A new approach to gene prediction, based on the self-organising map

Author(s):  
Veera Talukdar ◽  
Amit Konar ◽  
Shibram Paria ◽  
Subhasis Maity ◽  
Tapas Kumar Pal
2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>


2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>


Author(s):  
Hsiang-Yun Chen

This chapter addresses the assumed connection between de se attitude ascription and logophoricity in the case of Chinese ziji. It is widely believed that logophors are among the paradigm cases of de se marking, and that long-distance ziji is logophoric. Drawing on a critical examination of a variety of analyses, this chapter argues that long-distance anaphora, de se interpretation, and logophoric marking are overlapping but distinct phenomena. Even if ziji is logophoric, it does not automatically trigger de se requirement. A de se-neutral analysis of ziji is consistent with pragmatic derivations of interpretations that emphasize the self. The findings point to a new approach to long-distance binding, and identify the blocking effect as the key issue for further research.


2021 ◽  
Vol 8 (1) ◽  
pp. 205510292110090
Author(s):  
Milica Petrovic ◽  
Andrea Gaggioli

The existing interventions for informal caregivers assist with managing health outcomes of the role burden. However, the deeper meaning-making needs of informal caregivers have been generally neglected. This paper reflects on the meaning-making needs of informal caregivers, through the theory of narrative identity, and proposes a new approach – the Transformative Video Design technique delivered via video storytelling. Transformative Video Design assists informal caregivers to re-create a cohesive caregiving story and incorporate it into the narrative identity. The technique is used as a stimulus for triggering the self-re-structure within the narrative identity and facilitating role transformation.


10.1068/b3186 ◽  
2005 ◽  
Vol 32 (1) ◽  
pp. 89-110 ◽  
Author(s):  
Tom Kauko

The aim of exploring and monitoring housing-market fundamentals (prices, dwelling features, area density, residents, and so on) on a macrolocational level relates to both public and private sector policymaking. Housing market segmentation (that is, the emergence of housing submarkets), a concept with increasing relevance, is defined as the differentiation of housing in terms of the income and preferences of the residents and in terms of administrative circumstances. In order to capture such segmentation empirically, the author applies a fairly new and emerging technique known as the ‘self-organising’ map (SOM), or ‘Kohonen map’. The SOM is a type of (artificial) neural network—a nonlinear and flexible (that is, nonparametric or semiparametric) regression and ‘machine learning’ technique. By utilising the ability of the SOM to visualise patterns, one can analyse various dimensions within the variation of the dataset. Segmentation may then be detected depending on the resulting patterns across the map layers, each of which represents the data variation for one input variable. Utilising an inductive modelling strategy, the author runs cross-sectional and nationwide data on the owner-occupied housing markets of Finland (documentation presented elsewhere), the Netherlands, and Hungary with the SOM technique. On the basis of the resulting configurations certain regularities (similarities and differences) across the three national contexts are identified. In all three cases the segments are determined by physical and institutional differences between the housing bundles and localities. The exercise demonstrates how the inductive SOM-based approach is well-suited for illustrating the contextual factors that determine housing market structure.


2012 ◽  
Vol 472-475 ◽  
pp. 3384-3389
Author(s):  
Zai Qiang Huo ◽  
Xue Qun Zhu

It is valuable to be researched in the application of science of complexity to the forest ecosystem. Forest ecosystem is an adaptive complex system which is suggested to be at the edge of chaos or at the criticality. The inner interaction of a forest ecosystem is the main driving force for the self-organization, complexity and order in the forest ecosystem. Forest ecosystem complexity is one of the research frontiers of ecological and evolutionary problems presently. The application of science of complexity to the forest ecosystem complexity studies, its concept, background, methodology and theory are briefly introduced. The forest ecosystem complexity is defined as the structure and function diversity, self-organization and the order of an ecosystem. Its main methods include the cellular automaton, genetic algorithm, game theory, complex network, etc. This paper has discussed mechanism and development of forest ecosystem complexity, by applying the principle and methods of science of complexity, which is a new approach for understanding ecological and evolutionary problems.


1987 ◽  
Vol 17 (1) ◽  
pp. 71-91 ◽  
Author(s):  
Mohammed E. Ahrari

In explaining the making and unravelling of the synfuels policy in the United States, a new approach—the ambivalent-majoritarian paradigm—is presented in this article. This paradigm fills a significant conceptual gap for the study of domestic policy formulated under crisis conditions.It is argued that the self-imposed necessity to respond to a crisis condition involving a policy decision is likely to force legislators to adopt a policy option that they would not adopt under normal conditions. The crisis response is likely to be passed by a ‘majoritarian’ crisis coalition which would also include a significant number of ‘ambivalents’, i.e., those legislators who have serious misgivings about the correctness or feasibility of the policy. In order for such a policy response to survive, it must withstand the scrutiny of ‘normal’ conditions involving that policy.


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