Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects
Keyword(s):
Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessary functional properties. Lack of vitamin K-dependent carboxylation of these proteins leads to changes in their biological activity. In this literature review we cover the mechanisms of vitamin K-dependent carboxylation and none bone actions of osteocalcin and matrix Gla-protein with different degrees of carboxylation.
2021 ◽
Vol 80
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pp. 598-604
1994 ◽
Vol 108
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pp. 507-508
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2008 ◽
Vol 15
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pp. 504-508
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1999 ◽
Vol 82
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pp. 1764-1767
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2014 ◽
Vol 21
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pp. 153-158
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