Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis

Abstract Context: Significant controversy exists surrounding the possible association between recent packed red blood cell (PRBC) transfusion and the subsequent development of necrotizing enterocolitis (NEC) in infants. Previous studies and meta-analyses reporting a statistically significant association led to a practice change to withhold enteral feeds in the peri-transfusion period in many centers in an effort to prevent NEC; however, results from more recent studies do not support the existence of an association and, thus, question the validity of this practice change. Objective: This study aimed to perform a systematic review and meta-analysis to determine whether exposure to recent PRBC transfusion (defined as within 48 h) is associated with the subsequent development of NEC stage ≥II (Bell’s criteria) in infants. Methods: Medline, Embase, CINAHL, and the Cochrane Library were searched from inception to October 7, 2015. A gray literature search was also performed. Studies comparing the risk of NEC in infants exposed and unexposed to recent PRBC transfusion were included. Thirteen studies met eligibility criteria, and 10 (n=15,675 infants) were included in the meta-analysis. Three authors independently extracted data, and meta-analysis was performed using a random effects model. Results: We found a statistically significant 45% reduction in the unadjusted odds of NEC in infants exposed to a recent PRBC transfusion (odds ratio=0.55, 95% confidence interval=0.31–0.98). Conclusion: Our results show a protective effect of recent PRBC transfusion on the subsequent development of NEC. The practice of withholding enteral feeds during the peri-transfusion period should be re-evaluated in light of these results.

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Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

10.21203/rs.2.17842/v2 ◽

2020 ◽

Author(s):

Xuefeng Ma ◽

Shousheng Liu ◽

Jie Zhang ◽

Mengzhen Dong ◽

Yifen Wang ◽

...

Keyword(s):

Systematic Review ◽

Diagnostic Method ◽

Case Reports ◽

Meta Analysis ◽

Cochrane Library ◽

Random Effects Model ◽

Hepatic Inflammation ◽

Normal Alt ◽

Study Type ◽

The Cochrane Library

Abstract Background: ALT value is often used to reflect the hepatic inflammation and injury in NAFLD patients, but many studies proved that ALT values were normal in many NAFLD patients. The aim of this study was to identify the summarized proportion of NAFLD patients with normal ALT value in the overall NAFLD patients. Methods: Electronic databases PubMed, EMBASE, Ovid, and the Cochrane Library were searched for potential studies published from January 1, 2000 to September 30, 2019. Studies that have reported the number of NAFLD or NASH patients with normal and abnormal ALT value were included and analyzed. Abstracts, reviews, case reports, and letters were excluded. Results: A total of 11 studies with 4084 patients were included for assessing the summarized proportion of NAFLD patients with normal ALT in overall NAFLD patients. As the results shown, the summarized proportion of NAFLD patients with normal ALT value in overall NAFLD patients was 25% (95%CI: 20%-31%) which was calculated by the random-effects model. The summarized proportion of NASH patients with normal ALT value in overall NASH patients was 19% (95%CI: 13%-27%). Subgroup analysis includes region, study type, diagnostic method, and group size were conducted to investigate the resource of heterogeneity in the summarized proportion of NAFLD and NASH patients with normal ALT value. Conclusions: 25% NAFLD patients and 19% NASH patients possess the normal ALT value in the clinical manifestation. The value of ALT in the clinical diagnosis of NAFLD and NASH remains need be further testified.

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The Effect of Hysteroscopy on the Reproductive Outcomes of Infertile Women Without Intrauterine Pathologies: A Systematic Review and Meta-Analysis

10.20944/preprints202009.0649.v1 ◽

2020 ◽

Author(s):

