scholarly journals Atypical presentations of celiac disease

2016 ◽  
Vol 22 (3) ◽  
pp. 181-185
Author(s):  
Adriana Luminita Balasa ◽  
Cristina Maria Mihai ◽  
Tatiana Chisnoiu ◽  
Corina Elena Frecus
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Screening Method ◽  
Total Serum ◽  
Genetic Syndromes ◽  
Gliadin Antibodies ◽  
Pediatric Clinic ◽  
Endomysial Antibodies ◽  
Atypical Presentations ◽  
Celiac Disease Antibodies

Abstract In this study we evaluated the association of celiac disease in 81 children with autoimmune disease and genetic syndromes over a two years periods (January 2014 to July 2016) in Pediatric Clinic in Constanta. Because the extraintestinal symptoms are an atypical presentation of celiac disease we determined in these children the presence of celiac disease antibodies: Anti-tissue Transglutaminase Antibody IgA and IgA total serum level as a screening method followeds in selective cases by Anti-tissue Transglutaminase Antibody IgG, anti-endomysial antibodies, deamidated gliadin antibodies IgA and IgG and intestinal biopsia. In our study 8 patients had been diagnosed with celiac disease with extraintestinal symptoms, of which 4 with type 1 diabetes, 1 patient with ataxia, 2 patients with dermatitis herpetiformis and 1 patient with Down syndrome that associate also autoimmune thyroiditis, alopecia areata, enamel hypoplasia.

scholarly journals The analysis of the fine specificity of celiac disease antibodies using tissue transglutaminase fragments

2002 ◽  
Vol 269 (21) ◽  
pp. 5175-5181 ◽  
Author(s):  
Daniele Sblattero ◽  
Fiorella Florian ◽  
Elisabetta Azzoni ◽  
Trevin Zyla ◽  
Min Park ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Fine Specificity ◽  
Celiac Disease Antibodies

scholarly journals Serological screening for celiac disease in symptomatic 12 to 36 month-old children

2010 ◽  
Vol 47 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Inês Cristina Modelli ◽  
Lenora Gandolfi ◽  
Rodrigo Coutinho de Almeida ◽  
Gloria Maria A. C Araújo ◽  
Marilúcia de Almeida Picanço ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Positive Result ◽  
Tissue Transglutaminase ◽  
Correct Diagnosis ◽  
Screening Method ◽  
Failure To Thrive ◽  
Jejunal Biopsy ◽  
Serological Screening ◽  
Serologic Tests ◽  
Hla Genotyping

CONTEXT: The correct diagnosis of celiac disease in environmentally deprived children is frequently hindered by the common presence of other causes for the classical celiac disease symptoms: malnutrition, failure to thrive and frequent diarrheas. OBJECTIVES: To determine the prevalence of celiac disease in a group of 12 to 36 month-old children using immunoglobulin antibodies against gliadin (IgG and IgA-AGA), against endomysium (IgA-EMA), and against human tissue transglutaminase (IgA-tTG) as screening method. METHODS: A total of 214 children (114 boys), aged 12 to 36 months, on gluten-containing diet, were admitted to the study. IgG and IgA-AGA, IgA-tTG and IgA-EMA tests were performed in all sera. Biopsy was obtained from all children showing positive result in one or more of the serologic tests, excluding those in which IgG-AGA had been the only positive result. In those cases, polymerase chain reaction (PCR) HLA genotyping for the identification of celiac disease predisposing alleles was applied. HLA genotyping was also performed to confirm the diagnosis in children identified as celiac by means of positive serologic testing and compatible biopsy results. RESULTS: Normal results were obtained in 131 children. Ten children out of 68 identified as positive exclusively on the IgG-AGA test disclosed the presence of celiac disease predisposing alleles on PCR and underwent jejunal biopsy with normal results. All serologic tests were positive in four children. A fifth child showed positive IgG and IgA-AGA and IgA-tTG results but disclosed a negative IgA-EMA test. Jejunal biopsy of these five children revealed characteristic lesions of celiac disease. CONCLUSION: A prevalence of 2.3% was found among symptomatic 12- to 36-month-old children that had not been previously diagnosed as celiac.

scholarly journals Diagnostic Accuracy of IGA Anti-Tissue Transglutaminase Antibody Testing in Celiac Disease

