and long-term surgical outcomes of colorectal cancer (CRC). Methods The PubMed, Embase, and Cochrane Library databases were searched from inception to March 23, 2021. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of enrolled studies, and RevMan 5.3 was used for data analysis in this meta-analysis. The registration ID of this current meta-analysis on PROSPERO is CRD42021238042. Results In total, five studies with 2485 patients were included in this meta-analysis. For the baseline information, no significant differences in age, sex, tumor location, or tumor T staging were noted. Regarding short-term outcomes, the cirrhotic group had more major complications (OR=5.15, 95% CI=1.62 to 16.37, p=0.005), a higher re-operation rate (OR=2.04, 95% CI=1.07 to 3.88, p=0.03), and a higher short-term mortality rate (OR=2.85, 95% CI=1.93 to 4.20, p<0.00001) than the non-cirrhotic group. However, no significant differences in minor complications (OR=1.54, 95% CI=0.78 to 3.02, p=0.21) or the rate of intensive care unit (ICU) admission (OR=0.76, 95% CI=0.10 to 5.99, p=0.80) were noted between the two groups. Moreover, the non-cirrhotic group exhibited a longer survival time than the cirrhotic group (HR=2.96, 95% CI=2.28 to 3.85, p<0.00001). Conclusion Preexisting LC was associated with an increased postoperative major complication rate, a higher rate of re-operation, a higher short-term mortality rate, and poor overall survival following CRC surgery.

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Medical Acute Complications of Intracerebral Hemorrhage in Young Adults

Stroke Research and Treatment ◽

10.1155/2015/357696 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Riku-Jaakko Koivunen ◽

Elena Haapaniemi ◽

Jarno Satopää ◽

Mika Niemelä ◽

Turgut Tatlisumak ◽

...

Keyword(s):

Renal Failure ◽

Young Adults ◽

Intracerebral Hemorrhage ◽

Odds Ratio ◽

Young Patients ◽

Medical Complications ◽

Cardiac Complications ◽

Short Term ◽

Acute Complications ◽

Short Term Mortality

Background.Frequency and impact of medical complications on short-term mortality in young patients with intracerebral hemorrhage (ICH) have gone unstudied.Methods.We reviewed data of all first-ever nontraumatic ICH patients between 16 and 49 years of age treated in our hospital between January 2000 and March 2010 to identify medical complications suffered. Logistic regression adjusted for known ICH prognosticators was used to identify medical complications associated with mortality.Results.Among the 325 eligible patients (59% males, median age 42 [interquartile range 34–47] years), infections were discovered in 90 (28%), venous thrombotic events in 13 (4%), cardiac complications in 4 (1%), renal failure in 59 (18%), hypoglycemia in 15 (5%), hyperglycemia in 165 (51%), hyponatremia in 146 (45%), hypernatremia in 91 (28%), hypopotassemia in 104 (32%), and hyperpotassemia in 27 (8%). Adjusted for known ICH prognosticators and diabetes, the only independent complication associated with 3-month mortality was hyperglycemia (plasma glucose >8.0 mmol/L) (odds ratio: 5.90, 95% confidence interval: 2.25–15.48,P<0.001). Three or more separate complications suffered also associated with increased mortality (7.76, 1.42–42.49,P=0.018).Conclusions.Hyperglycemia is a frequent complication of ICH in young adults and is independently associated with increased mortality. However, multiple separate complications increase mortality even further.

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