scholarly journals Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 gene on lipid profile and adipokines levels in obese subjects

2017 ◽  
Vol 20 (1) ◽  
pp. 71-80 ◽  
Author(s):  
E Becer ◽  
A Çırakoğlu
Keyword(s):  
Serum Lipid ◽  
Peroxisome Proliferator ◽  
Model Assessment ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Pcr Rflp ◽  
Obese Subjects ◽  
Polymerase Chain ◽  
Lipid Parameters ◽  
Γ2 Gene

Abstract Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of metabolism, adipokines production and secretion. The aim of this study was to investigate the association between the PPARγ2 gene Pro12Ala polymorphism in obesity in terms of body mass index (BMI), lipid parameters, homeostasis model assessment of insulin resistance (HOMA-IR), serum lipid, leptin, adiponectin, resistin and chemerin levels. The study included 160 obese and 140 non obese subjects. The Pro12Ala polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum lipid, leptin, adiponectin, resistin and chemerin levels were measured. No association was found between the Pro12Ala polymorphism and BMI. Strikingly, in the study group, obese subjects with the AA genotype had significantly higher triglycerides (p = 0.046) and resistin (p <0.001) levels than those with the wild-type PP and heterozygous PA genotypes. Serum leptin and chemerin levels were significantly associated with Pro-12Ala poymorphism in the obese and non obese groups (p <0.01). In the obese group, subjects with the homozygous AA genotype had significantly lower adiponectin (p = 0.010) activity than the PP genotype. Our results suggest that the PPARγ2 gene Pro12Ala polymorphism has no direct association with obesity but does have significant influences on lipid profiles and adipokines levels.

scholarly journals The Pro12Ala Polymorphism of PPAR-γGene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population

PPAR Research ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Guoda Ma ◽  
Haiyang Wang ◽  
Guixi Mo ◽  
Lili Cui ◽  
You Li ◽  
...  
Keyword(s):  
Disease Severity ◽  
Peroxisome Proliferator ◽  
Healthy Controls ◽  
Chinese Han ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Significant Difference ◽  
Ligation Detection Reaction ◽  
Polymerase Chain ◽  
Sepsis Survivors

Peroxisome proliferator-activated receptor-γ(PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γhas been suggested as a candidate gene for sepsis. In the present study, we investigated the association between the Pro12Ala polymorphism of PPAR-γand sepsis in a Han Chinese population. A total of 308 patients with sepsis and 345 healthy controls were enrolled in this study. Genotyping was performed using the polymerase chain reaction-ligation detection reaction (PCR-LDR) method. No significant differences were detected in the allele and genotype distributions of the PPAR-γPro12Ala SNP between septic patients and controls (P=0.622for genotype;P=0.629for allele). However, stratification by subtypes (sepsis, septic shock, and severe sepsis) revealed a statistically significant difference in the frequency of the Ala allele and Ala-carrier genotype between the patients with the sepsis subtype and the healthy controls (P=0.014for allele andP=0.012, for genotype). Moreover, significant differences were found in the frequency of the Ala allele and genotype between the sepsis survivors and nonsurvivors (allP=0.002). In the survivors, the PPAR-γPro12Ala genotype was significantly associated with decreased disease severity and recovery time (allP<0.001). Thus, genetic polymorphism is thought to play a role in the development and outcome of sepsis.

Polymorphism of Pro12Ala in the Peroxisome Proliferator-Activated Receptor γ2 Gene in Iranian Diabetic and Obese Subjects

2009 ◽  
Vol 7 (5) ◽  
pp. 453-458 ◽  
Author(s):  
Hassan Mirzaei ◽  
Seyed Mohammad Akrami ◽  
Taghi Golmohammadi ◽  
Mahmood Doosti ◽  
Ramin Heshmat ◽  
...  
Keyword(s):  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Obese Subjects ◽  
Γ2 Gene

scholarly journals Two Polymorphisms in the Peroxisome Proliferator-Activated Receptor-γ Gene Are Associated with Severe Overweight among Obese Women*

1999 ◽  
Vol 84 (10) ◽  
pp. 3708-3712 ◽  
Author(s):  
R. Valve ◽  
K. Sivenius ◽  
R. Miettinen ◽  
J. Pihlajamäki ◽  
A. Rissanen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fat Mass ◽  
Adipocyte Differentiation ◽  
Population Based ◽  
Peroxisome Proliferator ◽  
Obese Women ◽  
Pro12ala Polymorphism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Obese Subjects ◽  
Pparγ Gene

Abstract Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor that regulates adipocyte differentiation. Variations in the PPARγ gene may affect the function of the PPARγ and, therefore, body adipocity. We investigated the frequencies of the Pro12Ala polymorphism in exon B and the silent CAC478CAT polymorphism in exon 6 of the PPARγ gene and their effects on body weight, body composition, and energy expenditure in obese Finns. One hundred and seventy obese subjects [29 men and 141 women; body mass index (BMI), 35.7 ± 3.8 kg/m2; age, 43 ± 8 yr; mean ± sd) participated in the study. The frequencies of the Ala12 allele in exon B and CAT478 allele in exon 6 were not significantly different between the obese and population-based control subjects (0.14 vs. 0.13 and 0.19 vs. 0.21, respectively). The polymorphisms were associated with increased BMI [Pro12Pro, 34.5 ± 3.8; Pro12Ala, 34.8 ± 3.1; Ala12Ala, 39.2± 4.6 kg/m2 (P = 0.011); CAC478CAC, 34.5 ± 3.8; CAC478CAT, 34.5 ± 3.3; CAT478CAT, 37.7 ± 4.1 kg/m2 (P = 0.046)]. In addition, the women with both Ala12Ala and CAT478CAT genotypes (n = 5) were significantly more obese compared with the women having both Pro12Pro and CAC478CAC genotypes (n = 85; BMI, 40.6 ± 3.3 vs. 34.4 ± 3.9 kg/m2; P = 0.001), and they had increased fat mass (46.8 ± 9.1 vs. 36.8 ± 7.5 kg; P = 0.005). In conclusion, the Pro12Ala and CAC478CAT polymorphisms in the PPARγ gene are associated with severe overweight and increased fat mass among obese women.

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