scholarly journals Mycoplasma pneumoniae Respiratory Tract Infection Prevailing among Infants at a Nursery School

1992 ◽  
Vol 66 (11) ◽  
pp. 1566-1571
Author(s):  
Kazuo MIMURA ◽  
Kumiko SUGITA ◽  
Kazuo TABUKI ◽  
Tadafumi NISHIMURA
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Nursery School

scholarly journals Clinical Value of Two Detection Methods for Mycoplasma Pneumoniae Antibody in the Diagnosis of Mycoplasma Pneumoniae Infection in North China

2021 ◽  
Author(s):  
Jupeng Wang ◽  
Lina Zhu ◽  
Mingkun Ma ◽  
Hui Chen ◽  
Suxiang Guo ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
North China ◽  
Detection Methods ◽  
Antibody Detection ◽  
Positive Rate ◽  
Adults And Children ◽  
Males And Females

Abstract Background: To analyze the detection of Mycoplasma pneumoniae in adults and children in North China using two antibody detection methods, and to guide prevention and treatment.Methods: A retrospective study was conducted from September 2017 to May 2021. Mycoplasma pneumoniae total antibody was detected using particle agglutination (PA). Anti-Mycoplasma pneumoniae IgM in patients with respiratory tract infection was detected by indirect immunofluorescence. All patients were divided into 9 groups according to age: ≤1, 2-3, 4-6, 7-14, 15-18, 19-39, 40-59, 60-79, ≥80,Results: The positive rate of Mycoplasma pneumoniae total antibody in 5,666 patients with community-acquired pneumonia was 40.13%. In adults and children, the positive rates were 19.92% and 77.3% (p<0.05), respectively. The positive rates in males and females was 37.89% and 42.40% (p<0.05), respectively. The positive rate for anti-Mycoplasma pneumoniae IgM in 5,746 patients with respiratory tract infection was 28.56%, and 10.37% and 36.82% in adults and children (p<0.05), respectively. In males and females, the positive rate for anti-Mycoplasma pneumoniae IgM was 24.56% and 33.38% (p<0.05). The highest positive rates for total antibody and anti-Mycoplasma pneumoniae IgM were recorded in autumn. Of the 1,975 patients tested for Mycoplasma pneumoniae antibody using both methods simultaneously, 26.71% were negative for total antibody and 8.63% had titers ranging between 1:40 and 1:80 when positive for IgM antibody. When negative for anti-Mycoplasma pneumoniae IgM, total antibody titer was ≥1:160 in 34.94% of the patients.Conclusion: Mycoplasma pneumoniae is the main cause of respiratory tract infection and its incidence is highest in autumn. Because Mycoplasma pneumoniae was more commonly detected in women and children, screening should be strengthened in these groups.

Asthmatic Children Have Increased Specific Anti–Mycoplasma pneumoniae IgM but not IgG or IgE—Values Independent of History of Respiratory Tract Infection

2013 ◽  
Vol 32 (6) ◽  
pp. 599-603 ◽  
Author(s):  
Tamar A. Smith-Norowitz ◽  
Jonathan I. Silverberg ◽  
Melanie Kusonruksa ◽  
Diana Weaver ◽  
David Ginsburg ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Asthmatic Children ◽  
History Of

scholarly journals Development of loop-mediated isothermal amplification coupled with nanoparticle-based lateral flow biosensor assay for Mycoplasma pneumoniae detection

AMB Express ◽  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yacui Wang ◽  
Yi Wang ◽  
Weiwei Jiao ◽  
Jieqiong Li ◽  
Shuting Quan ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Real Time ◽  
Mycoplasma Pneumoniae ◽  
Real Time Pcr ◽  
Lateral Flow ◽  
Isothermal Amplification ◽  
Dna Templates ◽  
Loop Mediated Isothermal Amplification

