Adipose, bone and muscle tissues as new endocrine organs: role of reciprocal regulation for osteoporosis and obesity development

2014 ◽  
Vol 17 (1) ◽  
Author(s):  
Silvia Migliaccio ◽  
Emanuela A. Greco ◽  
Francesca Wannenes ◽  
Lorenzo M. Donini ◽  
Andrea Lenzi
Keyword(s):  
Bone Mineral Density ◽  
Fragility Fractures ◽  
Mineral Density ◽  
Skeletal Health ◽  
Reciprocal Regulation ◽  
Muscle Tissues ◽  
Endocrine Organs ◽  
High Level ◽  
The Relationship

AbstractThe belief that obesity is protective against osteoporosis has recently been revised. In fact, the latest epidemiologic and clinical studies show that a high level of fat mass, but also reduced muscle mass, might be a risk factor for osteoporosis and fragility fractures. Furthermore, increasing evidence seems to indicate that different components such as myokines, adipokines and growth factors, released by both fat and muscle tissues, could play a key role in the regulation of skeletal health and in low bone mineral density and, thus, in osteoporosis development. This review considers old and recent data in the literature to further evaluate the relationship between fat, bone and muscle tissue.

scholarly journals The Role of Autoimmunity on the Relation Between Erosions and Bone Mineral Density in Rheumatoid Arthritis: A Clinical Research

2021 ◽  
Author(s):  
Margaux Moret ◽  
Caroline Morizot ◽  
Marcelo de Carvalho Bittencourt ◽  
Edem Allado ◽  
Isabelle Chary-Valckenaere ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
T Score ◽  
Erosion Score ◽  
Pathway Activation ◽  
The Relationship ◽  
Acpa Status

Abstract IntroductionBoth erosions and osteoporosis are present in rheumatoid arthritis and are related to RANK-L pathway activation. The aim of the study was to evaluate the relationship between erosion and bone mineral density (BMD) in RA and whether it can be driven by autoimmunity.Patients and methodsPatients followed in the Department of Rheumatology between January 2008 and May 2019 satisfied the 1987 ACR or 2010 ACR-EULAR criteria. Erosions were evaluated by the modified Sharp/van der Heidje erosion score (SHSe) on radiographs and bone mineral density (BMD) in g/cm2 and by the T-score at the hip on DXA. The presence and titers of ACPA as well as rheumatoid factor (RF) and anti-nuclear antibodies (ANAs) were recorded at intervals of less than 2 years for both DXA and radiography.ResultsA total of 149 patients met the inclusion criteria. A total of 61.1% were ACPA positive, 79.9% were erosive and 10.7% had a hip T-score ≤-2.5. ACPA status but not titers was associated with a higher erosion score (63.0 (53.2) for ACPA + vs. 45.5 (44.1) for ACPA – (p= 0.04)). ACPA titers were associated with lower BMD at the hip (value -0.216; p=0.01) but not with T-score. A higher erosion score was associated with a lower BMD (R2: 0,049 and value: -0.222; p=0.009) and T-score (R2: 0,158 and value -0.397; p<0.0001) at the hip. In linear regression, erosion and systemic bone loss were still associated with but not driven by ACPA status or titer. RF and ANA did not demonstrate any role in this association.ConclusionWe showed that the relationship between erosion and bone mineral density associated with RA does not seem to be driven by ACPA or other autoimmunity parameters. However, the presence of ACPA or erosion should lead to osteoporosis assessment.

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Bone ◽  
2001 ◽  
Vol 29 (2) ◽  
pp. 114-120 ◽  
Author(s):  
T Thomas ◽  
B Burguera ◽  
L.J Melton ◽  
E.J Atkinson ◽  
W.M O’Fallon ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Fat Mass ◽  
Mineral Density ◽  
Serum Leptin ◽  
The Relationship

scholarly journals Role of Fat and Bone Biomarkers in the Relationship Between Ethnicity and Bone Mineral Density in Older Men

2017 ◽  
Vol 102 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Grace M. F. Chan ◽  
Tessa Riandini ◽  
Sheryl Hui Xian Ng ◽  
Su Yen Goh ◽  
Chuen Seng Tan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Older Men ◽  
Bone Biomarkers ◽  
Mineral Density ◽  
The Relationship

The role of stress-induced cortisol in the relationship between depression and decreased bone mineral density

2005 ◽  
Vol 57 (8) ◽  
pp. 911-917 ◽  
Author(s):  
Patricia M. Furlan ◽  
Tom Ten Have ◽  
Mark Cary ◽  
Babette Zemel ◽  
Felix Wehrli ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
The Relationship

scholarly journals The Relationship between Dietary Patterns and Bone Mineral Density of 476 Middle-Aged and Aged People