Soo Yeon Yang ◽

Seon Heui Lee ◽

Seung-Joo Chon

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Cochrane Library ◽

Reproductive Outcomes ◽

Vitro Fertilization ◽

Infertile Women ◽

Ovid Medline ◽

Meta Analyses ◽

The Cochrane Library

(1) Background: The aim of this work was to systematically review existing studies on whether hysteroscopy improves the reproductive outcomes of women with infertility even in the absence of intrauterine pathologies when compared to women who did not receive a hysteroscopy. (2) Methods: We established the Participant-Intervention-Comparison-Outcome strategy and used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement to conduct a systematic review of 11 studies which were retrieved from 3 electronic databases: Ovid-Medline, Ovid-Embase, and the Cochrane Library. Two independent investigators extracted the data from the included studies and used the Cochrane risk-of-bias tool to assess their quality. (3) Results: The primary outcome measures were the clinical pregnancy rates (CPRs) and live birth rates (LBRs) in the in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Hysteroscopy in infertile women without intrauterine pathologies showed higher CPRs and LBRs than those in the same population who did not receive hysteroscopy in cases of recurrent implantation failure and IVF (odds ratio: 1.79 and 1.46, 95% confidence interval: 1.46-2.30 and 1.08-1.97 for CPR and LBR, respectively); however, the degree of significance was not as high for LBR. (4) Conclusions: Hysteroscopy before IVF/ICSI in infertile women without intrauterine pathologies may potentially be effective in improving the CPRs and LBRs in patients with RIF. Robust and high-quality randomized trials are warranted to confirm this finding.

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The Association between Season and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-1020061/v1 ◽

2021 ◽

Author(s):

Lingyun Liao ◽

Xiaohong Wei ◽

Min Liu ◽

Yijie Gao ◽

Yangxue Yin ◽

...

Keyword(s):

Systematic Review ◽

Quantitative Analysis ◽

Random Effects ◽

Web Of Science ◽

Meta Analysis ◽

Cochrane Library ◽

Random Effects Model ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

The Cochrane Library

Abstract Background: There is increasing and inconsistent evidence of a relationship between hypertensive disorders of pregnancy (HDP) and season of delivery or conception.Methods: Four databases, the Cochrane Library, PubMed, EMBASE and Web of Science, were searched until September 29th, 2021. Two authors extracted data independently. A random effects model and the Mantel-Haenszel method were used to calculate pooled ORs and 95% CIs.Results: Twenty articles were included in the systematic review, and 11 articles were included in the meta-analysis. The quantitative analysis of the association between delivery season and HDP showed that the odds of HDP was higher in women who deliver in winter than in those who delivered in summer (OR=1.18, 95% CI 1.02-1.38, p < 0.001) and all other seasons (OR = 1.17, 95% CI 1.03-1.34, p <0.001). In the qualitative analysis of the association between conception season and HDP, 4 of 7 studies suggested that women who conceived in summer had a higher risk of HDP than those who conceived in other seasons.Conclusions: Based on the evidence to date, we found weakly positive relationships between HDP and summer conception and winter delivery.

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Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis

Rheumatology ◽

10.1093/rheumatology/kez030 ◽

2019 ◽

Vol 58 (10) ◽

pp. 1839-1849 ◽

Cited By ~ 11

Author(s):

Martijn J H Doeleman ◽

Erik M van Maarseveen ◽

Joost F Swart

Keyword(s):

Systematic Review ◽

Treatment Failure ◽

Antibody Formation ◽

Meta Analysis ◽

Biologic Agents ◽

Cochrane Library ◽

Hypersensitivity Reactions ◽

Eligibility Criteria ◽

Paediatric Patients ◽

Meta Analyses

Abstract Objective The clinical impact of anti-drug antibodies (ADAbs) in paediatric patients with JIA remains unknown. This systematic review and meta-analysis aimed to summarize the prevalence of ADAbs in JIA studies; investigate the effect of ADAbs on treatment efficacy and adverse events; and explore the effect of immunosuppressive therapy on antibody formation. Methods PubMed, Embase and the Cochrane Library were systematically searched to identify relevant clinical trials and observational studies that reported prevalence of ADAbs. Studies were systematically reviewed in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses and appropriate proportional and pairwise meta-analyses were performed. Results A total of 5183 references were screened; 28 articles, involving 26 studies and 2354 JIA patients, met eligibility criteria. Prevalence of ADAbs ranged from 0% to 82% across nine biologic agents. Overall pooled prevalence of ADAbs was 16.9% (95% CI, 9.5, 25.9). Qualitative analysis of included studies indicated that antibodies to infliximab, adalimumab, anakinra and tocilizumab were associated with treatment failure and/or hypersensitivity reactions. Concomitant MTX uniformly reduced the risk of antibody formation during adalimumab treatment (risk ratio 0.33; 95% CI 0.21, 0.52). Conclusion The association of ADAbs with treatment failure and hypersensitivity reactions indicates their clinical relevance in paediatric patients with JIA. Based on our findings, we recommend a preliminary course of action regarding immunogenicity of biologic agents in patients with JIA. Further strategies to predict, prevent, detect and manage immunogenicity could optimize treatment outcomes and personalize treatment with biologic therapies.

