scholarly journals VLIYaNIE ISSLEDOVANIYa MINERAL'NOY PLOTNOSTI KOSTI (MPK) V STANDARTNYKh LOKALIZATsIYaKh I DOPOLNITEL'NYKh IZMERENIY MPK NA USTANOVLENIE DIAGNOZA OSTEOPOROZA

2005 ◽  
Vol 8 (2) ◽  
pp. 21-24
Author(s):  
M P RUBIN ◽  
R E ChEChURIN
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
X Ray ◽  
Diagnostic Categories ◽  
Fracture Threshold ◽  
Femur Neck ◽  
Two Sides ◽  
Adjacent Vertebra

The aim of the study was to improve the quality of densitometric evaluations of bone mineral density disorders. Dual-energy x-ray absorbtiometry data collected in 874 females were analyzed. All patients had got bone mineral density examination of the lumbar spine, proximal femur at the both sides; some of the patients also had been measured at the distal radius. We hypothesize that the judgment of diagnostic categories (osteoporosis stages) should include consideration of bone mineral density data both for L2-L4 and for any of two adjacent vertebra, as well as variations of the femur neck data between the two sides. Ultradistal forearm bone densitometry was carried out for osteopenic patients who had had a Colles'fracture -to estimate fracture risk for the opposite radius. The osteoporotic fracture threshold for such cases may be at T-Score of -.1.

scholarly journals Comparison of Bone Mineral Densitometry at 2 Sites Versus 3 Sites in Patients Suspicious for Osteoporosis

2019 ◽  
Vol 12 ◽  
pp. 117954411984901 ◽  
Author(s):  
Ahad Azami ◽  
Hasan Anari ◽  
Manouchehr Iranparvar ◽  
Amin Azizi ◽  
Afshin Habibzadeh
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
T Score ◽  
Femur Neck ◽  
Bone Mineral Densitometry

Objectives: In this study, we aim to evaluate the bone mineral density (BMD) results of 2 standard sites with 3 sites including wrist in diagnosing osteoporosis. Methods: We evaluated the BMD results of 1272 individuals referred for suspected osteoporosis between 2012 and 2015. Those individuals were included with BMD at lumbar spine, femur neck, and wrist. Bone mineral density was measured using a dual-energy X-ray absorptiometry (DXA) device. Bone mineral density and T score were measured for all 3 sites. Results: There was significant correlation between wrist T score with hip T score ( r = 0.606, P < .001) and lumbar T score ( r = 0.527, P < .001). With BMD of 2 sites, patients had osteopenia in 46.3% and osteoporosis in 23.7%, while by adding wrist T-BMD, subjects had osteopenia in 46.6% and osteoporosis in 33%. Between BMD at 2 sites and 3 sites, there was concordance in 81.9%, minor discordance in 17.6%, and major discordance in 0.5%. Conclusions: We observed discordance between BMD measurements of 2 sites and 3 sites, with latter detecting more cases with osteoporosis. In fact, measurement of T scores of wrist along with lumbar and femur neck improves the diagnosis.

scholarly journals Could procollagen type I N-terminal propeptide (PINP) and bone alkaline phosphatase (B-ALP) be valid alternative diagnostic markers to dual X-ray absorptiometry (DEXA) in elderly females with osteoporosis? An Egyptian radiological and laboratory monocentric study

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Marwa A. Saad ◽  
Reham A. Aboelwafa ◽  
Eman H. Elsayed
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Alkaline Phosphatase ◽  
Serum Markers ◽  
Type I ◽  
Mineral Density ◽  
X Ray ◽  
Procollagen Type ◽  
Procollagen Type I