2012 ◽  
Vol 31 (2) ◽  
pp. 100-106
Author(s):  
Nevena Eremić ◽  
Mirjana Đerić ◽  
Ljiljana Hadnađev
Keyword(s):  
Celiac Disease ◽  
Diagnostic Accuracy ◽  
Tissue Transglutaminase ◽  
Hdl Cholesterol ◽  
Total Serum ◽  
Antibody Testing ◽  
Cholesterol Levels ◽  
Serum Iga ◽  
Tissue Transglutaminase Antibodies

Diagnostic Accuracy of IGA Anti-Tissue Transglutaminase Antibody Testing in Celiac DiseaseContemporary guidelines for the first-line diagnosis of celiac disease recommend determination of IgA anti-tissue transglutaminase antibodies or IgA antiendomysial antibodies, as well as total serum IgA antibodies. The aim of our study was to assess the validity and clinical significance of serological testing for IgA anti-tissue transglutaminase antibodies in the diagnosis of celiac disease, and to investigate the presence of malabsorption symptoms in celiac patients. IgA anti-tissue transglutaminase antibody testing was performed in 50 subjects with clinically suspected celiac disease (21 men and 29 women). All subjects underwent endoscopy with small intestine biopsy. Celiac disease was confirmed by histopathological findings in four subjects, whereas the IgA anti-tissue transglutaminase test was positive in three subjects. The IgA anti-tissue transglutaminase test showed sensitivity of 75% and specificity of 100%. There were significant differences between men with biopsy-confirmed and excluded celiac disease in the erythrocyte parameters MCV (96.5±7.7 vs. 78.6 ±11.3; p<0.05), MCH (36.9±4.6 vs. 25.9±4.9; p<0.01), and MCHC (382.5±16.3 vs. 326.9±19.1; p<0.005), as well as in the levels of total protein (47.5 ±16.3 vs. 68.3 ± 7.6; p<0.01) and albumins (24.6±9.5 vs. 42.1 ± 6.9; p<0.01). In addition, HDL-cholesterol levels were significantly lower in men with biopsy-confirmed celiac disease (0.42.±0.12 vs. 0.90±0.30; p<0.05). Our results show a high correlation between IgA anti-tissue transglutaminase testing and endoscopy with biopsy as the gold diagnostic standard.

scholarly journals Prevalence of Celiac Disease and Celiac Autoimmunity in the Toba Native Amerindian Community of Argentina

2015 ◽  
Vol 29 (8) ◽  
pp. 431-434 ◽  
Author(s):  
Horacio Vázquez ◽  
María de la Paz Temprano ◽  
Emilia Sugai ◽  
Stella M Scacchi ◽  
Cecilia Souza ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Human Leukocyte ◽  
Screen Test ◽  
Leukocyte Antigen ◽  
Day Range ◽  
Gliadin Peptides ◽  
Endomysial Antibodies ◽  
Very High ◽  
Hla Dq2

BACKGROUND: Celiac disease (CD) is mostly recognized among subjects with a Caucasian ethnic ancestry. No studies have explored conditions predisposing Amerindians to CD.OBJECTIVE: To prospectively assess environmental, genetic and serological conditions associated with CD among members of the Toba native population attending a multidisciplinary sanitary mission.METHODS: An expert nutritionist determined daily gluten intake using an established questionnaire. Gene typing for the human leukocyte antigen (HLA) class II alleles was performed on DNA extracted from peripheral blood (HLA DQ2/DQ8 haplotype). Serum antibodies were immunoglobulin (Ig) A tissue transglutaminase (tTG) and the composite deamidated gliadin peptides/tTG Screen test. Positive cases were tested for IgA endomysial antibodies.RESULTS: A total of 144 subjects (55% female) were screened. The estimated mean gluten consumption was 43 g/day (range 3 g/day to 185 g/day). Genetic typing showed that 73 of 144 (50.7%) subjects had alleles associated with CD; 69 (94.5%) of these subjects had alleles for HLA DQ8 and four had DQ2 (5.5%). Four and six subjects had antibody concentrations above the cut-off established by the authors’ laboratory (>3 times the upper limit of normal) for IgA tTG and deamidated gliadin peptides/tTG screen, respectively. Four of these had concomitant positivity for both assays and endomysial antibodies were positive in three subjects who also presented a predisposing haplotype.CONCLUSION: The present study was the first to detect CD in Amerindians. The native Toba ethnic population has very high daily gluten consumption and a predisposing genetic background. We detected subjects with persistent CD autoimmunity and, at least, three of them fulfilled serological criteria for CD diagnosis.

scholarly journals Celiac disease screening in Brazilian patients with osteoporosis