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Clinician Barriers and Facilitators to Routine HIV Testing: A Systematic Review of the Literature

Journal of the International Association of Providers of AIDS Care (JIAPAC) ◽

10.1177/2325958220936014 ◽

2020 ◽

Vol 19 ◽

pp. 232595822093601 ◽

Cited By ~ 1

Author(s):

Ann Dalton Bagchi ◽

Tracy Davis

Keyword(s):

Systematic Review ◽

Hiv Testing ◽

Data Extraction ◽

Meta Analysis ◽

Cochrane Library ◽

Eligibility Criteria ◽

Data Synthesis ◽

Routine Hiv Screening ◽

Routine Hiv Testing ◽

The Cochrane Library

Background: Routine HIV screening rates are suboptimal. Objectives: This systematic review identified barriers to/facilitators of routine HIV testing, categorized them using the socioecological model (SEM), and provided recommendations for interventions to increase screening. Data Sources: Included articles were indexed in PubMed, EBSCO CINAHL, Scopus, Web of Science, and the Cochrane Library between 2006 and October 2018. Eligibility Criteria: Included studies were published in English or Spanish and directly assessed providers’ barriers/facilitators to routine screening. Data Extraction: We used a standardized Excel template to extract barriers/facilitators and identify levels in the SEM. Data Synthesis: Intrapersonal factors predominated as barriers, while facilitators were directed at the institutional level. Limitations: Policy barriers are not universal across countries. Meta-analysis was not possible. We could not quantify frequency of any given barrier/facilitator. Conclusions: Increasing reimbursement and adding screening as a quality measure may incentivize HIV testing; however, many interventions would require little resource investment.

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Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

10.21203/rs.2.17842/v1 ◽

2019 ◽

Author(s):

Xuefeng Ma ◽

Shousheng Liu ◽

Jie Zhang ◽

Mengzhen Dong ◽

Yifen Wang ◽

...

Keyword(s):

Systematic Review ◽

Subgroup Analysis ◽

Diagnostic Method ◽

Case Reports ◽

Meta Analysis ◽

Cochrane Library ◽

Random Effects Model ◽

Hepatic Inflammation ◽

Normal Alt ◽

The Cochrane Library

Abstract Background ALT value is often used to reflect hepatic inflammation and injury in NAFLD patients, but many studies suggested that ALT values are normal in many NAFLD patients. The aim of this study was to identify the summarized proportion of NAFLD patients with normal ALT value in the overall NAFLD patients.Methods Electronic databases PubMed, EMBASE, Ovid, and the Cochrane Library were searched for potential studies published from January 1, 2000, to September 30, 2019. We included studies that have reported the number of NAFLD or NASH patients with normal and abnormal ALT to allow our calculation. Abstracts, reviews, case reports, and letters were excluded.Results A total of 11 studies with 4084 patients were included for calculating the summarized proportion of NAFLD patients with normal ALT in overall NAFLD patients. As the results shown, the summarized proportion of NAFLD patients with normal ALT value in overall NAFLD patients was 25% (95%CI: 20% - 31%) according to the calculation by random-effects model. The summarized proportion of NASH patients with normal ALT value in overall NASH patients was 19% (95%CI: 13% - 27%). Subgroup analysis include region, type of study, diagnostic method, and group size were conducted to investigate the resource of heterogeneity in the summarized proportion of NAFLD and NASH patients with normal ALT value.Conclusions 25% NAFLD patients and 19% NASH patients possess the normal ALT value in the clinical manifestation. The value of ALT in the clinical diagnosis of NAFLD and NASH remains need be further testified.

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Risk of atrial fibrillation in athletes: a systematic review and meta-analysis

British Journal of Sports Medicine ◽

10.1136/bjsports-2021-103994 ◽

2021 ◽

pp. bjsports-2021-103994

Author(s):

William Newman ◽

Gemma Parry-Williams ◽

Jonathan Wiles ◽

Jamie Edwards ◽

Sabina Hulbert ◽

...

