Cystic Fibrosis Respiratory Microbiology Monitoring during a Global Pandemic: Lessons Learned from a Shift to Telehealth

Korea initiated a new experiment, called a dynamic response system for open democratic societies as a principle to respond to the novel coronavirus (COVID-19). The global pandemic of COVID-19 led to a surge in demand for healthcare medical masks and respirators, and strained the global supply chain of mask production and distribution systems. This study provides a systemic view of critical personal protective equipment for both healthcare staff and the public to stop the spread of COVID-19. This study investigates the dynamic response system of healthcare mask production to the coronavirus and discusses lessons learned in view of systems thinking. The study shows that it is critical to developing a quick and dynamic response system to the evolving market conditions with flexible and agile operations. Visibility with transparency with information sharing with the public is also critical under global pandemic. Due to the shortage of mask supply, smart consumption is required along with collaboration with public and private sectors, as well as global organizations. Democratic leadership and a well-prepared strategic plan for long-term period are essential to the open society to prepare the global pandemic in the future. This study serves as a benchmark for dynamic and timely responses to the global pandemic.

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CFTR: cystic fibrosis and beyond

European Respiratory Journal ◽

10.1183/09031936.00228013 ◽

2014 ◽

Vol 44 (4) ◽

pp. 1042-1054 ◽

Cited By ~ 105

Author(s):

Marcus A. Mall ◽

Dominik Hartl

Keyword(s):

Cystic Fibrosis ◽

Lung Disease ◽

Lessons Learned ◽

Chronic Obstructive ◽

Common Mutation ◽

Transmembrane Conductance Regulator ◽

Obstructive Pulmonary Disease ◽

Airway Diseases ◽

Δf508 Cftr

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the stage for: 1) unravelling the molecular and cellular basis of CF lung disease; 2) the generation of animal models to study in vivo pathogenesis; and 3) the development of mutation-specific therapies that are now becoming available for a subgroup of patients with CF. This article highlights major advances in our understanding of how CFTR dysfunction causes chronic mucus obstruction, neutrophilic inflammation and bacterial infection in CF airways. Furthermore, we focus on recent breakthroughs and remaining challenges of novel therapies targeting the basic CF defect, and discuss the next steps to be taken to make disease-modifying therapies available to a larger group of patients with CF, including those carrying the most common mutation ΔF508-CFTR. Finally, we will summarise emerging evidence indicating that acquired CFTR dysfunction may be implicated in the pathogenesis of chronic obstructive pulmonary disease, suggesting that lessons learned from CF may be applicable to common airway diseases associated with mucus plugging.

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Multiallelic Synthetic Quality Control Material: Lessons Learned from the Cystic Fibrosis External Quality Assessment Scheme

Genetic Testing and Molecular Biomarkers ◽

10.1089/gtmb.2011.0015 ◽

2011 ◽

Vol 15 (9) ◽

pp. 579-586 ◽

Cited By ~ 1

Author(s):

Sarah Berwouts ◽

Todd M. Christensen ◽

Jill Brandon ◽

Bassem A. Bejjani ◽

David E. Barton ◽

...

Keyword(s):

Cystic Fibrosis ◽

Quality Control ◽

Quality Assessment ◽

External Quality Assessment ◽

Lessons Learned ◽

Quality Control Material ◽

Control Material ◽

External Quality ◽

External Quality Assessment Scheme

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Youth First: A Canadian Youth-led Initiative in the Midst of the COVID-19 Pandemic

Canadian Journal of Children s Rights / Revue canadienne des droits des enfants ◽

10.22215/cjcr.v8i1.3148 ◽

2021 ◽

Vol 8 (1) ◽

pp. 136-152

Author(s):

Reah (Hyun Ju) Shin ◽

Harleen Kaur ◽

Catherine Howe ◽

Justin Whitty ◽

Kyla Quigley ◽

...

Keyword(s):

Young People ◽

Youth Care ◽

Lessons Learned ◽

Child And Youth Care ◽

Interactive Spaces ◽

Canadian Youth ◽

Global Pandemic ◽

Master Of Arts

This reflection writing was co-written by seven young people and three Master of Arts Child and Youth Care (MA CYC) students from Ryerson University. Our writing centres around a Canadian youth-led initiative called Youth First, developed as a MA CYC placement due to the lack of placement opportunities available during the pandemic. Youth First focused on creating safe and interactive spaces in cyberspace for young people during the pandemic. Through this reflection, we hope to share our experiences, accomplishments, lessons learned and overall reflection of being part of this initiative during a global pandemic.

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Virtual Capacity Building for International Research Collaborations in Times of COVID-19 and #Flygskam

Frontiers in Communication ◽

10.3389/fcomm.2020.562828 ◽

2021 ◽

Vol 5 ◽

Author(s):

Isabel Richter ◽

Elizabeth Gabe-Thomas ◽

Carya Maharja ◽

Thu Ha Nguyen ◽

Quyen Van Nguyen ◽

...

