scholarly journals Association of the Monocyte–to–High-Density Lipoprotein Cholesterol Ratio With Diabetic Retinopathy

2021 ◽  
Vol 8 ◽  
Author(s):  
Xixiang Tang ◽  
Ying Tan ◽  
Yi Yang ◽  
Mei Li ◽  
Xuemin He ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Macular Oedema ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Cross Sectional

Background: Chronic inflammation in type 2 diabetes mellitus (T2DM) is an essential contributor to the development of diabetic retinopathy (DR). The monocyte–to–high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel and simple measure related to inflammatory and oxidative stress status. However, little is known regarding the role of the MHR in evaluating the development of DR.Methods: A total of 771 patients with T2DM and 607 healthy controls were enrolled in this cross-sectional study. MHR determination and eye examination were performed. The association of MHR with the prevalence of DR in T2DM patients was analyzed.Results: The MHR in patients with DR was significantly higher than that in both non-DR diabetic patients (P < 0.05) and healthy controls (P < 0.01). No significance was observed in the MHR of different DR severity grades. Moreover, the MHR was similar between patients with non-macular oedema and those with macular oedema. Logistic regression analysis demonstrated that MHR was independently associated with the prevalence of DR in diabetic patients [odds ratio (OR) = 1.438, 95% confidence interval (CI): 1.249–1.655, P < 0.01]. After additional stratification by HbA1c level and diabetic duration, the MHR was still independently associated with the prevalence of DR.Conclusions: Our study suggests that the MHR can be used as a marker to indicate the prevalence of DR in patients with T2DM.

Cross-sectional correlates of nesfatin and lipopolysaccharide binding protein in metabolic syndrome patients with and without prediabetes

2018 ◽  
Vol 36 (3) ◽  
Author(s):  
Safa’a Ali Al-Qudah ◽  
Violet Kasabri ◽  
Mohammad Issa Saleh ◽  
Maysa Suyagh ◽  
Sundos AlAlawi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Healthy Controls ◽  
Lipopolysaccharide Binding Protein ◽  
Cross Sectional ◽  
Lipopolysaccharide Binding

Abstract Background Metabolic syndrome (MetS) and prediabetes (preDM) have crosslinked pathophysiologies with central obesity and insulin resistance (IR). This study aimed to compare and correlate nesfatin and lipopolysaccharide binding protein (LBP) plasma levels, adiposity, atherogenicity and hematological indices between non-diabetic MetS, newly diagnosed drug naive pre-diabetic MetS patients vs. normoglycemic lean controls. Materials and methods In a cross-sectional study, 29 apparently healthy controls, 29 non-diabetic MetS subjects and 30 preDM-MetS patients were recruited. Results The LBP level (ng/mL) was substantially higher in both MetS (non- and pre-diabetic) groups compared to healthy controls. In contrast, circulating level of nesfatin (pg/mL) was lower, though not significantly; in both pre-diabetic and non-diabetic MetS patients compared to lean normoglycemic controls. No correlation was found between nesfatin and LBP in MetS pool (n = 59). Remarkably unlike blood indices; adiposity indices [body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height (WHtR) ratio, hip circumference (HC), body adiposity index (BAI), visceral adiposity index (VAI), lipid accumulation product (LAP) but not conicity index (CI)], atherogenicity indices [(atherogenicity index of plasma (AIP = Log10(TG/HDL-C ratio)), low density lipoprotein cholesterol to high density lipoprotein cholesterol ratio (LDL-C/HDL-C) and non-high density lipoprotein cholesterol (non-HDL-C)] were substantially higher in both MetS (non- and pre-diabetic) groups vs. those of controls. Exceptionally pronounced and proportional nesfatin-DBP and LBP-BAI correlations were identified in total MetS pool (both non-diabetic and pre-diabetic). Conclusions Nesfatin and LBP can be potential targets and surrogate biomarkers to use as putative prognostic/predictive tools for the prevention and treatment for MetS and related disorders.

scholarly journals CORRELATION OF NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL WITH LIPOPROTEIN(A) IN DIABETIC PATIENTS

2018 ◽  
Vol 11 (9) ◽  
pp. 499
Author(s):  
Vasanthan M
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
The Other ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Lipoprotein A ◽  
Artery Disease

Objective: The objective of this study is to estimate the level of lipoprotein(a) and lipid profile, especially non-high-density lipoprotein cholesterol (non-HDL-C) in diabetic patients, and to correlate the same with healthy controls (non-diabetics).Methods: A total of 30 non-diabetic subjects and 30 diabetic patients were included in the study. Lipoprotein(a) (Lp[a]) was estimated by immunoturbidimetry and the other parameters by their respective methods in biochemistry auto-analyzer.Result: From the study, it was found that both Lp(a) and non-HDLC were increased in diabetics when compared to the non-diabetic controls. It was also evident that there is a positive correlation of Lp(a) levels with non-HDL C.Conclusion: Lp(a) and non-HDL C are responsible for atherogenic events in uncontrolled diabetic patients, leading to risks such as coronary artery disease.

scholarly journals “STUDY OF TOTAL CHOLESTEROL (TC), TRIACYLGLYCEROLS (TG), HIGH DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C) IN TYPE II DIABETES MELLITUS.”

