scholarly journals Flexible Multi-Electrode Array for Medical Applications

10.14311/1662 ◽  
2012 ◽  
Vol 52 (5) ◽  
Author(s):  
Nadine Winkin ◽  
Wilfried Mokwa
Keyword(s):  
Cochlear Implants ◽  
Action Potentials ◽  
Electrode Array ◽  
Medical Applications ◽  
Stress Tests ◽  
Novel Approach ◽  
First Results ◽  
Multi Electrode Array ◽  
Deep Brain ◽  
Stimulation Of

A flexible multi-electrode array (MEA) with an embedded silicon chip for electrical stimulation of neurons or for recording action potentials has been manufactured and characterized. Possible improvements for medical applications using this novel approach are presented. By connecting and addressing several of these MEAs via a bus system, the number and the density of electrodes can be increased significantly. This is interesting for medical applications such as retinal implants and cochlear implants, and also for deep brain stimulators. Design and fabrication techniques for the multi-electrode array are presented. Finally, first results of mechanical stress tests are shown.

scholarly journals Conductive hybrid carbon nanotube (CNT)–polythiophene coatings for innovative auditory neuron-multi-electrode array interfacing

RSC Advances ◽  
2016 ◽  
Vol 6 (48) ◽  
pp. 41714-41723 ◽  
Author(s):  
S. Ostrovsky ◽  
S. Hahnewald ◽  
R. Kiran ◽  
P. Mistrik ◽  
R. Hessler ◽  
...  
Keyword(s):  
Surface Modification ◽  
Carbon Nanotube ◽  
Cochlear Implants ◽  
Electrode Array ◽  
Auditory Neuron ◽  
Platinum Electrodes ◽  
Electrode Interface ◽  
Conductive Properties ◽  
Hybrid Carbon ◽  
Multi Electrode Array

Surface modification of platinum electrodes to improve neuron-electrode interface and electrode conductive properties in cochlear implants.

scholarly journals A lithographically-patterned, elastic multi-electrode array for surface stimulation of the spinal cord

2007 ◽  
Vol 10 (2) ◽  
pp. 259-269 ◽  
Author(s):  
Kathleen W. Meacham ◽  
Richard J. Giuly ◽  
Liang Guo ◽  
Shawn Hochman ◽  
Stephen P. DeWeerth
Keyword(s):  
Spinal Cord ◽  
Electrode Array ◽  
Multi Electrode Array ◽  
Stimulation Of

Practical Experimentation with Human Implants

2013 ◽  
pp. 64-132
Author(s):  
Kevin Warwick ◽  
Mark N. Gasson
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Electrode Array ◽  
Neural Implants ◽  
Social Pressures ◽  
Different Types ◽  
Multi Electrode Array ◽  
Deep Brain

In this chapter, the authors report on several different types of human implants with which the authors have direct, first hand, experience. An indication is given of the experimentation actually carried out and the subsequent immediate consequences are discussed. The authors also consider likely uses and opportunities with the technology should it continue to develop along present lines and the likely social pressures to adopt it. Included in the chapter is a discussion of RFID implants, tracking with implants, deep brain stimulation, multi-electrode array neural implants, and magnetic implants. In each case, practical results are presented along with expectations and experiences.

scholarly journals A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Matthew K. Hogan ◽  
Sean M. Barber ◽  
Zhoulyu Rao ◽  
Bethany R. Kondiles ◽  
Meng Huang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Therapeutic Potential ◽  
Cervical Spinal Cord ◽  
Electrode Array ◽  
Novel Approach ◽  
Cord Injury ◽  
Motor Region ◽  
Muscle Groups ◽  
Stimulation System ◽  
Stimulation Of

AbstractElectrical stimulation of the cervical spinal cord is gaining traction as a therapy following spinal cord injury; however, it is difficult to target the cervical motor region in a rodent using a non-penetrating stimulus compared with direct placement of intraspinal wire electrodes. Penetrating wire electrodes have been explored in rodent and pig models and, while they have proven beneficial in the injured spinal cord, the negative aspects of spinal parenchymal penetration (e.g., gliosis, neural tissue damage, and obdurate inflammation) are of concern when considering therapeutic potential. We therefore designed a novel approach for epidural stimulation of the rat spinal cord using a wireless stimulation system and ventral electrode array. Our approach allowed for preservation of mobility following surgery and was suitable for long term stimulation strategies in awake, freely functioning animals. Further, electrophysiology mapping of the ventral spinal cord revealed the ventral approach was suitable to target muscle groups of the rat forelimb and, at a single electrode lead position, different stimulation protocols could be applied to achieve unique activation patterns of the muscles of the forelimb.