Keyword(s):

Sustainable Development Goals ◽

International Travel ◽

Lessons Learned ◽

The Sustainable Development ◽

Research Collaborations ◽

Global Pandemic ◽

Travel Restrictions ◽

Development Goals ◽

Collaboration And Communication ◽

New Situation

In the wake of the current global pandemic, international travel is restricted. This poses substantial challenges for research relationships aiming to build capacity and foster co-creation to achieve the Sustainable Development Goals, where global collaboration and communication is paramount. This is especially challenging when it comes to interactive dialogues that go beyond the typical one-way structure of online learning. Considerations on structural, technical and behavioral levels are needed to not only deal with these challenges but rather to take advantage of the new situation. This commentary outlines the lessons learned from an internationally operating project, co-developed to cope with travel restrictions. We discuss implications for future reduction of international travel to reduce carbon in the context of climate change.

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Developing a decision aid to facilitate informed decision making about invasive mechanical ventilation and lung transplantation among adults with cystic fibrosis: lessons learned from usability testing (Preprint)

JMIR Human Factors ◽

10.2196/21270 ◽

2020 ◽

Author(s):

Katherine L. Dauber-Decker ◽

Melissa Basile ◽

D'Arcy King ◽

Jennifer Polo ◽

Karina Calise ◽

...

Keyword(s):

Cystic Fibrosis ◽

Decision Making ◽

Mechanical Ventilation ◽

Lung Transplantation ◽

Decision Aid ◽

Invasive Mechanical Ventilation ◽

Usability Testing ◽

Lessons Learned ◽

Informed Decision ◽

Informed Decision Making

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Developing a decision aid to facilitate patient-provider conversations about mechanical ventilation and lung transplantation to treat cystic fibrosis: lessons learned from usability testing (Preprint)

10.2196/preprints.21270 ◽

2020 ◽

Author(s):

Katherine L. Dauber-Decker ◽

Melissa Basile ◽

D'Arcy King ◽

Jennifer Polo ◽

Karina Calise ◽

...

Keyword(s):

Cystic Fibrosis ◽

Advance Care Planning ◽

Decision Aid ◽

Usability Testing ◽

Lessons Learned ◽

Care Planning ◽

Think Aloud ◽

System Usability Scale ◽

Average System ◽

Advance Care

BACKGROUND Cystic fibrosis (CF) is a life-limiting genetic disease that causes chronic lung infections. We developed an internet-based decision aid (decision aid) to help CF patients make better informed decisions regarding treatments and advance care planning (ACP). We built the decision aid around two major treatment decisions: whether or not to have a lung transplant, and whether or not to agree to intubation. OBJECTIVE To present results from iterative usability testing of the InformedChoices Cystic Fibrosis advance care planning decision aid among adults with cystic fibrosis, their clinicians and family caregivers. METHODS We performed a patient needs assessment and “think aloud” usability testing with CF patients, their surrogates, and clinicians caring for CF patients. “Think aloud” participants provided feedback while navigating the decision aid and answered surveys. Session transcripts and survey results were categorized into common, generalizable themes and optimizations for improving content, comprehension, and navigation. RESULTS Participants gave the decision aid an average System Usability Scale (SUS) score of 88.33 (“excellent”). Comments were coded into three themes: Functionality, Visibility and Navigation, and Content and Usefulness. Areas for improvement included reducing repetition, enhancing comprehension, and changing the flow. CONCLUSIONS Usability testing revealed areas for potential improvement. Testing also yielded positive feedback, suggesting the decision aid’s future success.Integrating changes prior to implementation should improve the decision aid’s comprehension, navigation, and usefulness, and lead to greater adoption.

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Response to the Coronavirus Disease-2019 Pandemic: Lessons Learned from the Taiwan Model

Asian Social Science ◽

10.5539/ass.v16n10p16 ◽

2020 ◽

Vol 16 (10) ◽

pp. 16

Author(s):

Charles Wu ◽

Catherine Wu ◽

Kun Chan Wu

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Taiwan Strait ◽

Associate Professor ◽

Lessons Learned ◽

Metapopulation Model ◽

Global Pandemic ◽

Johns Hopkins University ◽

The World ◽

The Taiwan Strait

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or coronavirus disease-2019 (COVID-19), emerged in December 2019 in Wuhan, China and has since then spurred a global pandemic (Lai et al., 2020). Taiwan and China, separated only by 130 km across the Taiwan Strait, have frequent cross-strait interactions with each other; millions of people travel to and from between the two countries (Wang & Lin, 2020). Considering these facts, Lauren Gardner, an associate professor at the Johns Hopkins University, even predicted that Taiwan will have the second highest number of COVID-19 cases among the world using a metapopulation model (Gardner et al., 2020). However, with a population of 23.7 million people, Taiwan leads one of the least COVID-19 cases worldwide. With the help of technology, swift reactions, advanced deployment of resources, and complete transparency, the Taiwan model has made its success. By analyzing the actions taken and how they functioned in Taiwan in preventing a nationwide epidemic, other countries may benefit in understanding how to design better models for the prevention of future epidemics and pandemics.

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