scholarly journals Environmental safety during the administration of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)

2016 ◽  
Vol 1 (4) ◽  
pp. 203-208 ◽  
Author(s):  
Martin Graversen ◽  
Peter B. Pedersen ◽  
Michael B. Mortensen
Keyword(s):  
Inductively Coupled Plasma ◽  
Healthcare Workers ◽  
Particle Concentration ◽  
Environmental Safety ◽  
Airborne Particles ◽  
Safety Measures ◽  
Blood Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

AbstractBackground:Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative technique for intraperitoneal drug delivery. This study investigates the efficacy of the occupational health safety measures taken to prevent exposition of healthcare workers to the toxic chemotherapy aerosol.Methods:Air samples were taken at the working place of the surgeon and of the anesthetist during 2 PIPAC procedures and analyzed for content of platinum by inductively coupled plasma mass spectrometry (ICP-MS). Airborne particles were quantified in real time. Biological monitoring was performed in two surgeons after 50 PIPAC by examining blood samples for possible traces of platinum. Analysis was performed by an independent company.Results:Safety measures included tightly closed abdomen, operating room (OR), ventilation meeting requirements of ISO norm 14644–1 class 5, closed aerosol waste system and remote control of PIPAC administration. No traces of platinum were found in the air of the OR (detection limit of 0.0001 mg/filter). No specific rise in particle concentration was detected in the air during the PIPAC procedure, patient closure and removal of the sterile drapes. Blood samples of the surgeons showed no traces of platinum.Conclusions:After implementation of adequate safety measures, no signs of environmental contamination or biological exposure of the surgeons were detected during PIPAC.

scholarly journals A preliminary report on bioavailability of Ayurvedic Gold Bhasma with four different accompanying media [anupana]

2021 ◽  
Vol 12 (3) ◽  
pp. 033-044
Author(s):  
Trupti Patil ◽  
Asmita Wele ◽  
Sangram Patil
Keyword(s):  
Inductively Coupled Plasma ◽  
Black Pepper ◽  
Healthy Human ◽  
Blood Samples ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Comparative Bioavailability ◽  
Human Participants

Background: Gold bhasma [Swarnabhasma] is a ancient Ayurvedic medicine used for rejuvenation and longevity. This is a preliminary attempt to study the bioavailability of this medicine. Objectives: It was aimed to estimate comparative bioavailability of gold bhasma up to five hours after oral dose with four different anupana. Materials and methods: In this in vivo study, 30 healthy human participants were allocated randomly into five groups having six individuals each. Gold bhasma in 30 mg dose was administered orally with four different anupana viz honey [2.5 gm], black pepper-ghee combination [250 mg and 2.5 gm respectively], lactose [250 mg], glucose [250 mg], and plain to participants in each group. Blood samples were collected at 0, 1, 3 and 5 hours after dose. Gold levels in blood were assessed by inductively coupled plasma mass spectrometry [ICP-MS]. Results: Gold levels in all blood samples were in traces. Average Cmax was 0.002333 microgram of gold per liter and Tmax was at 3 hours for honey anupana, showing maximum Cmax among all groups. Conclusions: Preliminary results indicate that bioavailability of gold from gold bhasma may be less than 0.01 % upto first five hours. Gold bhasma mixed with honey resulted in attainment of maximum Cmax. It is evident that accompanying media [anupana] play an important role in absorption of gold bhasma.

scholarly journals DETECÇÃO E QUANTIFICAÇÃO DE NANOPARTÍCULAS DE PRATA POR SPICP-MS

Química Nova ◽  
2021 ◽  
Author(s):  
Fabio Bazilio ◽  
Cristiane Silva ◽  
Lísia Santos ◽  
Santos Vicentini ◽  
Silvana Jacob ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Silver Nanoparticles ◽  
Satisfactory Result ◽  
Inductively Coupled Plasma ◽  
Metallic Nanoparticles ◽  
Particle Concentration ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Detection And Quantification

DETECTION AND QUANTIFICATION OF SILVER NANOPARTICLES BY spICP-MS. The growing interest in nanotechnology has led to an increase in the production and application of nanoparticles worldwide. Due to the unique functional properties of nanoparticles, these materials are being used by many industries, including the agricultural and food sectors. Among the commercially available nanomaterials, it is possible to highlight those produced with silver nanoparticles. One of the most promising techniques for the analysis of metallic nanoparticles is the Inductively coupled plasma mass spectrometry (ICP-MS) performed in single particle mode (spICP-MS). However, the use of the technique in the detection and measurement of nanoparticles requires that the equipment be operated differently than when used to analyze dissolved metal solutions. Thus, this article presents the use of the spICP-MS technique for the measurement and quantification of nanoparticles, as well as their validation. The method proved to be adequate for the purpose, presenting a satisfactory result for the selectivity test and recovery of 83.7 (40 nm) and 77.6% (80 nm). The detection limits, determined for the most frequent size, dissolved silver concentration and particle concentration, were 17.5 nm, 0.736 ng mL-1,146 particles mL-1, respectively. Thus, the results obtained indicated the possibility of using the technique to determine the size and concentration of silver nanoparticles.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

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