The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents

Obesity is one of the major health issues in developed and developing countries, which has been increasing in recent decades. Obesity is one of the important risk factors for type 2 diabetes by developing insulin resistance. The purpose of this study was to investigate the effect of vitamin D on insulin resistance in overweight and obese children and adolescents with vitamin D deficiency. In this interventional study, 53 overweight and obese children and adolescents with vitamin D deficiency referred to the Endocrinology Clinic of Shahrekord University of Medical Sciences were included. The height and weight of participants were measured, and their Body Mass Index (BMI) calculated. To participants, 50,000 units of vitamin D were administered weekly for 8 weeks, and then 1000 units were orally administered daily for 3 months. Before and after the intervention, levels of vitamin D, insulin, and fasting blood sugar were measured. The HOMAIR was also calculated as an indicator of insulin resistance. After the intervention, serum vitamin D significantly increased, and BMI and fasting blood sugar significantly decreased (P<0.05). The insulin resistance index did not change significantly during the intervention (P>0.05). After the intervention, HOMA-IR had a significant direct correlation with body mass index, insulin, and fasting blood sugar and a significant inverse correlation with vitamin D (P<0.05). Vitamin D had a significant inverse correlation with BMI, insulin, and fasting blood sugar after the intervention (P<0.05). Oral treatment with vitamin D significantly increased serum vitamin D levels and significantly decreased BMI and fasting blood sugar in obese and overweight children.

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Relationship Between Vitamin D Deficiency And Insulin Resistance In Obese Children

Global Journal of Health Science ◽

10.5539/gjhs.v13n1p82 ◽

2020 ◽

Vol 13 (1) ◽

pp. 82

Author(s):

Aidah Juliaty ◽

Putri Lestari Gabrilasari ◽

Dasril Daud ◽

Johan Setyawan Lisal

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

Obese Children ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Deficiency Group

INTRODUCTION: Obesity represents the major risk factor for development of insulin resistance during childhood and adolescents. In obesity, adipose tissue release free fatty acids, various hormones, and cytokines, resulting in insulin resistance. This study aimed to establish the correlation between vitamin D deficiency and the incidence of insulin resistance in obese children. DESIGN AND METHOD: This analytical cross-sectional study was arranged from December 2019 - February 2020 included 96 students aged 11 - 17 years old from junior and senior high school who met the criteria for obesity in Makassar. The study subjects were parted into two groups, obese children with vitamin D deficiency (levels of 25-hydroxyvitamin D ≤ 20 ng/ml) and obese children without vitamin D deficiency group (levels of 25-hydroxyvitamin D > 20 ng/ml). Data were analyzed using univariate and bivariate analysis. RESULTS: The frequency of insulin resistance in obese children with vitamin D deficiency was 28 (54.9%), while obese children without vitamin D deficiency was 10 (22.2%). Based on statistical analysis, the frequency of the occurrence of insulin resistance in vitamin D deficiency obese children was higher than in obese children without vitamin D deficiency with OR = 4.261 (95% CI 1.744 – 10.411), p = 0.001. CONCLUSION: The risk of insulin resistance in obese children with vitamin D deficiency is 4.261 times higher than obese children without vitamin D deficiency.

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Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2013-0465 ◽

2014 ◽

Vol 0 (0) ◽

Author(s):

Arnold H. Slyper ◽

Laurissa Kashmer ◽

Wei-Min Huang ◽

Yochai Re’em

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Children And Adolescents ◽

Acanthosis Nigricans ◽

Obese Children

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Is there a benefit of vitamin D supplementation in deficient children and adolescents suffering from obesity? A meta-analysis

QJM ◽

10.1093/qjmed/hcaa063.001 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

M F Nassar ◽

E K Emam ◽

M F Allam

Keyword(s):

Vitamin D ◽

Children And Adolescents ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Obese Children ◽

