scholarly journals Plasma creatinine medians from patients partitioned by gender and age used as a tool for assessment of analytical stability at different concentrations

2019 ◽  
Vol 58 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Steen Ingemann Hansen ◽  
Per Hyltoft Petersen ◽  
Flemming Lund ◽  
Callum G. Fraser
Keyword(s):  
Systematic Errors ◽  
Reference Intervals ◽  
Plasma Creatinine ◽  
Creatinine Concentration ◽  
Medical Laboratories ◽  
Analytical Stability ◽  
Plasma Creatinine Concentration ◽  
Gender And Age ◽  
Performance Specifications

Abstract Background Monthly medians of patient results are useful in assessment of analytical quality in medical laboratories. Separate medians by gender makes it possible to generate two independent estimates of contemporaneous errors. However, for plasma creatinine, reference intervals (RIs) are different by gender and also higher over 70 years of age. Methods Daily, weekly and monthly patient medians were calculated from the raw data of plasma creatinine concentrations for males between 18 and 70 years, males >70 years, females between 18 and 70 years and females >70 years. Results The medians of the four groups were all closely associated, with similar patterns. The mean of percentage bias from each group defined the best estimate of bias. The maximum half-range (%) of the bias evaluations provided an estimate of the uncertainty comparable to the analytical performance specifications: thus, bias estimates could be classified as optimum, desirable or minimum quality. Conclusions Medians by gender and age are useful in assessment of analytical stability for plasma creatinine concentration ranging from 60 to 90 μmol/L. The daily medians are valuable in rapid detection of large systematic errors, the weekly medians in detecting minor systematic errors and monthly medians in assessment of long-term analytical stability.

Changes in Plasma Creatinine Concentration after Cardiac Anesthesia with Isoflurane, Propofol, or Sevoflurane

2001 ◽  
Vol 95 (4) ◽  
pp. 842-848 ◽  
Author(s):  
David A. Story ◽  
Stephanie Poustie ◽  
Guoming Liu ◽  
P. Larry McNicol
Keyword(s):  
Coronary Artery ◽  
Renal Impairment ◽  
Plasma Creatinine ◽  
Coronary Artery Surgery ◽  
Primary Analysis ◽  
Creatinine Concentration ◽  
Sevoflurane Group ◽  
Isoflurane Group ◽  
Plasma Creatinine Concentration ◽  
Median Maximum

Background Renal impairment often follows cardiac surgery. The authors investigated whether sevoflurane produces greater increases in plasma creatinine concentration than isoflurane or propofol after elective coronary artery surgery. Methods As part of maintenance anesthesia, including during cardiopulmonary bypass, patients were randomly allocated to receive one of three agents: isoflurane (n = 118), sevoflurane (n = 118), or propofol (n = 118). Fresh gas flows were 3 l/min. The preoperative plasma creatinine concentration was subtracted from the highest creatinine concentration in the first 3 postoperative days. A median maximum increase greater than 44 microM (0.5 mg/dl) was regarded as clinically important. Data were analyzed on an intention-to-treat basis. Subgroup analyses were performed on per-protocol patients and those with preoperative renal impairment (creatinine concentration > 130 microM [1.47 mg/dl] or urea > 7.7 mM [blood urea nitrogen, 21.6 mg/dl]). Results The differences between the groups were small, clinically unimportant, and not statistically significant for the primary analysis and subgroups. The proportions of patients with creatinine increases greater than 44 microM were 15% in the isoflurane group, 17% in the sevoflurane group, and 11% in the propofol group (P = 0.45). The median increases were 8 microM in the isoflurane group, 4 microM in the sevoflurane group, and 6 microM in the propofol group. The differences between the three median maximum increases were 1-4 microM (P > 0.45). In the subgroup with preoperative renal impairment, the median increases were 10 microM in the isoflurane group, 15 microM in the sevoflurane group, and 5 microM in the propofol group (P = 0.72). Conclusions Sevoflurane did not produce greater increases in creatinine than isoflurane or propofol after elective coronary artery surgery.

scholarly journals PSVII-16 Dietary creatine and sulfur amino acids for finishing gilts

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 362-362
Author(s):  
Natália Y Sitanaka ◽  
Lucas Antonio C Esteves ◽  
Alice Murakami ◽  
Eliane Gasparino ◽  
Angélica Khatlab ◽  
...  
Keyword(s):  
Gene Expression ◽  
Plasma Concentrations ◽  
Blood Parameters ◽  
Plasma Creatinine ◽  
Sulfur Amino Acids ◽  
Creatinine Concentration ◽  
Creatine Transporter ◽  
Longissimus Dorsi Muscle ◽  
Plasma Creatinine Concentration

Abstract The objective of this study was to evaluate the effects of dietary creatine and SID methionine+cysteine (Met+Cys) levels on the performance, blood parameters and gene expression of the creatine transporter (SLC6A8) in finishing gilts. Forty gilts, averaging 75.26 ± 0.87 kg of initial weight, were distributed in a randomized blocks design in a 2x2 factorial scheme, consisting of two creatine monohydrate (CMH) supplementation levels (0.00 and 0.10%) and two levels of SID Met+Cys (0.40 and 0.44%, considering 0.44% as the requirement), with 10 replicates. DL methionine was used to ensure the dietary SID Met+Cys levels. Upon reaching a mean weight of 100± 5.85, blood was collected for the determination of urea, creatinine, lactate, glucose and homocysteine plasma concentrations. Afterwards, the gilts were slaughtered for the collection of Longissimus dorsi muscle samples, for further determination of the gene expression of the creatine transporter (SLC6A8). No interactions (P > 0.05) we observed between the CMH and SID Met+Cys on the performance and gene expression of the SLC6A8 transporter, and also were not affected (P > 0.05) by the dietary levels of CMH or SID Met+Cys, individually. However, there was an interaction (P = 0.03) between SID Met+Cys and CMH levels on the plasma creatinine concentration, showing a lower (P = 0.018) concentration (6.40 mg/dL) supplementing 0.10% CMH than not supplementing (8.96 mg/dL), only at 0.44% of SID Met+Cys. There were no interactions (P > 0.05) between SID Met+Cys and CMH on the other blood parameters, and also no individual effects were observed for the studied factors. It is concluded that supplementing 0.10% CMH reduced plasma creatinine concentration only at conventionally dietary SID Met+Cys level (0.44%), not affecting other blood parameters, growth performance and the gene expression of the creatine transporter SLC6A8 of finishing gilts.

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