Ingestion of non-caloric liquid diet is sufficient to restore plasma corticosterone level, but not to induce the hypothalamic c-Fos expression in food-deprived rats

2007 ◽  
Vol 10 (5-6) ◽  
pp. 261-267 ◽  
Author(s):  
Sang Bae Yoo ◽  
Jong-Ho Lee ◽  
Vitaly Ryu ◽  
Jeong Won Jahng
Keyword(s):  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Liquid Diet ◽  
Plasma Corticosterone Level ◽  
Fos Expression

Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Senthil Murugan Murugaiyan ◽  
Rajesh Bhargavan
Keyword(s):  
Oral Administration ◽  
Corticosterone Level ◽  
Tween 80 ◽  
Treated Group ◽  
Plasma Corticosterone ◽  
Bacopa Monnieri ◽  
Aluminium Chloride ◽  
Control Group ◽  
Plasma Corticosterone Level ◽  
Protective Groups

AbstractObjectivesAluminium is present in food preparations, antacids and many medications. It causes neurodegeneration thereby resulting in a spectrum of neurological disorders such as dementia, Alzheimer’s disease and anxiety. Bacopa monnieri (BM) is widely used in ayurvedic medicine to improve memory functions. Its anxiolytic property was investigated in this study by using elevated plus maze (EPM) and plasma corticosterone level.MethodsThirty rats were assigned into five groups. Control group received distilled water, and 0.5% tween 80, AlCl3 group received Aluminium Chloride (AlCl3), Protective groups (BM100 + AlCl3 group and BM200 + AlCl3 group) received AlCl3 and BM at two different doses, and the BM200 group received BM. The EPM experiment was performed at the end of the 4th week of oral administration of BM and AlCl3 followed by the measurement of plasma corticosterone.ResultsOral administration of AlCl3 to rats increases the levels of anxiety as seen in a decrease in the percentage of entries into the open arms of EPM, an increase in grooming frequency and defecation index. However, the rats in the protective groups shown an increase in the percentage of open arm entries and rearing frequency, and decreased grooming frequency and defecation index. AlCl3 alone treated group showed a significant increase in the plasma corticosterone levels compared to the control group. Whereas the protective groups have shown a significant decrease in the plasma corticosterone levels than the AlCl3 alone treated group.ConclusionsHence the BM has potential role in reverting the anxiogenic effect of AlCl3 in the amygdala as it is evident from the plasma corticosterone levels and the EPM parameters of different groups under study.

scholarly journals Inflammatory Pain and Corticosterone Response in Infant Rats: Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Irina P. Butkevich ◽  
Viktor A. Mikhailenko ◽  
Tat'yana R. Bagaeva ◽  
Elena A. Vershinina ◽  
Anna Maria Aloisi ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Inflammatory Pain ◽  
Formalin Test ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Male Rats ◽  
Plasma Corticosterone Level ◽  
Infant Rats ◽  
Corticosterone Response ◽  
Gestational Stress

Our researches have shown that gestational stress causes exacerbation of inflammatory pain in the offspring; the maternal 5-HT1A agonist buspirone before the stress prevents the adverse effect. The serotonergic system and hypothalamo-pituitary-adrenal (HPA) axis are closely interrelated. However, interrelations between inflammatory pain and the HPA axis during the hyporeactive period of the latter have not been studied. The present research demonstrates that formalin-induced pain causes a gradual and prolonged increase in plasma corticosterone level in 7-day-old male rats; twenty-four hours after injection of formalin, the basal corticosterone level still exceeds the initial basal corticosterone value. Chronic treatments of rat dams with buspirone before restraint stress during gestation normalize in the offspring pain-like behavior and induce during the acute phase in the formalin test the stronger corticosterone increase as compared to the stress hormonal elevation in animals with other prenatal treatments. Negative correlation between plasma corticosterone level and the number of flexes+shakes is revealed in buspirone+stress rats. The new data enhance the idea about relativity of the HPA axis hyporeactive period and suggest that maternal buspirone prior to stress during gestation may enhance an adaptive mechanism of the inflammatory nociceptive system in the infant male offspring through activation of the HPA axis peripheral link.

EFFECTS OF THE PINEAL GLAND IN UNILATERALLY ADRENALECTOMIZED RATS

1972 ◽  
Vol 70 (3) ◽  
pp. 438-444 ◽  
Author(s):  
Kenneth L. Dickson ◽  
David L. Hasty
Keyword(s):  
Pineal Gland ◽  
Plasma Levels ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Zona Fasciculata ◽  
Inhibitory Effects ◽  
Plasma Corticosterone Level ◽  
Pineal Extract ◽  
Environmental Lighting ◽  
Adrenalectomized Rats

ABSTRACT The following experiments were undertaken to determine the effects that the pineal secretory substance might have on compensatory adrenal hypertrophy and corticosterone plasma levels in unilaterally adrenalectomized rats. It was demonstrated that blinded animals and animals administered with a bovine pineal extract exhibited a reduction in the percentage compensatory adrenal hypertrophy, a reduction in the thickness of the zona fasciculata, and a reduction in the plasma corticosterone level. These inhibitory effects were reversed by pinealectomy and ACTH injections, suggesting that the pineal gland, acting as a mediator for environmental lighting, might influence synthesis and/or release of ACTH.

