scholarly journals Burkitt-like lymphoma with 11q aberration in a patient with AIDS and a patient without AIDS: Two cases reports and literature review

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 428-434
Author(s):  
Jing Wang ◽  
Li Ma ◽  
Jianghong Guo ◽  
Yanfeng Xi ◽  
Enwei Xu
Keyword(s):  
Partial Response ◽  
Literature Review ◽  
Lymph Nodes ◽  
Burkitt Lymphoma ◽  
Complete Response ◽  
Clinicopathological Features ◽  
Cervical Lymph Nodes ◽  
Cervical Mass ◽  
The Right

Abstract Objective The aim of this study is to evaluate the clinicopathological features and the treatment of the Burkitt-like lymphoma with 11q aberration. Methods We reported two patients with Burkitt-like lymphoma with 11q aberration: a 56-year-old man with AIDS (case 1) and a 37-year-old woman (case 2) without AIDS. The biopsy of cervical lymph nodes showed Burkitt-like morphologic and immunophenotypic features. But both of them lack MYC rearrangement and carry an 11q-arm aberration with proximal gains and/or telomeric losses. The diagnosis was confirmed by pathological morphology, immunohistochemistry, and fluorescence in situ hybridization. Result After a cycle of R-CTOEP (rituximab, cyclophosphamide, pirarubicin, vincristine, and prednisone) chemotherapy, case 1 refused to chemotherapy and radiotherapy and was followed up for 34 months without recurrence and new focus. Case 2 received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) for two cycles and achieved PR (partial response). Then, the patient in case 2 received EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) for three cycles, and the right cervical mass disappeared. She achieved complete response and was followed up for 16 months without recurrence and new focus. Conclusion Burkitt-like lymphoma with 11q abnormalities resembles Burkitt lymphoma morphologically but lacks MYC rearrangement and may have a better prognosis.

scholarly journals Pathological Complete Response After Immune-Checkpoint Inhibitor Followed by Salvage Surgery for Clinical Stage IV Pulmonary Adenocarcinoma with Continuous Low Neutrophil-to-Lymphocyte Ratio: A Case Report

2020 ◽  
Author(s):  
Mitsunori Higuchi ◽  
Takahiro Kawamata ◽  
Ikuro Oshibe ◽  
Nobutoshi Soeta ◽  
Takuro Saito ◽  
...  
Keyword(s):  
T Cells ◽  
Partial Response ◽  
Lymph Nodes ◽  
Pathological Complete Response ◽  
Clinical Stage ◽  
Lower Lobe ◽  
Stage Iv ◽  
Complete Response ◽  
Mediastinal Lymph Nodes ◽  
The Right

Abstract Background: Immune-checkpoint inhibitors (ICIs) play a crucial role in the treatment of advanced non-small cell lung cancer (NSCLC), however, most patients fail this treatment after a limited period. We here report a patient with a pathological complete response (CR) after treatment with ICI for stage IV pulmonary adenocarcinoma.Case presentation: A 73-year-old man was referred to our hospital because of hoarseness. A roentgenogram and chest CT scan revealed a huge (78-mm diameter) pulmonary tumor in the right upper lobe and a tumor with cavitation in the left lower lobe. A CT scan also showed enlarged upper mediastinal lymph nodes. Transbronchial lung biopsy (TBLB) of the tumors showed adenocarcinomas in both. The tumor in the right upper lobe was considered to be the primary with mediastinal lymph nodes metastasis and that in the left lower lobe a pulmonary metastasis. The disease was determined to be cT4N2M1a stage IVA after whole body evaluation . He was treated with first line chemotherapy comprising cisplatin, pemetrexed, and bevacizumab for six cycles, achieving a partial response. However, 6 months after initial treatment, the primary and metastatic tumors enlarged and he was treated with second line anti-PD-1 therapy for 7 months with a partial response. 18-fluorodeoxyglucose positron emission tomography (FDG-PET) revealed weak accumulation of FDG in the primary tumor only with no accumulation in the left pulmonary metastasis or mediastinal lymph nodes, despite the lymph nodes still being enlarged. He was diagnosed as having ycT1bN0M0 stage IA2 disease and underwent right upper lobectomy. Postoperative pathological findings revealed that cancer tissues had been replaced by scar tissue and that CD4 positive T cells, rather than CD8 positive T cells, were predominant. It was also noted that he had a lower neutrophil-to-lymphocyte ratio (NLR) during immunotherapy than before immunotherapy and after surgery. He was diagnosed to be ypT0N0M0 stage 0 (Ef.3). His postoperative course was uneventful and he remained well for twelve months after surgery with no further treatment.Conclusions: Neoadjuvant chemotherapy with ICIs for advanced NSCLC may be a promising modality, even for clinical stage IV disease, in the near future. Furthermore, NLR during immunotherapy may be a promising biomarker of ICIs treatment.

Ocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes

2019 ◽  
pp. 112067211987007
Author(s):  
Jayati Sarangi ◽  
Aanchal Kakkar ◽  
Diya Roy ◽  
Rishikesh Thakur ◽  
Chirom Amit Singh ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Histopathological Examination ◽  
Previous History ◽  
Rare Presentation ◽  
Cervical Lymph Nodes ◽  
Extranodal Extension ◽  
Positron Emission ◽  
Parotid Neoplasm ◽  
History Of ◽  
The Right

Purpose: To describe a rare presentation of a case of intraocular non-teratoid medulloepithelioma with teratoid metastases in ipsilateral intraparotid lymph nodes. Case description: A 9-year-old male child with previous history of ciliary body non-teratoid medulloepithelioma presented with a swelling in the right pre-auricular region for 1 month. Magnetic resonance imaging and positron emission tomography–computed tomography showed a right intraparotid mass with enlarged ipsilateral cervical lymph nodes. A core biopsy was taken from the lesion, which on microscopy showed a tumor composed of small round cells arranged in cords, tubules lined by multilayered cells, and in cribriform pattern. These cells were embedded in a hypocellular, loose myxoid matrix. Based on the histopathological characteristics and previous history, a diagnosis of medulloepithelioma metastastic to ipsilateral parotid gland was made. The patient underwent right total conservative parotidectomy and bilateral neck dissection. Histopathological examination revealed metastatic medulloepithelioma in five out of eight intraparotid lymph nodes, with extranodal extension into the adjacent parotid parenchyma. Foci of hyaline cartilage were identified within the tumor, leading to a diagnosis of metastatic teratoid medulloepithelioma. Conclusion: Intraparotid lymph node metastases from intraocular medulloepithelioma is a rare possibility and we recommend that the parotid should be evaluated in cases of intraocular medulloepithelioma at initial presentation as well as during the follow-up period. Also, metastasis should be considered in all pediatric patients with solitary mass lesions showing unconventional histology for a primary parotid neoplasm.

Extracranial Metastases of Oligodendroglioma

Neurosurgery ◽  
1981 ◽  
Vol 8 (3) ◽  
pp. 391-396 ◽  
Author(s):  
Nelson G. Ordóñez ◽  
Alberto G. Ayala ◽  
Milam E. Leavens
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lymph Nodes ◽  
Masseter Muscle ◽  
Lumbar Vertebrae ◽  
Cervical Lymph Nodes ◽  
Extraneural Metastases ◽  
The Central Nervous System ◽  
The Right ◽  
Extracranial Metastases

Abstract The case of a 33-year-old woman with oligodendroglioma with extraneural metastases involving the masseter muscle, the cervical lymph nodes, the lumbar vertebrae, and the right iliac bone is described. Oligodendroglioma with metastases outside the central nervous system is extremely rare, and only a very few cases have been reported.

scholarly journals Postoperative recurrence with right cervical lymph node metastasis in hepatocellular carcinoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kiyonori Tanoue ◽  
Yota Kawasaki ◽  
Yoichi Yamasaki ◽  
Satoshi Iino ◽  
Masahiko Sakoda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Metastatic Lymph Node ◽  
Cervical Region ◽  
Cervical Lymph Nodes ◽  
Lymph Node Recurrence ◽  
Metastatic Lymph ◽  
The Right

Abstract Background Hepatocellular carcinoma (HCC) patients with metastases to the cervical lymph nodes are extremely rare, and its clinical course is characterized by rapidly progressive disease. Hence, there have been no reports of metastatic cervical lymph node recurrence indicated after a long postoperative surveillance period. Case presentation The patient was a 63-year-old male who underwent right hepatectomy for HCC of the right upper lobe. Three years after resection, metastatic lymph node recurrence was detected in the subdiaphragm, superior mediastinum, and right cervical lymph nodes. The patient underwent excisional biopsy of the cervical lymph node, followed by molecular-targeted therapy and radiation therapy. Lenvatinib reduced the size of all metastatic lymph nodes and the patient survived for a relatively long period of 43 months after the recurrence was detected. Conclusions After resection of HCC in the right upper lobe, there is the possibility of metastatic lymph node recurrence in unusual sites, including the cervical region, and lenvatinib may be effective in those recurrences.

