scholarly journals New Research Progress in Mycoplasma pneumoniae Infection

2015 ◽  
Vol 4 (4) ◽  
pp. 91-95
Author(s):  
Fengtan Li
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Infectious Agent ◽  
Research Progress ◽  
School Age Children ◽  
Atypical Pneumonia ◽  
New Research ◽  
Clinical Prevention

AbstractAs an important pathogen of respiratory tract infection,Mycoplasma pneumoniae (MP)may not only lead to primary atypical pneumonia but also cause systemic organ conditions. MP causes respiratory tract infection among school-age children and is also an important infectious agent for adult respiratory tract infection. Intensive studies on roles ofMPinfection on the innate immune system significantly aid development of targeted therapy drugs. Epidemic studies on associated symptoms also help in clinical prevention and diagnosis and show importance to personalized treatment utilizing different drugs for different patients. This study summarizes the abovementioned three points based onMPstudies in recent years.

scholarly journals Molecular Diagnosis of Atypical Pneumonia Infection in Children Presenting with Acute Respiratory Tract Infection Attending Yangon Children’s Hospital

2019 ◽  
Vol 31 (2) ◽  
pp. 116-119
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Chlamydophila Pneumoniae ◽  
Acute Respiratory Tract Infection ◽  
High Morbidity ◽  
Atypical Pneumonia ◽  
Children's Hospital ◽  
Children’S Hospital

Acute respiratory tract infection (ARI) is a clinical condition which causes high morbidity and mortality, especially in infants and young children. Pneumonia is a common complication of respiratory tract infection. Atypical pneumonia, which is commonly caused by Mycoplasma pneumoniae, Chlamydophila pneumoniae and Legi-onella pneumophila, is difficult to be detected because the causal bacteria cannot be diagnosed by routine culture method and presenting with non-specific clinical symptoms. This study aimed to diagnose the atypical pneumonia infection in children presenting with ARI attending Yangon Children’s Hospital during 2014-15 by using multiplex polymerase chain reaction (M-PCR). The bacterial DNA was extracted from nasopharyngeal swab samples by using Qiagen DNA minikit and detected by M-PCR. Of 245 patients with ARI, 140(57%) were males and 105(43%) were females. Eleven samples (4.4%) were positive for atypical pneumonia infection, among which 4(1.6%) were Mycoplasma pneumoniae,5(2%) were Chlamydophila pneumoniae and 2(0.8%) were Legionella pneumophila. The atypical pneumonia cases were mostly seen among the age of 1 to 5 years and sex distribution was nearly equal. The infected cases were detected from pneumonia (36.4%), severe pneumonia (27.3%), viral-induced wheeze (18.2%), severe bronchiolitis (9.1%) and bronchiolitis (9.1%). This study highlights the role of atypical pneumonia infection in ARI cases among children.

scholarly journals Mycoplasma pneumoniae Respiratory Tract Infection Prevailing among Infants at a Nursery School

1992 ◽  
Vol 66 (11) ◽  
pp. 1566-1571
Author(s):  
Kazuo MIMURA ◽  
Kumiko SUGITA ◽  
Kazuo TABUKI ◽  
Tadafumi NISHIMURA
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Nursery School

scholarly journals Effectiveness of Strelinikova Breathing Exercise on Respiratory Signs and Parameters among School Children with Lower Respiratory Tract Infection

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 153-157
Author(s):  
Muthulakshmi C ◽  
Kalpana Devi V
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Peak Flow ◽  
School Age Children ◽  
School Age ◽  
Breathing Exercise ◽  
Significant Difference

