Increased Risk of Blount Disease in Obese Children and Adolescents With Vitamin D Deficiency

2010 ◽  
Vol 30 (8) ◽  
pp. 879-882 ◽  
Author(s):  
Corey O. Montgomery ◽  
Karen L. Young ◽  
Mark Austen ◽  
Chan-Hee Jo ◽  
Robert Dale Blasier ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Obese Children ◽  
Increased Risk ◽  
Blount Disease

scholarly journals Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

2021 ◽  
Vol 14 ◽  
pp. 117863882110187
Author(s):  
Hedyeh Saneifard ◽  
Marjan Shakiba ◽  
Ali Sheikhy ◽  
Leila Baniadam ◽  
Fatemeh Abdollah Gorji ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Tanner Stage ◽  
Additional Risk Factor ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Obese Children ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Vitamin D deficiency is common among children and adolescents and can be affected by several factors such as puberty and obesity. Objective: The aim of this study was to evaluate vitamin D status in children and adolescents and to analyse the influence of puberty and obesity on its level. Method: A cross-sectional study was carried-out, in which clinical and biochemical data were gathered from 384 healthy children and adolescents between May 2019 to May 2020. Results: 220 females and 164 males were enrolled (aged 7-16 years; mean ± SD: 11 ± 2.5). Vitamin D deficiency was found in 49% of the total cases and was significantly more prevalent in females than males (33.1% in female; 15.9% in male, P < .001). Mean vitamin D level was lower in obese children compared with non-obese ( P < .001). Non-obese group had significantly higher levels of vitamin D in Tanner stage IV of puberty than obese individuals (20.1 ± 17.0 vs 5.4 ± 2.0) ( P = .03). Vitamin D levels were significantly lower in females than males only in Tanner stage II (12.3 ± 9.0 vs 19.6 ± 16.6) ( P = .005). The lowest level of Vitamin D was in Tanner stage Ⅳ-Ⅴ in boys and in Tanner stage Ⅱ-Ⅲ in girls ( P < .001). Conclusion: Puberty is an additional risk factor for vitamin D deficiency especially in girls and obese children. This increased risk, together with the fact that most important time for building a proper skeleton is during childhood and adolescent, makes it essential to monitor vitamin D in these age groups.

scholarly journals Is there a benefit of vitamin D supplementation in deficient children and adolescents suffering from obesity? A meta-analysis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M F Nassar ◽  
E K Emam ◽  
M F Allam
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Obese Children ◽  
Intramuscular Dose ◽  
Vitamin D Levels ◽  
Pubmed Search ◽  
Lower Vitamin

Abstract Background and objectives Both childhood obesity and vitamin D deficiency are common in the Middle East. This systematic review/meta-analysis aims to highlight the effect of vitamin D supplementation in deficient children suffering from obesity. Methods Published clinical studies on vitamin D supplementation in obese children and adolescents with vitamin D deficiency were identified through a comprehensive MEDLINE/PubMed search (from July 1966 to November 2017). Outcomes intended after vitamin D supplementation were improvements in vitamin D status, BMI alterations and appetite changes. The inclusion criteria were children aged 2 to 18 years of both sexes in clinical trials that specified the oral and/or intramuscular dose of vitamin D supplementation. Results Ten studies were retrieved, but only six were relevant. First, supplemented obese children and adolescents were compared to non-obese controls; thereafter, supplemented obese children and adolescents were compared to matching obese peers given placebo. Pooled risks from the two studies that evaluated the number of obese and non-obese children and adolescents who improved upon vitamin D supplementation revealed that obesity poses a risk for not benefiting from the vitamin D supplementation regardless of the dose and the duration of supplementation. Pooled results from the six retrieved studies that compared supplemented obese children and adolescents to matching non-obese or obese peers given placebo revealed significantly lower vitamin D levels in obese participants than in non-obese peers. Conclusion Vitamin D levels are significantly lower in obese children and adolescents with obesity, posing a risk for not benefiting from vitamin D supplementation regardless of the dose and duration of supplementation. Our results suggest that only with simultaneous weight adjustment strategies, vitamin D sufficiency would be achieved more effectively. Vitamin D supplementation in deficient children suffering from obesity.

scholarly journals Are Indian obese children and adolescents at increased risk for Vitamin D deficiency?