Migration of Teflon after Vocal Cord Injection

1987 ◽  
Vol 96 (1) ◽  
pp. 63-66 ◽  
Author(s):  
John C. Ellis ◽  
Thomas V. Mccaffrey ◽  
Lawrence W. Desanto ◽  
Herbert V. Reiman
Keyword(s):  
Cerebral Cortex ◽  
Lymph Nodes ◽  
Vocal Cord ◽  
Vocal Fold ◽  
Mediastinal Lymph Nodes ◽  
Polarizing Microscopy ◽  
Cervical Lymph Nodes ◽  
Upper Cervical ◽  
The Right

Each of eight mongrel dogs received a 0.5 ml injection of polytef paste into the right vocal fold. These dogs were killed at 1 week, 1 month, 3 months, and 6 months after injection, and a number of organs were examined. Polarizing microscopy was used to examine the upper cervical lymph nodes, lower cervical lymph nodes, mediastinal lymph nodes, abdominal lymph nodes, cerebral cortex, brainstem, lung, liver, spleen, and kidney to determine if migration of polytef had occurred. Examination of these organs revealed that there was consistent migration of polytef particles into the cervical lymph nodes, with the highest incidence occurring in upper cervical lymph nodes on the side of injection. There was no evidence of migration of polytef particles to distant sites. The study shows that polytef particles may migrate to cervical lymph nodes after injection into the larynx; however, there is no evidence of distant migration.

scholarly journals Thyroid metastases from breast carcinoma: case report and review of literature

2020 ◽  
Author(s):  
Yichao Wang ◽  
Shengliang Zhou ◽  
Boyang Yu ◽  
Ping Zhou ◽  
Zhihui Li ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Lymph Nodes ◽  
Distant Metastases ◽  
Needle Aspiration ◽  
Thyroid Lesion ◽  
Cervical Lymph Nodes ◽  
Left Chest ◽  
History Of ◽  
Thyroid Metastases ◽  
The Right

Abstract Rationale: The thyroid is a rare site for distant metastases from breast carcinoma. The incidence of thyroid metastases in fine needle aspiration biopsy (FNAB) was less than 0.2%.Patient concerns: We report a case of 54-year-old woman with a history of breast carcinoma presented with diffuse scattered microcalcifications in thyroid and enlarged bilateral cervical lymph nodes detected on ultrasound (US). Physical examination of the patient revealed stiff and enlarged thyroid lobes.Diagnoses: FNAB and immunohistochemistry （IHC）of the thyroid lesion confirmed the thyroid metastases from breast cancer.Interventions and outcomes: Due to the comorbidities of breast carcinoma metastases to the right axillary, cervical lymph nodes and left chest wall, the patient received chemotherapy. After a follow-up of 10 months, the patient was alive without any new distant metastases.Lessons: Our case highlights that thyroid metastases should be considered in a patient combined with thyroid lesions and a history of breast carcinoma. IHC played an important role in differentiating thyroid metastases from primary thyroid cancer.

scholarly journals The use of the ultrasound for otorhinolaryngology, head and neck diseases (literature review)

2020 ◽  
pp. 92-100
Author(s):  
D. V. Trukhin ◽  
I. A. Kim ◽  
E. V. Nosulya ◽  
E. A. Zubareva ◽  
T. I. Garashchenko
Keyword(s):  
Literature Review ◽  
Lymph Nodes ◽  
High Sensitivity ◽  
Diagnostic Methods ◽  
Chronic Tonsillitis ◽  
Excision Biopsy ◽  
Malignant Neoplasms ◽  
Cervical Lymph Nodes ◽  
Systemic Complications ◽  
Ultrasound Diagnostics

