Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Senthil Murugan Murugaiyan ◽  
Rajesh Bhargavan
Keyword(s):  
Oral Administration ◽  
Corticosterone Level ◽  
Tween 80 ◽  
Treated Group ◽  
Plasma Corticosterone ◽  
Bacopa Monnieri ◽  
Aluminium Chloride ◽  
Control Group ◽  
Plasma Corticosterone Level ◽  
Protective Groups

AbstractObjectivesAluminium is present in food preparations, antacids and many medications. It causes neurodegeneration thereby resulting in a spectrum of neurological disorders such as dementia, Alzheimer’s disease and anxiety. Bacopa monnieri (BM) is widely used in ayurvedic medicine to improve memory functions. Its anxiolytic property was investigated in this study by using elevated plus maze (EPM) and plasma corticosterone level.MethodsThirty rats were assigned into five groups. Control group received distilled water, and 0.5% tween 80, AlCl3 group received Aluminium Chloride (AlCl3), Protective groups (BM100 + AlCl3 group and BM200 + AlCl3 group) received AlCl3 and BM at two different doses, and the BM200 group received BM. The EPM experiment was performed at the end of the 4th week of oral administration of BM and AlCl3 followed by the measurement of plasma corticosterone.ResultsOral administration of AlCl3 to rats increases the levels of anxiety as seen in a decrease in the percentage of entries into the open arms of EPM, an increase in grooming frequency and defecation index. However, the rats in the protective groups shown an increase in the percentage of open arm entries and rearing frequency, and decreased grooming frequency and defecation index. AlCl3 alone treated group showed a significant increase in the plasma corticosterone levels compared to the control group. Whereas the protective groups have shown a significant decrease in the plasma corticosterone levels than the AlCl3 alone treated group.ConclusionsHence the BM has potential role in reverting the anxiogenic effect of AlCl3 in the amygdala as it is evident from the plasma corticosterone levels and the EPM parameters of different groups under study.

scholarly journals CHRONIC UNPREDICTABLE STRESS-INDUCED BEHAVIORAL AND ELECTROPHYSIOLOGICAL ALTERATIONS AND ITS AMELIORATIVE EFFECT BY MYRICETIN MICROEMULSION

2018 ◽  
Vol 11 (3) ◽  
pp. 124
Author(s):  
Sakthivel G ◽  
Deva Karunya M ◽  
Prajisha P ◽  
Keerthipriya Cs ◽  
Ravindran R
Keyword(s):  
Decision Making ◽  
Corticosterone Level ◽  
Treated Group ◽  
Plasma Corticosterone ◽  
Albino Rats ◽  
Chronic Unpredictable Stress ◽  
Behavioral Alterations ◽  
Object Recognition Test ◽  
Open Field Behavior ◽  
Brain Wave

 Objective: The present study is designed to investigate the effects of chronic unpredictable stress (CUS) on electrophysiological and behavioral alterations in male Wistar albino rats and its ameliorating effect by myricetin-microemulsion (MYR-ME).Materials and Methods: Adult Wistar male albino rats were exposed to CUS for 21 days and treated with MYR-ME (10 mg/kg) for 21 days by oral administration. All the experimental animals were tested for anxiety and cognitive behavior by open-field behavior, light/dark test, eight-arm radial maze, spontaneous alteration T-maze, novel object recognition test, plasma corticosterone level, and electrophysiological activity.Results: The rats which were exposed to CUS showed memory impairment, increased anxiety, decreased novel explorations, deleterious effect on decision-making, increased corticosterone level, increased brain wave frequency and amplitude, and also heart rate. Whereas, CUS with MYR-ME-treated group showed a protective effect against CUS-induced behavioral alterations, electrophysiological activity, and corticosterone levels, which is characterized by the enhancement of cognitive function, decreased anxiety and improved decision-making, novel exploration, decreased corticosterone, and electrophysiological activity.Conclusion: From the present study, it is shown that MYR-ME may act as a potential anxiolytic and nootropic compound against CUS-induced alterations.

scholarly journals Inflammatory Pain and Corticosterone Response in Infant Rats: Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Irina P. Butkevich ◽  
Viktor A. Mikhailenko ◽  
Tat'yana R. Bagaeva ◽  
Elena A. Vershinina ◽  
Anna Maria Aloisi ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Inflammatory Pain ◽  
Formalin Test ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Male Rats ◽  
Plasma Corticosterone Level ◽  
Infant Rats ◽  
Corticosterone Response ◽  
Gestational Stress