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
Aashima Dabas ◽  
T. Aravind ◽  
Sangeeta Yadav ◽  
Mukta Mantan ◽  
Smita Kaushik
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Obese Children ◽  
Indian Children ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
High Risk Factor ◽  
25 Hydroxyvitamin D ◽  
Obese Subjects

Objectives: Obesity has been mentioned as a high risk factor for Vitamin D deficiency (VDD) requiring supplementation in Indian children. Material and Methods: Forty obese and age-matched non-obese subjects (age 5–18 years) were assessed for lifestyle parameters, metabolic profile, and serum 25-hydroxyvitamin D (25OHD). VDD was defined as serum 25OHD < 12 ng/mL. Results: Mean 25OHD was comparable among obese and controls (15.0 ± 9.95 and 15.1 ± 4.79 ng/mL; P = 0.97) with VDD seen in 82% of cases and 85% of controls. Pubertal cases had lower 25OHD values than prepubertal obese cases (10.78 ± 4.69 and 17.2 ± 11 ng/mL; P = 0.06). Mean duration of physical activity (<2 h/week) and screen time (>2 h/day) was similar across prepubertal and pubertal groups and between obese and controls. Obesity was not associated with risk for VDD among cases and controls (odds ratio 0.83, 95% C.I. 0.25–2.7, P = 0.76). Conclusion: Obese pubertal subjects were more at risk for VDD than prepubertal subjects. Routine Vitamin D supplementation to obese Indian children may be considered during adolescence.

scholarly journals Vitamin D deficiency in obese children and adolescents and relation to glucose homeostasis

QJM ◽  
2018 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
A Osman ◽  
N R Osman ◽  
D A Fouad ◽  
N N Toaima
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Glucose Homeostasis ◽  
Obese Children

scholarly journals Μελέτη λιποκυτοκινών στην παιδική παχυσαρκία

2012 ◽  
Author(s):  
Δήμητρα Μεθενίτη
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Morbidly Obese ◽  
Central Adiposity ◽  
Lipocalin 2 ◽  
Z Score ◽  
Obese Children ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Female Children

Childhood obesity is one of the biggest public health challenges of the 21st centurywhich has doubled over the last 20 years and is now an epidemic. Obese children andadolescents, especially those with central adiposity, are more likely to developglucose intolerance, insulin resistance, dyslipidemia as well as high blood pressure,conditions that consist the metabolic syndrome. The above comorbidities have beenlinked with an increased risk for diabetes type 2 and cardiovascular disease in laterlife.Hypovitaminosis D has been associated with adult obesity, while recent data havealso shown low vitamin D concentrations in obese children and adolescents. Retinolbindingprotein-4 and lipocalin-2 are altered in obese individuals. The aim of thisstudy was to examine circulating 25-(OH) D3 concentrations in female children andadolescents, according to BMI status, and to associate 25-(OH) D3 with RBP-4 andlipocalin-2 concentrations.Seventy-nine (79) female children and adolescents, aged 8-16 years, were studied.The children were divided into four groups according to their obesity status: 19 lean(mean BMI z-score <1.24), 20 overweight (mean BMI z-score 1.92 ± 0.58), 20 obese(mean BMI z-score 2.625 ± 0.225) and 20 morbidly obese (mean BMI z-score >3).Overweight and obese children were derived from the Obesity Clinic of ourDepartment. Plasma 25-(OH) D3, RBP-4 and lipocalin-2 concentrations weremeasured with specific assays.Plasma 25-(OH) D3 concentrations were decreased significantly in the morbidlyobese (p=0.005) and marginally in the obese group (p=0.05). In the entire BMI range, Spearman correlations revealed positive associations between 25-(OH) D3 and RBP-4(r=0.349, p=0.002) and between 25-(OH) D3 and lipocalin-2 (r=0.338, p=0.003).Decreased 25-(OH) D3 concentrations are present in female obese children andadolescents. 25-(OH) D3 concentrations are associated with other markers ofchildhood obesity, such as RBP-4 and lipocalin-2. These associations may reveal newnutritional interventions in childhood and adolescent obesity.Further investigation and research of larger groups of obese young individuals, takinginto account broader parameters is therefore adamant . The aim is to reveal atimeframe and a homeostatic pattern, in which the hormonal mechanisms fail andsubsequently result in the elevation of Vitamin D and the possible compensatoryresponses of RBP4 and NGAL. These associations may reveal new nutritionalinterventions in childhood and adolescent obesity.