2021 ◽  
Author(s):  
Yuguang Zhao ◽  
Jinhui Li ◽  
Zhigang Yuan ◽  
Xin Li ◽  
Hanghai Gu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Middle Aged ◽  
Mineral Density ◽  
Aged People ◽  
Balanced Diet ◽  
High Level ◽  
The Relationship ◽  
Prevalence Of Osteoporosis

Background: To investigate the relationship between different dietary patterns and the levels of bone mineral density (BMD) in middle-aged and aged people, and to provide references for the nutritional prevention of osteoporosis. Methods: A total of 476 residents aged 45 yr or more in Qiqihar City were enrolled from Aug 2018 to Feb 2019. They took a Food Frequency Questionnaire for dietary survey. Their dietary patterns were analyzed using the factor analysis method, and BMD were detected using ultrasound bone densitometer, to explore the relationship between different dietary patterns and BMD levels. Results: Four dietary patterns were obtained in the survey: relatively balanced, oil-salt, milk-tuber, and aquatic. Among them, the prevalence of osteoporosis reached 21.8%. High-level relatively balanced dietary pattern (OR=0.588, 95%CI= 0.363-0.951) and high-level dairy-potato food dietary pattern (OR=0.668, 95%CI= 0.370-0.983) were associated with lower risk of osteoporosis. Conclusion: A balanced diet and a high intake of dairy-potato food dietary pattern were associated with a lower prevalence of osteoporosis. It is recommended that middle-aged and aged people should have a balanced diet with more dairy products and potatoes to protect bone health.

scholarly journals Association between polymorphisms in GGPS1 and RANKL genes and postmenopausal osteoporosis in Romanian women

2019 ◽  
Vol 10 (Vol.10, No.3) ◽  
pp. 252-258
Author(s):  
Alina Deniza CIUBEAN ◽  
Laszlo IRSAY ◽  
Rodica Ana UNGUR ◽  
Viorela Mihaela CIORTEA ◽  
Ileana Monica BORDA ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Fracture Risk ◽  
Postmenopausal Osteoporosis ◽  
Bone Mineral ◽  
Strong Association ◽  
Fragility Fractures ◽  
Mineral Density ◽  
Density Values ◽  
Study Participants ◽  
The Relationship

Objectives: This study aimed to assess the relationship between bone mineral density, fragility fractures, fracture risk and polymorphisms of two osteoporosis-candidate genes (GGPS1 and RANKL) in Romanian women with postmenopausal osteoporosis. Methods: An analytical, prospective, transversal, observational, case-control study on 364 postmenopausal women, of which 228 were previously diagnosed with osteoporosis, was carried out between June 2016 and August 2017 in Cluj Napoca, Romania. Clinical data and blood samples were collected from all study participants. Polymorphisms in GGPS1 and RANKL genes were genotyped using TaqMan SNP Genotyping assays, run on a QuantStudio 3 real-time PCR machine. Results: The CT genotype in GGPS1 rs10925503 was associated with significant lower bone mineral density values at lumbar spine and femoral neck sites and a higher fracture risk compared to controls. No significant association was found between genotypes of RANKL rs2277439 with bone mineral density or fracture risk compared to the healthy controls. Conclusions: Our study showed a strong association between low bone mineral density and genotype CT of GGPS1 rs10925503 polymorphisms. No association was found for RANKL rs2277439 polymorphism.

130: Role of Calcium Intake on Bone Mineral Density in Rostate Cancer Patients Under Androgen Deprivation Therapy

2006 ◽  
Vol 175 (4S) ◽  
pp. 41-42
Author(s):  
Anna Orsola ◽  
Jacques Planas ◽  
Carlos Salvador ◽  
José M. Abascal ◽  
Enrique Trilla ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Androgen Deprivation ◽  
Mineral Density ◽  
Rostate Cancer

scholarly journals The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 938
Author(s):  
Jian Geng ◽  
Ling Wang ◽  
Qing Li ◽  
Pengju Huang ◽  
Yandong Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Magnetic Resonance Images ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Men And Women ◽  
The Relationship

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

scholarly journals DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Endocrine ◽  
2021 ◽  
Author(s):  
Enisa Shevroja ◽  
Francesco Pio Cafarelli ◽  
Giuseppe Guglielmi ◽  
Didier Hans
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Increased Risk

AbstractOsteoporosis, a disease characterized by low bone mass and alterations of bone microarchitecture, leading to an increased risk for fragility fractures and, eventually, to fracture; is associated with an excess of mortality, a decrease in quality of life, and co-morbidities. Bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA), has been the gold standard for the diagnosis of osteoporosis. Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA images, is an index of bone microarchitecture. TBS has been robustly shown to predict fractures independently of BMD. In this review, while reporting also results on BMD, we mainly focus on the TBS role in the assessment of bone health in endocrine disorders known to be reflected in bone.

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