scholarly journals New reference intervals for endocrinological biomarkers in pediatric patients: what can we learn from the LIFE child study?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Juergen Kratzsch ◽  
Mandy Vogel ◽  
Tanja Poulain ◽  
Wieland Kiess
Keyword(s):  
Weight Status ◽  
Pediatric Patients ◽  
Reference Intervals ◽  
Specific Reference ◽  
Healthy Children ◽  
Free Triiodothyronine ◽  
Age And Gender ◽  
Calciotropic Hormones ◽  
And Gender

Abstract Objectives We established reference intervals for serum concentrations of hormones from healthy pediatric subjects and investigated their associations with gender, body mass index (BMI), puberty and oral contraceptives (oC). Methods We calculated reference intervals for the thyroid parameters thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and calcitonin (Ct); the bone markers osteocalcin, procolagen type 1 N-propeptide, and carboxy-terminal cross-linking telopeptide of type 1 collagen; the calciotropic hormones 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone and the steroids cortisol, progesterone, 17-hydroxyprogesterone, androstenedione, testosterone, estradiol, dehydroepiandrosterone sulfate and aldosterone. Up to 10,002 blood serum samples from 3,229 healthy children and adolescents (age interval: 3 months to 20 years) were measured. To investigate the associations between the hormone levels with age, sex, weight status and the role of puberty-based changes, the measurement and BMI values were transformed into standard deviation scores. Results Most of the hormones depended on age- and gender. Puberty was linked to a, in part, temporary decrease in TSH, FT3 (for females), FT4, Ct, cortisol (for girls) and aldosterone (for boys) and peak in the bone marker and calciotropic hormones (excluding 25(OH)D) and nearly all remaining steroids. BMI had effects on the thyroid, bone, and calciotropic parameters, whereas oC led to increased cortisol, suppressed progesterone and estradiol values. Conclusions Age- and gender-specific reference intervals are essential for the interpretation of pediatric patients’ hormone measurements. Influencing factors as puberty, BMI, or oC should be taken into consideration for diagnosis and treatment monitoring.

Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument

2012 ◽  
Vol 50 (5) ◽  
Author(s):  
Peter Ridefelt ◽  
Mattias Aldrimer ◽  
Per-Olof Rödöö ◽  
Frank Niklasson ◽  
Leif Jansson ◽  
...  
Keyword(s):  
Clinical Chemistry ◽  
Population Based ◽  
Reference Intervals ◽  
Healthy Children ◽  
Age And Gender ◽  
Sodium Potassium ◽  
Daycare Centers ◽  
And Gender ◽  
Gender Specific ◽  
Abbott Architect

AbstractReference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete.Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid.Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles.The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.

Age- and Gender-Specific Reference Intervals of Carbohydrate Antigen 50

2018 ◽  
Vol 64 (04/2018) ◽  
Author(s):  
Shu-Fen Wang ◽  
Lan-Fu Li ◽  
Chun-Mei Ding ◽  
Zhi-De Hu
Keyword(s):  
Carbohydrate Antigen ◽  
Reference Intervals ◽  
Specific Reference ◽  
Age And Gender ◽  
And Gender ◽  
Gender Specific

scholarly journals Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation

1996 ◽  
Vol 42 (4) ◽  
pp. 630-636 ◽  
Author(s):  
K Rasmussen ◽  
J Møller ◽  
M Lyngbak ◽  
A M Pedersen ◽  
L Dybkjaer
Keyword(s):  
Folic Acid ◽  
Methylmalonic Acid ◽  
Reference Intervals ◽  
Vitamin Supplementation ◽  
Specific Reference ◽  
Age And Gender ◽  
Before And After ◽  
Total Homocysteine ◽  
And Gender ◽  
Gender Specific

Abstract We present reference intervals for total homocysteine and methylmalonic acid in plasma based on samples from 126 women (ages 20-85 years, median 49 years) and 109 men (ages 20-84 years, median 50 years). The central 0.95 interval for methylmalonic acid was 0.08-0.28 micromol/L. Supplementation with cyanocobalamin caused a nonsignificant decrease in methylmalonic acid. Supplementation with folic acid caused a decrease in homocysteine concentrations, with data analysis identifying two significantly different clusters: 182 subjects with the lowest initial concentrations (7.76 +/- 1.54 micromol/L, mean +/- SD) and the smallest decrease (1.26 +/- 0.96 micromol/L), and 53 subjects with the highest initial concentrations (12.33 +/- 2.04 micromol/L) and greatest decrease (4.14 +/- 1.32 micromol/L). We argue in favor of the age- and gender-specific central 0.95 intervals obtained for the 182 subjects before being supplemented with folic acid: 4.6-8.1 micromol/L for subjects at <30 years; 4.5-7.9 micromol/L for women, ages 30-59 years; 6.3-11.2 micromol/L for men, ages 30-59 years; and 5.8-11.9 micromol/L for subjects at >60 years.

Age- and gender-specific reference intervals for serum lipid levels (measured with an Advia 1650 analyzer) in school children

2011 ◽  
Vol 53 (6) ◽  
pp. 814-819 ◽  
Author(s):  
Waleed Tamimi ◽  
Hani Tamim ◽  
Naila Felimban ◽  
Angham AlMutair ◽  
Yasmin Altwaijri ◽  
...  
Keyword(s):  
School Children ◽  
Serum Lipid ◽  
Reference Intervals ◽  
Specific Reference ◽  
Lipid Levels ◽  
Age And Gender ◽  
Serum Lipid Levels ◽  
And Gender ◽  
Gender Specific

Age- and gender-specific reference intervals for serum glucose levels in school children measured by an Advia 1650 chemistry analyzer

2016 ◽  
Vol 02 (02) ◽  
pp. 101-108 ◽  
Author(s):  
Hani Tamim ◽  
Naila Felimban ◽  
Angham AlMutair ◽  
Yasmin Altwaijri ◽  
Ibrahim AlAlwan ◽  
...  
Keyword(s):  
School Children ◽  
Reference Intervals ◽  
Serum Glucose ◽  
Specific Reference ◽  
Age And Gender ◽  
Glucose Levels ◽  
And Gender ◽  
Gender Specific

scholarly journals Investigation of TAGAP gene polymorphism (rs1738074) in Turkish pediatric celiac patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Melek Pehlivan ◽  
Tülay K. Ayna ◽  
Maşallah Baran ◽  
Mustafa Soyöz ◽  
Aslı Ö. Koçyiğit ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Disease Risk ◽  
Polymerase Chain Reaction Method ◽  
Control Group ◽  
Healthy Children ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Allele Specific ◽  
And Control

Abstract Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group.

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