scholarly journals Increased Risk for Vitamin D Deficiency in Obese Children with Both Celiac Disease and Type 1 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nithya Setty-Shah ◽  
Louise Maranda ◽  
Benjamin Udoka Nwosu
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Vitamin D Deficiency ◽  
Normal Weight ◽  
Obese Children ◽  
Prepubertal Children ◽  
Increased Risk ◽  
Post Hoc

Background. It is unknown whether the coexistence of type 1 diabetes (T1D) and celiac disease (CD) increases the risk for vitamin D deficiency.Aims. To determine the vitamin D status and the risk for vitamin D deficiency in prepubertal children with both T1D and CD compared to controls, TID, and CD.Subjects and Methods. Characteristics of 62 prepubertal children of age 2–13 y with either CD + T1D (n=22, 9.9 ± 3.1 y), CD only (n=18, 8.9 ± 3.3 y), or T1D only (n=22, 10.1 ± 2.8 y) were compared to 49 controls of the age of 8.0 ± 2.6 years. Vitamin D deficiency was defined as 25(OH)D < 50 nmol/L, overweight as BMI of >85th but <95th percentile, and obesity as BMI > 95th percentile.Results. The 4 groups had no difference in 25(OH)D (ANOVAP=0.123) before stratification into normal-weight versus overweight/obese subtypes. Following stratification, 25(OH)D differed significantly between the subgroups (F(3,98)=10.109, ANOVAP<0.001). Post-hoc analysis showed a significantly lower 25(OH)D in the overweight/obese CD + T1D compared to the overweight/obese controls (P=0.039) and the overweight/obese CD (P=0.003). Subjects with CD + T1D were 3 times more likely to be vitamin D deficient (OR = 3.1 [0.8–11.9],P=0.098), compared to controls.Conclusions. The coexistence of T1D and CD in overweight/obese prepubertal children may be associated with lower vitamin D concentration.

Vitamin D deficiency and carbohydrate metabolism in obese children and adolescents

2021 ◽  
Vol 90 (1) ◽  
pp. 57-64
Author(s):  
G.N. Kostrova ◽  
◽  
S.I. Malyavskaya ◽  
A.V. Lebedev ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Carbohydrate Metabolism ◽  
Obese Children

scholarly journals Effect of Vitamin D on Insulin Resistance in Overweight and Obese Children and Adolescents With Vitamin D Deficiency

2020 ◽  
Author(s):  
Noushin Rostampour ◽  
Nabiollah Asadpour ◽  
Maryam Moradi ◽  
Elham Hashemi-Dehkordi ◽  
Soleiman Kheiri
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Blood Sugar ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Fasting Blood Sugar ◽  
Obese Children ◽  
Serum Vitamin D

Obesity is one of the major health issues in developed and developing countries, which has been increasing in recent decades. Obesity is one of the important risk factors for type 2 diabetes by developing insulin resistance. The purpose of this study was to investigate the effect of vitamin D on insulin resistance in overweight and obese children and adolescents with vitamin D deficiency. In this interventional study, 53 overweight and obese children and adolescents with vitamin D deficiency referred to the Endocrinology Clinic of Shahrekord University of Medical Sciences were included. The height and weight of participants were measured, and their Body Mass Index (BMI) calculated. To participants, 50,000 units of vitamin D were administered weekly for 8 weeks, and then 1000 units were orally administered daily for 3 months. Before and after the intervention, levels of vitamin D, insulin, and fasting blood sugar were measured. The HOMAIR was also calculated as an indicator of insulin resistance. After the intervention, serum vitamin D significantly increased, and BMI and fasting blood sugar significantly decreased (P<0.05). The insulin resistance index did not change significantly during the intervention (P>0.05). After the intervention, HOMA-IR had a significant direct correlation with body mass index, insulin, and fasting blood sugar and a significant inverse correlation with vitamin D (P<0.05). Vitamin D had a significant inverse correlation with BMI, insulin, and fasting blood sugar after the intervention (P<0.05). Oral treatment with vitamin D significantly increased serum vitamin D levels and significantly decreased BMI and fasting blood sugar in obese and overweight children.

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