2014 ◽  
Vol 58 (3) ◽  
pp. 270-273 ◽  
Author(s):  
Luiza Gusso ◽  
Mariana Cionek Simões ◽  
Thelma L. Skare ◽  
Renato Nisihara ◽  
Claudine C. Burkiewicz ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Indirect Immunofluorescence ◽  
Gastrointestinal Endoscopy ◽  
Tissue Transglutaminase ◽  
Geographic Region ◽  
Duodenal Biopsy ◽  
Elisa Assay ◽  
Immunofluorescence Method ◽  
Endomysial Antibodies ◽  
Low Prevalence

Objective : To analyze if it is worthwhile to screen Brazilian osteoporotic patients for celiac disease (CD).Subjects and methods : One hundred patients with osteoporosis and 97 controls were evaluated for IgA-EmA (IgA anti-endomysial antibodies) by indirect immunofluorescence method and IgG-anti-tTG (tissue transglutaminase) by ELISA assay. Positive patients were invited to have gastrointestinal endoscopy with jejunal biopsy.Results : Two patients had positive IgG-anti-tTG test and one of them also showed positive IgA-EmA. Only the latter had a positive duodenal biopsy for CD. None of the controls were positive for either auto-antibodies.Conclusion : We observed low prevalence of CD in osteoporotic Brazilian patients. This finding does not support routine screening for CD in patients with osteoporosis in our geographic region. Arq Bras Endocrinol Metab. 2014;58(3):270-3

Positive tissue transglutaminase antibodies with negative endomysial antibodies: Unresolved issues in diagnosing celiac disease

2020 ◽  
pp. 112910
Author(s):  
Maria Infantino ◽  
Mario Merone ◽  
Mariangela Manfredi ◽  
Valentina Grossi ◽  
Alessandra Landini ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Tissue Transglutaminase Antibodies ◽  
Endomysial Antibodies

The relation between ischemia modified albumin level and autoimmunity/chronic inflammation in celiac disease

2017 ◽  
Vol 42 (3) ◽  
Author(s):  
Mahmut Yuksel ◽  
Mustafa Kaplan ◽  
Ihsan Ates ◽  
Yasemin Ozderin Ozin ◽  
Hasan Kilic ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Chronic Inflammation ◽  
Immunoglobulin G ◽  
Tissue Transglutaminase ◽  
Immunoglobulin A ◽  
Chronic Inflammatory Disease ◽  
Albumin Level ◽  
Control Group ◽  
Ischemia Modified Albumin ◽  
Gliadin Antibodies

AbstractObjective:We established an expectation that ischemia-modified albumin (IMA) levels are higher in the celiac disease since it is an autoimmune/chronic inflammatory disease. In this study, we determined the level of IMA and its relation to autoimmunity/chronic inflammation in celiac disease.Material and methods:The level of IMA of 65 patients diagnosed with celiac disease and 65 healthy volunteers, was measured with the serum ELISA kit. C-reactive protein (CRP), anti-gliadin antibodies immunoglobulin A (AGA-lgA), anti-gliadin antibodies immunoglobulin G (AGA-lgG), anti-tissue transglutaminase immunoglobulin A antibodies (Anti-t-TGA), anti-tissue transglutaminase immunoglobulin G antibodies (Anti-t-TGG) levels were studied.Results:IMA (30.8 ng/mL vs. 20.1 ng/mL, p=0.006; respectively) levels in celiac patients were higher than the control group. In celiac patients who were antibody positive, IMA level was found to be higher compared to antibody negative patients. A positive correlation was determined between IMA level and AGA-IgA (r=0.504, p<0.001), AGA-IgG (r=0.445, p<0.001), Anti-t TGA (r=0.485, p<0.001), Anti-t TGG (r=0.477, p<0.001) and CRP (r=0.385, p=0.011) levels.Conclusion:Chronic inflammation and autoimmunity were found to be associated with high levels of IMA. To use IMA as a diagnosis and follow-up criterion in celiac disease, IMA levels must be compared before and after treatment of active celiac disease.

