Comparison of Vitamin D Deficiency and Secondary Hyperparathyroidism in Obese and Non-obese Children and Adolescents

2012 ◽  
Vol 15 (3) ◽  
pp. 147-151 ◽  
Author(s):  
Robabeh Ghergherec ◽  
Nazanin Hazhir ◽  
Ali Tabrizi
Keyword(s):  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Obese Children

scholarly journals Is there a benefit of vitamin D supplementation in deficient children and adolescents suffering from obesity? A meta-analysis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M F Nassar ◽  
E K Emam ◽  
M F Allam
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Obese Children ◽  
Intramuscular Dose ◽  
Vitamin D Levels ◽  
Pubmed Search ◽  
Lower Vitamin

Abstract Background and objectives Both childhood obesity and vitamin D deficiency are common in the Middle East. This systematic review/meta-analysis aims to highlight the effect of vitamin D supplementation in deficient children suffering from obesity. Methods Published clinical studies on vitamin D supplementation in obese children and adolescents with vitamin D deficiency were identified through a comprehensive MEDLINE/PubMed search (from July 1966 to November 2017). Outcomes intended after vitamin D supplementation were improvements in vitamin D status, BMI alterations and appetite changes. The inclusion criteria were children aged 2 to 18 years of both sexes in clinical trials that specified the oral and/or intramuscular dose of vitamin D supplementation. Results Ten studies were retrieved, but only six were relevant. First, supplemented obese children and adolescents were compared to non-obese controls; thereafter, supplemented obese children and adolescents were compared to matching obese peers given placebo. Pooled risks from the two studies that evaluated the number of obese and non-obese children and adolescents who improved upon vitamin D supplementation revealed that obesity poses a risk for not benefiting from the vitamin D supplementation regardless of the dose and the duration of supplementation. Pooled results from the six retrieved studies that compared supplemented obese children and adolescents to matching non-obese or obese peers given placebo revealed significantly lower vitamin D levels in obese participants than in non-obese peers. Conclusion Vitamin D levels are significantly lower in obese children and adolescents with obesity, posing a risk for not benefiting from vitamin D supplementation regardless of the dose and duration of supplementation. Our results suggest that only with simultaneous weight adjustment strategies, vitamin D sufficiency would be achieved more effectively. Vitamin D supplementation in deficient children suffering from obesity.

scholarly journals Vitamin D Deficiency in Children and Adolescents: Role of Puberty and Obesity on Vitamin D Status

2021 ◽  
Vol 14 ◽  
pp. 117863882110187
Author(s):  
Hedyeh Saneifard ◽  
Marjan Shakiba ◽  
Ali Sheikhy ◽  
Leila Baniadam ◽  
Fatemeh Abdollah Gorji ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Tanner Stage ◽  
Additional Risk Factor ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Obese Children ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Vitamin D deficiency is common among children and adolescents and can be affected by several factors such as puberty and obesity. Objective: The aim of this study was to evaluate vitamin D status in children and adolescents and to analyse the influence of puberty and obesity on its level. Method: A cross-sectional study was carried-out, in which clinical and biochemical data were gathered from 384 healthy children and adolescents between May 2019 to May 2020. Results: 220 females and 164 males were enrolled (aged 7-16 years; mean ± SD: 11 ± 2.5). Vitamin D deficiency was found in 49% of the total cases and was significantly more prevalent in females than males (33.1% in female; 15.9% in male, P < .001). Mean vitamin D level was lower in obese children compared with non-obese ( P < .001). Non-obese group had significantly higher levels of vitamin D in Tanner stage IV of puberty than obese individuals (20.1 ± 17.0 vs 5.4 ± 2.0) ( P = .03). Vitamin D levels were significantly lower in females than males only in Tanner stage II (12.3 ± 9.0 vs 19.6 ± 16.6) ( P = .005). The lowest level of Vitamin D was in Tanner stage Ⅳ-Ⅴ in boys and in Tanner stage Ⅱ-Ⅲ in girls ( P < .001). Conclusion: Puberty is an additional risk factor for vitamin D deficiency especially in girls and obese children. This increased risk, together with the fact that most important time for building a proper skeleton is during childhood and adolescent, makes it essential to monitor vitamin D in these age groups.