Respiratory problems are significant gathering of ailment influencing kids particularly in India and are the significant reasons for youth horribleness and mortality. Specifically, obstructive aviation route illnesses ascend in youngsters because of natural contamination and different causes. In this way, evaluation of aspiratory work test in such kids is significant. Henceforth the current investigation focused on to evaluate the adequacy of strelinikova breathing activity on respiratory signs and boundaries among younger students with respiratory parcel infection. The research configuration utilized was semi exploratory pre-test post-test plan. Purposive examining strategy was utilized to choose the 60 sample. The demographic data was collected by using the structured questionnaire and the oxygen level was measured by using the Pulse Oximeter. The peak flow rate was measured by using the Peak Flow Meter. The findings of the study revealed that there was significant difference in the measurement of oxygen saturation and respiratory rate between the experimental and control group which infers that Strelinikova Breathing Exercise on respiratory signs and parameters administered to the school age children with lower respiratory tract infection in the experimental group was found to be effective in maintaining the respiratory parameters among school age children and the current findings suggests that more extensive studies can be done at different settings and also as comparative studies.

scholarly journals Clinical Value of Two Detection Methods for Mycoplasma Pneumoniae Antibody in the Diagnosis of Mycoplasma Pneumoniae Infection in North China

2021 ◽  
Author(s):  
Jupeng Wang ◽  
Lina Zhu ◽  
Mingkun Ma ◽  
Hui Chen ◽  
Suxiang Guo ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
North China ◽  
Detection Methods ◽  
Antibody Detection ◽  
Positive Rate ◽  
Adults And Children ◽  
Males And Females

Abstract Background: To analyze the detection of Mycoplasma pneumoniae in adults and children in North China using two antibody detection methods, and to guide prevention and treatment.Methods: A retrospective study was conducted from September 2017 to May 2021. Mycoplasma pneumoniae total antibody was detected using particle agglutination (PA). Anti-Mycoplasma pneumoniae IgM in patients with respiratory tract infection was detected by indirect immunofluorescence. All patients were divided into 9 groups according to age: ≤1, 2-3, 4-6, 7-14, 15-18, 19-39, 40-59, 60-79, ≥80,Results: The positive rate of Mycoplasma pneumoniae total antibody in 5,666 patients with community-acquired pneumonia was 40.13%. In adults and children, the positive rates were 19.92% and 77.3% (p<0.05), respectively. The positive rates in males and females was 37.89% and 42.40% (p<0.05), respectively. The positive rate for anti-Mycoplasma pneumoniae IgM in 5,746 patients with respiratory tract infection was 28.56%, and 10.37% and 36.82% in adults and children (p<0.05), respectively. In males and females, the positive rate for anti-Mycoplasma pneumoniae IgM was 24.56% and 33.38% (p<0.05). The highest positive rates for total antibody and anti-Mycoplasma pneumoniae IgM were recorded in autumn. Of the 1,975 patients tested for Mycoplasma pneumoniae antibody using both methods simultaneously, 26.71% were negative for total antibody and 8.63% had titers ranging between 1:40 and 1:80 when positive for IgM antibody. When negative for anti-Mycoplasma pneumoniae IgM, total antibody titer was ≥1:160 in 34.94% of the patients.Conclusion: Mycoplasma pneumoniae is the main cause of respiratory tract infection and its incidence is highest in autumn. Because Mycoplasma pneumoniae was more commonly detected in women and children, screening should be strengthened in these groups.

Asthmatic Children Have Increased Specific Anti–Mycoplasma pneumoniae IgM but not IgG or IgE—Values Independent of History of Respiratory Tract Infection

2013 ◽  
Vol 32 (6) ◽  
pp. 599-603 ◽  
Author(s):  
Tamar A. Smith-Norowitz ◽  
Jonathan I. Silverberg ◽  
Melanie Kusonruksa ◽  
Diana Weaver ◽  
David Ginsburg ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Asthmatic Children ◽  
History Of

scholarly journals Development of loop-mediated isothermal amplification coupled with nanoparticle-based lateral flow biosensor assay for Mycoplasma pneumoniae detection

AMB Express ◽  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yacui Wang ◽  
Yi Wang ◽  
Weiwei Jiao ◽  
Jieqiong Li ◽  
Shuting Quan ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Real Time ◽  
Mycoplasma Pneumoniae ◽  
Real Time Pcr ◽  
Lateral Flow ◽  
Isothermal Amplification ◽  
Dna Templates ◽  
Loop Mediated Isothermal Amplification

