PO-229 Physiology of Aerobic Exercise in Atherosclerosis

Objective - Methods - Results - Conclusions Clinicians has always been excessively reliant on drugs to treat patients with Atherosclerosis.Resently, it is advocated to do aerobic exercise. Such knowledge should aid in preventing and treating dyslipidemia, oxidative stress,inflammation, vascular endothelial dysfunction while reducing the risks of atherosclerosis.

Primary Prevention of Age‐ and Western Diet‐Associated Vascular Endothelial Dysfunction by Voluntary Aerobic Exercise in Mice: Role of Mitochondrial Oxidative Stress

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.696.20 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Zachary S Clayton ◽

Rachel A Gioscia‐Ryan ◽

Matthew J Rossman ◽

James J Richey ◽

Lauren M Cuevas ◽

...

Keyword(s):

Oxidative Stress ◽

Primary Prevention ◽

Endothelial Dysfunction ◽

Aerobic Exercise ◽

Western Diet ◽

Vascular Endothelial ◽

Mitochondrial Oxidative Stress

B6D2F1 mouse model to study the effects of habitual aerobic exercise on vascular endothelial dysfunction with aging

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.1235.11 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Jessica Ruth Durrant ◽

Melanie L Connell ◽

Brian J Folian ◽

Molly J Russell ◽

Douglas R Seals ◽

...

Keyword(s):

Endothelial Dysfunction ◽

Mouse Model ◽

Aerobic Exercise ◽

Vascular Endothelial ◽

Stretching Exercises Improve Vascular Endothelial Dysfunction Through Attenuation of Oxidative Stress in Chronic Heart Failure Patients With an Implantable Cardioverter Defibrillator

Journal of Cardiopulmonary Rehabilitation and Prevention ◽

10.1097/hcr.0000000000000229 ◽

2017 ◽

Vol 37 (2) ◽

pp. 130-138 ◽

Cited By ~ 10

Author(s):

Michitaka Kato ◽

Takashi Masuda ◽

Michio Ogano ◽

Kazuki Hotta ◽

Hisato Takagi ◽

...

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Chronic Heart Failure ◽

Endothelial Dysfunction ◽

Implantable Cardioverter Defibrillator ◽

Vascular Endothelial ◽

Cardioverter Defibrillator ◽

Heart Failure Patients ◽

Stretching Exercises

Metformin prevents hyperglycaemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor, Nr4a1 (Nur77).

Molecular Pharmacology ◽

10.1124/molpharm.120.000148 ◽

2021 ◽

pp. MOLPHARM-AR-2020-000148

Author(s):

Vivek Krishna Pulakazhi Venu ◽

Mahmoud Saifeddine ◽

Koichiro Mihara ◽

Muniba Faiza ◽

Evgueni Gorobets ◽

...

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Nuclear Receptor ◽

Essential Role ◽

Vascular Endothelial ◽

Orphan Nuclear Receptor ◽

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

Aging Cell ◽

10.1111/j.1474-9726.2010.00557.x ◽

2010 ◽

Vol 9 (3) ◽

pp. 304-312 ◽

Cited By ~ 102

Author(s):

Catarina Rippe ◽

Lisa Lesniewski ◽

Melanie Connell ◽

Thomas LaRocca ◽

Anthony Donato ◽

...

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Endothelial Dysfunction ◽

Calorie Restriction ◽

Vascular Endothelial ◽

Short Term ◽

Old Mice

Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

Circulation ◽

10.1161/circulationaha.108.804294 ◽

2009 ◽

Vol 119 (9) ◽

pp. 1284-1292 ◽

Cited By ~ 152

Author(s):

Gary L. Pierce ◽

Lisa A. Lesniewski ◽

Brooke R. Lawson ◽

Stacy D. Beske ◽

Douglas R. Seals

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Nuclear Factor Κb ◽

Vascular Endothelial ◽

Nuclear Factor ◽

Middle Aged

Vascular Endothelial Dysfunction Caused by Oxidative Stress is a Predictor Factor for Complications of Obstructive Sleep Apnea Syndrome

West Indian Medical Journal ◽

10.7727/wimj.2015.383 ◽

2016 ◽

Cited By ~ 2

Author(s):

K Kilic ◽

B Aktan ◽

MS Sakat ◽

A Kızıltunç ◽

O Yoruk

Keyword(s):

Oxidative Stress ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Endothelial Dysfunction ◽

Sleep Apnea Syndrome ◽

Vascular Endothelial ◽

Obstructive Sleep ◽

Apnea Syndrome ◽

Predictor Factor

Anti-fatigue and vasoprotective effects of quercetin-3-O-gentiobiose on oxidative stress and vascular endothelial dysfunction induced by endurance swimming in rats

Food and Chemical Toxicology ◽

10.1016/j.fct.2014.03.026 ◽

2014 ◽

Vol 68 ◽

pp. 290-296 ◽

Cited By ~ 36

Author(s):

Yin Lin ◽

Hua-Liang Liu ◽

Jie Fang ◽

Chen-Huan Yu ◽

Yao-Kang Xiong ◽

...

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Vascular Endothelial ◽

Effect of agmatine on experimental vascular endothelial dysfunction

Human & Experimental Toxicology ◽

10.1177/0960327115597311 ◽

2015 ◽

Vol 35 (5) ◽

pp. 573-582 ◽

Cited By ~ 6

Author(s):

MA Nader ◽

NM Gamiel ◽

H El-Kashef ◽

MS Zaghloul

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Lipid Profile ◽

Thiobarbituric Acid ◽

Nuclear Factor Κb ◽

Cellular Adhesion ◽

Vascular Endothelial ◽

Cellular Adhesion Molecule ◽

Nitrite Nitrate

This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduced glutathione, superoxide dismutase generation, serum nitrite/nitrate, serum vascular cellular adhesion molecule-1 (VCAM-1), and aortic nuclear factor κB (NF-κB) levels were analyzed.Treatment with AG markedly improves lipid profile and prevented NIC-induced VED and oxidative stress. The mechanism of AG in improving NIC-induced VED may be due to the significant reduction in serum VCAM-1 levels and aortic NF-κB. Thus, it may be concluded that AG reduces the oxidative stress, nitric oxide production, VCAM-1 levels, and aortic NF-κB expression, thereby consequently improving the integrity of vascular endothelium.