Abstract Background Osteoporosis is a major health problem of elders. Dual X-ray absorptiometry (DEXA) is the commonly used modality for diagnosis osteoporosis; serum markers have been suggested for predicting osteoporosis and discriminate osteoporotic from healthy subjects. We aimed to analyze the status of some bone turnover biochemical markers namely PINP, B-ALP, estrogen, and progesterone in the elderly osteoporotic and osteopenic women as probable markers for the discrimination between patients and healthy individual in diagnosing osteoporosis, and also, to detect the impact of osteoporosis on quality of life of patients using assessment of the quality of life for osteoporosis (ECOS-16). Post-menopausal 108 females were involved in the current study, divided into two groups (osteoporotic group (60 with BMD˂-2.5), osteopenic group (48 with BMD between − 1 and − 2.5)), and 60 healthy elderly females as control group were involved in the study. Serum levels of procollagen type I N-terminal propeptide (PINP), bone alkaline phosphatase (B-ALP), estrogen, and progesterone were measured by ELISA technique. Results PINP and B-ALP significantly differ between studied groups. Also, PINP and B-ALP levels had high sensitivity and specificity to discriminate osteoporotic patients from healthy individuals. PINP and B-ALP significantly correlated with bone mineral density (BMD) and with ECOS-16. Estrogen differs significantly between osteoporotic and osteopenic groups and significantly correlated with bone mineral density of femur (BMD-F) and bone mineral density of spine (BMD-S) in the osteopenic group. Progesterone differed significantly between patients and controls and significantly correlated with BMD-F in the osteoporotic group. Conclusion We can consider PINP and B-ALP as biomarkers for early detection then monitoring of osteoporosis. Measuring these serum markers can replace the assessment of BMD if not available. Also, it could replace the gap between BMD subsequently spaced assessment or could be of value in cases with severe spondylosis, DISH syndrome, old spondylarthritis, and/or previous spinal surgery. Sex hormones could not differentiate the normal from the osteoporotic/osteopenic patients, so they cannot be used as diagnostic or prognostic markers. Validation of this assumption needs large and longitudinal studies.

scholarly journals AB0908 ASSESSMENT OF THE IMPACT OF THE LEAN MASS WITH BODY COMPOSITION BY DUAL-ENERGY X-RAY ABSORPTIOMETRY ON THE BONE MINERAL DENSITY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1756.3-1756
Author(s):  
M. Nikolov ◽  
N. Nikolov
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Lean Mass ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
T Score ◽  
The Impact

Background:Lean mass, mainly composed of muscle, has been correlated to bone mineral density (BMD) [4]. Studies reported that lean mass has an important impact on BMD not only in young women but also in postmenopausal women [1]. High lean mass is more favorable for the BMD than low lean mass. Some studies suggested that genetic factors responsible for both lean mass and BMD are shared [3]. Low muscle mass and low BMD could impair the quality of the patient’s life [2, 5].Objectives:The aim of this study is to assess the impact of the lean mass with body composition by dual-energy X-ray absorptiometry on the bone mineral density.Methods:107 women underwent body composition analysis by dual-energy X-ray absorptiometry (DXA). Lean mass in kg and BMD in kg/cm2 were analyzed. Normal BMD was defined as T-score > -1.0 standard deviation (SD). Osteopenia was defined as T-score between -1.0 SDs and -2.5 SDs and osteoporosis was defined as T-score ≤ - 2.5 SDs.Results:The mean age of the women was 57 years (yrs.) ± 11 yrs. (range 41 yrs. – 80 yrs.). Subjects had mean weight of 75 kg ± 12 kg (range 50 kg – 110 kg) and mean height of 156 cm ± 9 cm (range 151 cm – 172 cm). 73/107 women (68.2%) were with normal BMD, 24/107 women (22.4%) were with osteopenia and 10/107 women (9.4%) were with osteoporosis. Lean mass differed significantly between the groups (p = 0.000). Women with normal BMD had the highest mean lean mass (58.47 kg) and the mean lean mass of the women with osteopenia and osteoporosis decreased as follow: 47.56 kg for women with osteopenia and 36.22 kg for women with osteoporosis.Conclusion:Women with osteoporosis have the lowest lean mass compared to the women with osteopenia and osteoporosis.References:[1]Ilesanmi-Oyelere BL, Coad J, Roy N, Kruger MC. Lean Body Mass in the Prediction of Bone Mineral Density in Postmenopausal Women. Biores Open Access. 2018;7(1):150–158. Published 2018 Oct 10. doi:10.1089/biores.2018.0025.[2]Kirilov N., Vladeva SG, Kirilova E. Assessment on the Improvement of the Quality of Life after One Year of Regular Physical Activity and Treatment in Patients with Postmenopausal OsteoporosisCOR 2017: 19th International Conference on Orthopedics and Rheumatology Miami, USA March 9 - 10, 2017, WASET, Paper Code 17US030051.[3]Nguyen TV, Howard GM, Kelly PJ, Eisman JA. Bone mass, lean mass, and fat mass: same genes or same environments? Am J Epidemiol. 1998 Jan 1;147(1):3-16.[4]Patel HP, Dawson A, Westbury LD, et al. Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS). Calcif Tissue Int. 2018;103(1):35–43. doi:10.1007/s00223-018-0388-2.[5]Kirilova E, Kirilov N, Vladeva S. A study on the physical activity in women with decreased bone mineral density. Abstract book 13thscience conference MC, PlevenDisclosure of Interests:None declared

