scholarly journals Diaminomaleonitrile as a versatile building block for the synthesis of 4,4′-biimidazolidinylidenes and 4,4′-bithiazolidinylidenes

2018 ◽  
Vol 24 (6) ◽  
pp. 303-306
Author(s):  
Mahsa Doomanlou ◽  
Hassan Kabirifard ◽  
Mehdi Asadi ◽  
Maryam Moloudi ◽  
Seyedeh Sara Mirfazli
Keyword(s):  
Building Block ◽  
Ring Closure ◽  
Wide Range ◽  
New Strategy ◽  
Aryl Isocyanates ◽  
Aryl Isothiocyanates

Abstract Ring closure reactions of diaminomaleonitrile (DAMN) with electrophilic aryl isocyanates and aryl isothiocyanates lead to the formation of the target 5,5′-diimino-1,1′-diaryl-4,4′-biimidazolidinylidene-2,2′-diones 2a,b and 2,2′-diarylimino-4,4′-bithiazolidinylidenes 4a–e, respectively. The protocol provides a new strategy for the synthesis of a wide range of alkenes with two electron-donating and two withdrawing substituents of DAMN in moderate to good yields.

The chemistry of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5- ones as a privileged scaffold in synthesis of heterocycles

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohsen A.-M. Gomaa ◽  
Huda A. Ali
Keyword(s):  
Building Block ◽  
Heterocyclic Compounds ◽  
Recent Progress ◽  
Reaction Conditions ◽  
Azacrown Ethers ◽  
Wide Range ◽  
Privileged Scaffold ◽  
Number Of Publications ◽  
Near Future

Background : The reactivity of 4-(dicyanomethylene)-3-methyl-l-phenyl-2-pyrazoline-5-one DCNP 1 and its derivatives makes it valuable as a building block for the synthesis of heterocyclic compounds like pyrazolo-imidazoles, - thiazoles, spiropyridines, spiropyrroles, spiropyrans and others. As a number of publications have reported on the reactivity of DCNP and its derivatives, we compiled some features of this interesting molecule. Objective: This article aims to review the preparation of DCNP, its reactivity and application in heterocyclic and dyes synthesis. Conclusion: In this review we have provided an overview of recent progress in the chemistry of DCNP and its significance in synthesis of various classes of heterocyclic compounds and dyes. The unique reactivity of DCNP offers unprecedentedly mild reaction conditions for the generation of versatile cynomethylene dyes from a wide range of precursors including amines, α-aminocarboxylic acids, their esters, phenols, malononitriles and azacrown ethers. We anticipate that more innovative transformations involving DCNP will continue to emerge in the near future.

scholarly journals Clothoid fitting and geometric Hermite subdivision

2021 ◽  
Vol 47 (4) ◽  
Author(s):  
Ulrich Reif ◽  
Andreas Weinmann
Keyword(s):  
Building Block ◽  
Numerical Results ◽  
Normal Vector ◽  
Subdivision Schemes ◽  
Planar Curves ◽  
Nonlinear Subdivision ◽  
New Strategy ◽  
Vector Information ◽  
Hermite Subdivision

AbstractWe consider geometric Hermite subdivision for planar curves, i.e., iteratively refining an input polygon with additional tangent or normal vector information sitting in the vertices. The building block for the (nonlinear) subdivision schemes we propose is based on clothoidal averaging, i.e., averaging w.r.t. locally interpolating clothoids, which are curves of linear curvature. To this end, we derive a new strategy to approximate Hermite interpolating clothoids. We employ the proposed approach to define the geometric Hermite analogues of the well-known Lane-Riesenfeld and four-point schemes. We present numerical results produced by the proposed schemes and discuss their features.

scholarly journals Classifying Counterparty Sector in EMIR Data

2021 ◽  
pp. 117-143
Author(s):  
Francesca D. Lenoci ◽  
Elisa Letizia
Keyword(s):  
Case Studies ◽  
Greedy Algorithm ◽  
Euro Area ◽  
Building Block ◽  
European Market ◽  
Data Sources ◽  
Wide Range ◽  
Sector Classification ◽  
Market Infrastructure ◽  
Research And Policy

AbstractThe data collected under the European Market Infrastructure Regulation (“EMIR data”) provide authorities with voluminous transaction-by-transaction details on derivatives but their use poses numerous challenges. To overcome one major challenge, this chapter draws from eight different data sources and develops a greedy algorithm to obtain a new counterparty sector classification. We classify counterparties’ sector for 96% of the notional value of outstanding contracts in the euro area derivatives market. Our classification is also detailed, comprehensive, and well suited for the analysis of the derivatives market, which we illustrate in four case studies. Overall, we show that our algorithm can become a key building block for a wide range of research- and policy-oriented studies with EMIR data.