AFFERENT PATHWAYS OF STRESSFUL STIMULI: CORTICOTROPHIN RELEASE AFTER PARTIAL DEAFFERENTATION OF THE MEDIAL BASAL HYPOTHALAMUS

1969 ◽  
Vol 44 (2) ◽  
pp. 187-193 ◽  
Author(s):  
G. B. MAKARA ◽  
E. STARK ◽  
M. PALKOVITS ◽  
T. RÉVÉSZ ◽  
K. MIHÁLY
Keyword(s):  
Escherichia Coli ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Neural Pathways ◽  
Plasma Corticosterone Level ◽  
Nerve Fibres ◽  
Afferent Pathways ◽  
Medial Basal Hypothalamus ◽  
Noise And Vibration ◽  
Acth Release

SUMMARY Corticotrophin (ACTH) release induced by various stressful stimuli has been studied in rats with antero-lateral deafferentation of the medial basal hypothalamus (MBH). The plasma corticosterone level was determined as an index of ACTH release. In rats with antero-lateral deafferentation of the MBH, ACTH release was prevented after exposure to noise and vibration, sham adrenalectomy and s.c. injection of 1% formalin. ACTH release induced by the injection of histamine (1 mg./100 g., i.p.) and capsaicin (0·25 mg./100 g., s.c.) was significantly less than in the controls. Escherichia coli lipopolysaccharide (25 μg./100 g., i.p.) induced an ACTH release that could not be distinguished from that in the controls. We suggest that (a) noise and vibration, sham adrenalectomy and injection of 1% formalin trigger ACTH release through neural pathways arriving at the MBH from anterior, lateral and dorsal directions, (b) histamine or capsaicin releases ACTH partly through antero-lateral neural afferents to the MBH. In contrast, the ACTH-releasing stimulus of bacterial endotoxin injection reaches the hypothalamo—hypophysial unit by humoral pathways and/or posterior nerve fibres.

Plasma Corticosterone Level as an Indicator of Stress in the Eastern Wild Turkey

1977 ◽  
Vol 41 (2) ◽  
pp. 189 ◽  
Author(s):  
Harry E. Whatley ◽  
Michael E. Lisano ◽  
James Earl Kennamer
Keyword(s):  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Wild Turkey ◽  
Plasma Corticosterone Level ◽  
Eastern Wild Turkey

Blood corticosterone levels in growing geese around feather gathering

2012 ◽  
Vol 60 (4) ◽  
pp. 477-487 ◽  
Author(s):  
Péter Tóth ◽  
László Bódi ◽  
Katalin Maros ◽  
Endre Szűcs ◽  
Janbaz Janan
Keyword(s):  
Plasma Concentration ◽  
Research Group ◽  
Present Experiment ◽  
Corticosterone Level ◽  
Plasma Corticosterone ◽  
Not Given ◽  
Plasma Corticosterone Level ◽  
Blood Samples ◽  
Series Of Experiments

Feather production is realised by gathering feathers from geese right as they start their natural moulting. The adequate gathering time coincides with the time of moulting. There is still scarce information as to whether or not gathering causes distress and pain to geese. A series of experiments was carried out by our research group to determine the effect of gathering on plasma corticosterone level in growing geese. In the present experiment, the reactions of five groups (two gathered and three not gathered groups) of 9-week-old Babat Hungarian Upgraded geese were compared regarding gathering. Blood samples were taken right before, during and 5 min, 1 and 3 h after gathering into heparinised tubes from all groups. The plasma concentration of corticosterone was determined by radioimmunoassay (RIA). The results show that the plasma concentration of corticosterone is high in the first sample of all groups but is significantly lower at subsequent blood samplings compared to the first samples, especially in gathered geese. Compared to the first sampling, we observed higher corticosterone levels in samples collected 1 and 3 h after gathering. This was true only for groups which were not gathered, especially for the group which was not given any antistress material. From these results it can be concluded that the handling of geese causes an elevation in plasma corticosterone level and that feather gathering does not result in a higher corticosterone level than the handling or catching of the bird. Therefore, it can be concluded that feather gathering — especially when it is done adequately in time — does not cause more distress than the handling or catching of the bird.

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