Potential drug-drug interactions in ICU patients: a retrospective study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Iyad Ali ◽  
Alaa Bazzar ◽  
Nadine Hussein ◽  
Emile Sahhar
Keyword(s):  
Diabetes Mellitus ◽  
Healthcare Professionals ◽  
Chronic Illnesses ◽  
Potential Drug ◽  
Past Medical History ◽  
Icu Patients ◽  
The Past ◽  
Adequate Knowledge ◽  
Ensure Patient Safety ◽  
History Of

AbstractObjectivesA “potential drug-drug interaction” (pDDI) is the possibility one drug has to alter the effects of another when both are administered simultaneously. Intensive care unit (ICU) patients are especially prone to these pDDIs. This study aimed to determine the frequency and severity of pDDIs during the hospitalization of patients in the ICU.MethodsThis study was conducted retrospectively in three hospitals, including both governmental and non-governmental hospitals in Nablus, Palestine, over the course of six months; starting in January 2018 and ending in June 2018. The sample size included 232 ICU patients, and medications prescribed during the hospitalization of these patients were evaluated for pDDIs using the drugs.com application.ResultsA total of 167 patients (72%) were found to have at least one pDDI, while the total number of pDDIs in the study was 422, resulting in an average of 1.82 pDDIs per patient. Out of the total identified pDDIs, 41 interactions (9.7%) were major interactions, 281 (66.6%) were moderate interactions and 100 (23.7%) were minor interactions. The past medical history of these patients showed that many had hypertension (29%), diabetes mellitus (25%) and ischemic heart disease (10%). A serious combination, enoxaparin and aspirin, was found in six patients. Furthermore, as the number of administered drugs increased, the number of interactions increased as well.ConclusionsThe pDDIs are common in ICU patients. The most common and clinically most important pDDIs require special attention. Polypharmacy significantly increases the number and level of pDDIs, especially in patients with multiple chronic illnesses. Adequate knowledge regarding the most common pDDIs is necessary to enable healthcare professionals to implement ICU strategies that ensure patient safety.

scholarly journals Ossification of the Posterior Longitudinal Ligament

2003 ◽  
Vol 30 (1) ◽  
pp. 61-62
Author(s):  
A.P. Mitha ◽  
J.H. Wong ◽  
S.J. du Plessis
Keyword(s):  
Diabetes Mellitus ◽  
Neck Pain ◽  
Type Ii Diabetes ◽  
Posterior Longitudinal Ligament ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Past Medical History ◽  
The Past ◽  
Chinese Descent ◽  
History Of

A 51-year-old gentleman of Chinese descent presented for neurological evaluation following a two-year history of cervical neck pain associated with left arm numbness. His symptoms were initially stable, but had progressed over the past six months to include weakness of his entire left arm and leg and symptoms of bladder urgency. Two weeks prior to presentation, he suffered repeated falls due to worsening gait difficulties. The past medical history was significant for type II diabetes mellitus.

Rhabdomyolysis: An evidence-based approach

2021 ◽  
pp. 175114372110507
Author(s):  
Sarah Burgess
Keyword(s):  
Fluid Overload ◽  
Kidney Injury ◽  
Community Acquired Pneumonia ◽  
Evidence Based ◽  
Shortness Of Breath ◽  
Past Medical History ◽  
Urine Dipstick ◽  
The Past ◽  
Acting Insulin ◽  
History Of

A 76-year-old lady was found on the floor following a fall at home. She was uninjured, but unable to get up, and had been lying on the floor for roughly 18 hours before her son arrived. She had been unwell for the past 3 days with a cough and shortness of breath. She had a past medical history of diabetes, hypertension, hypercholesterolaemia and atrial fibrillation (AF). On examination, she was alert but distressed, clinically dehydrated, febrile and tachycardic. She was treated for community acquired pneumonia with co-amoxiclav and was fluid resuscitated with Hartmann’s solution. Her hyperkalaemia was treated with 50 mL of 50% glucose containing 10 units of rapid-acting insulin. Her creatinine kinase (CK) on admission was 200,000, and she had an acute kidney injury (AKI). Urine dipstick was positive for blood. However, her renal function continued to deteriorate over the succeeding 48 h, when she required renal replacement therapy (RRT) due to fluid overload and anuria.

scholarly journals Drugs as diagnostic tools

2016 ◽  
Vol 85 (1) ◽  
pp. 43-45
Author(s):  
Nicole Arseneau ◽  
Carlos Muzlera
Keyword(s):  
Illicit Drugs ◽  
Diagnostic Tools ◽  
Past Medical History ◽  
Fat Pad ◽  
Mild Depression ◽  
Family History Of Diabetes ◽  
The Past ◽  
Multivitamin Supplement ◽  
History Of ◽  
Alcoholic Drinks

Mr Simon, age 36, presents to his family physician with concerns about his weight. He has gained 20 kg in the past 4 months, and has developed purple striae on his abdomen. His body mass index (BMI) is currently 34, and on physical examination, he is found to have a rounded face, a large dorsal fat pad, and a waist circumference of 112 cm. His blood pressure is elevated at 145/95 mmHg, while all other vitals are normal. He also mentions worsening acne on his face, shoulders, and upper back, as well as mild depression for the past 3 months. His past medical history is significant only for an appendectomy at age 10. He has no family history of diabetes, obesity, or cardiac disease. The only medication he has been on for the past 3 years is a multivitamin supplement. He does not smoke, drinks approximately 5 alcoholic drinks per week, and does not take any illicit drugs.

scholarly journals HolaDoctor®: Helping the Hispanic Community Navigate the Changing Healthcare Landscape