Frequency of celiac disease is not increased among multiple sclerosis patients

2008 ◽  
Vol 14 (5) ◽  
pp. 698-700 ◽  
Author(s):  
A Nicoletti ◽  
F Patti ◽  
S Lo Fermo ◽  
A Sciacca ◽  
P Laisa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Celiac Disease ◽  
Neurological Disorders ◽  
Tissue Transglutaminase ◽  
Specific Antibodies ◽  
Endomysial Antibodies ◽  
Multiple Sclerosis Patients

We evaluated the presence of IgA and IgG celiac disease–related antibodies in a sample of 217 patients with multiple sclerosis (MS) and in a sample of 200 controls not affected by neurological disorders. None of the 217 patients with MS presented IgG and IgA anti-gliadin, anti-endomysial antibodies, anti-tissue transglutaminase and anti-reticulin, whereas only one of the selected controls presented specific antibodies; this subject resulted to be effectively affected by celiac disease. Our data did not show an increased frequency of celiac disease among patients with MS.

scholarly journals Serological Study for Celiac Disease among Sample of Iraqi Patients

2017 ◽  
Vol 11 (2) ◽  
pp. 25-29
Author(s):  
Mohammed Waheed ◽  
Amina N. AL-Thwani ◽  
Rabab Q. AL-Segar
Keyword(s):  
Celiac Disease ◽  
Serological Test ◽  
Tissue Transglutaminase ◽  
Serological Markers ◽  
Serological Study ◽  
Central Public Health ◽  
Gliadin Antibodies ◽  
Wheat Gliadin ◽  
Males And Females ◽  
Small Intestinal

 This study aimed to detect the celiac disease by using serological markers including AGA and Ttg. Celiac disease (CD) is a complex small intestinal disorder due to a dysregulated immune response to wheat gliadin in children and adults. A total of 412 suspected patients with celiac disease of males and females with age rang (1-48) year, attended Central Public Health Laboratory (CPHL) Baghdad/ Iraq during the period between December 2015 - April 2016, only fifty patients with celiac disease with age rang 1-40 were confirmed by two serological test which were Anti-gliadin antibodies (AGA) and Anti-Tissue transglutaminase (tTG) conducted by ELISA. The results, showed that 73 (17.72 %) of patients were seropositive AGA-IgA, and 83 (20.15%) were seropositive for AGA-IgG, whereas 67 (16.27%) were seropositive for both IgA and IgG of AGA test. The seropositive patients for tTG- IgA and tTG -IgG were 60 (14.56 %), and 69 (16.75 %) respectively. The seropositive for both (tTG -IgA and IgG) represented 53 (12.87 %) patient.

scholarly journals FREQUENCY OF CELIAC DISEASE

2016 ◽  
Vol 23 (07) ◽  
pp. 812-816
Author(s):  
Amir Shahzad ◽  
Abdul Aziz Sahto ◽  
Miss Samina
Keyword(s):  
Celiac Disease ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Tissue Transglutaminase ◽  
Tertiary Care ◽  
Deficiency Anemia ◽  
Outcome Variable ◽  
Positive Finding ◽  
Care Hospital ◽  
Endomysial Antibodies

Objectives: The aim behind this study was to determine the frequency of Celiacdisease in patients presenting with Iron deficiency anemia at tertiary care hospital. StudyDesign: Descriptive cross sectional hospital based study. Setting: Non-probability consecutivesampling technique in a department of medicine at Medical Unit II, People’s Medical University,Shaheed Benazeerabad. Period: Six months from 26th October 2014 to 25th April 2015. Patientsand Methods: A standard sample bottle was used to collect the blood sample from the peripheralvein followed by testing for Anti-tissue transglutaminase antibodies (tTG) and anti-endomysialantibodies (EMA). On these patients upper GI endoscopy for jejunal biopsy was done by anexpert having an experience of >5 years in relevant field. Data regarding Hemoglobin, antitTG antibodies, anti Endomysial antibodies and diagnosis of celiac disease (outcome variable)were collected. Data were entered and analyzed by using Statistical Package for the SocialSciences version 20.0. Results: Out of total 77 patients, the mean age and SD of age andhemoglobin levels were 37.65±11.26 years and 8.81±1.23 g/dl, respectively. Celiac disease(CD) Positive finding was observed in 27.27% cases by anti-tTG antibodies and in 16.88% casesby anti-endomysial antibodies. Prevalenc Frequency of celiac disease in patients presentingwith iron deficiency anemia was observed in Around 12.99% (10/77) of the cases who hadunderlying iron deficiency anemia were observed to have concomitant. Conclusion: There isa high prevalence of Celiac disease in patients presenting with Iron deficiency anemia. Earlydeduction and prompt treatment should be necessary for this disease. Screening of celiacdisease by anti-tissue transglutaminase antibody should be done as a routine investigation inpatient with iron-deficiency anemia.

Sign in / Sign up

Export Citation Format

Share Document