Cross-sectional correlates of nesfatin and lipopolysaccharide binding protein in metabolic syndrome patients with and without prediabetes

2018 ◽  
Vol 36 (3) ◽  
Author(s):  
Safa’a Ali Al-Qudah ◽  
Violet Kasabri ◽  
Mohammad Issa Saleh ◽  
Maysa Suyagh ◽  
Sundos AlAlawi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Healthy Controls ◽  
Lipopolysaccharide Binding Protein ◽  
Cross Sectional ◽  
Lipopolysaccharide Binding

Abstract Background Metabolic syndrome (MetS) and prediabetes (preDM) have crosslinked pathophysiologies with central obesity and insulin resistance (IR). This study aimed to compare and correlate nesfatin and lipopolysaccharide binding protein (LBP) plasma levels, adiposity, atherogenicity and hematological indices between non-diabetic MetS, newly diagnosed drug naive pre-diabetic MetS patients vs. normoglycemic lean controls. Materials and methods In a cross-sectional study, 29 apparently healthy controls, 29 non-diabetic MetS subjects and 30 preDM-MetS patients were recruited. Results The LBP level (ng/mL) was substantially higher in both MetS (non- and pre-diabetic) groups compared to healthy controls. In contrast, circulating level of nesfatin (pg/mL) was lower, though not significantly; in both pre-diabetic and non-diabetic MetS patients compared to lean normoglycemic controls. No correlation was found between nesfatin and LBP in MetS pool (n = 59). Remarkably unlike blood indices; adiposity indices [body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height (WHtR) ratio, hip circumference (HC), body adiposity index (BAI), visceral adiposity index (VAI), lipid accumulation product (LAP) but not conicity index (CI)], atherogenicity indices [(atherogenicity index of plasma (AIP = Log10(TG/HDL-C ratio)), low density lipoprotein cholesterol to high density lipoprotein cholesterol ratio (LDL-C/HDL-C) and non-high density lipoprotein cholesterol (non-HDL-C)] were substantially higher in both MetS (non- and pre-diabetic) groups vs. those of controls. Exceptionally pronounced and proportional nesfatin-DBP and LBP-BAI correlations were identified in total MetS pool (both non-diabetic and pre-diabetic). Conclusions Nesfatin and LBP can be potential targets and surrogate biomarkers to use as putative prognostic/predictive tools for the prevention and treatment for MetS and related disorders.

scholarly journals Association of the Monocyte–to–High-Density Lipoprotein Cholesterol Ratio With Diabetic Retinopathy

2021 ◽  
Vol 8 ◽  
Author(s):  
Xixiang Tang ◽  
Ying Tan ◽  
Yi Yang ◽  
Mei Li ◽  
Xuemin He ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Macular Oedema ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Cross Sectional

Background: Chronic inflammation in type 2 diabetes mellitus (T2DM) is an essential contributor to the development of diabetic retinopathy (DR). The monocyte–to–high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel and simple measure related to inflammatory and oxidative stress status. However, little is known regarding the role of the MHR in evaluating the development of DR.Methods: A total of 771 patients with T2DM and 607 healthy controls were enrolled in this cross-sectional study. MHR determination and eye examination were performed. The association of MHR with the prevalence of DR in T2DM patients was analyzed.Results: The MHR in patients with DR was significantly higher than that in both non-DR diabetic patients (P < 0.05) and healthy controls (P < 0.01). No significance was observed in the MHR of different DR severity grades. Moreover, the MHR was similar between patients with non-macular oedema and those with macular oedema. Logistic regression analysis demonstrated that MHR was independently associated with the prevalence of DR in diabetic patients [odds ratio (OR) = 1.438, 95% confidence interval (CI): 1.249–1.655, P < 0.01]. After additional stratification by HbA1c level and diabetic duration, the MHR was still independently associated with the prevalence of DR.Conclusions: Our study suggests that the MHR can be used as a marker to indicate the prevalence of DR in patients with T2DM.

scholarly journals High-density lipoprotein-cholesterol functionality and metabolic syndrome

Medicine ◽  
2018 ◽  
Vol 97 (24) ◽  
pp. e11094
Author(s):  
Leonardo Roever ◽  
Elmiro Santos Resende ◽  
Angélica Lemos Debs Diniz ◽  
Nilson Penha-Silva ◽  
João Lucas O’Connell ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol

scholarly journals Effect of selenium and melatonin on some parameters Related to metabolic syndrome induced by Acryl amide in male rats (Part I)

2017 ◽  
Vol 40 (2) ◽  
pp. 140-146
Author(s):  
Khalisa Khadim Khudair
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Central Obesity ◽  
Sodium Selenite ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Male Rats

     This study was designed to investigate the ameliorative role of sodium selenite and melatonin on   acryl amide induced metabolic syndrome in adult male rats. Twenty (20) adult male rats were randomly and equally divided into 4 groups (G1, G2, G3 and G4) and were treated orally for seven weeks G1, (control group) was given distilled water, G2 were given orally 1mg/kg /B.W of Acryl amide, G3 group received 1mg/kg /B.W of Acryl amide followed by 0.5 mg/Kg/ B.W. of sodium selenite orally. G4 group received 1 mg/kg /B.W of acryl amide (orally) followed by 8 mg/Kg/ B.W. melatonin (IP/ injection). Fasting blood samples were collected by cardiac puncture at (0, 7 weeks) of the experiment for measuring serum total cholesterol, triacylglycerol, high density lipoprotein-cholesterol and serum uric acid, in addition to measuring waist circumference .The results showed an occurrence of central obesity, hyper uricemia, dyslipidemia (hyper cholesterolemia, triacyleglycerolemia and lowered high density lipoprotein-cholesterol concentration) in acryl amide treated animals. The results also indicated the alleviation of the changes in the above- mentioned parameters related to metabolic syndrome by sodium selenite and melatonin through lowering central obesity, total cholesterol, triacylglycerol, elevation of serum high density lipoprotein-cholesterol and lowering in serum uric acid.

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