scholarly journals Genetic ancestry, skin reflectance and pigmentation genotypes in association with serum vitamin D metabolite balance

2011 ◽  
Vol 7 (1) ◽  
Author(s):  
Robin Taylor Wilson ◽  
Alanna N. Roff ◽  
P. Jenny Dai ◽  
Tracey Fortugno ◽  
Jonathan Douds ◽  
...  
Keyword(s):  
Vitamin D ◽  
African Ancestry ◽  
Skin Pigmentation ◽  
Serum Vitamin ◽  
Genetic Ancestry ◽  
Vitamin D Metabolites ◽  
Serum Vitamin D ◽  
Skin Reflectance ◽  
Melanin Index ◽  
American Heritage

AbstractLower serum vitamin D (25(OH)D) among individuals with African ancestry is primarily attributed to skin pigmentation. However, the influence of genetic polymorphisms controlling for skin melanin content has not been investigated. Therefore, we investigated differences in non-summer serum vitamin D metabolites according to self-reported race, genetic ancestry, skin reflectance and key pigmentation genes (Healthy individuals reporting at least half African American or half European American heritage were frequency matched to one another on age (±2 years) and sex. One hundred and seventy-six autosomal ancestry informative markers were used to estimate genetic ancestry. Melanin index was measured by reflectance spectrometry. Serum vitamin D metabolites [25(OH)DFifty African Americans and 50 European Americans participated in the study. Compared withThe

scholarly journals Assessment of Vitamin D Metabolism in Patients with Cushing’s Disease in Response to 150,000 IU Cholecalciferol Treatment

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4329
Author(s):  
Alexandra Povaliaeva ◽  
Viktor Bogdanov ◽  
Ekaterina Pigarova ◽  
Artem Zhukov ◽  
Larisa Dzeranova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cushing’S Disease ◽  
Serum Vitamin ◽  
Urinary Free Cortisol ◽  
Cushing's Disease ◽  
Control Group ◽  
Vitamin D Metabolites ◽  
Vitamin D Metabolism ◽  
Serum Vitamin D ◽  
Free Cortisol

In this study we aimed to assess vitamin D metabolism in patients with Cushing’s disease (CD) compared to healthy individuals in the setting of bolus cholecalciferol treatment. The study group included 30 adults with active CD and the control group included 30 apparently healthy adults with similar age, sex and BMI. All participants received a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. All data were analyzed with non-parametric statistics. Patients with CD had similar to healthy controls 25(OH)D3 levels (p > 0.05) and higher 25(OH)D3/24,25(OH)2D3 ratios (p < 0.05) throughout the study. They also had lower baseline free 25(OH)D levels (p < 0.05) despite similar DBP levels (p > 0.05) and lower albumin levels (p < 0.05); 24-h urinary free cortisol showed significant correlation with baseline 25(OH)D3/24,25(OH)2D3 ratio (r = 0.36, p < 0.05). The increase in 25(OH)D3 after cholecalciferol intake was similar in obese and non-obese states and lacked correlation with BMI (p > 0.05) among patients with CD, as opposed to the control group. Overall, patients with CD have a consistently lower 25(OH)D3/24,25(OH)2D3 ratio, which is indicative of a decrease in 24-hydroxylase activity. This altered activity of the principal vitamin D catabolism might influence the effectiveness of cholecalciferol treatment. The observed difference in baseline free 25(OH)D levels is not entirely clear and requires further study.

scholarly journals Association of Degree of European Genetic Ancestry With Serum Vitamin D Levels in African Americans

2018 ◽  
Vol 187 (7) ◽  
pp. 1420-1423 ◽  
Author(s):  
Stephen A Haddad ◽  
Edward A Ruiz-Narváez ◽  
Yvette C Cozier ◽  
Hanna Gerlovin ◽  
Lynn Rosenberg ◽  
...  
Keyword(s):  
Vitamin D ◽  
African Americans ◽  
Serum Vitamin ◽  
Genetic Ancestry ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Intestinal Calcium Absorption and Serum Vitamin D Metabolites in Normal Subjects and Osteoporotic Patients

1979 ◽  
Vol 64 (3) ◽  
pp. 729-736 ◽  
Author(s):  
J. C. Gallagher ◽  
B. Lawrence Riggs ◽  
John Eisman ◽  
Alan Hamstra ◽  
Sara B. Arnaud ◽  
...  
Keyword(s):  
Vitamin D ◽  
Calcium Absorption ◽  
Serum Vitamin ◽  
Normal Subjects ◽  
Intestinal Calcium Absorption ◽  
Vitamin D Metabolites ◽  
Serum Vitamin D

Prostate cancer and prediagnostic levels of serum vitamin D metabolites (Maryland, United States)

1995 ◽  
Vol 6 (3) ◽  
pp. 235-239 ◽  
Author(s):  
M. Miles Braun ◽  
Kathy J. Helzlsouer ◽  
Bruce W. Hollis ◽  
George W. Comstock
Keyword(s):  
Prostate Cancer ◽  
United States ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Vitamin D Metabolites ◽  
Serum Vitamin D

scholarly journals Vitamin D deficiency increases prostatic megalin expression and globulin-bound testosterone import, increasing prostatic androgens in African American men

2021 ◽  
Author(s):  
Jason Garcia ◽  
Kirsten Krieger ◽  
Candice Loitz ◽  
Lillian M Perez ◽  
Zachary A Richards ◽  
...  
Keyword(s):  
Vitamin D ◽  
African American ◽  
African Americans ◽  
Vitamin D Deficiency ◽  
African American Men ◽  
African Ancestry ◽  
Serum Vitamin ◽  
Vitamin D Metabolites ◽  
Increased Risk ◽  
Vitamin D Levels

Vitamin D deficiency associates with an increased risk of prostate cancer (PCa) mortality and is hypothesized to contribute to PCa aggressiveness and disparities in African Americans. We reported a relationship between African-ancestry, circulating and intraprostatic vitamin D metabolites and prostatic expression of megalin, an endocytic membrane receptor that internalizes globulin-bound hormones. Here, we show that megalin imports sex hormone-binding globulin (SHBG)-bound testosterone, potentially regulating intraprostatic hormone levels. Vitamin D levels regulated megalin expression in cell lines, patient-derived prostate epithelial cells, and prostate tissue explants, and mice with prostatic knockout of Lrp2 (megalin) showed reduced prostatic testosterone. Notably, prostatic 5α-dihydrotestosterone levels were higher in African American men and correlated inversely with serum vitamin D status, while megalin protein levels were reduced in PCa tissue. Our findings highlight the negative impact of vitamin D deficiency on PCa and the potential link to PCa disparities observed in African Americans.

Serum vitamin D metabolites in very low birth weight infants with and without rickets and fractures

1989 ◽  
Vol 114 (6) ◽  
pp. 1017-1022 ◽  
Author(s):  
Winston W.K. Koo ◽  
Roberta Sherman ◽  
Paul Succop ◽  
Mona Ho ◽  
Donna Buckley ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Serum Vitamin ◽  
Vitamin D Metabolites ◽  
Low Birth Weight Infants ◽  
Serum Vitamin D
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