scholarly journals Gamma-glutamyl transferase is associated with sarcopenia and sarcopenic obesity in community-dwelling older adults: results from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011

2015 ◽  
Vol 62 (7) ◽  
pp. 585-592 ◽  
Author(s):  
Namki Hong ◽  
Eun Young Lee ◽  
Chang Oh Kim
Keyword(s):  
Older Adults ◽  
National Health ◽  
Community Dwelling ◽  
Sarcopenic Obesity ◽  
Gamma Glutamyl Transferase ◽  
Nutrition Examination Survey ◽  
Gamma Glutamyl ◽  
Health And Nutrition ◽  
Glutamyl Transferase ◽  
Community Dwelling Older Adults

Heart Failure and Disability in Community-Dwelling Older Adults in the United States—1999 to 2018: Data From National Health and Nutrition Examination Survey

2021 ◽  
pp. 105477382110616
Author(s):  
Yaewon Seo ◽  
Jing Wang ◽  
Donelle Barnes ◽  
Surendra Barshikar
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Logistic Regression ◽  
National Health ◽  
The United States ◽  
Community Dwelling ◽  
Nutrition Examination Survey ◽  
Mediating Effects ◽  
Health And Nutrition ◽  
Community Dwelling Older Adults

To examine the associations of heart failure (HF) with five domains of disability while controlling for covariates. Subjects with HF and aged ≥ 50 years were selected from the 1999 to 2018 National Health and Nutrition Examination Survey data. Five domains of disability were measured with 19 physical tasks. Logistic regression with adjustment for covariates was conducted. The prevalence of HF in 27,185 adults aged ≥ 50 years was 6.37%. After controlling for demographics and smoking, logistic regression showed that HF was associated with 2.8 to 3.4 times increased odds of all domains of disability compared to adults without HF, but with additional adjustments of covariates, the association was attenuated indicating the mediating effects of covariates. The future study may examine the mediating effects of covariates when intervening difficulties with lower extremity mobility and activities of daily living while considering in community-dwelling older adults with HF.

scholarly journals An Exposome-Wide Association Study On Body Mass Index In Adolescents Using The National Health And Nutrition Examination Survey (NHANES) 2003-2004 And 2013-2014 Data

2021 ◽  
Author(s):  
Nadine Haddad ◽  
Xanthi Andrianou ◽  
Christa Parrish ◽  
Stavros Oikonomou ◽  
Konstantinos Makris
Keyword(s):  
Body Mass Index ◽  
Association Study ◽  
Body Mass ◽  
National Health ◽  
Population Characteristics ◽  
Gamma Glutamyl Transferase ◽  
Nutrition Examination Survey ◽  
Mean Cell Volume ◽  
Health And Nutrition ◽  
Glutamyl Transferase

Abstract Background: Excess weight is a public health challenge affecting millions worldwide, including younger age groups. The human exposome concept presents a novel opportunity to comprehensively characterize all non-genetic disease determinants at susceptible time windows. Objective: Our study aimed to describe the association between multiple lifestyle and nutritional exposures and body mass index (BMI) in adolescents using the exposome framework. Methods: We conducted an exposome-wide association study using the U.S. National Health and Nutrition Examination Survey (NHANES) 2003-2004 survey for discovery of associations between the study population characteristics and BMI, and the 2013-2014 survey to replicate analysis. We included non-diabetic and non-pregnant adolescents aged 12-18 years. We analyzed variables available in both survey rounds, with <20% of missing values in relation to BMI z-scores. We performed univariable and multivariable linear regression analysis adjusted for age, sex, race/ethnicity, household smoking, and income to poverty ratio, and corrected for false-discovery rate (FDR). Results: A total of 1899 and 1224 participants were eligible from the 2003-2004 and 2013-2014 survey waves. The weighted proportions of overweight were 18.4% and 18.5% whereas those for obese were 18.1% and 20.6% in 2003-2004 and 2013-2014, respectively. Retained exposure agents included 63 dietary, 57 clinical and 1 physical activity variables. After FDR correction, univariable regression identified 35 and 18 predictors in the discovery and replication datasets, respectively, while multivariable regression identified 20 and 9 predictors in the discovery and replication datasets, respectively. Seven were significant in both datasets: alanine aminotransferase, gamma glutamyl transferase, mean cell volume, segmented neutrophils number, triglycerides; uric acid and white blood cell count. Discussion: This is the first ExWAS study in NHANES describing associations between zBMI, nutritional and clinical factors in adolescents. Future studies are warranted to investigate the role of the identified predictors as early-stage biomarkers of increased BMI and associated pathologies among adolescents and to replicate findings to other populations.

scholarly journals Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3957
Author(s):  
Shama D. Karanth ◽  
Caretia Washington ◽  
Ting-Yuan D. Cheng ◽  
Daohong Zhou ◽  
Christiaan Leeuwenburgh ◽  
...  
Keyword(s):  
Older Adults ◽  
Logistic Regression ◽  
National Health ◽  
Dose Response ◽  
Body Height ◽  
Sarcopenic Obesity ◽  
Nutrition Examination Survey ◽  
Response Curves ◽  
Health And Nutrition ◽  
Chronic Comorbidities