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Dirk Schroeder
Keyword(s):  
Cultural Awareness ◽  
Vice President ◽  
Chronic Illnesses ◽  
Health And Wellness ◽  
The Past ◽  
Aggressive Management ◽  
Hispanic Community ◽  
Executive Vice President ◽  
History Of ◽  
Medicine Today

No abstract available. Editor’s note: During the past 15 years, HolaDoctor® has applied cultural awareness to connect with the Hispanic community and inform them about health insurance, access to care, the importance of leading a health-filled life, and both early detection and aggressive management of chronic illnesses.  In this TMT interview, Dr. Dirk Schroeder, who is Executive Vice-President for Multicultural Insights and Research, discusses the history of HolaDoctor®, its current initiatives, and the future for this Spanish-language health and wellness service.  Telehealth and Medicine Today encourages our readers to download this audio presentation. You many listen to it and share it with your colleagues at your convenience. Reproduction of the interview is encouraged, with attribution to Telehealth and Medicine Today, 2016,  

scholarly journals Early and complete vitrectomy versus tap and inject in acute post cataract surgery endophthalmitis presenting with hand motion vision; a quasi-experimental study

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Seyed Ali Tabatabaei ◽  
Soran Aminzade ◽  
Aliasghar Ahmadraji ◽  
Mohammad Soleimani ◽  
Bahram Bohrani Sefidan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cataract Surgery ◽  
Medical History ◽  
Demographic Data ◽  
Diabetic Patients ◽  
Past Medical History ◽  
Motion Vision ◽  
Initial Management ◽  
Significant Difference ◽  
History Of

Abstract Background Based on endophthalmitis vitrectomy study, intravitreal injection of antibiotics is preferred for initial management of cases of acute post cataract surgery endophthalmitis (APCE) with presenting vision of hand motions (HM). This study aimed to compare outcomes of early and complete vitrectomy (VIT) and vitreous tap and antibiotic injection (T&I) in cases of APCE presented with vision of HM. Methods In this prospective study, cases of APCE with vision of HM between 2018 and 2020 were enrolled. According to the time of presentation, the patients were arranged into two groups (VIT vs. T&I). Demographic data, elapsed time to developing endophthalmitis, past medical history, microbiology results, complications, and final visual acuity were recorded and analyzed. Results Seventy-six eyes of 76 patients were enrolled. Fifty-three eyes underwent T&I and twenty-three were arranged into the VIT group. Past medical history of 34.2% of patients was significant for diabetes mellitus. There was a statistically significant lower logMAR in VIT group compared to T&I group (diff = 0.14, 95% CI: 0.04 to 0.24, P-value = 0.007). The comparison of the diabetic and non-diabetic patients in both groups showed that the visual outcome was better in non-diabetic cases compared to the diabetic subjects. There was no statistically significant difference between the diabetic and non-diabetic groups regarding the superiority of procedure. Conclusion Based on our results, we could recommend that it’s maybe better to do early and complete vitrectomy as the initial management of APCE with the vision of HM. Past medical history of diabetes mellitus is not a determining factor for choosing initial management between vitrectomy and antibiotic injection.

Carbohydrate Sources Preferences of Women With Past Medical History of Gestational Diabetes Mellitus in Puncak Alam, Malaysia

2019 ◽  
Vol 18 (11) ◽  
pp. 1028-1035
Author(s):  
Farhanah Ahmad Shuhaimi ◽  
Norazmir Md Nor ◽  
Siti Sabariah Buhari ◽  
Emmy Hainida Khairul Ikram ◽  
Ummy Syalshabella Mu Zamri
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Medical History ◽  
Past Medical History ◽  
History Of

scholarly journals Spinal Cord Constriction Secondary to Scaphoid Nonunions

2017 ◽  
Vol 1 (3) ◽  
pp. 01-01
Author(s):  
Samuel Langhorne
Keyword(s):  
Diabetes Mellitus ◽  
Spinal Cord ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
The Past ◽  
History Of ◽  
Spinal Fusions

A 57 year old female with history of diabetes mellitus, diabetic peripheral neuropathy and scoliosis with four previous spinal fusions (T4 to pelvis) presented with worsening ambulating for the past one month. She was previously at baseline ambulating with a walker.

scholarly journals Diabetic Muscle Infarction

2020 ◽  
Vol 4 (1) ◽  
pp. 99-100
Author(s):  
Sophia Ahmed ◽  
Romeo Fairley
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diabetes Mellitus ◽  
Magnetic Resonance ◽  
Medical History ◽  
Lower Extremities ◽  
Past Medical History ◽  
Resonance Imaging ◽  
Muscle Infarction ◽  
History Of

A 58-year-old male with past medical history of diabetes mellitus presented with pain to the bilateral groin for six weeks. Magnetic resonance imaging of the patient’s lower extremities revealed acute myoedema, and he was diagnosed with myositis secondary to diabetic muscle infarction.

scholarly journals Acute pericarditis: A peculiar manifestation of common variable immune deficiency

2021 ◽  
Vol 49 (3) ◽  
pp. 115-119
Author(s):  
Nasim Ramzi ◽  
Shahrooz Yazdani ◽  
Hamed Talakoob ◽  
Hossein Karim ◽  
Mahnaz Jamee ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Medical History ◽  
Inborn Error ◽  
Common Variable Immune Deficiency ◽  
Recurrent Infections ◽  
Past Medical History ◽  
Acute Pericarditis ◽  
The Past ◽  
History Of ◽  
Common Variable

Common variable immune deficiency (CVID) is known as the most prevalent symptomatic inborn error of immunity associated with autoimmune and inflammatory complications in addition to recurrent infections. In this study, we investigated the prevalence of acute pericarditis as a complication in the past medical history of 337 CVID patients. We found five patients (1.5%) that had experienced acute pericarditis, and described the medical history of three patients.

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