scholarly journals Bone mineral density in healthy Syrian women measured by dual energy X-ray absorptiometry

2018 ◽  
Vol 81 (1) ◽  
pp. 18-28
Author(s):  
Mohamed Adel Bakir ◽  
Kholoud B Hammad ◽  
Khuzama M Habil
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Reference Values ◽  
Standard Technique ◽  
Dual Energy ◽  
Specific Reference ◽  
Mineral Density ◽  
X Ray ◽  
Femur Neck

Abstract Assessment of bone mineral density (BMD) using dual energy X-ray absorptiometry (DXA) technique is considered as a standard technique for diagnosing osteopenia and osteoporosis and evaluating the severity of such diseases. Numerous studies have demonstrated the necessity to establish an ethnic-specific reference data for Bone mineral density measurements. Such data are lacking for the Syrian population. The objectives of this study are (1) to establish BMD reference values in a group of healthy Syrian women using DXA technique, (2) to compare with values from other populations, (3) to study the prevalence of osteopenia and osteoporosis in Syrian women using the manufacturer reference values. A total of 951 healthy Syrian women aged 20-79 years participated in this study. Weight, height, and BMI have been determined. BMD measurements were performed using Lunar Prodigy Advance System (GE). The data were compared with those from other populations. The results have demonstrated the expected decline in BMD with age after peaking at 30-39 years old group. The peak values of the lumbar spine and femur neck were 1.16 (0.12), and 0.95 (0.13) g/cm2, respectively. The results of the Syrian women were compared with those from other populations and the differences were presented. Osteopenia was diagnosed in 35.80% and 60.31% and osteoporosis in 6.23% and 2.72% in lumbar spine and femur neck, respectively, of women 50-59 years of age. These ratios increased to 36.84%, 68.42% and 23.68%, 13.10%, respectively, in the age group more than 59 years. BMD values of the Syrian women were determined for the first time. The results demonstrate the importance of establishing population-specific reference range for BMD values for an accurate assessment of Osteoporosis. High prevalence of osteopenia and osteoporosis was demonstrated in Syrian using the manufacturer reference values.

scholarly journals Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up

2021 ◽  
Vol 18 (15) ◽  
pp. 8144
Author(s):  
Gabriella Martino ◽  
Federica Bellone ◽  
Carmelo M. Vicario ◽  
Agostino Gaudio ◽  
Andrea Caputo ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Rating Scale ◽  
Osteoporotic Fractures ◽  
Oral Bisphosphonates ◽  
Mineral Density ◽  
X Ray ◽  
Hamilton Anxiety Rating Scale ◽  
Anxiety Levels

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (β = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.

scholarly journals POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 227.2-228
Author(s):  
D. Claire ◽  
M. Geoffroy ◽  
L. Kanagaratnam ◽  
C. Isabelle ◽  
A. Hittinger ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
General Population ◽  
Bone Mineral ◽  
Bone Densitometry ◽  
Dual Energy ◽  
Mineral Density ◽  
Least Significant Change ◽  
X Ray ◽  
Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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