Long-Term, Multisite, Parallel, In-Cell Recording and Stimulation by an Array of Extracellular Microelectrodes

2010 ◽  
Vol 104 (1) ◽  
pp. 559-568 ◽  
Author(s):  
Aviad Hai ◽  
Joseph Shappir ◽  
Micha E. Spira
Keyword(s):  
Action Potentials ◽  
Signal To Noise Ratio ◽  
Information Storage ◽  
The Novel ◽  
Novel Approach ◽  
Novel Drugs ◽  
Cell Recording ◽  
Machine Systems ◽  
Stimulation Of

Here we report on the development of a novel neuroelectronic interface consisting of an array of noninvasive gold-mushroom-shaped microelectrodes (gMμEs) that practically provide intracellular recordings and stimulation of many individual neurons, while the electrodes maintain an extracellular position. The development of this interface allows simultaneous, multisite, long-term recordings of action potentials and subthreshold potentials with matching quality and signal-to-noise ratio of conventional intracellular sharp glass microelectrodes or patch electrodes. We refer to the novel approach as “in-cell recording and stimulation by extracellular electrodes” to differentiate it from the classical intracellular recording and stimulation methods. This novel technique is expected to revolutionize the analysis of neuronal networks in relations to learning, information storage and can be used to develop novel drugs as well as high fidelity neural prosthetics and brain-machine systems.

scholarly journals Anterior nuclear deep brain stimulation guided by concordant hippocampal recording

2015 ◽  
Vol 38 (6) ◽  
pp. E9 ◽  
Author(s):  
Jamie J. Van Gompel ◽  
Bryan T. Klassen ◽  
Gregory A. Worrell ◽  
Kendall H. Lee ◽  
Cheolsu Shin ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Intractable Epilepsy ◽  
Anterior Nucleus ◽  
Novel Approach ◽  
The Us ◽  
Papez Circuit ◽  
Treatment Paradigm ◽  
Electroencephalographic Recording ◽  
Deep Brain ◽  
Stimulation Of

OBJECT Anterior nuclear (AN) stimulation has been reported to reduce the frequency of seizures, in some cases dramatically; however, it has not been approved by the US Food and Drug Administration. The anterior nucleus is difficult to target because of its sequestered location, partially surrounded by the ventricle. It has traditionally been targeted by using transventricular or lateral transcortical routes. Here, the authors report a novel approach to targeting the anterior nucleus and neurophysiologically confirming effective stimulation of the target, namely evoked potentials in the hippocampus. METHODS Bilateral AN 3389 electrodes were placed in a novel trajectory followed by bilateral hippocampal 3391 electrodes from a posterior trajectory. Each patient was implanted bilaterally with a Medtronic Activa PC+S device under an investigational device exemption approval. Placement was confirmed with CT. AN stimulation-induced hippocampal evoked potentials were measured to functionally confirm placement in the anterior nucleus. RESULTS Two patients had implantations by way of a novel AN trajectory with concomitant hippocampal electrodes. There were no lead misplacements. Postoperative stimulation of the anterior nucleus with a PC+S device elicited evoked potentials in the hippocampus. Thus far, both patients have reported a > 50% improvement in seizure frequency. CONCLUSIONS Placing AN electrodes posteriorly may provide a safer trajectory than that used for traditionally placed AN electrodes. In addition, with a novel battery that is capable of electroencephalographic recording, evoked potentials can be used to functionally assess the Papez circuit. This treatment paradigm may offer increased AN stimulation efficacy for medically intractable epilepsy by assessing functional placement more effectively and thus far has proven safe.

scholarly journals Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Pauline Duc ◽  
Michel Vignes ◽  
Gérald Hugon ◽  
Audrey Sebban ◽  
Gilles Carnac ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Neuromuscular Junction ◽  
Motor Neurons ◽  
Action Potentials ◽  
Electrode Array ◽  
Microfluidic Devices ◽  
Muscle Action ◽  
Human Motor ◽  
Micro Electrode Array ◽  
Stimulation Of

Microfluidic devices were coupled with custom MEA and used for co-culture of human motor neurons and muscles. This allowed to assess human NMJ activity by electrical stimulation of axons and recording of subsequent muscle action potentials.

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