After two prosperous decades, the European Union suffered a serious setback in the late 1970s and early 1980s, with sluggish growth and weak competitiveness in high-tech sectors compared to the USA and Japan. The creation of the single European market in 1993 was a major boost to growth and competitiveness in Europe. Yet, today, even abstracting from the coronavirus crisis, the European Union again faces some economic troubles. Growth has been subdued for a while and the EU is suffering yet again from weak competitiveness in high-tech sectors compared to the USA and to China, which has replaced Japan as the main Asian powerhouse. At the same time, however, the geopolitical situation has changed dramatically. In the earlier days, the world was divided between East and West, and all three main economic powers, the EU, Japan, and the USA, were in the same political camp. Their rivalry was therefore purely economic. Today, there are political dividing lines between the three main economic powers. The EU’s competitiveness problem vis-à-vis China and the USA in some key technologies is therefore not just economic but also geopolitical. Yet, the European Union remains largely an economic entity, though it has started to think and even to act geopolitically. The obvious question is whether Europe will be able to repeat its achievement of nearly 30 years ago and come up with a new design that will boost its growth and competitiveness in this new geopolitical era, or whether this quest will prove elusory.