Characterization of Metabolites of α-mangostin in Bio-samples from SD Rats by UHPLC-Q-Exactive Orbitrap MS

2021 ◽  
Vol 22 ◽  
Author(s):  
Fan Dong ◽  
Shaoping Wang ◽  
Ailin Yang ◽  
Haoran Li ◽  
Pingping Dong ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Garcinia Mangostana ◽  
Sd Rats ◽  
Metabolic Route ◽  
Wide Range ◽  
New Strategy ◽  
Q Exactive ◽  
Orbitrap Ms

Background: α-mangostin, a typical xanthone, often exists in Garcinia mangostana L. (Clusiaceae). α-mangostin was found to have a wide range of pharmacological properties. However, its specific metabolic route in vivo remains unclear, while these metabolites may accumulate to exert pharmacological effects, too. Objective: This study aimed to clarify the metabolic pathways of α-mangostin after oral administration to the rats. Methods: Here, an UHPLC-Q-Exactive Orbitrap MS was used for the detection of potential metabolites formed in vivo. A new strategy for the identification of unknown metabolites based on typical fragmentation routes was implemented. Results: A total of 42 metabolites were detected, and their structures were tentatively identified in this study. The results showed that major in vivo metabolic pathways of α-mangostin in rats included methylation, demethylation, methoxylation, hydrogenation, dehydrogenation, hydroxylation, dehydroxylation, glucuronidation, and sulfation. Conclusions: This study is significant to expand our knowledge of the in vivo metabolism of α-mangostin and to understand the mechanism of action of α-mangostin in rats in vivo.

A Generalized Approach for the Kinematic Analysis of Planar Mechanisms

1995 ◽  
Vol 209 (4) ◽  
pp. 237-244
Author(s):  
D J A Simpson ◽  
J E L Simmons ◽  
G Moldovean
Keyword(s):  
Computer Program ◽  
Analytical Method ◽  
Building Block ◽  
Kinematic Analysis ◽  
Displacement Velocity ◽  
Planar Mechanisms ◽  
New Approach ◽  
Wide Range ◽  
Complex Mechanisms

This paper describes a new approach to the kinematic analysis of planar mechanisms. The basis of the analytical method is a generic four-bar sub-mechanism which is used as the single building block from which other composite mechanisms may be created. A computer program has been written embodying this method and has been demonstrated to operate successfully providing animated displays of displacement, velocity and acceleration diagrams for a wide range of complex mechanisms.

One-Pot Synthesis of Thiazolo[3,4-a]Quinoxalines from 1,2-Diamines, Aryl Isothiocyanates and Ethyl Bromopyruvate

2017 ◽  
Vol 41 (12) ◽  
pp. 712-714 ◽  
Author(s):  
Mohammad Piltan
Keyword(s):  
Chromatographic Separations ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
Wide Range ◽  
Quinoxaline Derivatives ◽  
First Time ◽  
Aryl Isothiocyanates ◽  
Ethyl Bromopyruvate

Some hitherto unreported thiazolo[3,4- a]quinoxaline derivatives have been synthesised in excellent yields via a one-pot, three-component reaction of benzene-1,2-diamines, ethyl bromopyruvate and aryl isothiocyanates in MeCN, for the first time. The protocol avoids the use of any catalysts or chromatographic separations and provides a wide range of novel thiazolo[3,4- a]quinoxalines.

Cu(i) catalysed annulation of isothiocyanates/isocyanates with 2-iodo-sulfonamides: synthesis of benzodithiazines, benzothiadiazinones, benzothiazinylidene-anilines and benzothiazolylidene-anilines

2019 ◽  
Vol 17 (28) ◽  
pp. 6880-6894 ◽  
Author(s):  
K. Sandeep ◽  
Alla Siva Reddy ◽  
K. C. Kumara Swamy
Keyword(s):  
Catalysed Reaction ◽  
Aryl Isocyanates ◽  
Aryl Isothiocyanates

Cu(i)-catalysed reaction of 2-iodobenzene sulfonamides with aryl isothiocyanates leads to benzodithiazines but the corresponding reaction with aryl isocyanates affords benzothiadiazinones.

scholarly journals Reactions of 2-Triphenylphosphoimino-1-azaazulenes with Aryl Isocyanates and Aryl Isothiocyanates.

ChemInform ◽  
2006 ◽  
Vol 37 (17) ◽  
Author(s):  
Kentaro Nagamatsu ◽  
Ai Serita ◽  
Jun-Hau Zeng ◽  
Hiroyuki Fujii ◽  
Noritaka Abe ◽  
...  
Keyword(s):  
Aryl Isocyanates ◽  
Aryl Isothiocyanates

scholarly journals Bridged Bicyclic Building Block Upgrading: Photochemical Synthesis of bicyclo[3.1.1]heptan-1-Amines

2020 ◽  
Author(s):  
Alexander Harmata ◽  
Madison Sowden ◽  
Corey Stephenson
Keyword(s):  
Building Block ◽  
Primary Amine ◽  
Medicinal Chemistry ◽  
Building Blocks ◽  
Photochemical Synthesis ◽  
Wide Range ◽  
Hydrolysis Of

Compounds containing bridged bicyclic carbon skeletons are desirable building blocks for medicinal chemistry. However, as a result of their inefficient, linear syntheses, commercially available compounds of this sort are plagued by high costs and/or a lack of diversity in substitution patterns. Herein we report the conversion of the readily available bicyclo[1.1.1]pentan-1-amine substructure to a wide range of poly-substituted bicyclo[3.1.1]pentan-1-amines using imine photochemistry. To our knowledge, this is the first reported method to convert the bicyclo[1.1.1]pentane skeleton to the bicyclo[3.1.1]heptane skeleton. Hydrolysis of the imine products gives complex, sp<sup>3</sup>-rich primary amine building blocks.

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