Keyword(s):

Atrial Fibrillation ◽

Systematic Review ◽

Meta Analysis ◽

A Priori ◽

Cochrane Library ◽

Eligibility Criteria ◽

Physically Active ◽

Endurance Sport ◽

Meta Regression ◽

The Cochrane Library

ObjectiveA systematic review, meta-analysis and meta-regression were performed on selected studies to investigate the incidence of atrial fibrillation (AF) among athletes compared with non-athlete controls.DesignMeta-analysis with heterogeneity analysis and subsequent meta-regression to model covariates were performed. The mode of exercise (endurance and mixed sports) and age were the a priori determined covariates.Data sourcesPubMed, MEDLINE, Science Direct, SPORTDiscus and the Cochrane library were searched.Eligibility criteriaResearch articles published after 1990 and before 2 December 2020 were included if they reported the number of AF cases in athletes with non-athlete (physically active or inactive) control groups, were case–control or cohort studies and if data allowed calculation of OR.ResultsThe risk of developing AF was significantly higher in athletes than in non-athlete controls (OR: 2.46; 95% CI 1.73 to 3.51; p<0.001, Z=4.97). Mode of exercise and risk of AF were moderately correlated (B=0.1259, p=0.0193), with mixed sport conferring a greater risk of AF than endurance sport (B=−0.5476, p=0.0204). Younger (<55 years) athletes were significantly more likely to develop AF compared with older (≥55 years) athletes (B=−0.02293, p<0.001).ConclusionAthletes have a significantly greater likelihood of developing AF compared with non-athlete controls, with those participating in mixed sport and younger athletes at the greatest risk. Future studies of AF prevalence in athletes according to specific exercise dose parameters, including training and competition history, may aid further in delineating those at risk.

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The risk of cardiovascular disease in women after miscarriage, stillbirth, and therapeutic abortion: a protocol for a systematic review and meta-analysis

Systematic Reviews ◽

10.1186/s13643-020-01444-0 ◽

2020 ◽

Vol 9 (1) ◽

Author(s):

Charlotte Muehlschlegel ◽

Harry Kyriacou ◽

Abdulrahman Al-Mohammad ◽

Lowri A. Foster-Davies ◽

Fiona Simmons-Jones ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Pregnancy Loss ◽

Cardiovascular Health ◽

Meta Analysis ◽

Subsequent Development ◽

Cochrane Library ◽

Therapeutic Abortion ◽

Cardiovascular Disease In Women ◽

Meta Analyses

Abstract Background Cardiovascular disease (CVD) is the leading cause of death in women, responsible for approximately a third of all female deaths. Pregnancy complications are known to be associated with a greater risk of incident CVD in mothers. However, the relationships between pregnancy loss due to miscarriage, stillbirth, or therapeutic abortion, and future maternal cardiovascular health are under-researched. This study seeks to provide an up-to-date systematic review and meta-analysis of the relationship between these three forms of pregnancy loss and the subsequent development of CVD. Methods This systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analysis checklist (PRISMA) and the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) Checklist. A systematic search will be undertaken using publications identified in MEDLINE (PubMed), Scopus, Web of Knowledge, the CINAHL Nursing Database, and the Cochrane Library. The eligibility of each publication will be determined by predefined selection criteria. The quality of the included studies will be rated using the Newcastle-Ottawa Scale. Pooled measures of association will be computed using random-effects model meta-analyses. Between-study heterogeneity will be assessed using the I2 statistic and the Cochrane χ2 statistic. Small study effects will be evaluated for meta-analyses with sufficient studies through the use of funnel plots and Egger’s test. Discussion The results of this systematic review will discuss the long-term risks of multiple types of cardiovascular disease in women who have experienced miscarriage, stillbirth, and/or therapeutic abortion. It will contribute to the growing field of cardio-obstetrics as the first to consider the full breadth of literature regarding the association between all forms of pregnancy loss and future maternal cardiovascular disease. Systematic review registration PROSPERO registration number [CRD42020167587]

