[18O]-Labeled Singlet Oxygen as a Tool for Mechanistic Studies of 8-Oxo-7,8-Dihydroguanine Oxidative Damage: Detection of Spiroiminodihydantoin, Imidazolone and Oxazolone Derivatives

2002 ◽  
Vol 383 (3-4) ◽  
Author(s):  
G.R. Martinez ◽  
M.H.G. Medeiros ◽  
J.-L. Ravanat ◽  
J. Cadet ◽  
P. Di Mascio
Keyword(s):  
Oxidative Damage ◽  
Damage Detection ◽  
Singlet Oxygen ◽  
Mechanistic Studies

Fluorescent proteins as singlet oxygen photosensitizers: mechanistic studies in photodynamic inactivation of bacteria

2013 ◽  
Author(s):  
Rubén Ruiz-González ◽  
John H. White ◽  
Aitziber L. Cortajarena ◽  
Montserrat Agut ◽  
Santi Nonell ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Fluorescent Proteins ◽  
Photodynamic Inactivation ◽  
Mechanistic Studies ◽  
Inactivation Of Bacteria

MECHANISTIC STUDIES OF SINGLET OXYGEN-OLEFIN REACTION

1979 ◽  
Author(s):  
ΜΙΧΑΗΛ ΟΡΦΑΝΟΠΟΥΛΟΣ
Keyword(s):  
Singlet Oxygen ◽  
Mechanistic Studies

scholarly journals Mechanism of Resveratrol Dimers Isolated from Grape Inhibiting 1O2 Induced DNA Damage by UHPLC-QTOF-MS2 and UHPLC-QQQ-MS2 Analyses

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 271
Author(s):  
Qingjun Kong ◽  
Qingzhi Zeng ◽  
Jia Yu ◽  
Hongxi Xiao ◽  
Jun Lu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Damage ◽  
Singlet Oxygen ◽  
Theoretical Basis ◽  
Antioxidative Activity ◽  
Oxidation Products ◽  
Characteristic Structure ◽  
First Time ◽  
Quench Singlet Oxygen

Resveratrol dimers have been extensively reported on due to their antioxidative activity. Previous studies revealed that resveratrol dimer has been shown to selectively quench singlet oxygen (1O2), and could protect DNA from oxidative damage. The mechanism of resveratrol dimers protecting DNA against oxidative damage is still not clear. Therefore, in this project, the reactants and products of resveratrol dimers protecting guanine from oxidative damage were qualitatively monitored and quantitatively analyzed by UHPLC-QTOF-MS2 and UHPLC-QQQ-MS2. Results showed that when guanine and resveratrol dimers were attacked by 1O2, mostly resveratrol dimers were oxidized, which protected guanine from oxidation. Resveratrol dimers’ oxidation products were identified and quantified at m/z 467.1134 [M-H]− and 467.1118 [M-H]−, respectively. The resorcinol of resveratrol dimers reacted with singlet oxygen to produce p-benzoquinone, protecting guanine from 1O2 damage. Therefore, it is hereby reported for the first time that the resorcinol ring is the characteristic structure in stilbenes inhibiting 1O2 induced-DNA damage, which provides a theoretical basis for preventing and treating DNA damage-mediated diseases.

Effects of the Interaction Between β-Carboline-3-carboxylic acid N-Methylamide and Polynucleotides on Singlet Oxygen Quantum Yield and DNA Oxidative Damage

2007 ◽  
Vol 83 (6) ◽  
pp. 1455-1464 ◽  
Author(s):  
Iñigo X. García-Zubiri ◽  
Hugh D. Burrows ◽  
J. Sérgio Seixas de Melo ◽  
Joao Pina ◽  
María Monteserín ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Quantum Yield ◽  
Oxidative Damage ◽  
Singlet Oxygen ◽  
Dna Oxidative Damage

Mechanistic studies on the photodegradation of 2,5-dialkyloxyl-substituted para-phenylenevinylene oligomers by singlet oxygen

2010 ◽  
Vol 9 (7) ◽  
pp. 942 ◽  
Author(s):  
Hugh D. Burrows ◽  
Oliver Narwark ◽  
Ralf Peetz ◽  
Emma Thorn-Csányi ◽  
Andrew P. Monkman ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Mechanistic Studies

In situ and real time muscle chemiluminescence determines singlet oxygen involvement in oxidative damage during endotoxemia

2010 ◽  
Vol 184 (3) ◽  
pp. 313-318 ◽  
Author(s):  
Virginia Vanasco ◽  
Pablo Evelson ◽  
Alberto Boveris ◽  
Silvia Alvarez
Keyword(s):  
Oxidative Damage ◽  
Singlet Oxygen ◽  
Real Time
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