Incorporating first trimester analytes to predict delivery of a large for gestational infant in women with impaired glucose tolerance

AbstractTo investigate first trimester maternal characteristics of women with impaired glucose tolerance that deliver large for gestational age (LGA) infants.Nested analysis from a prospective study of singleton pregnancies enrolled at first trimester. We studied women with an abnormal 1 h glucose challenge test that had normal follow-up oral glucose tolerance testing. Maternal characteristics, ultrasound parameters and serum analytes were stratified by subsequent delivery of an LGA infant. Parameters identified as significant on univariate analysis were used for a derivation of prediction by logistic regression. Odds ratio and prediction performance was determined using receiver operator curve (ROC) statistics.A total of 33/114 (28.9%) women meeting the criteria delivered LGA infants. Maternal height (cm), and first trimester pregnancy-associated protein-A and free β-hCG (MoM) predicted delivery of an LGA infant (ROC area under curve 0.73; 95% CI 0.63–0.83). At a cutoff value of 0.172 the prediction rule achieved 91% sensitivity, 44% specificity, 41% positive predictive and 92% negative predictive value.Maternal height and first trimester high free β-hCG and PAPP-A levels may be used as predictors for delivery of LGA infants in women with impaired glucose tolerance.

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First trimester prediction of maternal glycemic status

Journal of Perinatal Medicine ◽

10.1515/jpm-2014-0149 ◽

2015 ◽

Vol 43 (3) ◽

Cited By ~ 8

Author(s):

Rinat Gabbay-Benziv ◽

Lauren E. Doyle ◽

Miriam Blitzer ◽

Ahmet A. Baschat

Keyword(s):

Risk Score ◽

Predictive Value ◽

Challenge Test ◽

Area Under The Curve ◽

First Trimester ◽

Tolerance Test ◽

Oral Glucose ◽

Operating Characteristics ◽

Maternal Characteristics ◽

Predictive Algorithm

AbstractTo predict gestational diabetes mellitus (GDM) or normoglycemic status using first trimester maternal characteristics.We used data from a prospective cohort study. First trimester maternal characteristics were compared between women with and without GDM. Association of these variables with sugar values at glucose challenge test (GCT) and subsequent GDM was tested to identify key parameters. A predictive algorithm for GDM was developed and receiver operating characteristics (ROC) statistics was used to derive the optimal risk score. We defined normoglycemic state, when GCT and all four sugar values at oral glucose tolerance test, whenever obtained, were normal. Using same statistical approach, we developed an algorithm to predict the normoglycemic state.Maternal age, race, prior GDM, first trimester BMI, and systolic blood pressure (SBP) were all significantly associated with GDM. Age, BMI, and SBP were also associated with GCT values. The logistic regression analysis constructed equation and the calculated risk score yielded sensitivity, specificity, positive predictive value, and negative predictive value of 85%, 62%, 13.8%, and 98.3% for a cut-off value of 0.042, respectively (ROC-AUC – area under the curve 0.819, CI – confidence interval 0.769–0.868). The model constructed for normoglycemia prediction demonstrated lower performance (ROC-AUC 0.707, CI 0.668–0.746).GDM prediction can be achieved during the first trimester encounter by integration of maternal characteristics and basic measurements while normoglycemic status prediction is less effective.

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The size of the loading dose as an important determinant of the results of the oral glucose tolerance test: a study in subjects with slightly impaired glucose tolerance

Diabetes ◽

10.2337/diabetes.27.1.42 ◽

1978 ◽

Vol 27 (1) ◽

pp. 42-48 ◽

Cited By ~ 10

Author(s):

E. de Nobel ◽

A. van't Laar

Keyword(s):

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Impaired Glucose Tolerance ◽

Glucose Tolerance Test ◽

Important Determinant ◽

Tolerance Test ◽

Oral Glucose ◽

Loading Dose ◽

Oral Glucose Tolerance

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Abnormal glucose challenge test in absence of oral glucose tolerance test – are there consequences?

Journal of Obstetrics and Gynaecology ◽

10.1080/01443615.2020.1867964 ◽

2021 ◽

pp. 1-7

Author(s):

Alexandra Berezowsky ◽

Oded Raban ◽

Amir Aviram ◽

Rony Chen ◽

Arnon Wiznitzer ◽

...

Keyword(s):

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Glucose Tolerance Test ◽

Challenge Test ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Glucose Challenge Test ◽

Glucose Challenge

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QOL-43. ENDOCRINE AND METABOLIC CHANGES IN CHILDREN TREATED FOR MEDULLOBLASTOMA

Neuro-Oncology ◽

10.1093/neuonc/noaa222.700 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii439-iii439

Author(s):

Alexey Kalinin ◽

Natalia Strebkova ◽

Olga Zheludkova

Keyword(s):

Insulin Resistance ◽

Body Composition ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Impaired Glucose Tolerance ◽

Glucose Tolerance Test ◽

Tolerance Test ◽

Hormone Deficiency ◽

Oral Glucose ◽

Oral Glucose Tolerance

Abstract We examined 63 patients (40 males/23 females) after complex treatment of medulloblastoma. Patients had a median age (range) of 11.3 (5.5 ÷ 17.9) years. The median time after the end of treatment was 3.7 (1.5 ÷ 11.6) years. Endocrine disorders were detected with the following frequency: growth hormone deficiency - 98.41% (62 of 63 patients), thyroid hormone deficiency – 69.8% (44/63), adrenal hormone deficiency - 17.4% (11/63). Three cases (4.7%) of premature sexual development were also detected. Lipids levels, beta-cell function and insulin resistance (IR) during 2-h oral glucose tolerance test were evaluated. A mono frequent bioelectrical impedanciometer was used to measure body composition. Overweight (SDS BMI> 1) was observed only in 16 patients (3 girls and 13 boys), obesity (SDS BMI> 2) in 1 boy. Dyslipidemia was found in 34 patients (54%). All patients underwent oral glucose tolerance test. Insulin resistance (ISI Matsuda <2.5 and/or HOMA-IR> 3.2) was detected in 7 patients (11/1%), impaired glucose tolerance (120 min glucose ≥7.8 mmol / l) was observed in 2 patients with IR and in 2 patients without IR. At the same time, IR and impaired glucose tolerance were encountered in only 5 children with overweight and no one with obesity. All patients with impaired glucose tolerance had normal values of fasting glucose (4.3 ÷ 5.04 mmol / l) and HbA1c (4.8 ÷ 5.8%). A bioelectrical impedanciometer was used to measure body composition in 49 cases, the percentage of adipose tissue was increased in 14 patients (28%) with normal BMI.

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