2017 ◽  
Vol 10 (2) ◽  
pp. 116 ◽  
Author(s):  
Smita V Patil ◽  
Anita P Mandare ◽  
Gaikwad B Pandurang
Keyword(s):  
Diabetes Mellitus ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Type 2 Dm

Objective: There are probably 100 million people in the world with diabetes mellitus (DM), and incidences of diabetes are on the rise. Dyslipidemia is one of the common disorders which are seen in most of the diabetes patients, which causes cardiovascular disorders. The aim of this study is to investigate the total cholesterol (TC), triacylglycerols (TGs), high-density lipoprotein cholesterol (HDL-C) in Type 2 DM, and healthy controls.Methods: The study was conducted on 50 controls and 50 Type 2 diabetic subjects between age group of 30 and 60 years. Serum TC was determined by an enzymatic (cholesterol oxidase/phenol-aminophenazone [PAP]) colorimetric method and TGs were determined by an enzymatic (glycerol phosphate oxidase-PAP) method, and HDL-C was estimated by a precipitant method. Statistical analysis was done using unpaired t-test.Results: The mean value of TC, TGs, and HDL-C in normal subjects is 165.5±24.24, 118.7±41.58, 28.38±7.85 mg/dl, respectively, and the value of TC, TGs, and HDL-C in diabetic patients is 179±31.69, 164.35±27.93, 25.4±6.86 mg/dl, respectively. The observed difference in the means of TC, TGs, and HDL-C in normal and diabetic are statistically significant (p<0.05).Conclusion: From the present study, it is concluded that TC, TGs, and HDL-C levels for all persons with Type 2 DM should be done as a routine test. Furthermore, early diagnosis and treatment of dyslipidemia can be used as a preventive measure for the development of cardiovascular disease in Type 2 diabetes.Keywords: Diabetes mellitus, Dyslipidemia, Lipid profile, Total cholesterol, Triglycerides, High-density lipoprotein cholesterol.

Comparison of Intraperitoneal and Subcutaneous Insulin Administration on Insulin Sensitivity and Serum Lipids in Type I Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis Treatment

1995 ◽  
Vol 88 (4) ◽  
pp. 427-432 ◽  
Author(s):  
Jorma T. Lahtela ◽  
Jukka Mustonen ◽  
Amos Pasternack
Keyword(s):  
Peritoneal Dialysis ◽  
Insulin Sensitivity ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Subcutaneous Insulin ◽  
Intraperitoneal Insulin

1. The metabolic effects of intraperitoneal and subcutaneous insulin delivery were compared in a crossover manner in six C-peptide-negative diabetic patients with end-stage renal disease on continuous ambulatory peritoneal dialysis. Each treatment period lasted at least 3 months. Hyperinsulinaemic euglycaemic clamp was performed and glucose turnover assessed using [3-3H]glucose as a tracer. 2. During intraperitoneal delivery the daily insulin dose was 2.4 times higher than during subcutaneous administration and glycaemic control was significantly better (HbA1c 7.63% ± 0.46% and 9.52% ± 0.51% during intraperitoneal and subcutaneous insulin respectively, P < 0.01). The number of hypoglycaemic episodes was lower during intraperitoneal insulin than during subcutaneous therapy. 3. Intraperitoneal insulin resulted in an enhanced glucose disposal rate (P < 0.01) and reduced fasting hepatic glucose production (P < 0.01). High-density lipoprotein-cholesterol decreased and the ratio of low-density lipoprotein/high-density lipoprotein-cholesterol increased significantly (P < 0.05) during intraperitoneal insulin delivery. 4. The results suggest that intraperitoneal insulin, while resulting in better glycaemic control and improved insulin sensitivity than subcutaneous insulin, increases serum triacylglycerol and total cholesterol and reduces high-density lipoprotein-cholesterol, possibly via a direct effect on the liver.

scholarly journals COMPARISON OF LIPID PROFILE IN PATIENTS WITH DIABETIC NEUROPATHY AND WITHOUT NEUROPATHY; A CROSS SECTIONAL STUDY

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S202-06
Author(s):  
Kanwal Huma ◽  
Khadija Mehbob ◽  
Amir Rashid ◽  
Fatima Fuad ◽  
Muhammad Mamoon Mujahid ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Group I ◽  
Significant Difference