scholarly journals Vitamin D deficiency in obese children and adolescents and relation to glucose homeostasis

QJM ◽  
2018 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
A Osman ◽  
N R Osman ◽  
D A Fouad ◽  
N N Toaima
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Glucose Homeostasis ◽  
Obese Children

Vitamin D deficiency and carbohydrate metabolism in obese children and adolescents

2021 ◽  
Vol 90 (1) ◽  
pp. 57-64
Author(s):  
G.N. Kostrova ◽  
◽  
S.I. Malyavskaya ◽  
A.V. Lebedev ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Carbohydrate Metabolism ◽  
Obese Children

Increased Risk of Blount Disease in Obese Children and Adolescents With Vitamin D Deficiency

2010 ◽  
Vol 30 (8) ◽  
pp. 879-882 ◽  
Author(s):  
Corey O. Montgomery ◽  
Karen L. Young ◽  
Mark Austen ◽  
Chan-Hee Jo ◽  
Robert Dale Blasier ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Obese Children ◽  
Increased Risk ◽  
Blount Disease

scholarly journals Effect of Vitamin D on Insulin Resistance in Overweight and Obese Children and Adolescents With Vitamin D Deficiency

2020 ◽  
Author(s):  
Noushin Rostampour ◽  
Nabiollah Asadpour ◽  
Maryam Moradi ◽  
Elham Hashemi-Dehkordi ◽  
Soleiman Kheiri
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Blood Sugar ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Fasting Blood Sugar ◽  
Obese Children ◽  
Serum Vitamin D

Obesity is one of the major health issues in developed and developing countries, which has been increasing in recent decades. Obesity is one of the important risk factors for type 2 diabetes by developing insulin resistance. The purpose of this study was to investigate the effect of vitamin D on insulin resistance in overweight and obese children and adolescents with vitamin D deficiency. In this interventional study, 53 overweight and obese children and adolescents with vitamin D deficiency referred to the Endocrinology Clinic of Shahrekord University of Medical Sciences were included. The height and weight of participants were measured, and their Body Mass Index (BMI) calculated. To participants, 50,000 units of vitamin D were administered weekly for 8 weeks, and then 1000 units were orally administered daily for 3 months. Before and after the intervention, levels of vitamin D, insulin, and fasting blood sugar were measured. The HOMAIR was also calculated as an indicator of insulin resistance. After the intervention, serum vitamin D significantly increased, and BMI and fasting blood sugar significantly decreased (P<0.05). The insulin resistance index did not change significantly during the intervention (P>0.05). After the intervention, HOMA-IR had a significant direct correlation with body mass index, insulin, and fasting blood sugar and a significant inverse correlation with vitamin D (P<0.05). Vitamin D had a significant inverse correlation with BMI, insulin, and fasting blood sugar after the intervention (P<0.05). Oral treatment with vitamin D significantly increased serum vitamin D levels and significantly decreased BMI and fasting blood sugar in obese and overweight children.

Vitamin D Deficiency and Intoxication - A concern either way

JMS SKIMS ◽  
2011 ◽  
Vol 14 (2) ◽  
pp. 40-42
Author(s):  
Muzafar Maqsood Wani ◽  
Imtiaz Ahmed Wani
Keyword(s):  
Vitamin D ◽  
Cell Growth ◽  
Bone Turnover ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Bone Mineralization ◽  
Normal Blood ◽  
Blood Levels ◽  
Calcium And Phosphorus ◽  
Biologic Function

Major biologic function of activated vitamin D is to maintain normal blood levels of calcium and phosphorus, thus regulating bone mineralization. Research suggests that vitamin D may help in immunomodulation, regulating cell growth and 1,4 differentiation as well as some diverse unspecified functions. Overt vitamin D deficiency leads to hypocalcaemia, secondary hyperparathyroidism and increased bone turnover, which in prolonged and severe cases may cause rickets in children and osteomalacia in elderly.... JMS 2011;14(2):40-42

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