The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves' disease

2005 ◽  
Vol 43 (4) ◽  
Author(s):  
Vesna Bacic-Vrca ◽  
Franjo Skreb ◽  
Ivana Cepelak ◽  
Ljiljana Mayer ◽  
Zvonko Kusic ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Status ◽  
Therapy Group ◽  
Total Antioxidant Status ◽  
Superoxide Dismutase Activity ◽  
Graves Disease ◽  
Antioxidant Supplementation ◽  
Study Results ◽  
Significant Difference ◽  
Total Antioxidant

AbstractThe effects of supplementation with a fixed combination of antioxidants (vitamins C and E, β-carotene and selenium) on superoxide dismutase activity, copper and zinc concentrations, and total antioxidant status were monitored in erythrocytes derived from a group of patients with Graves' disease treated with methimazole, with respect to the rate of achieving euthyroidism. Thyroid-stimulating hormone (TSH), thyroid hormones and the above-mentioned parameters were measured before therapy, and on days 30 and 60 after therapy initiation. The patients receiving antioxidant supplementation along with methimazole therapy (group A, n=27) achieved euthyroidism at a faster rate than those treated with methimazole alone (group B, n=28). The activity of superoxide dismutase decreased significantly in both patient groups during the treatment; however, there was no significant difference between the groups. There was no significant change in the erythrocyte concentration of copper, whereas the zinc concentration and total antioxidant status showed significant between-group differences. The study results clearly show that antioxidant supplementation in the treatment of Graves' disease is justified, while zinc and total antioxidant status in erythrocytes seem to be sensitive indicators of the efficacy of supplemental therapy.

scholarly journals Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Nasrin Sheikh ◽  
Heidar Tavilani ◽  
Aliakbar Rezaie ◽  
Asad Vaisi-raygani ◽  
Saeedeh Salimi
Keyword(s):  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Ischemic Stroke ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Control Group ◽  
Significant Difference ◽  
Total Antioxidant ◽  
And Control

Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic stroke subjects. The study population consisted of 30 patients with acute ischemic stroke and 30 controls. There was no significant difference between estradiol in stroke and control group. The activity of superoxide dismutase and level of ferritin was higher in stroke compared with control group (P<.05,P<.001, resp.). There was no significant correlation between estradiol and glutathione peroxidase, glutathione reductase, catalase, total antioxidant status, and ferritin in stroke and control groups. We observed inverse correlation between estradiol with superoxide dismutase in males of stroke patients (r=−0.54,P=.029). Our results supported that endogenous estradiol of elderly men and women of stroke or control group has no antioxidant activity.

Antioxidative mechanism in the course of varicose veins

2017 ◽  
Vol 33 (7) ◽  
pp. 464-469 ◽  
Author(s):  
Anna Horecka ◽  
Jadwiga Biernacka ◽  
Anna Hordyjewska ◽  
Wojciech Dąbrowski ◽  
Piotr Terlecki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Varicose Vein ◽  
Antioxidant Status ◽  
Antioxidant Defense ◽  
Total Antioxidant Status ◽  
Superoxide Dismutase Activity ◽  
Clinical State ◽  
Vein Wall ◽  
Total Antioxidant

Objective Our objective was to evaluate the state of oxidative stress in the great saphenous varicose vein wall and blood of varicose vein patients taken from the antecubital vein. Methods The superoxide dismutase, reduced glutathione (GSH) and total antioxidant status were measured with commercially available colorimetric kits in erythrocytes, plasma and varicose vein wall of 65 patients (second degree of clinical state classification, etiology, anatomy and pathophysiology) aged 22–70 (49 women, 16 men) in comparison to normal great saphenous vein walls collected from 10 patients who underwent coronary artery bypass graft and blood collected from 20 healthy individuals. Results A statistically significant decrease (p < 0.001) in superoxide dismutase activity in erythrocytes and the increase (p < 0.05) in superoxide dismutase activity in varicose vein has been observed. There have been no significant changes in the concentration of GSH in plasma and in varicose vein. The decreased concentration of total antioxidant status in plasma (p < 0.001) and in varicose vein wall (p < 0.05) in comparison to the control has been noticed. Conclusion The varicose vein patients are affected by oxidative stress. Our results indicate impaired antioxidant defense mechanism in the blood of varicose vein patients. In contrast to the blood, an increased process of antioxidant defense in the varicose vein wall was noticed.