Objective: To compare lipid profile in patients with diabetic neuropathy and without neuropathy. Study Design: Cross-sectional comparative study. Place and Duration of Study: This study was carried out at Multidisciplinary Lab-1, Department of Biochemistry and Molecular Biology, Army Medical College, from Jan 2020 to Sep 2020 in collaboration with Pak-Emirates Military Hospital, Rawalpindi. Methodology: Eighty-four subjects were selected and divided into three groups, twenty-eight in each. Group Iincluded diagnosed patients with type 2 diabetes mellitus with peripheral neuropathy, group II included diagnosed patients with type 2 diabetes mellitus without peripheral neuropathy and group III consisted of healthy individuals. Biochemical parameters including total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured. Data was analyzed by SPSS version 22.0. One way ANOVA test was used that followed by post-Hoc Tukey test for group comparison. Results: There was significant difference in triglycerides (p-value 0.001) and high density lipoprotein cholesterol(0.003) levels among group I and III. While, between group II and III significant difference of high density lipoprotein cholesterol was present. There was no significant difference between group I and II regarding all lipid profile parameters. Conclusion: There was significant increase of triglycerides levels and decrease of high density lipoproteincholesterol in patients with diabetic peripheral neuropathy as compared to healthy controls. No significantdifference was observed for all parameters of lipid profile between patients with diabetic peripheral neuropathyand without peripheral neuropathy.

scholarly journals Relationship between serum triglyceride to high-density lipoprotein cholesterol ratio and sarcopenia occurrence rate in community-dwelling Chinese adults

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Na Wang ◽  
Mengjun Chen ◽  
Danhong Fang
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Community Dwelling ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Occurrence Rate ◽  
Chinese Adults ◽  
Cross Sectional

Abstract Background A study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to determine such an association in community-dwelling Chinese adults. Methods From May 2016 to August 2017, we conducted a cross-sectional study on Chinese adults at the First Affiliated Hospital of Wenzhou Medical University. Univariate and multivariate logistic regression analyses were applied to evaluate a possible relationship between TG/HDL-C ratio and sarcopenia occurrence. Results We included 2613 adults in this study, with 13.85% presenting with sarcopenia. The odds ratios (ORs) for TG and HDL-C were 0.67 (95% confidence interval [CI]: 0.51–0.87), and 1.97 (95% CI: 1.49–2.61), respectively. Moreover, TG/HDL-C ratio was independently associated with sarcopenia status (OR: 0.63; 95% CI: 0.49–0.81). Conclusions We found that TG and HDL-C were, respectively, negatively and positively associated with sarcopenia occurrence rate in community-dwelling Chinese adults. However, a negative association was found between sarcopenia occurrence rate and TG/HDL-C ratio.

Comparison of the Diagnostic Value Between Triglyceride-Glucose Index and Triglyceride-to-High Density Lipoprotein Cholesterol Ratio in MAFLD Patients: A Retrospective Cross-Sectional Study

2022 ◽  
Author(s):  
Zhi Liu ◽  
He He ◽  
Yuzhao Dai ◽  
Shenling Liao ◽  
Zhenmei An ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cholesterol Ratio

Abstract Background The triglyceride and glucose index (TyG) and triglyceride-to-high density lipoprotein cholesterol ratio (TG/HDL-C) were found to be substitute markers of insulin resistance (IR). We aimed to compare the efficacy of the two indicators in the diagnosis of Metabolic-Associated Fatty Liver Disease (MAFLD), which was rarely covered in the literature, and to construct a novel disease diagnosis model.Methods A retrospective cross-sectional study was carried out in West China Hospital of Sichuan University and 229 people (97 MAFLD and 132 Non-MAFLD) were included. Biochemical indexes were collected and analyzed by logistic regression to screen out indicators that expressed differently in MAFLD patients and healthy controls and incorporate them into a diagnostic model. MAFLD was diagnosed by Ultrasound.Results After adjusting for age, gender and BMI, Serum ALT, AST, AST/ALT (A/A), FPG, Cys-C, URIC, TG, HDL-C, ALP, GGT, nonHDL-C, LDL-C/HDL-C, nonHDL-C/HDL-C, TG/HDL-C, TC/HDL-C, TyG and TyG-BMI were risk factors of MAFLD through binary logistics regression analysis. The odds ratio of TG/HDL-C and TyG were 5.387 (95%CI: 2.986-9,718) and 107.945 (95% CI: 25.824-451.222). In identifying MAFLD, TyG, TG/HDL-C and TG were found to be the most vital indexes by the random forest method and the area under the curve (AUC) of them are all greater than 0.9 respectively. In addition, the combination of gender, BMI, ALT, TG, HDL-C, TyG and TyG-BMI had a great diagnostic efficiency for MAFLD.Conclusions TyG and TG/HDL-C were potential risk factors for MAFLD and the former made a better performance in diagnosing MAFLD. The combination of gender, BMI, ALT, TG, HDL-C, TyG and TyG-BMI improved the diagnostic capability of MAFLD.

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