2016 IUPAC-Richter Prize—Call for Nominations

2016 ◽  
Vol 38 (1) ◽  
Keyword(s):  
Drug Discovery ◽  
Human Health ◽  
Medicinal Chemistry ◽  
Outstanding Contribution ◽  
New Drug

IUPAC and Gedeon Richter, Plc. are pleased to announce the 2016 IUPAC-Richter Prize in Medicinal Chemistry. The Prize was established in 2006 by a generous gift from the Chemical Works of Gedeon Richter, Plc. (Budapest, Hungary) to acknowledge the key role that medicinal chemistry plays in improving human health. The prize—USD 10000—is awarded to an internationally recognized scientist, preferably a medicinal chemist, whose activities or published accounts have made an outstanding contribution to the practice of medicinal chemistry, or to an outstanding example of new drug discovery. Previous IUPAC-Richter Prizes were awarded to Malcolm F.G. Stevens in 2006, Jan Heeres in 2008, Arun K. Ghosh in 2010, Stephen Hanessian in 2012, and Helmut Buschmann in 2014.

2018 IUPAC-Richter Prize—Call for Nominations

2017 ◽  
Vol 39 (4) ◽  
Keyword(s):  
Drug Discovery ◽  
Human Health ◽  
Medicinal Chemistry ◽  
Outstanding Contribution ◽  
New Drug

AbstractIUPAC and Gedeon Richter, Plc. are pleased to announce the 2018 IUPAC-Richter Prize in Medicinal Chemistry. The prize was established in 2006 by a generous gift from the Chemical Works of Gedeon Richter, Plc. (Budapest, Hungary) to acknowledge the key role that medicinal chemistry plays toward improving human health. The prize—USD 10 000—is to be awarded to an internationally recognized scientist, preferably a medicinal chemist, whose activities or published accounts have made an outstanding contribution to the practice of medicinal chemistry or to an outstanding example of new drug discovery.

scholarly journals Current advances of carbene-mediated photoaffinity labeling in medicinal chemistry

RSC Advances ◽  
2018 ◽  
Vol 8 (51) ◽  
pp. 29428-29454 ◽  
Author(s):  
Sha-Sha Ge ◽  
Biao Chen ◽  
Yuan-Yuan Wu ◽  
Qing-Su Long ◽  
Yong-Liang Zhao ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Uv Irradiation ◽  
Binding Sites ◽  
Drug Targets ◽  
Medicinal Chemistry ◽  
Photoaffinity Labeling ◽  
Chemical Probe ◽  
New Drug ◽  
Considerable Promise

Photoaffinity labeling (PAL) in combination with a chemical probe to covalently bind its target upon UV irradiation has demonstrated considerable promise in drug discovery for identifying new drug targets and binding sites.

Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances

2019 ◽  
Vol 22 (8) ◽  
pp. 509-520
Author(s):  
Cauê B. Scarim ◽  
Chung M. Chin
Keyword(s):  
Drug Discovery ◽  
Chagas Disease ◽  
Drug Candidates ◽  
Lead Compounds ◽  
New Drug ◽  
Compound Libraries ◽  
Screening Assays ◽  
Cruzi Infection

Background: In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. Objective: Current approaches to drug discovery for Chagas disease. Method: This review article examines the contribution of these methodological advances in medicinal chemistry in the last four years, focusing on Trypanosoma cruzi infection, obtained from the PubMed, Web of Science, and Scopus databases. Results: Here, we have shown that the promise is increasing each year for more lead compounds for the development of a new drug against Chagas disease. Conclusion: There is increased optimism among those working with the objective to find new drug candidates for optimal treatments against Chagas disease.

Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

2020 ◽  
Vol 20 (5) ◽  
pp. 342-368 ◽  
Author(s):  
Juliana de Oliveira Carneiro Brum ◽  
Tanos Celmar Costa França ◽  
Steven R. LaPlante ◽  
José Daniel Figueroa Villar
Keyword(s):  
Biological Activity ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
New Drugs ◽  
New Drug ◽  
Cancer Inflammation

Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer’s, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

2014 ◽  
Vol 14 (7) ◽  
pp. 941-951 ◽  
Author(s):  
Gregory Landelle ◽  
Armen Panossian ◽  
Frederic Leroux
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry
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