Mental Simulation and Preference Consistency over Time: The Role of Process- versus Outcome-Focused Thoughts

2007 ◽  
Vol 44 (3) ◽  
pp. 379-388 ◽  
Author(s):  
Min Zhao ◽  
Steve Hoeffler ◽  
Gal Zauberman
Keyword(s):  
Process Simulation ◽  
Mental Simulation ◽  
Distant Future ◽  
Future Events ◽  
Near Future ◽  
Integrate Research ◽  
Over Time

Research on choice over time has found that people tend to focus on concrete aspects of near-future events and abstract aspects of distant-future events. Furthermore, a focus on concrete aspects heightens the feasibility-related components, whereas a focus on abstract aspects heightens the desirability-related components, which can lead to preference inconsistency over time. In this research, the authors integrate research on choice over time with mental simulation. They propose and show that counter to people's natural tendencies, outcome simulation for near-future events and process simulation for distant-future events lead to preference consistency over time. The results also suggest that outcome timing moderates the effectiveness of process versus outcome simulation.

Divergent theories, converging evidence: The constructional semantics of competing future constructions

2018 ◽  
Vol 6 (1) ◽  
pp. 91-114
Author(s):  
Stefan Hartmann
Keyword(s):  
Experimental Study ◽  
The Other ◽  
Temporal Distance ◽  
Corpus Study ◽  
Distant Future ◽  
Other Hand ◽  
Future Events ◽  
The One ◽  
Near Future ◽  
Lines Of Evidence

Abstract This paper investigates the alternation between two competing German future constructions, the werden + Infinitive construction and the futurate present, from a usage-based perspective. Two lines of evidence are combined: On the one hand, a pilot corpus study indicates that werden + Infinitive is more likely to be used for referring to distant-future events than to near-future events. However, syntactic factors seem to be at least as decisive as semantic ones for speakers’ choice between the two constructions. On the other hand, an experimental study taps into language users’ interpretation of sentences framed in one of the two constructions. It can be shown that the grammatical framing does not significantly affect participants’ estimates of the temporal distance of the events to which the stimuli sentences refer. This suggests that the meaning differences between the two constructions be more nuanced, e.g. pertaining to discourse-pragmatic functions.

Role of gustatory thalamus in anticipation and comparison of rewards over time in rats

2005 ◽  
Vol 288 (4) ◽  
pp. R966-R980 ◽  
Author(s):  
Pearl Lee Schroy ◽  
Robert A. Wheeler ◽  
Collin Davidson ◽  
Giuseppe Scalera ◽  
Robert C. Twining ◽  
...  
Keyword(s):  
Saccharin Solution ◽  
Interstimulus Interval ◽  
Sucrose Solution ◽  
Ibotenic Acid ◽  
Neural Substrates ◽  
Reinforcement Effect ◽  
Neurotoxic Lesions ◽  
Near Future ◽  
Over Time

Rats reduce intake of a palatable saccharin solution when it is followed by access to a preferred sucrose solution. This phenomenon, referred to as an anticipatory contrast effect (ACE), is thought to occur because the value of the saccharin conditioned stimulus pales in comparison to the highly rewarding sucrose unconditioned stimulus expected in the near future. Although relatively little is known about the underlying neural substrates, lesions of the gustatory thalamus fully disrupt the phenomenon (Reilly S, Bornovalova M, and Trifunovic R. Behav Neurosci 118: 365–376, 2004; Reilly S and Pritchard TC. Behav Neurosci 110: 746–759, 1996). The present set of experiments revisited this issue to determine the nature of this deficit. Rats with bilateral ibotenic acid lesions of the gustatory thalamus were given 3-min access to 0.15% saccharin and, after a 0-s or 5-min interval, were given 3-min access to either the same saccharin solution or a highly preferred 1.0 M sucrose solution. In experiment 1, ACE testing began with the 5-min interstimulus interval (ISI) and then switched to the 0-s ISI. For experiment 2, the order of ISI testing was reversed. The results show that axon-sparing, neurotoxic lesions of the gustatory thalamus prevent ACEs with a 0-s ISI and lead to a reversal (i.e., a reinforcement effect) with a 5-min ISI. Together, the results suggest that the lesion leads to a specific reward comparison deficit, whereby the rats fail to compare the value of an available reward with the memory of a preferred reward that is anticipated in the near future.

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

Overview of Biological Therapy in Ulcerative Colitis: Current and Future Directions

2015 ◽  
Vol 24 (2) ◽  
pp. 203-213 ◽  
Author(s):  
Federica Furfaro ◽  
Cristina Bezzio ◽  
Sandro Ardizzone ◽  
Alessandro Massari ◽  
Roberto De Franchis ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Immunosuppressive Agents ◽  
Mucosal Healing ◽  
Aminosalicylic Acid ◽  
Proinflammatory Mediators ◽  
Experimental Drugs ◽  
New Treatments ◽  
Aggressive Clinical Course ◽  
Near Future

The treatment of ulcerative colitis (UC) has changed over the last decade. It is extremely important to optimize the therapies which are available nowadays and commonly used in daily clinical practice, as well as to stimulate the search for more powerful drugs for the induction and maintenance of sustained and durable remission, thus preventing further complications. Therefore, it is mandatory to identify the patients' prognostic variables associated with an aggressive clinical course and to test the most potent therapies accordingly.To date, the conventional therapeutic approach based on corticosteroids, salicylates (sulfasalazine, 5-aminosalicylic acid) or immunosuppressive agents is commonly used as a first step to induce and to maintain remission. However, in recent years, knowledge of new pathogenetic mechanisms of ulcerative colitis have allowed us to find new therapeutic targets leading to the development of new treatments that directly target proinflammatory mediators, such as TNF-alpha, cytokines, membrane migration agents, cellular therapies.The aim of this review is to provide the most significant data regarding the therapeutic role of drugs in UC and to give an overview of biological and experimental drugs that will become available in the near future. In particular, we will analyse the role of these drugs in the treatment of acute flare and maintenance of UC, as well as its importance in mucosal healing and in treating patients at a high risk of relapse.

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis

2011 ◽  
Vol 11 (1) ◽  
pp. 130-133
Author(s):  
Astra Zviedre ◽  
Arnis Engelis ◽  
Mohit Kakar ◽  
Aigars Pētersons
Keyword(s):  
Early Detection ◽  
Acute Appendicitis ◽  
Inflammatory Mediators ◽  
Potential Role ◽  
Clinical Symptoms ◽  
Future Research ◽  
Mesenteric Lymphadenitis ◽  
Proper Diagnosis ◽  
Near Future

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis Although, AAP and AML have different etiological factors, clinical symptoms are very much similar but treatment tactics in both the disease differ a lot. In case of AML, treatment is more conservative and does not require hospitalization while in case of AAP immediate hospitalization and maybe further surgery can be mandatory. With the identification of group of cytokines serum inflammatory mediators IL-8, IL-10, IL-12[p70], IL-17, TNF-a and MCP-1, it is believed early and proper diagnosis of AAP in the near future. Research of cytokines-serum inflammatory mediators has opened new opportunities for an early detection and differentiation of these two diseases in children.

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