S1942 Microscopic Hematuria Leading to the Diagnosis of Appendiceal Mucinous Carcinoma

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

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Histopathological and genetic characterization of colorectal mucinous carcinoma

Gastroenterology ◽

10.1016/s0016-5085(01)80821-0 ◽

2001 ◽

Vol 120 (5) ◽

pp. A166-A166

Author(s):

S FUJII ◽

T KUSAKA ◽

T KAIHARA ◽

Y UEDA ◽

T CHIBA ◽

...

Keyword(s):

Genetic Characterization ◽

Mucinous Carcinoma

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Faculty Opinions recommendation of Microscopic hematuria is associated with low bone mineral density in aged women and men.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1163269.623962 ◽

2009 ◽

Author(s):

Jon Tobias ◽

Emma Clark

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Microscopic Hematuria ◽

Mineral Density ◽

Low Bone Mineral Density

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Mucinous carcinoma of the breast: potential false-negative MR imaging interpretation.

American Journal of Roentgenology ◽

10.2214/ajr.167.2.8686654 ◽

1996 ◽

Vol 167 (2) ◽

pp. 539-540 ◽

Cited By ~ 4

Author(s):

R W Miller ◽

S Harms ◽

A Alvarez

Keyword(s):

Mr Imaging ◽

False Negative ◽

Mucinous Carcinoma ◽

Carcinoma Of The Breast

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Immunohistochemical Biomarkers as a Surrogate of Molecular Analysis in Ovarian Carcinomas: A Review of the Literature

Diagnostics ◽

10.3390/diagnostics11020199 ◽

2021 ◽

Vol 11 (2) ◽

pp. 199 ◽

Cited By ~ 1

Author(s):

Giacomo Santandrea ◽

Simonetta Piana ◽

Riccardo Valli ◽

Magda Zanelli ◽

Elisa Gasparini ◽

...

Keyword(s):

Ovarian Carcinoma ◽

Molecular Analysis ◽

Immunohistochemical Analysis ◽

Cost Effective ◽

Mucinous Carcinoma ◽

Serous Carcinoma ◽

Malignant Neoplasms ◽

Low Grade ◽

Ovarian Carcinomas ◽

Novel Target

The term “ovarian carcinoma” encompasses at least five different malignant neoplasms: high-grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous carcinoma, and clear cell carcinoma. These five histotypes demonstrated distinctive histological, molecular, and clinical features. The rise of novel target therapies and of a tailored oncological approach has demanded an integrated multidisciplinary approach in the setting of ovarian carcinoma. The need to implement a molecular-based classification in the worldwide diagnostic and therapeutic setting of ovarian cancer demanded a search for easy-to-use and cost-effective molecular-surrogate biomarkers, relying particularly on immunohistochemical analysis. The present review focuses on the role of immunohistochemistry as a surrogate of molecular analysis in the everyday diagnostic approach to ovarian carcinomas.

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