Loss of muscle mass and waning in muscle strength are common in older adults, and inflammation may play a key role in pathogenesis. This study aimed to examine associations of C-reactive protein (CRP) and systemic immune-inflammation index (SII) with sarcopenia and sarcopenic obesity in older adults with chronic comorbidities. Cross-sectional data from the National Health and Nutrition Examination Survey (1999–2006) were obtained for participants aged ≥60 years. Sarcopenia was defined by a lean mass and body height (males < 7.26 kg/m2, females < 5.45 kg/m2). Sarcopenic obesity was defined by the concurrent presence of sarcopenia and obesity (defined by relative fat mass). Logistic regression was used to assess the associations of CRP and SII with sarcopenia and sarcopenic obesity. The dose–response relationship was examined via restricted cubic splines. Of the participants (n = 2483), 23.1% (n = 574) and 7.7% (n = 190) had sarcopenia and sarcopenic obesity, respectively. The multivariable logistic regression models suggested a positive association of SII with sarcopenia and sarcopenic obesity, but a positive statistically significant association was not consistently observed for CRP. Dose–response curves suggested similar association patterns for these biomarkers. In clinical practice, measures to prevent sarcopenia and sarcopenic obesity are needed for older vulnerable people with high systemic inflammation.

scholarly journals Sarcopenic Obesity in Older Adults: Findings From the National Health and Aging Trends Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 617-618
Author(s):  
Kathleen Dondero ◽  
Jason Falvey ◽  
Brock Beamer ◽  
Odessa Addison
Keyword(s):  
Older Adults ◽  
National Health ◽  
The United States ◽  
Community Dwelling ◽  
Sarcopenic Obesity ◽  
European Working ◽  
National Burden ◽  
Nationally Representative ◽  
Socially Isolated ◽  
Community Dwelling Older Adults

Abstract Sarcopenic obesity increases risk for dysmobility and loss of independence, (Gandham et al., 2021). However, the national burden of sarcopenic obesity and the resultant impacts for older adults has yet to be described. Within a nationally representative sample from the National Health and Aging Trends Study (NHATS), 2066 community-dwelling older adults were obese, representing 12,136,374 individuals in the United States, or 31.8% of all community dwelling older adults. Based on the European Working Group definition, 18% of the obese older adults were sarcopenic. Sarcopenic obese older adults were more likely to have fallen in the last month and been hospitalized over the prior year. After adjusting for age and sex, sarcopenic obese older adults were 3.7 times more likely (95% CI 2.2-5.0) to have 2 or more comorbid conditions and frailty was 6.4 times more likely (95% CI 4.4-9.5) compared to nonsarcopenic obese older adults. Sarcopenic obese older adults were also more likely to have 1+ ADL disabilities (OR 3.7; 95% CI 2.5-5.4). Further, they were more likely to be socially isolated (OR 2.1; 95% CI 1.3-3.2) and report food insecurity (OR 1.5; 95% CI 0.8-2.9). These findings suggest older adults with obesity and sarcopenia have higher rates of geriatric vulnerabilities, which might indicate a need for caution when recommending weight loss alone as an intervention. A more comprehensive intervention may be necessary to address social and physiological risks. Future studies should examine whether early intervention in sarcopenic obese older adults can reduce chronic health risk and preserve independence.

scholarly journals Healthcare provider counselling for weight management behaviours among adults with overweight or obesity: a cross-sectional analysis of National Health and Nutrition Examination Survey, 2011–2018

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e039295
Author(s):  
Mary L. Greaney ◽  
Steven A. Cohen ◽  
Furong Xu ◽  
Christie L Ward-Ritacco ◽  
Deborah Riebe
Keyword(s):  
Older Adults ◽  
National Health ◽  
Weight Status ◽  
Calorie Intake ◽  
Nutrition Examination Survey ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Race Ethnicity ◽  
Sectional Analysis ◽  
Overweight Or Obesity

ObjectivesTo determine if adults with overweight or obesity received counselling from their healthcare providers (HCPs) to lose weight and/or adopt healthful behaviours associated with weight loss, and whether they took action on their HCPs’ recommendations.DesignCross-sectional analysis of 2011–2018 National Health and Nutrition Examination Survey (NHANES) data.SampleNHANES respondents aged 18+ who were overweight/obese and had seen an HCP in the previous 12 months (n=13 158).MethodsRespondents reported if their HCPs recommended they control/lose weight, increase exercise/physical activity (PA) and/or reduce fat/calorie intake, and if they adopted the offered recommendation(s). Weighted logistic regression models examined receipt of HCP counselling by sex, age, race/ethnicity, and weight status accounting for demographic characteristics and complex sampling. Similar analyses examined reported adoption of HCPs’ recommendations.ResultsThe sample was 53.1% women, 45.0% were overweight and 55.0% had obesity. In total, 40.4% received counselling to control/lose weight, 49.5% to increase exercise/PA and 38.9% to reduce fat/calorie intake. The following groups were less likely (p<0.001) to receive counselling: men; younger adults (aged 18–39) versus middle-aged (aged 40–64) and older adults (aged 65+); White versus Black and Hispanic respondents; overweight respondents versus respondents with obesity. Approximately half of those advised to make changes reported doing so (53.6% controlled/lost weight, 57.3% increased exercise/PA, 51.8% reduced fat/calorie intake). Differences in the adoption of recommendations were identified by sex, age group, race/ethnicity and weight status (all p<0.05); women, middle-aged and older adults, Black and Hispanic respondents and individuals with obesity were more likely to adopt one or more recommendations.ConclusionMost respondents did not receive HCP counselling, and approximately half of those who received counselling reported taking action. HCPs may need training to provide counselling and to offer recommendations tailored to the social contexts of populations less likely to adopt weight control related recommendations.

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