AbstractMycoplasma pneumoniae (MP) is one of the most common pathogens causing respiratory tract infection, especially for community-acquired pneumonia (CAP) in school-age children. There was considerable amount of studies on loop-mediated isothermal amplification (LAMP) assay for MP detection. However, the result interpretation of these developed LAMP assays was sophisticated and subjective. Therefore, we developed and evaluated a LAMP coupled with nanoparticle-based lateral flow biosensor (LFB) assay (LAMP-LFB) for simple, reliable, and objective identification of MP (MP-LAMP-LFB). Six primers specific to P1 gene of MP were designed, and the preferred temperature for this assay was confirmed to be 65 °C. The amplification products could be visually interpreted by LFB within 2 min. The MP-LAMP-LFB assay specifically identified DNA templates of MP, and no cross-reactivity with other pathogens was obtained. The limit of the detection for this assay was 600 fg of DNA templates in pure cultures, which was in complete accordance with colorimetric indicator detection and agarose gel electrophoresis analysis. This assay was applied to 209 oropharyngeal swab specimens collected from children with acute respiratory tract infection for clinical evaluation, and compared to real-time PCR detection. Using the LAMP-LFB and real-time PCR assay, the positive rates of MP were 47.8% and 31.6%, respectively. Results suggested that the LAMP-LFB assay displayed high sensitivity compared to real-time PCR method. In summary, LAMP-LFB assay established here was a simple, objective, and sensitive assay for MP detection, which can be widely applied in clinical settings, especially in rural areas.

scholarly journals New Research Progress in Mycoplasma pneumoniae Infection

2015 ◽  
Vol 4 (4) ◽  
pp. 91-95
Author(s):  
Fengtan Li
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Infectious Agent ◽  
Research Progress ◽  
School Age Children ◽  
Atypical Pneumonia ◽  
New Research ◽  
Clinical Prevention

AbstractAs an important pathogen of respiratory tract infection,Mycoplasma pneumoniae (MP)may not only lead to primary atypical pneumonia but also cause systemic organ conditions. MP causes respiratory tract infection among school-age children and is also an important infectious agent for adult respiratory tract infection. Intensive studies on roles ofMPinfection on the innate immune system significantly aid development of targeted therapy drugs. Epidemic studies on associated symptoms also help in clinical prevention and diagnosis and show importance to personalized treatment utilizing different drugs for different patients. This study summarizes the abovementioned three points based onMPstudies in recent years.

scholarly journals Serum sTREM-1 and CXCL-16 Levels in Children with Mycoplasma pneumoniae Pneumonia and Their Diagnostic Value

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Chengchao Fang ◽  
Yueyan Mao ◽  
Mingfen Jiang ◽  
Wei Yin
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Mycoplasma Pneumoniae ◽  
Myeloid Cell ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Critically Ill Children ◽  
Trigger Receptor ◽  
Mycoplasma Pneumoniae Pneumonia

Mycoplasma pneumoniae pneumonia (MPP) is an acute respiratory tract infection caused by Mycoplasma pneumoniae. It is characterized by severe symptoms, long course of disease, many intrapulmonary complications, and poor therapeutic effect. In recent years, the incidence of Mycoplasma infection have been gradually rising trend, and the children’s own immune system development is not mature, cases differences, children with mild can only show the upper respiratory tract infection, and critically ill children can lead to lung infection and even lead to multiple organ dysfunction, affect life and health of children. Soluble triggering receptors expressed on myeloid cell-1 (sTREM-1) is a subtype secreted by myeloid cell trigger receptor-1, which is released into blood in large amounts when the body is infected, and is a newly discovered inflammatory indicator in recent years. CXC chemokine 16 (CXCL-16) can recruit lymphocytes by chemotaxis through binding to its receptor CXCR6 to participate in the body’s immune regulation. The purpose of this study was to investigate serum sTREM-1 and CXCL-16 levels in children with MPP and to analyze their correlation with the disease and diagnostic value. The results showed that the serum levels of sTREM-1 and CXCL-16 were increased in children with Mycoplasma. Serum levels of sTREM-1 and CXCL-16 were positively correlated with the severity of the disease. sTREM-1 combined with CXCL-16 has an important value in the diagnosis of children with MPP.

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