Amyloid-like fibrils labeled with magnetic nanoparticles

AbstractA number of human diseases are associated with the formation of insoluble protein aggregates commonly known as amyloid fibrils or amyloid plaques. Similar materials can be prepared in vitro resulting in so-called amyloid-like fibrils. Herein is discussed how to prepare such fibrils labeled with magnetic nanoparticles. Such materials have the potential to be used as magnetic probes for magnetic resonance imaging applications.

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Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)

Biomaterials ◽

10.1016/j.biomaterials.2014.12.005 ◽

2015 ◽

Vol 44 ◽

pp. 155-172 ◽

Cited By ~ 130

Author(s):

Kwok Kin Cheng ◽

Pui Shan Chan ◽

Shujuan Fan ◽

Siu Ming Kwan ◽

King Lun Yeung ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Magnetic Nanoparticles ◽

Magnetic Resonance ◽

Amyloid Plaques ◽

Resonance Imaging ◽

Magnetic Resonance Imaging Mri

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Influence of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1–T2 magnetic resonance imaging performance

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2016.03.040 ◽

2016 ◽

Vol 472 ◽

pp. 229-236 ◽

Cited By ~ 17

Author(s):

Noelia Guldris ◽

Bárbara Argibay ◽

Yury V. Kolen’ko ◽

Enrique Carbó-Argibay ◽

Tomás Sobrino ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Nanoparticles ◽

Magnetic Resonance ◽

Separation Procedure ◽

Resonance Imaging ◽

Imaging Performance ◽

In Vitro Stability

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Dependence of Blood Clot Lysis on the Mode of Transport of Urokinase into the Clot - A Magnetic Resonance Imaging Study in Vitro

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648188 ◽

1991 ◽

Vol 65 (05) ◽

pp. 549-552 ◽

Cited By ~ 55

Author(s):

A Blinc ◽

G Planinšič ◽

D Keber ◽

O Jarh ◽

G Lahajnar ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Pressure Difference ◽

Volume Flow Rate ◽

Blood Clot ◽

Linear Regression Analysis ◽

Imaging Study ◽

Clot Lysis ◽

Resonance Imaging

SummaryMagnetic resonance imaging was employed to study the dependence of clot lysing patterns on two different modes of transport of urokinase into whole blood clots. In one group of clots (nonperfused clots, n1 = 10), access of urokinase to the fibrin network was possible by diffusion only, whereas in the other group (perfused clots, n2 = 10) bulk flow of plasma containing urokinase was instituted through occlusive clots by a pressure difference of 3 .7 kPa (37 cm H2O) across 3 cm long clots with a diameter of 4 mm. It was determined separately that this pressure difference resulted in a volume flow rate of 5.05 ± 2.4 × 10−2 ml/min through occlusive clots. Perfused clots diminished in size significantly in comparison to nonperfused ones already after 20 min (p <0.005). Linear regression analysis of two-dimensional clot sizes measured by MRI showed that the rate of lysis was more than 50-times faster in the perfused group in comparison to the nonperfused group. It was concluded that penetration of the thrombolytic agent into clots by perfusion is much more effective than by diffusion. Our results might have some implications for understanding the differences in lysis of arterial and venous thrombi.

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