The -1535 Promoter Variant of The Visfatin Gene Is Associated with Serum Triglyceride and HDL-cholesterol Levels in Japanese Subjects

Metabolic syndrome is a health problem that often occurs among populations in Indonesia. Data on the characteristics of patients with metabolic syndrome is still very limited, despite the importance of cardiovascular disease prevention. The study aims to explain the prevalence and characteristics of patients with metabolic syndrome in Indonesia. The research methodology used descriptive research using a cross-sectional design. The number of respondents was seven men and 34 women, counted by consecutive sampling. The data was collected from the SQ-FFQ questionnaire and calculating the DQI-I score, analyzing physical activity through the GPAQ questionnaire converted into METs, measuring blood pressure, taking blood, measuring waist circumference, measuring fasting blood sugar. Through enzymatic tests, Serum triglyceride levels through the enzymatic colorimetric GPO-PAP test and HDL cholesterol levels were measured by the CHODPAP method. The results showed that the prevalence of SM was 20.45%, and the majority were women. The largest age group were the elderly. Most cases of metabolic syndrome have three components, with the largest components being central obesity (100%) and blood pressure (88.89%). Most categories of activity were moderate, and diet quality was low. All metabolic syndrome patients in this study were found not to smoke and not to consume alcohol. Based on these results, it can be concluded that SM incidence was high. Further research is needed regarding the relationship between acquired risk factors and metabolic syndrome.

Download Full-text

Effect of Dietary Fish Oil on Hyperlipidaemia due to Isotretinoin and Etretinate

Human Toxicology ◽

10.1177/096032718700600308 ◽

1987 ◽

Vol 6 (3) ◽

pp. 219-222 ◽

Cited By ~ 26

Author(s):

J.R. Marsden

Keyword(s):

Fish Oil ◽

Serum Lipids ◽

Serum Triglyceride ◽

Dietary Supplementation ◽

Hdl Cholesterol ◽

Cholesterol Levels ◽

Apoprotein B ◽

Dietary Fish ◽

Lipoprotein Composition

Treatment with retinoids results in increased serum triglyceride and cholesterol and reduced HDL-cholesterol; dietary supplementation with fish oil lowers serum lipids. Therefore combining retinoids with fish oil may reduce retinoid hyperlipidaemia. Increased triglyceride due to isotretinoin was reduced by 70% (P < 0.05) and cholesterol by 45% (P < 0.05) after addition of fish oil; placebo oil had no effect. These decreases were not associated with changes in levels of HDL-cholesterol or reduction of increased levels of apoprotein B. Increased triglyceride due to etretinate was reversed after the addition of fish oil (P < 0.01), but cholesterol levels did not change. Therefore fish oil inhibits hypertriglyceridaemia due to isotretinoin and etretinate and reduces increased cholesterol levels due to isotretinoin; this effect is likely to be due to altered lipoprotein composition.

Download Full-text

PERBANDINGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN DARAH PADA WANITA OBES DAN NON OBES

Jurnal e-Biomedik ◽

10.35790/ebm.1.2.2013.5473 ◽

2013 ◽

Vol 1 (2) ◽

Author(s):

Hanif B. S. Gani

Keyword(s):

Serum Triglyceride ◽

Hdl Cholesterol ◽

Female Students ◽

Serum Triglyceride Level ◽

Obese People ◽

Cross Sectional ◽

Cholesterol Levels ◽

Obese Female ◽

Significant Difference ◽

Cross Sectional Design

Abstract: In general, obesity is associated with a decrease of blood HDL-cholesterol level and an increase of serum triglyceride level. In obese people, the triglyceride is deposited in the subcutaneous layer of the skin. This triglyceride plays an important role in the formation of VLDL and LDL-cholesterol in the liver which will be released into the blood. This was an observational study with a cross-sectional design. Samples were 22 obese female students and 22 non-obese female students of Faculty of Medicine, University of Sam Ratulangi Manado aged 18-22 years. The results showed that the mean HDL-cholesterol levels in obese females was 57.64 mg/dL, meanwhile of the non-obese females was 61.77 mg/dL. Albeit, the statistical analysis showed no significant difference between the HDL-cholesterol levels of obese and non-obese females (P-value 0.974). Conclusion: There was no significant difference between the HDL-cholesterol levels of obese females and non obese females. Keywords: HDL-cholesterol levels, females, obese, non obese Abstrak: Obesitas berhubungan dengan penurunan kadar kolesterol HDL darah dan peningkatan kadar serum trigliserida.3 Pada individu obes, trigliserida disimpan pada jaringan subkutan. Trigliserida itu merupakan bahan utama pembentukan VLDL dan LDL di hati yang akan dilepaskan ke dalam darah. Penelitian ini bersifat observasional dengan menggunakan cross-sectional design. Sampel penelitian terdiri dari 22 mahasiswi Fakultas Kedokteran Universitas Sam Ratulangi yang obes dan 22 mahasiswi yang non-obes. Hasil penelitian memperlihatkan bahwa rerata kadar kolesterol HDL pada sampel yang obes 57,64 mg/dL dan pada yang non-obes 61,77 mg/dL. Uji statistik memperlihatkan tidak terdapat perbedaan bermakna antara kadar kolesterol HDL darah pada wanita yang obes dan yang non-obes (P = 0,974). Simpulan: Tidak terdapat perbedaan bermakna antara kadar kolesterol HDL darah pada wanita obes dan wanita non-obes. Kata kunci: kadar kolestrol HDL, wanita, obes, non-obes.