Despite the fact that otorhinolaryngologists are already very busy finding a solution to the problem of chronic tonsillitis, it remains unresolved. The prevalence of chronic tonsillitis does not decrease, but rather increases. Diseases of the tonsils are characteristic primarily of the child and adult working population. Chronic tonsillitis attracts attention not only as an independent disease, but as a cause of frequent local and especially systemic complications, which number more than 100. All these facts speak about the unresolved and urgency of the problem of chronic tonsil disease. In the diagnosis of neck diseases, one of the most common methods is ultrasound. It has a number of significant advantages over other methods, such as high sensitivity and specificity, the ability to detect minor changes in the organs, non-invasiveness of the study, painlessness, accessibility, and the absence of ionizing radiation. The aim of the literature review is to identify, analyze, and systematize literature data on the application of the ultrasonic research method in neck organ pathology. Ultrasound diagnostics in the neck is widely used and is actively studied in acute inflammatory-purulent pathology (paratonsillar abscesses, phlegmon), in the pathology of the larynx and trachea, salivary and thyroid glands, as well as in the metastasis of malignant neoplasms to the lymph nodes. There are several methods for diagnosing lymph nodes, such as: puncture and excision biopsy, lymphography, scintigraphy, thermography and ultrasound ultrasound. Despite such a variety of diagnostic methods, ultrasound is the method of choice for imaging cervical lymph nodes. One of the most modern methods in ultrasound diagnostics is elastography. This method is most informative in cases when changes in tissues are small in size and cannot be detected using standard ultrasound modes.

scholarly journals Mengenal gambaran ultrasound lesi jinak, ganas dan metastasis pada nodus limfa leher menggunakan ultrasonografi

2020 ◽  
Vol 3 (3) ◽  
pp. 21
Author(s):  
Lusi Epsilawati ◽  
Hendra Polii ◽  
Erna Herawati
Keyword(s):  
Literature Review ◽  
Lymph Nodes ◽  
Ultrasound Imaging ◽  
Cervical Lymph Nodes ◽  
Imaging Characteristic ◽  
Pathological Conditions ◽  
Different Characteristics ◽  
Neck Lymph Nodes

Objectives: This study is aimed to review the ultrasound imaging (USG) of benign, malignant and metastases lesions in cervical lymph nodes. Literature Review: This article was written based on some scientific literatures in which will explain the interpretation technique and imaging characteristic to distinguish between benign, malignancies and metastases lesions in cervical lymph nodes through ultrasound imaging. There are many pathological conditions may occur in cervical lymph nodes that can be analyzed in ultrasound. The signs of benign, malignant and metastases lesions in cervical lymph nodes, all may have different characteristics. Those characteristics could help the practitioners and radiologists to distinguish the lesions based on several assessment categories. Hopefully, the reader of this article could understand the technique to distinguish benign, malignant and metastases lesions in neck lymph nodes in ultrasound. Conclusion: Ultrasonography is the most commonly used modality for lymph nodes examination, although the accuracy cannot be trusted or guaranteed 100% but this modality always be used and becoming one of all choices. Through the ultrasound, it could be concluded that some of the characteristics of the assessment can be a guide to distinguish benign, malignant and metastases lesions in cervical lymph nodes.

Aseptic Meningitis in the Decennium of Borrelia burgdorferi Infection (Lyme Disease)

PEDIATRICS ◽  
1991 ◽  
Vol 87 (2) ◽  
pp. 268-269
Author(s):  
CHRISTOPH AUFRICHT ◽  
WILLI TENNER ◽  
GEROLD STANEK
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Physical Examination ◽  
Lymph Nodes ◽  
Sore Throat ◽  
Aseptic Meningitis ◽  
Cervical Lymph Nodes ◽  
Nuchal Rigidity ◽  
History Of ◽  
The Right

To the Editor.— A 7-year-old boy with a 2-week history of fatigue, sore throat, and swelling of the right cheek was admitted to our hospital in May 1989. He had no history of intoxication, trauma, fever, or bite. He lived in Vienna and did not travel outside Austria.1 His mother was concerned about his irritability and emotional liability. Physical examination revealed mild hyperemia of his pharynx and ear drums. There were enlarged cervical lymph nodes and mild nuchal rigidity.

Sign in / Sign up

Export Citation Format

Share Document