Antioxidant Status, Oxidative Stress, and Damage in Elite Trained Kayakers and Canoeists and Sedentary Controls

2009 ◽  
Vol 19 (5) ◽  
pp. 443-456 ◽  
Author(s):  
Vitor Teixeira ◽  
Hugo Valente ◽  
Susana Casal ◽  
Franklim Marques ◽  
Pedro Moreira
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Uric Acid ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Antioxidant Defense System ◽  
Strenuous Exercise ◽  
Antioxidant Intake ◽  
Total Antioxidant ◽  
Β Carotene

Strenuous physical activity is known to generate reactive oxygen species to a point that can exceed the antioxidant defense system and lead to oxidative stress. Dietary intake of antioxidants, plasma enzymatic (superoxide dismutase, glutathione reductase [Gr], and glutathione peroxidase [GPx]) activities, nonenzymatic (total antioxidant status [TAS], uric acid, α-tocopherol, retinol, α-carotene, β-carotene, lycopene, and lutein + zeaxanthin) antioxidants, and markers of lipid peroxidation (thiobarbituricacid-reactive substances [TBARS]) and muscle damage (creatine kinase [CK]) were measured in 17 elite male kayakers and canoeists under resting conditions and in an equal number of age- and sex-matched sedentary individuals. Athletes showed increased plasma values of α-tocopherol (p = .037), α-carotene (p = .003), β-carotene (p = .007), and superoxide dismutase activity (p = .002) and a lower TAS level (p = .030). Antioxidant intake (α-tocopherol, vitamin C, and β-carotene) and plasmatic GPx, Gr, lycopene, lutein + zeaxanthin, retinol, and uric acid levels were similar in both groups. Nevertheless, TBARS (p < .001) and CK (p = .011) levels were found to be significantly higher in the kayakers and canoeists. This work suggests that despite the enhanced levels of antioxidants, athletes undergoing regular strenuous exercise exhibited more oxidative stress than sedentary controls.

scholarly journals Oxidant/Antioxidant Status Assessment of Blood in Selected Equine Diseases

2013 ◽  
Vol 57 (2) ◽  
pp. 225-230
Author(s):  
Wiesław Krumrych ◽  
Janusz Zbylut ◽  
Marcin Gołyński ◽  
Hanna Markiewicz
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Oxygen Metabolism ◽  
Upper Respiratory Tract ◽  
Total Antioxidant ◽  
Status Assessment ◽  
Upper Respiratory ◽  
Equine Diseases

Abstract The objective of the study was to assess ratio of oxidation to antioxidation in the blood of horses in selected equine diseases. The study was conducted on 47 Polish half-breed horses (36 mares, six stallions, and five geldings) aged 2 to 16 years. Nineteen mares were diagnosed with endometritis, seven horses with symptoms of colic, and six with upper respiratory tract infection. The remaining clinically healthy horses (n=15) served as control. The following parameters were measured: oxygen metabolism in neutrophils using a chemiluminescence (CL) method, total antioxidant status (TAS) of blood plasma, as well as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activity in whole blood. The results demonstrate increased CL of neutrophils in mares with endometritis, as well as in horses with symptoms of colic. This finding was associated with decreased values of SOD, GPx, and TAS (chiefly in mares with endometritis), which suggests oxidative stress. These results underscore the importance of a broader use of oxidant/antioxidant status assessment in studies of the pathogenesis and pathomechanisms of equine diseases.

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