Download Full-text

Dyslipidaemia in Cortical Versus Subcortical Infarction

Bangladesh Journal of Neuroscience ◽

10.3329/bjn.v24i1.3037 ◽

1970 ◽

Vol 24 (1) ◽

pp. 24-33

Author(s):

Tarun Kanti Sarker ◽

Md Ruhul Kuddus ◽

Md Rezaul Karim Khan ◽

AKM Anwar Ullah ◽

Md Rafiqul Islam ◽

...

Keyword(s):

Ischaemic Stroke ◽

Serum Triglyceride ◽

Hdl Cholesterol ◽

Lacunar Infarct ◽

Total Serum ◽

Total Serum Cholesterol ◽

Case Group ◽

Control Subjects ◽

Cholesterol Levels ◽

Subcortical Infarct

Objectives: The aim of the study was to predict risk of cerebral infarction either cortical or lacunar in population having dyslipidaemia and to create awareness regarding it as a risk factor for ischaemic stroke and to take preventive measures for the prevention of a first or recurrent ischaemic stroke. Method: This study was conducted in the Department of Nurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from March to October, 2006. This study included 30 acute ischaemic stroke patients diagnosed by history, clinical findings and confirmed by CT/MRI scan of head within 2 weeks of attack. Both man and woman age ranging from 40-90 years were eligible to enter into the study. The same number of age and sex matched nonstroke patients who gave blood for analysis were included as control. Result: In this study among other risk factors total serum cholesterol was raised in both cortical and lacunar infarct in 50% of cases in comparison to 33.3% controls (P<0.05). LDL-cholesterol levels were raised in both cortical and lacunar infarct in 50% of cases compared to 30% controls (P<0.05). HDL-cholesterol levels were significantly low in cases (70%) compared to control subjects (26.7%). It was significantly low in cases of cortical infarct (77.3%) compared to 50% cases of lacunar infarct (P<0.01). Serum triglyceride levels were raised in 60% of case group and 26.7% of control subjects (P<0.01). Serum triglyceride levels were raised in 54.5% cases of cortical infarcts compared to 75% cases of lacunar infarcts. Conclusion: The results indicate an association between dyslipidaemia and the risk of ischaemic stroke, specially cortical type. Dyslipidaemia more related to cortical infarct than subcortical infarct. Low level of HDL-cholesterol was related to cortical infarct but not with subcortical infarct. DOI: http://dx.doi.org/10.3329/bjn.v24i1.3037 Bangladesh Journal of Neuroscience 2008; Vol. 24 (1) : 24-33

Download Full-text

Lipid Responses in Mildly Hypertriglyceridemic Men and Women to Consumption of Docosahexaenoic Acid-Enriched Eggs

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.73.5.357 ◽

2003 ◽

Vol 73 (5) ◽

pp. 357-368 ◽

Cited By ~ 32

Author(s):

Maki ◽

Van Elswyk ◽

McCarthy ◽

Seeley ◽

Veith ◽

...

Keyword(s):

Docosahexaenoic Acid ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Hdl Cholesterol ◽

