scholarly journals Endothelial function in men with type 2 diabetes without clinical signs of cardiovascular disease

2016 ◽  
Vol 19 (5) ◽  
pp. 383-387 ◽  
Author(s):  
Irina Alexandrovna Khripun ◽  
Sergey Vladislavovich Vorobyev ◽  
Maxim Nikolaevich Morgunov ◽  
Michail Iosifovich Kogan
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Endothelial Function ◽  
Reactive Hyperemia ◽  
Clinical Signs ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Group 2 ◽  
Group 1

Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease that is based on endothelial dysfunction (ED). Currently, conventional diagnostic methods are unreliable, especially at early stages of disease.Aims. The aim of this work was to assess endothelial function in men with T2DM without clinical signs of cardiovascular disease.Materials and methods. The study included 100 patients (mean age, 54.3 ± 5.3 years) with a T2DM duration of less than 10 years and without signs of cardiovascular disease. The patients were divided into two groups: group 1 consisted of 60 patients with a T2DM duration of less than five years. Group 2 included 40 men with a history of diabetes between 5 and 10 years. Endothelial function was assessed by the levels of nitric oxide (NO), endothelial NO synthase type 3 (eNOS3), ICAM-1, VCAM-1, E-selectin, P-selectin, resistin and C-reactive protein and the arterial vasoreactivity of the brachial artery (BA) using the D. Celermajer method.Results. Results revealed decreases in levels of both eNOS3 by 2.5 fold (P = 0.0005) and NO by 1.9 fold (P = 0.043) in group 2 patients, compared to those in group 1 patients. When the duration of diabetes was greater than five years, levels of VCAM-1, resistin and C-reactive protein increased by 12.1% (P = 0.048), 62% (P = 0.01) and 45.6%, respectively. Additionally, the time until maximal BA vasodilatation during reactive hyperemia was observed to be higher in group 2 [105 (90; 180) seconds] than those in group 1 [90 (60; 120) seconds].Conclusions. Biochemical and imaging signs of ED begin to appear in the first five years of T2DM, long before clinical manifestations. The earliest symptoms are decreases in eNOS3 and NO levels, increases in VCAM-1 and resistin concentrations and increased time until maximal BA vasodilatation during reactive hyperemia.

scholarly journals Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial

Diabetologia ◽  
2015 ◽  
Vol 58 (7) ◽  
pp. 1494-1502 ◽  
Author(s):  
Sabita S. Soedamah-Muthu ◽  
◽  
Shona J. Livingstone ◽  
Valentine Charlton-Menys ◽  
D. John Betteridge ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Relationship between Indices of Vascular Function and Presence of Overt Cardiovascular Disease among Persons with Poorly Controlled Type 2 Diabetes

2021 ◽  
Vol 8 (12) ◽  
pp. 185
Author(s):  
Sofia Antoniou ◽  
Katerina K. Naka ◽  
Marios Papadakis ◽  
Aris Bechlioulis ◽  
Dimitrios Makriyiannis ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Glycemic Control ◽  
Vascular Function ◽  
Disease Duration ◽  
Vascular Dysfunction ◽  
Macrovascular Disease ◽  
Group 2 ◽  
Group 1

The aim of this study was to assess the factors associated with impaired vascular function in patients with poorly controlled type 2 diabetes (DM2) with and without overt cardiovascular disease (CVD). Ninety-five patients with DM2 and poor glycemic control were recruited and divided into two groups: Group 1, with known CVD (n = 38), and Group 2, without CVD (n = 57). Patients in Group 2 were further subdivided into those with short (<5 years, group 2b) and long (>5 years, group 2a) diabetes duration. Subclinical markers of atherosclerosis were assessed. Glycemic control was similar in the two groups (HbA1c: 9.2% (1.5) vs. 9.4% (1.8), p = 0.44). In Group 1, lower FMD (3.13 (2.16)% vs. 4.7 (3.4)%, p < 0.05) and higher cIMT (1.09 (0.3) mm vs. 0.96 (0.2) mm, p < 0.05) was seen compared with Group 2, whereas PWV was similar (12.1 (3.4) vs. 11.3 (3.0) m/s, p = 0.10). Patients in Group 2b had significantly lower PWV and cIMT and higher FMD compared to Group 1 (p < 0.05). Among patients with poorly controlled T2D, more pronounced vascular dysfunction was present in those with overt macrovascular disease. In patients with T2D without known CVD, vascular dysfunction was associated with disease duration. The use of vascular indices for cardiovascular risk stratification in patients with T2D requires further study.

scholarly journals Physical Activity, High-Sensitivity C-Reactive Protein, and Total and Cardiovascular Disease Mortality in Type 2 Diabetes

Diabetes Care ◽  
2011 ◽  
Vol 34 (7) ◽  
pp. 1492-1496 ◽  
Author(s):  
T. Vepsalainen ◽  
M. Soinio ◽  
J. Marniemi ◽  
S. Lehto ◽  
A. Juutilainen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cardiovascular Disease Mortality ◽  
Reactive Protein ◽  
Disease Mortality

scholarly journals GLYCEMIC CONTROL MODIFIES THE ASSOCIATION BETWEEN MICROALBUMINURIA AND C-REACTIVE PROTEIN IN TYPE 2 DIABETES MELLITUS

2020 ◽  
pp. 4-5
Author(s):  
Krishkumar A. Jivani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetes Mellitus Patient ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Group 2

BACKGROUND: HbA1c is most commonly used parameter for glycemic control in type 2 diabetes mellitus patient. AIM The aim of the study was to evaluate whether any association exists between C-reactive protein and microalbuminuria in well controlled and poorly controlled Type 2 DM patients. METHOD : In this study, we included total 90 patients of type 2 Diabetes Mellitus admitted in GKGH , Bhuj during the period from Aug. 2018 to June 2019. The subjects were divided into two groups according to glycemic control as Group 1(Poorly controlled Diabetics) and Group 2( Well controlled Diabetics ) The groups 1 and 2 (based on Glycemic control) were further divided into 3 subgroups A, B and C (based on CRP level) with 15 subjects in each of these six subgroups. RESULT: Subjects with poor glycemic control had elevated values of MAU at all comparative levels of CRP. Further, it was shown that the level of MAU increased considerably with increasing level of CRP. CONCLUSION : There is a significant positive correlation between the level of MAU and CRP status in poorly controlled Type 2 diabetics.

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