Our researches have shown that gestational stress causes exacerbation of inflammatory pain in the offspring; the maternal 5-HT1A agonist buspirone before the stress prevents the adverse effect. The serotonergic system and hypothalamo-pituitary-adrenal (HPA) axis are closely interrelated. However, interrelations between inflammatory pain and the HPA axis during the hyporeactive period of the latter have not been studied. The present research demonstrates that formalin-induced pain causes a gradual and prolonged increase in plasma corticosterone level in 7-day-old male rats; twenty-four hours after injection of formalin, the basal corticosterone level still exceeds the initial basal corticosterone value. Chronic treatments of rat dams with buspirone before restraint stress during gestation normalize in the offspring pain-like behavior and induce during the acute phase in the formalin test the stronger corticosterone increase as compared to the stress hormonal elevation in animals with other prenatal treatments. Negative correlation between plasma corticosterone level and the number of flexes+shakes is revealed in buspirone+stress rats. The new data enhance the idea about relativity of the HPA axis hyporeactive period and suggest that maternal buspirone prior to stress during gestation may enhance an adaptive mechanism of the inflammatory nociceptive system in the infant male offspring through activation of the HPA axis peripheral link.

EFFECTS OF THE PINEAL GLAND IN UNILATERALLY ADRENALECTOMIZED RATS

1972 ◽  
Vol 70 (3) ◽  
pp. 438-444 ◽  
Author(s):  
Kenneth L. Dickson ◽  
David L. Hasty
Keyword(s):  
Pineal Gland ◽  
Plasma Levels ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Zona Fasciculata ◽  
Inhibitory Effects ◽  
Plasma Corticosterone Level ◽  
Pineal Extract ◽  
Environmental Lighting ◽  
Adrenalectomized Rats

ABSTRACT The following experiments were undertaken to determine the effects that the pineal secretory substance might have on compensatory adrenal hypertrophy and corticosterone plasma levels in unilaterally adrenalectomized rats. It was demonstrated that blinded animals and animals administered with a bovine pineal extract exhibited a reduction in the percentage compensatory adrenal hypertrophy, a reduction in the thickness of the zona fasciculata, and a reduction in the plasma corticosterone level. These inhibitory effects were reversed by pinealectomy and ACTH injections, suggesting that the pineal gland, acting as a mediator for environmental lighting, might influence synthesis and/or release of ACTH.

AFFERENT PATHWAYS OF STRESSFUL STIMULI: CORTICOTROPHIN RELEASE AFTER PARTIAL DEAFFERENTATION OF THE MEDIAL BASAL HYPOTHALAMUS

1969 ◽  
Vol 44 (2) ◽  
pp. 187-193 ◽  
Author(s):  
G. B. MAKARA ◽  
E. STARK ◽  
M. PALKOVITS ◽  
T. RÉVÉSZ ◽  
K. MIHÁLY
Keyword(s):  
Escherichia Coli ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Neural Pathways ◽  
Plasma Corticosterone Level ◽  
Nerve Fibres ◽  
Afferent Pathways ◽  
Medial Basal Hypothalamus ◽  
Noise And Vibration ◽  
Acth Release

SUMMARY Corticotrophin (ACTH) release induced by various stressful stimuli has been studied in rats with antero-lateral deafferentation of the medial basal hypothalamus (MBH). The plasma corticosterone level was determined as an index of ACTH release. In rats with antero-lateral deafferentation of the MBH, ACTH release was prevented after exposure to noise and vibration, sham adrenalectomy and s.c. injection of 1% formalin. ACTH release induced by the injection of histamine (1 mg./100 g., i.p.) and capsaicin (0·25 mg./100 g., s.c.) was significantly less than in the controls. Escherichia coli lipopolysaccharide (25 μg./100 g., i.p.) induced an ACTH release that could not be distinguished from that in the controls. We suggest that (a) noise and vibration, sham adrenalectomy and injection of 1% formalin trigger ACTH release through neural pathways arriving at the MBH from anterior, lateral and dorsal directions, (b) histamine or capsaicin releases ACTH partly through antero-lateral neural afferents to the MBH. In contrast, the ACTH-releasing stimulus of bacterial endotoxin injection reaches the hypothalamo—hypophysial unit by humoral pathways and/or posterior nerve fibres.

Plasma Corticosterone Level as an Indicator of Stress in the Eastern Wild Turkey

1977 ◽  
Vol 41 (2) ◽  
pp. 189 ◽  
Author(s):  
Harry E. Whatley ◽  
Michael E. Lisano ◽  
James Earl Kennamer
Keyword(s):  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Wild Turkey ◽  
Plasma Corticosterone Level ◽  
Eastern Wild Turkey
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