AbstractMycoplasma pneumoniae (MP) is one of the most common pathogens causing respiratory tract infection, especially for community-acquired pneumonia (CAP) in school-age children. There was considerable amount of studies on loop-mediated isothermal amplification (LAMP) assay for MP detection. However, the result interpretation of these developed LAMP assays was sophisticated and subjective. Therefore, we developed and evaluated a LAMP coupled with nanoparticle-based lateral flow biosensor (LFB) assay (LAMP-LFB) for simple, reliable, and objective identification of MP (MP-LAMP-LFB). Six primers specific to P1 gene of MP were designed, and the preferred temperature for this assay was confirmed to be 65 °C. The amplification products could be visually interpreted by LFB within 2 min. The MP-LAMP-LFB assay specifically identified DNA templates of MP, and no cross-reactivity with other pathogens was obtained. The limit of the detection for this assay was 600 fg of DNA templates in pure cultures, which was in complete accordance with colorimetric indicator detection and agarose gel electrophoresis analysis. This assay was applied to 209 oropharyngeal swab specimens collected from children with acute respiratory tract infection for clinical evaluation, and compared to real-time PCR detection. Using the LAMP-LFB and real-time PCR assay, the positive rates of MP were 47.8% and 31.6%, respectively. Results suggested that the LAMP-LFB assay displayed high sensitivity compared to real-time PCR method. In summary, LAMP-LFB assay established here was a simple, objective, and sensitive assay for MP detection, which can be widely applied in clinical settings, especially in rural areas.

scholarly journals Association of Schistosoma haematobium Infection Morbidity and Severity on Co-infections status in Pre-school Age Children Living in a Rural Endemic Area in Zimbabwe

2020 ◽  
Author(s):  
Tariro Lavender Mduluza-Joko ◽  
Thajasvarie Naicker ◽  
Luxwell Jokonya ◽  
Herald Midzi ◽  
Arthur Vengesai ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Schistosoma Haematobium ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
School Age Children ◽  
School Age ◽  
Upper Respiratory Tract ◽  
Upper Respiratory

Abstract Background: Individuals living in Schistosoma haematobium endemic areas are often at risk of having other communicable diseases, simultaneously. This usually creates diagnostic difficulties leading to misdiagnosis and overlooking schistosomiasis infection. In this study we investigated the prevalence and effects of coinfections in pre-school age children and further investigated association between S. haematobium prevalence and under 5 mortality.Methods: Four hundred and sixty five Preschool age children (1-5 years old) with 51% being male were clinically examined for the following top morbidity causing conditions: respiratory tract infections, dermatophytosis, malaria and fever of unknown origin. The conditions were diagnosed as per approved WHO standards. S. haematobium infection was diagnosed by urine filtration and the children were screened for conditions common in the study area which included HIV, tuberculosis, malnutrition and typhoid. Results: Prevalence of S. haematobium was 35% (145). The clinical conditions assessed had the following prevalence in the study population: upper respiratory tract infection 40% (229), fever of unknown origin 45% (189), dermatophytosis and malaria both had 18% (75), The odds of co-infections observed with S. haematobium infection were: upper respiratory tract infection AOR = 1.22 (95% CI 0.80 to 1.87), dermatophytosis AOR = 4.79 ( 95% CI 2.78 to 8.25), fever of unknown origin AOR = 10.63 ( 95% CI 6.48-17.45) and malaria AOR = 0.91 ( 95% CI 0.51 to1.58). Relative risks of the severe sequels when coinfected were: Severe pneumonia RR=7.5 (95% CI 2.92-19.23), p<0.0001, complicated malaria RR=12 (95%CI 11.53-94.53), p=0.02, severe dermatophytosis RR=8.5 (95% CI 1.2-60.2):p=0.03, and fever of unknown origin RR=2.32 (95% CI 1.12-4.80), p=0.02.Conclusion: This study is novel as it identifies a possible association relationship between S. haematobium infection and top morbidity conditions in children under five years. There is need to alert policy makers so as to initiate early treatment of schistosomiasis in pre-school age children.

Sign in / Sign up

Export Citation Format

Share Document