scholarly journals Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system

2017 ◽  
Vol 67 (2) ◽  
pp. 149-168 ◽  
Author(s):  
Pijush Kumar Paul ◽  
Alongkot Treetong ◽  
Roongnapa Suedee
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Oral Drug Delivery ◽  
Three Dimensional ◽  
In Vivo Studies ◽  
Oral Drug ◽  
Functional Monomers ◽  
Oral Drug Delivery System ◽  
Nanosized Material ◽  
Glucose Reduction

AbstractIn this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.

In vitro and in vivo studies of enzyme-digestible hydrogels for oral drug delivery

1992 ◽  
Vol 19 (1-3) ◽  
pp. 131-144 ◽  
Author(s):  
Waleed S.W. Shalaby ◽  
William E. Blevins ◽  
Kinam Park
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
In Vivo Studies ◽  
Oral Drug

Design, Optimization and Evaluation of Lurasidone Hydrochloride Nanocrystals as Fast Disintegrating Tablets

2019 ◽  
Vol 4 (2) ◽  
pp. 121-129
Author(s):  
Satya Sankar Sahoo ◽  
Chandu Babu Rao
Keyword(s):  
Patient Compliance ◽  
Oral Drug Delivery ◽  
Particle Diameter ◽  
Water Soluble ◽  
In Vivo Studies ◽  
Oral Drug ◽  
Water Soluble Drugs ◽  
Fast Disintegrating Tablets ◽  
Lurasidone Hydrochloride

Formulation of poorly water-soluble drugs for oral drug delivery has always been a difficult task for formulation scientists. Lurasidone hydrochloride is one such agent which is used to control bipolar depre-ssion. The objective of this study was to formulate and optimize lurasi-done nanosuspension, further formulating optimized nanosuspensions as fast disintegrating tablets for improved patient compliance. In the present study, lurasidone nanosuspension was prepared by nanomilling technique. Optimized nanosuspension has mean particle diameter of 248.9 nm, polydispersity index of 0.127 and zeta potential of 18.1 mV. The lyophilized optimized nanocrystals, optimize nanosuspension as granulating fluid and as top spraying dispersion for granulation in fluid bed granulator being used to formulate fast disintegrating tablets with suitable super disintegrant. Croscarmellose sodium was found to be best superdisintegrant compared to sodium starch glycolate and crospovidone, as its acts by both mechanism swelling and wicking. Its swells 4-8 folds in less than 10 s. Many folds increase in the rate of drug release observed compare to micronized lurasidone and marketed product. There was no change in crystalline nature after nanomilling as characterized by XRD and FTIR, and it was found to be chemically stable with high drug content. The developed fast disintegrating tablets would be an alternative better formulation than its conventional formulation to address its bioavailability issue and for improved patient compliance. However, this should be further confirmed by appropriate in vivo studies.

Design of a Soft, Self-Uncoiling Stent for Extended Retention of Drug Delivery in the Small Intestine

2020 ◽  
Author(s):  
Sunandita Sarker ◽  
Ryan Jones ◽  
Gabriel Chow ◽  
Benjamin Terry
Keyword(s):  
Drug Delivery ◽  
Small Intestine ◽  
Oral Drug Delivery ◽  
Ileocecal Valve ◽  
Drug Carriers ◽  
Oral Formulation ◽  
In Vivo Studies ◽  
Oral Drug ◽  
Biological Drugs

Abstract Despite being the preferred route of drug administration, the oral formulation of biological drugs is limited due to its intrinsic instability, low permeability, and physical, chemical and immunological barriers. Various innovative swallowable technologies such as drug-loaded, dissolvable microneedles, mucoadhesive patches, and various microdevices present unique drug-carrying capabilities. The current work presents a novel soft stent platform that can facilitate contact between the small intestine tissue and drug carriers to enhance drug absorption and increase residence time. This study aims to prove the concept of this novel platform and determine if the soft stent will retain orally to the ileocecal valve longer than a capsule-shaped bolus. Benchtop studies on an intestinal simulator showed successful retention of the soft stent compared to a control capsule. In vivo studies in pig models also showed that the soft stent was retained longer than the control capsule. Overall, this study shows promise that this novel platform could be used for oral drug delivery of biologics.

Novel Insulin Thiomer Nanoparticles: In Vivo Evaluation of an Oral Drug Delivery System

2008 ◽  
Vol 9 (1) ◽  
pp. 278-285 ◽  
Author(s):  
Britta Deutel ◽  
Melanie Greindl ◽  
Michael Thaurer ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
In Vivo Evaluation ◽  
Oral Drug Delivery System

scholarly journals Efficient Treatment of Fish Intestinal Parasites Applying Biocompatible Membrane-penetrating Oral Drug Delivery Nanoparticles

2021 ◽  
Author(s):  
Patrick D. Mathews ◽  
Ana C.M.F. Patta ◽  
Rafael R.M. Madrid ◽  
Carlos A.B. Ramirez ◽  
Omar Mertins
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Intestinal Parasites ◽  
Drug Stability ◽  
Pharmacological Action ◽  
Oral Route ◽  
In Vivo Studies ◽  
Oral Drug ◽  
Efficient Treatment

