scholarly journals Cocaine- and Amphetamine-Regulated Transcript (CART ) Peptide in Mammals Gastrointestinal System – A Review

2017 ◽  
Vol 17 (1) ◽  
pp. 3-21 ◽  
Author(s):  
Krystyna Makowska ◽  
Sławomir Gonkowski
Keyword(s):  
Nervous System ◽  
Digestive System ◽  
Gastrointestinal System ◽  
Stress Reactions ◽  
System A ◽  
Cart Peptide ◽  
Different Types ◽  
The Central Nervous System ◽  
The Subject ◽  
Active Substances

Abstract Since its first description over 30 years ago, cocaine- and amphetamine-regulated transcript (CART) peptide has been the subject of many studies. Most of these investigations pertain to occurrence and functions of CART within the central nervous system, where this peptide first of all takes part in regulation of feeding, stress reactions, as well as neuroprotective and neuroregenerative processes. However, in recent years more and more studies concern the presence of CART in the gastrointestinal system. This peptide has been described both in stomach and intestine, as well as in other digestive organs such as pancreas or gallbladder. Particularly much information relates to distribution of CART in the enteric nervous system, which is located within the wall of digestive tract. Other studies have described this peptide in intestinal endocrinal cells. Moreover, it is known that CART can be present in various types of neuronal cells and may co-localize with different types of other neuronal active substances, which play roles of neuromediators and/or neuromodulators. On the other hand precise functions of CART in the gastrointestinal system still remain unknown. It is assumed that this peptide is involved in the regulation of gastrointestinal motility, intestinal blood flow, secretion of intestinal juice, somatostatin and/or insulin, as well as takes part in pathological processes within the gastrointestinal tract. The large number of recent studies concerning the above mentioned problems makes that knowledge about occurrence and functions of CART in the digestive system rather piecemeal and requires clarifying, which is the aim of the present article.

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

Mills' syndrome. A clinical case of a rare degenerative pathology of the central nervous system

2020 ◽  
pp. 57-60
Author(s):  
Konstantin Gulyabin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurological Diseases ◽  
Cortical Atrophy ◽  
Primary Lateral Sclerosis ◽  
System A ◽  
The Central Nervous System ◽  
Primary Lateral ◽  
Lateral Sclerosis ◽  
Mills Syndrome

Mills' syndrome is a rare neurological disorder. Its nosological nature is currently not completely determined. Nevertheless, Mills' syndrome is considered to be a rare variant of the degenerative pathology of the central nervous system – a variant of focal cortical atrophy. The true prevalence of this pathology is unknown, since this condition is more often of a syndrome type, observed in the clinical picture of a number of neurological diseases (primary lateral sclerosis, frontotemporal dementia, etc.) and is less common in isolated form.

Solitary fibrous tumor of the central nervous system: a clinicopathologic study of 24 cases

2011 ◽  
Vol 154 (2) ◽  
pp. 237-248 ◽  
Author(s):  
Hong Chen ◽  
Xian-Wei Zeng ◽  
Jin-Song Wu ◽  
Ya-Fang Dou ◽  
Yin Wang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Solitary Fibrous Tumor ◽  
Clinicopathologic Study ◽  
System A ◽  
The Central Nervous System ◽  
Fibrous Tumor

scholarly journals Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3028
Author(s):  
George I. Lambrou ◽  
Apostolos Zaravinos ◽  
Maria Braoudaki
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cns Tumors ◽  
Normal Brain ◽  
Cns Tumor ◽  
Different Types ◽  
Receiver Operator Curve Analysis ◽  
The Central Nervous System ◽  
Tumor Types ◽  
Operator Curve

Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related to both prognosis, diagnosis and treatment, the understanding of pathogenesis and etiology of the disease remains scarce. MicroRNAs are known to be involved in CNS tumor oncogenesis. We hypothesized that CNS tumors possess commonly deregulated miRNAs across different CNS tumor types. Aim: The current study aims to reveal the co-deregulated miRNAs across different types of pediatric CNS tumors. Materials: A total of 439 CNS tumor samples were collected from both in-house microarray experiments as well as data available in public databases. Diagnoses included medulloblastoma, astrocytoma, ependydoma, cortical dysplasia, glioblastoma, ATRT, germinoma, teratoma, yoc sac tumors, ocular tumors and retinoblastoma. Results: We found miRNAs that were globally up- or down-regulated in the majority of the CNS tumor samples. MiR-376B and miR-372 were co-upregulated, whereas miR-149, miR-214, miR-574, miR-595 and miR-765 among others, were co-downregulated across all CNS tumors. Receiver-operator curve analysis showed that miR-149, miR-214, miR-574, miR-595 and miR765 could distinguish between CNS tumors and normal brain tissue. Conclusions: Our approach could prove significant in the search for global miRNA targets for tumor diagnosis and therapy. To the best of our knowledge, there are no previous reports concerning the present approach.

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