Controlled Clinical Trial ◽

Nuclear Magnetic Resonance Analysis ◽

Double Blind ◽

Men And Women ◽

Cholesterol Levels ◽

Ldl Particles

This randomized, double-blind, controlled clinical trial assessed lipid responses in mildly hypertriglyceridemic men and women to consumption of docosahexaenoic acid (DHA)-enriched eggs or ordinary chicken eggs. The study included 153 subjects aged 21–80 years, with serum triglyceride concentrations between 140 and 450 mg/dL, inclusive, and serum total cholesterol concentrations < 300 mg/dL. Subjects were randomly assigned to receive either DHA-enriched (147 mg DHA/egg) or ordinary eggs (20 mg DHA/egg), added to their usual diets for six weeks (10 eggs/week). Both treatments significantly lowered triglycerides and increased high-density lipoprotein (HDL) cholesterol levels from baseline; however, these changes were not significantly different between treatments. Low-density lipoprotein (LDL) cholesterol concentrations increased significantly in subjects who consumed DHA-enriched eggs (p = 0.047 vs. control). This increase was significantly higher than that observed with ordinary eggs. However, there was no significant increase in cholesterol carried by small, dense LDL particles, as determined by nuclear magnetic resonance analysis. Results of exploratory analyses suggest favorable effects of the DHA-enriched eggs over ordinary eggs on triglyceride and HDL cholesterol levels in subjects with body mass index ≥ 30 kg/m2; the DHA treatment produced a larger reduction in serum triglyceride concentration vs. ordinary eggs (–12.3 vs. 2.1%; p = 0.027), and there was a greater increase for HDLcholesterol in the DHA-enriched vs. ordinary egg group (5.0 vs. 1.1%; p = 0.040).

Download Full-text

Effects of Canola oil-based high fat diets on growth, fat deposition and serum triglyceride and cholesterol levels in lines of mice selected for high and low fat percentage]]>

Brazilian Journal of Genetics ◽

10.1590/s0100-84551997000200009 ◽

1997 ◽

Vol 20 (2) ◽

Keyword(s):

Canola Oil ◽

Serum Triglyceride ◽

Fat Deposition ◽

High Fat ◽

Fat Percentage ◽

Low Fat ◽

Cholesterol Levels ◽

High Fat Diets ◽

Fat Diets

Download Full-text

The Effects of L-Carnitine Supplementation on Serum Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Current Pharmaceutical Design ◽

10.2174/1381612825666190830154336 ◽

2019 ◽

Vol 25 (30) ◽

pp. 3266-3281 ◽

Cited By ~ 1

Author(s):

Hadis Fathizadeh ◽

Alireza Milajerdi ◽

Željko Reiner ◽

Fariba Kolahdooz ◽

Maryam Chamani ◽

...

Keyword(s):

Serum Lipids ◽

Ldl Cholesterol ◽

Meta Analysis ◽

Hdl Cholesterol ◽

Health Conditions ◽

Carnitine Supplementation ◽

Randomized Controlled ◽

Cholesterol Levels ◽

Vldl Cholesterol ◽

Subgroup Analyses

Background: The findings of trials investigating the effects of L-carnitine administration on serum lipids are inconsistent. This meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effects of L-carnitine intake on serum lipids in patients and healthy individuals. Methods: Two authors independently searched electronic databases including MEDLINE, EMBASE, Cochrane Library, Web of Science, PubMed and Google Scholar from 1990 until August 1, 2019, in order to find relevant RCTs. The quality of selected RCTs was evaluated using the Cochrane Collaboration risk of bias tool. Cochrane’s Q test and I-square (I2) statistic were used to determine the heterogeneity across included trials. Weight mean difference (SMD) and 95% CI between the two intervention groups were used to determine pooled effect sizes. Subgroup analyses were performed to evaluate the source of heterogeneity based on suspected variables such as, participant’s health conditions, age, dosage of L-carnitine, duration of study, sample size, and study location between primary RCTs. Results: Out of 3460 potential papers selected based on keywords search, 67 studies met the inclusion criteria and were eligible for the meta-analysis. The pooled results indicated that L-carnitine administration led to a significant decrease in triglycerides (WMD: -10.35; 95% CI: -16.43, -4.27), total cholesterol (WMD: -9.47; 95% CI: - 13.23, -5.70) and LDL-cholesterol (LDL-C) concentrations (WMD: -6.25; 95% CI: -9.30, -3.21), and a significant increase in HDL-cholesterol (HDL-C) levels (WMD: 1.39; 95% CI: 0.21, 2.57). L-carnitine supplementation did not influence VLDL-cholesterol concentrations. When we stratified studies for the predefined factors such as dosage, and age, no significant effects of the intervention on triglycerides, LDL-C, and HDL-C levels were found. Conclusion: This meta-analysis demonstrated that L-carnitine administration significantly reduced triglycerides, total cholesterol and LDL-cholesterol levels, and significantly increased HDL-cholesterol levels in the pooled analyses, but did not affect VLDL-cholesterol levels; however, these findings were not confirmed in our subgroup analyses by participant’s health conditions, age, dosage of L-carnitine, duration of study, sample size, and study location.

Download Full-text