Abstract Nanodelivery of drugs aims to ensure drug stability in the face of adverse biochemical conditions in the course of administration, concomitant with appropriate pharmacological action provided by delivery at the targeted site. In this study, the application potential of nanoparticles produced with biopolymers chitosan-N-arginine and alginate as an oral drug delivery material is evaluated. Being both macromolecules weak polyelectrolytes, the bioparticle presents strong thermodynamic interaction with a biological model membrane consisting of charged lipid liposome bilayer, leading to membrane disruption and membrane penetration of the bioparticles in ideal conditions of pH corresponding to the oral route. The powder form of the bioparticle was obtained by lyophilization and with a high percentage of entrapment of the anthelmintic drug praziquantel. In vivo studies were conducted with oral administration to Corydoras schwartzi fish with high intensity of intestinal parasites infection. The in vivo experiments confirmed the mucoadhesive and revealed membrane-penetrating properties of the bioparticle by translocating the parasite cyst, which provided target drug release and reduction of over 97% of the fish intestinal parasites. Thus, it was evidenced that the bioparticle was effective in transporting and releasing the drug to the target, providing an efficient treatment.

scholarly journals Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Shahrooz Saremi ◽  
Rassoul Dinarvand ◽  
Abbas Kebriaeezadeh ◽  
Seyed Nasser Ostad ◽  
Fatemeh Atyabi
Keyword(s):  
Oral Bioavailability ◽  
Oral Drug Delivery ◽  
Drug Loading ◽  
Cell Monolayer ◽  
Chitosan Nanoparticles ◽  
Positive Control ◽  
In Vivo Studies ◽  
Oral Drug ◽  
Thiolated Chitosan

The aim of this study was to evaluate a nanoparticulate system with mucoadhesion properties composed of a core of polymethyl methacrylate surrounded by a shell of thiolated chitosan (Ch-GSH-pMMA) for enhancing oral bioavailability of docetaxel (DTX), an anticancer drug. DTX-loaded nanoparticles were prepared by emulsion polymerization method using cerium ammonium nitrate as an initiator. Physicochemical properties of the nanoparticles such as particle size, size distribution, morphology, drug loading, and entrapment efficiency were characterized. The pharmacokinetic study was carried out in vivo using wistar rats. The half-life of DTX-loaded NPs was about 9 times longer than oral DTX used as positive control. The oral bioavailability of DTX was increased to 68.9% for DTX-loaded nanoparticles compared to 6.5% for positive control. The nanoparticles showed stronger effect on the reduction of the transepithelial electrical resistance (TEER) of Caco-2 cell monolayer by opening the tight junctions. According to apparent permeability coefficient (Papp) results, the DTX-loaded NPs showed more specific permeation across the Caco-2 cell monolayer in comparison to the DTX. In conclusion, the nanoparticles prepared in this study showed promising results for the development of an oral drug delivery system for anticancer drugs.

scholarly journals Unique catanionic vesicles as a potential “Nano-Taxi” for drug delivery systems. In vitro and in vivo biocompatibility evaluation

RSC Advances ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. 5372-5380 ◽  
Author(s):  
Soledad Stagnoli ◽  
M. Alejandra Luna ◽  
Cristian C. Villa ◽  
Fabrisio Alustiza ◽  
Ana Niebylski ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Catanionic Surfactant ◽  
Catanionic Vesicles ◽  
System P ◽  
Oral Drug Delivery System

We evaluatein vitroandin vivotoxicity and stability in an acidic environment of new vesicles formed by the catanionic surfactant AOT-BHD in order to investigate their potential application as an oral drug delivery system.

In vivo evaluation of an oral drug delivery system for peptides based on S-protected thiolated chitosan

2012 ◽  
Vol 160 (3) ◽  
pp. 477-485 ◽  
Author(s):  
Sarah Dünnhaupt ◽  
Jan Barthelmes ◽  
Javed Iqbal ◽  
Glen Perera ◽  
Clemens C. Thurner ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
In Vivo Evaluation ◽  
Thiolated Chitosan ◽  
Oral Drug Delivery System

scholarly journals Updates on Approaches to Increase the Residence Time of Drug in the Stomach for Site Specific Delivery: Brief Review

2018 ◽  
Vol 6 (11) ◽  
pp. 81-91
Author(s):  
Shashank Soni ◽  
Veerma Ram ◽  
Anurag Verma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Residence Time ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Site Specific ◽  
Oral Drug Delivery System ◽  
In Vivo Characterization

In the field of oral drug delivery system, a gastroretentive system is gaining popularity day by day. Numerous of research work and extensive literature are published in past few years on gastroretentive drug delivery system. It is the one of the best and appropriate approaches for increasing the residence time of drug in the stomach and diffuses drug slowly in the sustained manner which helps in the site-specific delivery of the drug as well also increases the bioavailability at site-specific of delivery. This helps in many challenges associated with conventional oral drug delivery system. Different ways are used for approaching gastroretention viz. swelling and expandable system, high-density system, magnetic system, bioadhesive system and buoyant system with or without gas generating agents. During data mining well in vitro characterization and in vivo characterization including gamma scintigraphic and MRI techniques are well established and reported. But, still, today in vivo characterization technique is major challenging for the researcher due to its limitation. The documented literature explains the use of animal models like beagle dogs, rabbits and human subjects for in vivo evaluation parameter but it leads to increase in variation that’s why this delivery system is limited in the market. This paper contains the latest literature compilation and various techniques used for gastroretention with its pros and cons. This review paper helps the researcher to take an overview of basics of gastroretentive drug delivery system and helps in understanding the basics of the system.Soni et al., International Current Pharmaceutical Journal, April 2018, 6(11): 81-91http://www.icpjonline.com/documents/Vol6Issue11/02.pdf

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