Intramuscular Dose ◽

Vitamin D Levels ◽

Pubmed Search ◽

Lower Vitamin

Abstract Background and objectives Both childhood obesity and vitamin D deficiency are common in the Middle East. This systematic review/meta-analysis aims to highlight the effect of vitamin D supplementation in deficient children suffering from obesity. Methods Published clinical studies on vitamin D supplementation in obese children and adolescents with vitamin D deficiency were identified through a comprehensive MEDLINE/PubMed search (from July 1966 to November 2017). Outcomes intended after vitamin D supplementation were improvements in vitamin D status, BMI alterations and appetite changes. The inclusion criteria were children aged 2 to 18 years of both sexes in clinical trials that specified the oral and/or intramuscular dose of vitamin D supplementation. Results Ten studies were retrieved, but only six were relevant. First, supplemented obese children and adolescents were compared to non-obese controls; thereafter, supplemented obese children and adolescents were compared to matching obese peers given placebo. Pooled risks from the two studies that evaluated the number of obese and non-obese children and adolescents who improved upon vitamin D supplementation revealed that obesity poses a risk for not benefiting from the vitamin D supplementation regardless of the dose and the duration of supplementation. Pooled results from the six retrieved studies that compared supplemented obese children and adolescents to matching non-obese or obese peers given placebo revealed significantly lower vitamin D levels in obese participants than in non-obese peers. Conclusion Vitamin D levels are significantly lower in obese children and adolescents with obesity, posing a risk for not benefiting from vitamin D supplementation regardless of the dose and duration of supplementation. Our results suggest that only with simultaneous weight adjustment strategies, vitamin D sufficiency would be achieved more effectively. Vitamin D supplementation in deficient children suffering from obesity.

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VITAMIN D DEFICIENCY AND OBESITY IN CHILDREN AND ADOLESCENTS: HOW THE TWO GLOBAL PANDEMIAS ARE INTERCONNECTED. VITAMIN D ROLE IN PATHOGENESIS OF OBESITY AND INSULIN RESISTANCE (PART 1)

Medical Council ◽

10.21518/2079-701x-2017-19-214-220 ◽

2017 ◽

pp. 214-220 ◽

Cited By ~ 2

Author(s):

L. Y. Klimov ◽

I. N. Zakharova ◽

V. A. Kurianinova ◽

I. L. Nikitina ◽

T. L. Karonova ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Children And Adolescents ◽

Vitamin D Deficiency ◽

Obesity In Children

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Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

Nutrition and Metabolic Insights ◽

10.1177/11786388211018726 ◽

2021 ◽

Vol 14 ◽

pp. 117863882110187

Author(s):

Hedyeh Saneifard ◽

Marjan Shakiba ◽

Ali Sheikhy ◽

Leila Baniadam ◽

Fatemeh Abdollah Gorji ◽

...

Keyword(s):

Vitamin D ◽

Children And Adolescents ◽

Vitamin D Deficiency ◽

Tanner Stage ◽

Additional Risk Factor ◽

Healthy Children ◽

Vitamin D Status ◽

Obese Children ◽

Increased Risk ◽

Vitamin D Levels

Background: Vitamin D deficiency is common among children and adolescents and can be affected by several factors such as puberty and obesity. Objective: The aim of this study was to evaluate vitamin D status in children and adolescents and to analyse the influence of puberty and obesity on its level. Method: A cross-sectional study was carried-out, in which clinical and biochemical data were gathered from 384 healthy children and adolescents between May 2019 to May 2020. Results: 220 females and 164 males were enrolled (aged 7-16 years; mean ± SD: 11 ± 2.5). Vitamin D deficiency was found in 49% of the total cases and was significantly more prevalent in females than males (33.1% in female; 15.9% in male, P < .001). Mean vitamin D level was lower in obese children compared with non-obese ( P < .001). Non-obese group had significantly higher levels of vitamin D in Tanner stage IV of puberty than obese individuals (20.1 ± 17.0 vs 5.4 ± 2.0) ( P = .03). Vitamin D levels were significantly lower in females than males only in Tanner stage II (12.3 ± 9.0 vs 19.6 ± 16.6) ( P = .005). The lowest level of Vitamin D was in Tanner stage Ⅳ-Ⅴ in boys and in Tanner stage Ⅱ-Ⅲ in girls ( P < .001). Conclusion: Puberty is an additional risk factor for vitamin D deficiency especially in girls and obese children. This increased risk, together with the fact that most important time for building a proper skeleton is during childhood and adolescent, makes it essential to monitor vitamin D in these age groups.

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