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Influence of CYP2C9 Genetic Polymorphisms on the Pharmacokinetics of Losartan and Its Active Metabolite E-3174: A Systematic Review and Meta-Analysis

Journal of Personalized Medicine ◽

10.3390/jpm11070617 ◽

2021 ◽

Vol 11 (7) ◽

pp. 617

Author(s):

Yoon-A Park ◽

Yu-bin Song ◽

Jeong Yee ◽

Ha-Young Yoon ◽

Hye-Sun Gwak

Keyword(s):

Systematic Review ◽

Genetic Polymorphisms ◽

Active Metabolite ◽

Meta Analysis ◽

Area Under The Curve ◽

Cochrane Library ◽

Lower Maximum ◽

Meta Analyses ◽

The Cochrane Library ◽

Review Manager

This study aimed to investigate the influence of CYP2C9 genetic polymorphisms on the pharmacokinetics of losartan and its active metabolite, E-3174, through a systematic review and meta-analysis. Eight studies published before March 2021 were included in this study. We used PubMed, the Cochrane Library, EMBASE, and Web of Science, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The data analysis was conducted through Review Manager (RevMan), version 5.3, and R software. We found that healthy volunteers with CYP2C9*2 or *3 carriers had higher area under the curve (AUC0-∞) of losartan (mean difference (MD) 0.17 μg·h/mL; 95% confidence intervals (CI): 0.04, 0.29) and lower AUC0-∞ of E-3174 (MD −0.35 μg·h/mL; 95% CI: −0.62, −0.08) than those with CYP2C9*1/*1. Subjects with CYP2C9*2 or *3 carriers showed lower maximum concentration (Cmax) of E-3174 than those with CYP2C9*1/*1 (MD −0.13 μg/mL; 95% CI: −0.17, −0.09). For half-life, subjects with CYP2C9*2 or *3 carriers had longer half-lives of losartan and E-3174 than those with CYP2C9*1/*1 (MD 0.47 h; 95% CI: 0.32, 0.61 and MD 0.68 h; 95% CI: 0.44, 0.92, respectively). This meta-analysis suggests that the pharmacokinetics of losartan and E-3174 are associated with the CYP2C9 polymorphisms

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Laser Influence on Dental Sensitivity Compared to Other Light Sources Used During In-office Dental Bleaching: Systematic Review and Meta-analysis

Operative Dentistry ◽

10.2341/19-064-l ◽

2020 ◽

Vol 45 (6) ◽

pp. 589-597

Author(s):

BGS Casado ◽

EP Pellizzer ◽

JR Souto Maior ◽

CAA Lemos ◽

BCE Vasconcelos ◽

...

Keyword(s):

Randomized Clinical Trials ◽

Color Change ◽

Meta Analysis ◽

Present Review ◽

Cochrane Library ◽

Light Sources ◽

Eligibility Criteria ◽

Tooth Color ◽

Significant Difference ◽

Meta Analyses

Clinical Relevance The use of laser light during bleaching will not reduce the incidence or severity of sensitivity and will not increase the degree of color change compared with nonlaser light sources. SUMMARY Objective: To evaluate whether the use of laser during in-office bleaching promotes a reduction in dental sensitivity after bleaching compared with other light sources. Methods: The present review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and is registered with PROSPERO (CDR42018096591). Searches were conducted in the PubMed/Medline, Web of Science, and Cochrane Library databases for relevant articles published up to August 2018. Only randomized clinical trials among adults that compared the use of laser during in-office whitening and other light sources were considered eligible. Results: After analysis of the texts retrieved during the database search, six articles met the eligibility criteria and were selected for the present review. For the outcome dental sensitivity, no significant difference was found favoring any type of light either for intensity (mean difference [MD]: −1.60; confidence interval [CI]: −3.42 to 0.22; p=0.09) or incidence (MD: 1.00; CI: 0.755 to 1.33; p=1.00). Regarding change in tooth color, no significant differences were found between the use of the laser and other light sources (MD: −2.22; CI: −6.36 to 1.93; p=0.29). Conclusions: Within the limitations of the present study, laser exerts no influence on tooth sensitivity compared with other light sources when used during in-office bleaching. The included studies demonstrated that laser use during in-office bleaching may have no influence on tooth color change.

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